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Information on EC 2.5.1.48 - cystathionine gamma-synthase
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EC Tree
2.5.1.48 cystathionine gamma-synthaseIUBMB Comments
A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
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Word Map
- 2.5.1.48
- homocystinuria
-
transsulfuration
-
beta-lyase
-
gamma-lyase
-
sulfhydrylase
- o-acetylhomoserine
-
gamma-replacement
- l-cystathionine
- cystathionase
- o-phosphohomoserine
- paucicostata
-
gamma-elimination
- homocystine
- s-methylmethionine
-
remethylation
- synthesis
The enzyme appears in viruses and cellular organisms
Synonyms
cystathionine gamma-synthase, cystathionine synthase, atcgs, cystathionine synthetase, cystathionine-gamma-synthase, o-succinylhomoserine synthetase, o-succinylhomoserine synthase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CGS
CS,26
-
-
-
-
cystathionine gamma-synthase
cystathionine synthase
-
-
-
-
cystathionine synthetase
-
-
-
-
cystathionine-gamma-synthase
-
-
-
-
EC 4.2.99.9
-
-
formerly
-
homoserine O-transsuccinylase
-
-
-
-
homoserine transsuccinylase
MetB
O-succinyl-L-homoserine succinate-lyase (adding cysteine)
-
-
-
-
O-succinylhomoserine (Thiol)-lyase
-
-
-
-
O-succinylhomoserine synthase
-
-
-
-
O-succinylhomoserine synthetase
-
-
-
-
synthase, cystathionine gamma-
-
-
-
-
CGS
-
-
-
-
homoserine transsuccinylase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate
-
-
-
-
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate
ping-pong mechanism
-
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate
ping-pong mechanism
-
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate
can also use hydrogen sulfide and methanethiol as substrates producing homocysteine and methionine respectively. In the absence of thiol, the enzyme can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia
-
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate
enzyme performs an elimination or a replacement reaction, reaction mechanism, formation of an aldimine intermediate, overview
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
elimination
-
-
-
-
gamma-replacement
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
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CAS REGISTRY NUMBER
COMMENTARY
9030-70-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutyrate
-
beta-elimination
-
?
L-cystathionine + L-cysteine
L-cystathionine + L-cysteine
-
-
observed via 35S-exchange
?
O-acetyl-L-homoserine + 2-mercaptoethanol
S-hydroxyethyl-L-homocysteine + acetate
-
150% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine + acetate
-
50% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine + acetate
-
65% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + allyl mercaptan
S-allyl-L-homocysteine + acetate
-
4% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + benzyl mercaptan
S-benzyl-L-homocysteine + acetate
-
41% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + CH3SH
L-methionine + acetate
-
11% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + D-Cys
D-allocystathionine + acetate
-
101% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + D-homocysteine
meso-homolanthionine + acetate
-
125% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + ethyl mercaptan
L-thionine + acetate
-
24% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + isobutyl mercaptan
S-isobutyl-L-homocysteine + acetate
-
13% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + isopropyl mercaptan
S-isopropyl-L-homocysteine + acetate
-
1% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + L-Cys ethyl ester
S-[(2R)-2-amino-3-ethoxy-3-oxopropyl]-L-homocysteine + acetate
-
15% relative activity to O-acetyl-L-homoserine + L-cysteine
i.e. L-cystathionine monoethyl ester + acetate
?
O-acetyl-L-homoserine + L-Cys methyl ester
S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + acetate
O-acetyl-L-homoserine + L-homocysteine
L-homolanthionine + acetate
-
92% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + m-thiocresol
S-m-tolyl-L-homocysteine + acetate
-
150% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + N-acetyl-L-Cys
S-(L-acetylamino-2-carboxyethyl)-L-homocysteine + acetate
-
12% relative activity to O-acetyl-L-homoserine + L-cysteine
i.e. mono-N-acetyl-L-cystathionine + acetate
?
O-acetyl-L-homoserine + n-butyl mercaptan
S-n-butyl-L-homocysteine + acetate
-
5% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + n-propyl mercaptan
S-n-propyl-L-homocysteine + acetate
-
13% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + o-thiocresol
S-o-tolyl-L-homocysteine + acetate
-
3% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + p-nitrothiophenol
S-p-nitrophenyl-L-homocysteine + acetate
-
41% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + p-thiocresol
S-p-tolyl-L-homocysteine + acetate
-
25% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + phenyl mercaptan
S-phenyl-L-homocysteine + acetate
-
98% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + S2-
L-homocysteine + acetate
-
163% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + sec-butyl mercaptan
S-sec-butyl-L-homocysteine + acetate
-
5% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + tert-butyl mercaptan
S-tert-butyl-L-homosysteine + acetate
-
2% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thioacetic acid
S-acetyl-L-homocysteine + acetate
-
3% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thioglycolate ethyl ester
S-ethoxycarbonyl-L-homocysteine + acetate
-
348% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thioglycolate n-butyl ester
S-n-butoxycarbonyl-L-homocysteine + acetate
-
274% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thiosalicylic acid
S-o-carboxyphenyl-L-homocysteine + acetate
-
63% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-malonyl-L-homoserine + L-cysteine
L-cystathionine + malonate
-
14% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-phenyl-L-homoserine + L-cysteine
L-cystathionine + phenol
-
1% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-phospho-L-homoserine + L-cysteine ethyl ester
S-[(2R)-2-amino-3-ethoxy-3-oxopropyl]-L-homocysteine + phosphate
-
1% relative activity to O-phospho-L-homoserine + L-cysteine
-
-
?
O-phospho-L-homoserine + L-cysteine methyl ester
S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + phosphate
-
15% relative activity to O-phospho-L-homoserine + L-cysteine
-
-
?
O-phospho-L-homoserine + L-selenocysteine
selenocystathionine + phosphate
-
-
-
?
O-succinyl-L-homoserine
succinate + pyruvate + NH3
-
elimination reaction
-
-
?
O-succinyl-L-homoserine + 2-mercaptoethanol
S-ethyl-L-homocysteine + succinate
-
32% of the activity with L-cysteine
-
-
?
O-succinyl-L-homoserine + beta-mercaptopropionate
S-carboxyethyl-L-homocysteine + succinate
-
-
-
?
O-succinyl-L-homoserine + D-cysteine
?
-
20% of the activity with L-cysteine
-
-
?
O-succinyl-L-homoserine + sodium sulfide
L-homocysteine + sodium succinate
-
62% of the activity with L-cysteine
-
-
?
O-succinyl-L-serine + L-cysteine
lanthionine + succinate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
beta-elimination
-
?
O-acetyl-L-homoserine + L-Cys methyl ester
S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + acetate
-
20% relative activity to O-acetyl-L-homoserine + L-cysteine
i.e. L-cystathionine monomethyl ester + acetate
?
O-acetyl-L-homoserine + L-Cys methyl ester
S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + acetate
-
26% of the activity with L-Cys
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
gamma-replacement
-
-
r
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
gamma-replacement
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
Neptunia amplexicaulis
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + S2-
L-homocysteine + phosphate
-
13% relative activity to O-phospho-L-homoserine + L-cysteine
-
?
O-succinyl-L-homoserine + CH3SH
L-methionine + succinate
-
-
-
?
O-succinyl-L-homoserine + CH3SH
L-methionine + succinate
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
gamma-elimination
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
gamma-elimination
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
gamma-elimination, in absence of L-cysteine
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
gamma-elimination, in absence of L-cysteine
-
-
?
O-succinyl-L-homoserine + H2S
L-homocysteine + succinate
-
-
-
?
O-succinyl-L-homoserine + H2S
L-homocysteine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
constitutive overexpression of the enzyme in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
key enzyme of Met biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
enzyme catalyzes the first step in methionine biosynthesis, overview
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
the second enzyme of the methionine biosynthetic pathway
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
key intermediate in transsulfuration pathways
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
first step in bacterial transsulfuration pathway
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
replacement reaction
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
methionine biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
the enzyme catalyzes the first reaction specific for methionine biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
Pseudomonas dacunhae
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
essential step in bacterial methionine biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
the expression of the enzyme is light-inducible
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
the enzyme catalyzes a near-equilibrium reaction and does not display features of a pathway-regulating enzyme
-
-
?
O-succinyl-L-homoserine + L-selenocysteine
selenocystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-selenocysteine
selenocystathionine + succinate
-
first step in conversion of selenocysteine to volatile dimethylselenide
-
-
?
O-succinyl-L-serine + H2O
succinate + pyruvate + NH3
-
beta-elimination
-
?
O-succinyl-L-serine + H2O
succinate + pyruvate + NH3
-
beta-elimination
-
?
O-succinyl-L-serine + L-homocysteine
succinate + L-cystathionine
-
beta-replacement, very low reaction rate
-
?
O-succinyl-L-serine + L-homocysteine
succinate + L-cystathionine
-
beta-replacement, very low reaction rate
-
?
O4-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O4-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
additional information
?
-
S-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the CGS1 gene
-
-
?
additional information
?
-
-
S-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the CGS1 gene
-
-
?
additional information
?
-
-
the enzyme might by rate-limiting in selenium volatilization
-
-
?
additional information
?
-
-
catalyzes alpha or beta proton exchange with a number of amino acids and L-allylglycine
-
-
?
additional information
?
-
-
enzyme performs an elimination or a replacement reaction
-
-
?
additional information
?
-
-
beta-elimination and gamma-elimination barely catalyzed
-
-
?
additional information
?
-
-
exchange of tritium from water into both alpha and beta positions of a wide variety of amino acids which are otherwise no substrates
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
O-succinyl-L-homoserine + L-selenocysteine
selenocystathionine + succinate
-
first step in conversion of selenocysteine to volatile dimethylselenide
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
constitutive overexpression of the enzyme in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
key enzyme of Met biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
enzyme catalyzes the first step in methionine biosynthesis, overview
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
the second enzyme of the methionine biosynthetic pathway
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
key intermediate in transsulfuration pathways
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
first step in bacterial transsulfuration pathway
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
methionine biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
the enzyme catalyzes the first reaction specific for methionine biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
essential step in bacterial methionine biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
the expression of the enzyme is light-inducible
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
the enzyme catalyzes a near-equilibrium reaction and does not display features of a pathway-regulating enzyme
-
-
?
O4-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O4-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
additional information
?
-
S-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the CGS1 gene
-
-
?
additional information
?
-