Literature summary for 4.2.1.3 extracted from

Gupta, P.; Aggarwal, N.; Batra, P.; Mishra, S.; Chaudhuri, T.K.
Co-expression of chaperonin GroEL/GroES enhances in vivo folding of yeast mitochondrial aconitase and alters the growth characteristics of Escherichia coli (2006), Int. J. Biochem. Cell Biol., 38, 1975-1985.

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Application

Application	Comment	Organism
synthesis	overexpression of enzyme in Escherichia coli. Presence of co-expressed GroEL reduces the aconitase over-expression drastically, however, exogenous GroEL and GroES together compensate this reduction. For over-expressing cells, growth-rate decreases by 30% at 25°C, however, in presence of co-expressed GroEL and GroES the growth rate of aconitase producing cells is enhanced by 30% at 37°C	Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of enzyme in Escherichia coli. Presence of co-expressed GroEL reduces the aconitase over-expression drastically, however, exogenous GroEL and GroES together compensate this reduction. For over-expressing cells, growth-rate decreases by 30% at 25°C, however, in presence of co-expressed GroEL and GroES the growth rate of aconitase producing cells is enhanced by 30% at 37°C	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Saccharomyces cerevisiae	5739	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

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Release 2023.1 (January 2023)