Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3',5'-cyclic nucleoside monophosphate phosphodiesterase
-
-
-
-
3',5'-cyclonucleotide phosphodiesterase
-
-
-
-
3',5'-nucleotide phosphodiesterase
-
-
-
-
3':5'-cyclic nucleotide 5'-nucleotidohydrolase
-
-
-
-
Ca2+/calmodulin-stimulated phosphodiesterase
-
-
cGMP-binding cGMP-specific phosphodiesterase
-
-
-
-
cyclic 3',5'-mononucleotide phosphodiesterase
-
-
-
-
cyclic 3',5'-nucleotide phosphodiesterase
-
-
-
-
cyclic 3',5'-phosphodiesterase
-
-
-
-
cyclic 3',5-nucleotide monophosphate phosphodiesterase
-
-
-
-
Cyclic GMP stimulated phosphodiesterase
-
-
-
-
cyclic nucleotide phosphodiesterase
-
-
-
-
cyclic nucleotide phosphodiesterase 10A
-
-
cyclic nucleotide phosphodiesterase 3B
-
-
High-affinity cAMP phosphodiesterase
-
-
-
-
Learning/ memory process protein
-
-
-
-
Low-affinity cAMP phosphodiesterase
-
-
-
-
nucleoside 3',5'-cyclic phosphate diesterase
-
-
-
-
nucleoside-3',5-monophosphate phosphodiesterase
-
-
-
-
phosphodiesterase 10A
-
-
phosphodiesterase, cyclic 3',5'-nucleotide
-
-
-
-
phosphodiesterase-10A
-
-
PDE10A
-
-
PDE10A
-
hydrolyses both 3',5'-cAMP and 3',5'-cGMP although with different kinetic parameters
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cervical spinal cord, expression of isoforms PDE2, PDE5, and PDE9 in all lamina, in ventral motor neurons and in ependymal cells lining the central canal. Study on the influence of enzyme activity on NO-stimulated cGMP levels
brenda
-
primary
brenda
-
-
brenda
-
PDE 1 vascular expression is increased in arteries from angiotensin II hypertensive rats
brenda
-
-
brenda
-
age-related increases in isoforms PDE11A4, PDE8A3, PDE8A4/5, and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents. Relative to young rats, the hippocampi of old rats demonstrate strikingly decreased phosphorylation of GluR1, CaMKIIalpha, and CaMKIIbeta, decreased expression of the transmembrane AMPA regulatory proteins gamma2 (a.k.a. stargazin) and gamma8, and increased trimethylation of H3K27. Expression of isoforms of PDE11A4, and PDE1C1 correlate with these functional endpoints in young but not old rats
brenda
-
in freshly isolated peritoneal exudate macrophage, isoforms PDE1, PDE2, PDE3, PDE10, PDE11 are expressed. After 24h of cultures, levels of isoforms PDE2, PDE3, and PDE11 are markedly decreased. Their expression and activity are recovered after treatment of cultured cells with lipopolysaccharide
brenda
-
splice variant PDE1A is distributed in outer retina, especially in the outer segments of photoreceptors. Variant PDE1B is uniformly distributed across the retina, PDE1C is confined mainly to the inner retina with precise localization to the inner nuclear layer
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
PDE1
brenda
-
PDE10
brenda
-
PDE11
brenda
-
PDE2
brenda
-
PDE3
brenda
-
-
brenda
-
striatum and olfactory tubercle
brenda
-
PDE10A is strongly expressed in the brain, highly expressed in striatal complex including caudate putamen, nucleus accumbens, and olfacory tubercle
brenda
-
isoforms PDE1B, PDE1C, PDE2A, PDE10A, and PDE11A show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE1A, PDE3A, PDE3B, PDE4B, and PDE9A does not change with age. Age-related increases in PDE11A4, and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents, as are age-related increases in PDE8A3 protein expression in the striatum
brenda
-
-
brenda
-
dorsal striatum
brenda
-
PDE10A is highly expressed in the medium spiny neurons of the striatum
brenda
-
olfactory sensory
brenda
-
PDE10A is highly expressed in striatal medium-sized spiny projection neurons
brenda
-
-
brenda
-
acinar epithelial cell
brenda
-
PDE1 is present in young and adult gland
brenda
-
PDE2 is present in young gland, not in adult
brenda
-
PDE3 is present in young and adult gland
brenda
-
-
brenda
-
enzyme isoform PDE1A is predominantly cytoplasmic in medial contractile vascular smoth muscle cell and nuclear in neointimal synthetic vascular smoth muscle cell
brenda
additional information
-
no activity of PDE3 in A5 epithelial duct cells
brenda
additional information
-
tissue-specific expression of splice-variants
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Purvis, K.; Rui, H.
High-affinity, calmodulin-dependent isoforms of cyclic nucleotide phosphodiesterase in rat testis
Methods Enzymol.
159
675-685
1988
Rattus norvegicus
brenda
Hansen, R.S.; Charbonneau, H.; Beavo, J.A.
Purification of calmodulin-stimulated cyclic nucleotide phosphodiesterase by monoclonal antibody affinity chromatography
Methods Enzymol.
159
543-557
1988
Bos taurus, Rattus norvegicus
brenda
Yan, C.; Zhao, A.Z.; Bentley, J.K.; Lougney, K.; Ferguson, K.; Beavo, J.A.
Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons
Proc. Natl. Acad. Sci. USA
92
9677-9681
1995
Rattus norvegicus
brenda
Leroy, M.J.; Degerman, E.; Taira, M.; Murata, T.; Wang, L.H.; Movsesian, M.A.; Meacci, E.; Manganiello, V.C.
Characterization of two recombinant PDE3 (cGMP inhibited cyclic nucleotide phosphodiesterase) isoforms, RcGIP1 and HcGIP2, expressed in NIH 3006 murine fibroblasts and Sf9 insect cells
Biochemistry
35
10194-10202
1996
Homo sapiens, Rattus norvegicus
brenda
Mukai, J.; Asai, T.; Naka, M.; Tanaka, T.
Separation and characterization of a novel isoenzyme of cyclic nucleotide phosphodiesterase from rat cerebrum
Br. J. Pharmacol.
111
389-390
1994
Rattus norvegicus
brenda
Fujishige, K.; Kotera, J.; Omori, K.
Striatum- and testis-specific phosphodiesterase PDE10A. Isolation and characterization of a rat PDE10A
Eur. J. Biochem.
266
1118-1127
1999
Rattus norvegicus
brenda
Murata, T.; Sugatani, T.; Tagawa, T.
Expression of phosphodiesterase 3 in rat submandibular gland
Arch. Oral Biol.
45
1043-1047
2000
Rattus norvegicus
brenda
Murata, T.; Sugatani, T.; Manganiello, V.C.; Shimizu, K.; Tagawa, T.
Expression of phosphodiesterase 3 in rat submandibular gland cell lines
Arch. Oral Biol.
46
453-457
2001
Rattus norvegicus
brenda
Tanaka, S.; Shimooka, S.; Shimomura, H.
Changes in phosphodiesterase activity in the developing rat submandibular gland
Arch. Oral Biol.
47
567-576
2002
Rattus norvegicus
brenda
Yuasa, K.; Ohgaru, T.; Asahina, M.; Omori, K.
Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A). Comparison of rat and human PDE11A splicing variants
Eur. J. Biochem.
268
4440-4448
2001
Rattus norvegicus
brenda
Nilsson, R.; Ahmad, F.; Sward, K.; Andersson, U.; Weston, M.; Manganiello, V.; Degerman, E.
Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes
Cell. Signal.
18
1713-1721
2006
Rattus norvegicus
brenda
Keravis, T.; Thaseldar-Roumie, R.; Lugnier, C.
Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts
Methods Mol. Biol.
307
63-74
2005
Rattus norvegicus
brenda
Yan, C.
Determination of Ca2+/calmodulin-stimulated phosphodiesterase activity in intact cells
Methods Mol. Biol.
307
85-92
2005
Rattus norvegicus
brenda
Witwicka, H.; Kobialka, M.; Siednienko, J.; Mitkiewicz, M.; Gorczyca, W.A.
Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages
Biochim. Biophys. Acta
1773
209-218
2007
Rattus norvegicus
brenda
Nagel, D.J.; Aizawa, T.; Jeon, K.I.; Liu, W.; Mohan, A.; Wei, H.; Miano, J.M.; Florio, V.A.; Gao, P.; Korshunov, V.A.; Berk, B.C.; Yan, C.
Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival
Circ. Res.
98
777-784
2006
Rattus norvegicus
brenda
Rutten, K.; Prickaerts, J.; Hendrix, M.; van der Staay, F.J.; Sik, A.; Blokland, A.
Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors
Eur. J. Pharmacol.
558
107-112
2007
Rattus norvegicus
brenda
de Vente, J.; Markerink-van Ittersum, M.; Vles, J.S.
The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord
J. Chem. Neuroanat.
31
275-303
2006
Rattus norvegicus (Q01062)
brenda
Santone, R.; Giorgi, M.; Maccarone, R.; Basso, M.; Deplano, S.; Bisti, S.
Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina
J. Neurosci. Res.
84
1020-1026
2006
Rattus norvegicus
brenda
Siuciak, J.A.
The role of phosphodiesterases in schizophrenia: therapeutic implications
CNS Drugs
22
983-993
2008
Homo sapiens, Rattus norvegicus
brenda
van Donkelaar, E.L.; Rutten, K.; Blokland, A.; Akkerman, S.; Steinbusch, H.W.; Prickaerts, J.
Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion
Eur. J. Pharmacol.
600
98-104
2008
Rattus norvegicus
brenda
Schmidt, C.J.; Chapin, D.S.; Cianfrogna, J.; Corman, M.L.; Hajos, M.; Harms, J.F.; Hoffman, W.E.; Lebel, L.A.; McCarthy, S.A.; Nelson, F.R.; Proulx-LaFrance, C.; Majchrzak, M.J.; Ramirez, A.D.; Schmidt, K.; Seymour, P.A.; Siuciak, J.A.; Tingley, F.D.; Williams, R.D.; Verhoest, P.R.; Menniti, F.S.
Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia
J. Pharmacol. Exp. Ther.
325
681-690
2008
Rattus norvegicus
brenda
Threlfell, S.; Sammut, S.; Menniti, F.S.; Schmidt, C.J.; West, A.R.
Inhibition of phosphodiesterase 10A increases the responsiveness of striatal projection neurons to cortical stimulation
J. Pharmacol. Exp. Ther.
328
785-795
2009
Rattus norvegicus
brenda
Dlaboga, D.; Hajjhussein, H.; ODonnell, J.M.
Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum
Neuropharmacology
54
745-754
2008
Rattus norvegicus
brenda
Giachini, F.R.; Lima, V.V.; Carneiro, F.S.; Tostes, R.C.; Webb, R.C.
Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1
Hypertension
57
655-663
2011
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Kelly, M.P.; Adamowicz, W.; Bove, S.; Hartman, A.J.; Mariga, A.; Pathak, G.; Reinhart, V.; Romegialli, A.; Kleiman, R.J.
Select 3,5-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
Cell. Signal.
26
383-397
2014
Mus musculus, Rattus norvegicus
brenda