Ligand cis-aconitate

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Basic Ligand Information

Molecular Structure
Picture of cis-aconitate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H6O6
cis-aconitate
GTZCVFVGUGFEME-IWQZZHSRSA-N
Synonyms:
cis-aconitic acid


Show all pahtways known for Show all BRENDA pathways known for cis-aconitate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cis-aconitate + H2O = isocitrate
show the reaction diagram
-
cis-aconitate = trans-aconitate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
citrate = cis-aconitate + H2O
show the reaction diagram
-
-
trans-Aconitate = cis-Aconitate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cis-aconitic acid + NADPH + ATP = ? + NADP+ + AMP + phosphate
show the reaction diagram
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S-adenosyl-L-methionine + cis-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate
show the reaction diagram
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S-adenosyl-L-methionine + cis-aconitate = S-adenosyl-L-homocysteine + (Z)-2-(methoxycarbonylmethyl)butenedioate
show the reaction diagram
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cis-aconitate + H2O = citrate
show the reaction diagram
-
cis-aconitate = ?
show the reaction diagram
-
cis-aconitate = trans-aconitate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
citrate = cis-aconitate + H2O
show the reaction diagram
-
-
citrate = cis-aconitate + H2O
show the reaction diagram
-
trans-Aconitate = cis-Aconitate
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
isozyme ICDH2, not isozyme ICDH1
-
activation
-
more than 2fold stimulation only for phlorizin activity
-
activates
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Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2-oxoglutarate dehydrogenase complex
-
22% inhibition at 50 mM
-
brain, not heart
-
50% inhibition of the hydrolase activity at 0.025 mM
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weak inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
4500
-
at pH 6.0 and 37°C

KM Value (22 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
74
-
-
2.45
-
pH 6.2, 37°C

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.1
-
brain PFK

References & Links

Links to other databases for cis-aconitate

ChEBI
PubChem
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PubChem