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Literature summary for 4.2.1.3 extracted from

  • Scandroglio, F.; Tortora, V.; Radi, R.; Castro, L.
    Metabolic control analysis of mitochondrial aconitase: influence over respiration and mitochondrial superoxide and hydrogen peroxide production (2014), Free Radic. Res., 48, 684-693.
    View publication on PubMed
Search for more literature for 4.2.1.3

Inhibitors

Inhibitors Comment Organism Structure
Fluorocitrate
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain aconitase-specific activity increases by 42% at 2% O2 compared to 21% O2 Rattus norvegicus
-
heart aconitase-specific activity increases by 12% at 2% O2 compared to 21% O2 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cis-aconitate + H2O
-
 Rattus norvegicus isocitrate
-
 ?

Synonyms

Synonyms Comment Organism
aconitase
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.007
-
 pH 7.4, temperature not specified in the publication, tissue: brain Rattus norvegicus Fluorocitrate
0.012
-
 pH 7.4, temperature not specified in the publication, tissue: heart Rattus norvegicus Fluorocitrate
0.024
-
 pH 7.4, temperature not specified in the publication, tissue: kidney Rattus norvegicus Fluorocitrate
0.024
-
 pH 7.4, temperature not specified in the publication, tissue: liver Rattus norvegicus Fluorocitrate