Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dipyridamole | inhibits with micromolar potency | Homo sapiens | |
dipyridamole | inhibits with micromolar potency | Rattus norvegicus | |
isobutylmethylxanthine | inhibits with micromolar potency | Homo sapiens | |
isobutylmethylxanthine | inhibits with micromolar potency | Rattus norvegicus | |
MP-10 | - |
Homo sapiens | |
papaverine | competitive inhibitor | Homo sapiens | |
papaverine | competitive inhibitor | Rattus norvegicus | |
PQ-10 | - |
Homo sapiens | |
TP-10 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | PDE10A is strongly expressed in the brain, highly expressed in striatal complex including caudate putamen, nucleus accumbens, and olfacory tubercle | Homo sapiens | - |
brain | PDE10A is strongly expressed in the brain, highly expressed in striatal complex including caudate putamen, nucleus accumbens, and olfacory tubercle | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? | |
3',5'-cAMP + H2O | - |
Rattus norvegicus | 5'-AMP | - |
? | |
3',5'-cGMP + H2O | - |
Homo sapiens | 5'-GMP | - |
? | |
3',5'-cGMP + H2O | - |
Rattus norvegicus | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE10A | hydrolyses both 3',5'-cAMP and 3',5'-cGMP although with different kinetic parameters | Homo sapiens |
PDE10A | hydrolyses both 3',5'-cAMP and 3',5'-cGMP although with different kinetic parameters | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000036 | - |
- |
Rattus norvegicus | papaverine |