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Information on EC 2.5.1.48 - cystathionine gamma-synthase

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IUBMB Comments

A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse β,γ-elimination to form 2-oxobutanoate, succinate and ammonia.

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
cystathionine gamma-synthase, cystathionine synthase, atcgs, cystathionine synthetase, cystathionine-gamma-synthase, o-succinylhomoserine synthetase, o-succinylhomoserine synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate
show the reaction diagram