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Literature summary for 2.5.1.48 extracted from

  • Kreft, B.D.; Townsend, A.; Pohlenz, H.D.; Laber, B.
    Purification and properties of cystathionine gamma-synthase from wheat (Triticum aestivum L.) (1994), Plant Physiol., 104, 1215-1220.
    View publication on PubMed
Search for more literature for 2.5.1.48

Inhibitors

Inhibitors Comment Organism Structure
(Z)-3-(2-phosphonethen-1-yl)pyridine-2-carboxylic acid Ki: 0.04 mM Triticum aestivum
4-(phosphonomethyl)pyridine-2-carboxylic acid Ki: 0.045 mM Triticum aestivum
aminooxyacetic acid
-
 Triticum aestivum
DL-(E)-2-amino-5-phosphono-3-pentenoic acid Ki: 0.0011 mM Triticum aestivum
hydroxylamine
-
 Triticum aestivum
additional information no inhibition by 2-amino-1-hydroxycyclobutane-1-acetic acid Triticum aestivum
propargylglycine
-
 Triticum aestivum
S-adenosyl-L-methionine 9.5 mM, 50% inhibition Triticum aestivum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
 L-cysteine pH 7.5, 37°C Triticum aestivum
3.6
-
 O-phospho-L-homoserine pH 7.5, 37°C Triticum aestivum

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Triticum aestivum 9507
-

Organism

Organism UniProt Comment Textmining
Triticum aestivum
-
 wheat
-

Reaction

Reaction Comment Organism Reaction ID
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate ping-pong mechanism Triticum aestivum
a

Source Tissue

Source Tissue Comment Organism Textmining
seed
-
 Triticum aestivum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-phospho-L-homoserine + L-cysteine
-
 Triticum aestivum L-cystathionine + phosphate
-
 ?
O-phospho-L-homoserine + L-cysteine ethyl ester 1% relative activity to O-phospho-L-homoserine + L-cysteine Triticum aestivum S-[(2R)-2-amino-3-ethoxy-3-oxopropyl]-L-homocysteine + phosphate
-
 ?
O-phospho-L-homoserine + L-cysteine methyl ester 15% relative activity to O-phospho-L-homoserine + L-cysteine Triticum aestivum S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + phosphate
-
 ?
O-phospho-L-homoserine + S2- 13% relative activity to O-phospho-L-homoserine + L-cysteine Triticum aestivum L-homocysteine + phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Triticum aestivum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Triticum aestivum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0011
-
 DL-(E)-2-amino-5-phosphono-3-pentenoic acid pH 7.5, 37°C Triticum aestivum
0.04
-
 (Z)-3-(2-phosphonethen-1-yl)pyridine-2-carboxylic acid pH 7.5, 37°C Triticum aestivum
0.045
-
 4-(phosphonomethyl)pyridine-2-carboxylic acid pH 7.5, 37°C Triticum aestivum
9.5
-
 S-adenosyl-L-methionine pH 7.5, 37°C Triticum aestivum