Literature summary for 1.2.3.1 extracted from

Weigert, J.; Neumeier, M.; Bauer, S.; Mages, W.; Schnitzbauer, A.A.; Obed, A.; Groeschl, B.; Hartmann, A.; Schaeffler, A.; Aslanidis, C.; Schoelmerich, J.; Buechler, C.
Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release (2008), FEBS Lett., 582, 2965-2972.

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Protein Variants

Protein Variants	Comment	Organism
additional information	knock-down of isoform AOX1 by siRNA impairs adipogenesis and reduces adiponectin release	Mus musculus
additional information	knock-down of isoform AOX1 by siRNA impairs adipogenesis and reduces adiponectin release	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
fenofibrate	in mature adipocytes, enzyme expression is reduced in presence of 50 microM fenofibrate	Homo sapiens
fenofibrate	in mature adipocytes, enzyme expression is reduced in presence of 50 microM fenofibrate	Mus musculus
palmitic acid	enzyme expression is reduced in 3T3-L1 cells differentiated in presence of 400 microM palmitic acid	Homo sapiens
palmitic acid	enzyme expression is reduced in 3T3-L1 cells differentiated in presence of 400 microM palmitic acid	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
3T3-L1 cell	preadipocytes have a very low expression of AOX1, in 2 days differentiated cells AOX1 is induced and is not further upregulated in 3, 7 and 9 days differentiated cells. AOX1 mRNA is nearly four-fold higher in 2 days differentiated cells when compared to preadipocytes and doubles from days 2 to 6	Mus musculus	-
adipose tissue	isoform AOX1 mRNA is higher in visceral compared to subcutaneous adipose tissue, Aox1 protein is detected in both fat depots	Homo sapiens	-

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Release 2023.1 (January 2023)