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Literature summary for 1.2.3.1 extracted from

  • Dick, R.A.; Kanne, D.B.; Casida, J.E.
    Identification of aldehyde oxidase as the neonicotinoid nitroreductase (2005), Chem. Res. Toxicol., 18, 317-323.
    View publication on PubMed
Search for more literature for 1.2.3.1

Inhibitors

Inhibitors Comment Organism Structure
chlorpromazine 0.5 mM, 48% inhibition of reaction without added electron donor Oryctolagus cuniculus
cimetidine 0.5 mM, 50% inhibition of reaction without added electron donor Oryctolagus cuniculus
KCN 1 mM, 18% inhibition of reaction without added electron donor Oryctolagus cuniculus
menadione 0.2 mM, 78% inhibition of reaction without added electron donor Oryctolagus cuniculus
Promethazine 0.5 mM, 28% inhibition of reaction without added electron donor Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Gallus gallus 5829
-
cytosol
-
 Homo sapiens 5829
-
cytosol
-
 Rattus norvegicus 5829
-
cytosol
-
 Oryctolagus cuniculus 5829
-
cytosol
-
 Macaca fascicularis 5829
-

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Macaca fascicularis
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Oryctolagus cuniculus
-
liver
-
 Macaca fascicularis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
imidacloprid + H2O + O2
-
 Oryctolagus cuniculus nitroso-imidacloprid without addition of an electron donor, product is nitroso-imidacloprid ?
imidacloprid + H2O + O2 + N-methylnicotinamide
-
 Oryctolagus cuniculus nitroso-imidacloprid + amino-imidacloprid + H2O2 + ? in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 10 to 269 ?
imidacloprid + H2O + O2 + N-methylnicotinamide
-
 Gallus gallus nitroso-imidacloprid + amino-imidacloprid + H2O2 + ? in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 2.0 to 1.8 ?
imidacloprid + H2O + O2 + N-methylnicotinamide
-
 Rattus norvegicus nitroso-imidacloprid + amino-imidacloprid + H2O2 + ? in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 23 to 14 ?
imidacloprid + H2O + O2 + N-methylnicotinamide
-
 Homo sapiens nitroso-imidacloprid + amino-imidacloprid + H2O2 + ? in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 26 to 50 ?
imidacloprid + H2O + O2 + N-methylnicotinamide
-
 Macaca fascicularis nitroso-imidacloprid + amino-imidacloprid + H2O2 + ? in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 80 to 41 ?