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Literature summary for 3.1.4.17 extracted from

  • Threlfell, S.; Sammut, S.; Menniti, F.S.; Schmidt, C.J.; West, A.R.
    Inhibition of phosphodiesterase 10A increases the responsiveness of striatal projection neurons to cortical stimulation (2009), J. Pharmacol. Exp. Ther., 328, 785-795.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.17

Application

Application Comment Organism
medicine genetic disruption or pharmacological inhibition of PDE10A reverses behavioral abnormalities associated with subcortical hyperdopaminergia Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-[[4-[4-pyridin-4-yl-1-(2,2, 2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline succinic acid selective PDE10A inhibitor, inhibition of striatal PDE10A activity increases the responsiveness of medium-sized spiny projection neurons to depolarising stimuli Rattus norvegicus
papaverine selective PDE10A inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corpus striatum dorsal striatum Rattus norvegicus
-
neuron PDE10A is highly expressed in striatal medium-sized spiny projection neurons Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Rattus norvegicus 5'-AMP
-
 ?
3',5'-cGMP + H2O
-
 Rattus norvegicus 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
cyclic nucleotide phosphodiesterase 10A
-
 Rattus norvegicus
PDE10A
-
 Rattus norvegicus