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(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine + H2O + O2
?
-
i.e. (S)-RS-8359
-
-
?
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
?
-
i.e. (S)-RS-8359
-
-
?
(+)-biotin (+)-sulfoxide methyl ester + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
(+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine + H2O + O2
?
-
i.e. RS-8359
-
-
?
(1S)-camphor oxime + H2O + 2-hydroxypyrimidine
(1S)-camphor + (1S)-camphor imine + NH3
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
(2E)-hex-2-enal + H2O + O2
(2E)-hex-2-enoic acid + H2O2
-
-
-
?
(2E)-non-2-enal + H2O + O2
(2E)-non-2-enoic acid + H2O2
-
-
-
?
(S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
-
i.e. S-8359
-
-
?
(S)-RS-8359 + H2O + O2
2-keto-(S)-RS-8359 + H2O2
(Z)-11-hexadecenal + H2O + O2
(Z)-11-hexadecenoic acid + H2O2
-
-
-
-
?
(Z)-7-dodecenal + H2O + O2
(Z)-7-dodecenoic acid + H2O2
-
-
-
-
?
(Z)-7-tetradecenal + H2O + O2
(Z)-7-tetradecenoic acid + H2O2
-
-
-
-
?
(Z)-9-hexadecenal + H2O + O2
(Z)-9-hexadecenoic acid + H2O2
-
-
-
-
?
(Z)-9-tetradecenal + H2O + O2
(Z)-9-tetradecenoic acid + H2O2
-
-
-
-
?
1-methoxy-2-naphthaldehyde + H2O + O2
1-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
1-methyl-acetylpyridine + H2O + ferricyanide
?
-
-
-
-
?
1-naphthaldehyde + H2O + O2
1-naphthalene carboxylic acid + H2O2
-
-
-
?
1-naphthaldehyde + H2O + O2
1-naphthoic acid + H2O2
-
-
-
-
?
1-nitropyrene + H2O + O2
?
-
-
-
?
13-cis-retinal + O2 + H2O
13-cis-retinoate + H2O2
-
-
-
?
2,3-diazanaphthalene + O2
1-phthalazinone
-
-
-
-
?
2,4-dihydroxybenzaldehyde + H2O + O2
2,4-dihydroxybenzoate + H2O2
-
-
-
?
2-ethylbutylaldehyde + H2O + O2
2-ethylbutanoate + H2O2
2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide + H2O + O2
?
-
i.e. c-met inhibitor capmatinib
-
-
?
2-hydroxybenzaldehyde + H2O + O2
2-hydroxybenzoate + H2O2
-
-
-
-
?
2-hydroxypyrimidine + ferricyanide
?
2-hydroxypyrimidine + H2O + ferricyanide + O2
?
-
-
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
2-hydroxypyrimidine + O2 + H2O
?
-
-
-
-
?
2-hydroxypyrimidine + O2 + H2O
? + H2O2
-
-
-
?
2-methoxybenzaldehyde + H2O + O2
2-methoxybenzoate + H2O2
2-methyl-E-2-butenal + H2O + O2
2-methyl-E-2-butenoic acid + H2O2
-
-
-
?
2-methylbenzaldehyde + H2O + O2
2-methylbenzoate + H2O2
2-naphthaldehyde + H2O + O2
2-naphthoic acid + H2O2
-
-
-
-
?
2-pyrimidone + H2O + O2
? + H2O2
-
-
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
3,4-dihydroxybenzaldehyde + H2O + O2
3,4-dihydroxybenzoate + H2O2
-
38.2% of the rate with benzaldehyde
-
-
?
3,4-dimethoxybenzaldehyde + H2O + O2
3,4-dimethoxybenzoate + H2O2
-
-
-
-
?
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine N-oxide + electron donor
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine + an electron acceptor
-
electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde under anaerobic conditions
-
-
?
3-aminocarbonyl-1-methylpyridinium chloride + H2O + O2
?
-
-
-
-
?
3-hydroxybenzaldehyde + H2O + O2
3-hydroxybenzoate + H2O2
-
-
-
-
?
3-hydroxypropionaldehyde + H2O + O2
3-hydroxypropionate + H2O2
3-methoxy-2-naphthaldehyde + H2O + O2
3-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
3-methoxy-4-hydroxybenzaldehyde + H2O + O2
3-methoxy-4-hydroxybenzoate + H2O2
-
-
-
-
?
3-methoxybenzaldehyde + H2O + O2
3-methoxybenzoate + H2O2
3-methylbenzaldehyde + H2O + O2
3-methylbenzoate + H2O2
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
4-(dimethylamino)-cinnamaldehyde + H2O + O2
?
-
-
-
-
?
4-(dimethylamino)cinnamaldehyde + H2O + O2
4-(dimethylamino)cinnamic acid + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + H2O + O2
?
-
-
-
-
?
4-(dimethylamino)cinnamaldehyde + nitrite + H2O + O2
? + nitric oxide
-
in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide
-
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
4-hydroxybenzaldehyde + H2O + O2
4-hydroxybenzoate + H2O2
4-hydroxyl-2-nonenal + H2O + O2
4-hydroxy-2-nonenoate + H2O2
-
-
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
4-hydroxypyrimidine + H2O + O2
?
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
4-methoxybenzaldehyde + H2O + O2
4-methoxybenzoate + H2O2
4-methylbenzaldehyde + H2O + O2
4-methylbenzoate + H2O2
4-nitrobenzaldehyde + H2O + O2
4-nitrobenzoate + H2O2
-
-
-
?
4-nitrobenzaldehyde + H2O + O2
4-nitrobenzoic acid + H2O2
-
-
-
-
?
5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine + H2O + O2
?
-
i.e. brimonidine
-
-
?
5-fluoropyrimidine + H2O + O2
5-fluorouracil + H2O2
-
-
-
-
?
5-nitroquinoline + H2O + O2
2-oxo-5-nitroquinoline + 5-aminoquinoline + 2-oxo-5-aminoquinoline
-
-
-
?
6-benzylguanine + H2O + O2
?
-
-
-
-
?
6-chloroquinazolin-4(3H)-one + H2O + O2
6-chloroquinazoline-2,4(1H,3H)-dione + H2O2
-
-
-
-
?
6-deoxypenciclovir
penciclovir
-
is catalyzed by AOX1
-
-
?
6-deoxypenciclovir + H2O + O2
?
-
-
-
-
?
6-dimethyloamino-2-naphthaldehyde + H2O + O2
6-dimethylamino-2-naphthoic acid + H2O2
-
-
-
-
?
6-ethyl-5H-dibenz(c,e)azepine + H2O + O2
?
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
6-mercaptopurine + H2O + O2
?
-
-
-
-
?
6-methoxy-2-naphthaldehyde + H2O + O2
6-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
6-methoxyquinazolin-4(3H)-one + H2O + O2
6-methoxyquinazoline-2,4(1H,3H)-dione + H2O2
-
-
-
-
?
6-methylpurine + H2O + chromate
?
-
-
-
-
?
6-methylquinazolin-4(3H)-one + H2O + O2
6-methylquinazoline-2,4(1H,3H)-dione + H2O2
-
-
-
-
?
6-methylthiopurine + H2O + O2
6-methylthio-8-hydroxypurine + H2O2
-
2,6-dichlorophenol indophenol can also act as electron acceptor
-
-
?
6-thioxanthine + H2O + O2
6-thiouric acid + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
7-methoxy-1-naphthaldehyde + H2O + O2
7-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
9-cis-retinal + O2 + H2O
9-cis-retinoate + H2O2
-
-
-
?
abscisic aldehyde + H2O + O2
abscisic acid + H2O2
abscisic aldehyde + O2 + H2O
abscisic acid + H2O2
-
-
-
-
?
acetaldehyde + 2 ferricyanide + H2O
acetate + 2 ferrocyanide + 2 H+
acetaldehyde + H2O + O2
acetate + H2O2
acetaldehyde + H2O + O2
acetic acid + H2O2
acetaldehyde + O2 + H2O
acetate + H2O2
acetamiprid + H2O + O2
? + H2O2
-
i.e. (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
acrolein + H2O + O2
?
results indicate that AtraAOX2 also functions as a xenobiotic-degrading enzyme
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
aldicarb + H2O + O2
? + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
allopurinol + H2O + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
anthracene-9-carboxaldehyde + H2O + O2
anthracene-9-carboxylate + H2O2
-
-
-
-
?
azelnidipine + H2O + O2
? + H2O2
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
benzaldehyde + 2,6-dichlorophenol indophenol
?
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
benzaldehyde + H2O + 2,6-dichlorophenolindophenol
benzoate + reduced 2,6-dichlorophenolindophenol
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
benzaldehyde + H2O + O2
benzoic acid + H2O2
benzaldehyde + O2 + H2O
benzoate + H2O2
benzamidoxime + H2O + 2-hydroxypyrimidine
benzamidine + ?
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
-
-
?
BIBX1382 + H2O + O2
BIBU1476 + ?
-
high hepatic clearance of 17 to 18 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
butanal + 2 ferricyanide + H2O
butanoate + 2 ferrocyanide + 2 H+
butanal + H2O + O2
butanoic acid + H2O2
butanal + H2O + O2
butyric acid + H2O2
butylaldehyde + H2O + O2
butanoate + H2O2
butyraldehyde + H2O + O2
butanoate + H2O2
carbazeran + H2O + O2
?
-
-
-
-
?
carbazeran + H2O + O2
? + H2O2
-
-
-
?
carbazeran + H2O + O2
carbazeran phthalazinone + ?
-
high hepatic clearance of 17 to 18 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
chloroacetaldehyde + H2O + O2
chloroacetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
cinchonidine + H2O + O2
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylindenyl]indene-3-acetic acid + electron acceptor + H2O
5-fluoro-2-methyl-1-[p-(methylthio)benzylindenyl]indene-3-acetic acid + ?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
clonazepam + H2O + O2
? + H2O2
-
-
-
?
clothianidin + H2O + O2
? + H2O2
-
i.e. (2E)-2-[([(2-chloro-1,3-thiazol-5-yl)methyl]amino)(methylamino)methylene]-1-hydroxy-1-oxodiazanium, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
clothianidin + NMNH
nitroso-clothianidin + amino-clothianidin + ?
-
-
-
-
?
crotonaldehyde + H2O + O2
crotonate + H2O2
crotonaldehyde + H2O + O2
crotonic acid + H2O2
decylaldehyde + H2O + O2
decanoate + H2O2
desmethyl-thiamethoxam + H2O + O2
? + H2O2
-
i.e. (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-nitro-1,3,5-oxadiazinan-4-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
dibenzyl sulfoxide + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?