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Literature summary for 3.1.4.17 extracted from

  • Nagel, D.J.; Aizawa, T.; Jeon, K.I.; Liu, W.; Mohan, A.; Wei, H.; Miano, J.M.; Florio, V.A.; Gao, P.; Korshunov, V.A.; Berk, B.C.; Yan, C.
    Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival (2006), Circ. Res., 98, 777-784.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information decrease in enzyme activity by RNAi results in significantly attenuated vascular smoth muscle cell growth by decreasing proliferation via G1 arrest and inducing apoptosis. Application of RNAi also leads to intracellular cGMP elevation, p27Kip1 upregulation, cyclin D1 downregulation, and p53 activation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm enzyme isoform PDE1A is predominantly cytoplasmic in medial contractile vascular smoth muscle cell and nuclear in neointimal synthetic vascular smoth muscle cell. Cytoplasmic isoform PDE1A regulates myosin light chain phosphorylation with little effect on apoptosis Rattus norvegicus 5737
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nucleus enzyme isoform PDE1A is predominantly cytoplasmic in medial contractile vascular smoth muscle cell and nuclear in neointimal synthetic vascular smoth muscle cell. Nuclear enzyme isoform PDE1A is important in vascular smoth muscle cell growth and survival Rattus norvegicus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus cytoplasmic isoform PDE1A regulates myosin light chain phosphorylation with little effect on apoptosis, whereas nuclear enzyme isoform PDE1A is important in vascular smoth muscle cell growth and survival ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 isoform PDE1A
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Source Tissue

Source Tissue Comment Organism Textmining
aorta
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 Rattus norvegicus
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vascular smooth muscle cell enzyme isoform PDE1A is predominantly cytoplasmic in medial contractile vascular smoth muscle cell and nuclear in neointimal synthetic vascular smoth muscle cell Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cytoplasmic isoform PDE1A regulates myosin light chain phosphorylation with little effect on apoptosis, whereas nuclear enzyme isoform PDE1A is important in vascular smoth muscle cell growth and survival Rattus norvegicus ?
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 ?

Subunits

Subunits Comment Organism
More nuclear and cytoplasmic enzyme isoform PDE1A are associated with contractile marker SM-calponin and growth marker Ki-67, respectively Rattus norvegicus