EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
    3.1.4.17 | 0.00000031 |
- |
(S)-N-(2-hydroxy-2-methyl-1-(4-(trifluoromethoxy)-phenyl)propyl)-6-methyl-5-(4-methyl-1H-1,2,3-triazol-1-yl)-pyrazolo[1,5-a]pyrimidine-3-carboxamide |
at pH 7.4 and 25°C |
750304 |
| 3.1.4.17 | 0.00000032 |
- |
6-(3-(3-cyclooctyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone |
IC50: 0.00000032 mM, PDE3A, highly selective PDE3 inhibitor |
649785 |
| 3.1.4.17 | 0.00000034 |
- |
2-cyclohexyl-2-methyl-N1-[3-(2-oxo-1,2-dihydro-6-quinolyl,oxy)propyl]-1-hydrazinecarboxamide |
IC50: 0.00000034 mM, PDE3A, highly selective PDE3 inhibitor |
649785 |
| 3.1.4.17 | 0.00000051 |
- |
N-((1S)-2-hydroxy-2-methyl-1-(4-(trifluoromethoxy)phenyl)propyl)-6-methyl-5-(3-methyl-1H-1,2,4-triazol-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide |
at pH 7.4 and 25°C |
750304 |
| 3.1.4.17 | 0.00000077 |
- |
N-((1S)-2-hydroxy-2-methyl-1-(4-(trifluoromethoxy)-phenyl)propyl)-5-(2-methylpyridin-4-yl)pyrazolo[1,5-a]-pyrimidine-3-carboxamide |
at pH 7.4 and 25°C |
750304 |
| 3.1.4.17 | 0.00000098 |
- |
N-((1S)-2-hydroxy-2-methyl-1-(4-(trifluoromethoxy)-phenyl)propyl)-5-(6-methylpyridin-3-yl)pyrazolo[1,5-a]-pyrimidine-3-carboxamide |
at pH 7.4 and 25°C |
750304 |
| 3.1.4.17 | 0.000001 |
- |
2-[[4-[4-pyridin-4-yl-1-(2,2, 2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline succinic acid |
the IC50 of the compound for inhibition of PDE10A in vitro is less than 1 nM |
693820 |
| 3.1.4.17 | 0.0000012 |
- |
N-((1S)-2-hydroxy-2-methyl-1-(4-(trifluoromethoxy)-phenyl)propyl)-5-(4-methyl-1H-imidazol-1-yl)pyrazolo [1,5-a]pyrimidine-3-carboxamide |
at pH 7.4 and 25°C |
750304 |
| 3.1.4.17 | 0.0000012 |
- |
N-((1S)-2-hydroxy-2-methyl-1-(4-(trifluoromethoxy)-phenyl)propyl)-5-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide |
at pH 7.4 and 25°C |
750304 |
| 3.1.4.17 | 0.0000015 |
- |
6-(3-(3-cyclooctyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone |
IC50: 0.0000015 mM, PDE3B |
649785 |
