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Literature summary for 3.1.4.17 extracted from

  • Rutten, K.; Prickaerts, J.; Hendrix, M.; van der Staay, F.J.; Sik, A.; Blokland, A.
    Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors (2007), Eur. J. Pharmacol., 558, 107-112.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme inhibitors can reverse the time-dependent forgetting in the object recognition test. The efficacy of the different inhibitors is dependent on the time point of administration after acquisition. Support for a role for cGMP in early stages of memory formation and for cAMP in the late stages of memory formation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
BAY 60-7550
-
Rattus norvegicus
rolipram
-
Rattus norvegicus
vardenafil
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
isoform PDE2
-