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Literature summary for 3.1.4.17 extracted from

  • Giachini, F.R.; Lima, V.V.; Carneiro, F.S.; Tostes, R.C.; Webb, R.C.
    Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1 (2011), Hypertension, 57, 655-663.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.17

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates in vivo Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery PDE 1 vascular expression is increased in arteries from angiotensin II hypertensive rats Rattus norvegicus
-
vascular smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanosine 3',5'-cyclic phosphate + H2O
-
 Rattus norvegicus guanosine 5'-phosphate
-
 ?
guanosine 3',5'-cyclic phosphate + H2O
-
 Rattus norvegicus Sprague-Dawley guanosine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDE1
-
 Rattus norvegicus
phosphodiesterase 1
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus angiotensin II is able to increase PDE1 expression in vascular smooth muscle cells up

General Information

General Information Comment Organism
malfunction phosphodiesterase-1 inhibition decreases vascular contraction in arteries from angiotensin II hypertensive, but not control, rats. The inhibition of PDE1 in smooth muscle cells isolated from normal aorta or from atherosclerotic lesions results in suppression of smooth muscle cell proliferation Rattus norvegicus
additional information three different isoforms of calmodulin-dependent PDE isoforms are reported, PDE1A and PDE1B, which display higher affinity to hydrolyze cGMP compared to cAMP, and PDE1C, which has a similar ability to hydrolyze cGMP and cAMP Rattus norvegicus
physiological function when Ca2 is high, PDE1 is activated, resulting in lower levels of cGMP, which theoretically facilitates the smooth muscle cell contraction Rattus norvegicus