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Mammalian aldehyde oxidases: genetics, evolution and biochemistry

Garattini, E.; Fratelli, M.; Terao, M.; Cell. Mol. Life Sci. 65, 1019-1048 (2008)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
1-hydroxyphthalazine
administration to female rabbits causes an increase in the specific activity of liver aldehyde oxidase
Oryctolagus cuniculus
dioxin
induces AOX1 in mouse hepatoma cells
Mus musculus
methyl methanesulfonate
causes induction of liver aldehyde oxidase; causes induction of liver aldehyde oxidase; causes induction of liver aldehyde oxidase; causes induction of liver aldehyde oxidase
Rattus norvegicus
additional information
aldehyde oxidase activity rapidly increases with age up to about one year after birth
Homo sapiens
additional information
fatty liver disease is associated with elevated hepatic AOX1
Rattus norvegicus
N-methyl-N'-nitro-N-nitrosoguanidine
causes induction of liver aldehyde oxidase; causes induction of liver aldehyde oxidase; causes induction of liver aldehyde oxidase; causes induction of liver aldehyde oxidase
Rattus norvegicus
N-methyl-N-nitrosourea
causes induction of liver aldehyde oxidase; causes induction of liver aldehyde oxidase; causes induction of liver aldehyde oxidase; causes induction of liver aldehyde oxidase
Rattus norvegicus
phenethyl isothiocyanate
induces AOX1 transcript through a transcriptional mechanism
Mus musculus
Phthalazine
administration to female rabbits causes an increase in the specific activity of liver aldehyde oxidase
Oryctolagus cuniculus
testosterone
significantly increases activity in castrated males and normal female mice; significantly increases activity in castrated males and normal female mice; significantly increases activity in castrated males and normal female mice; significantly increases activity in castrated males and normal female mice; significantly increases activity in castrated males and normal female mice
Mus musculus
Application
Application
Commentary
Organism
medicine
aldehyde oxidases represent an important drug-metabolizing system in the cytosol of the hepatic cell. AOX1 is potentially useful in the bioactivation of pro-drugs in human liver and lung, given that the two tissues are the only ones reported to express significant amounts of this enzymatic activity. Variability in the levels of liver aldehyde oxidase in the human population
Homo sapiens
additional information
aldehyde oxidase is involved in the chemo-reception of pheromonal stimuli in the antennae
Mamestra brassicae
additional information
variations in the levels of aldehyde oxidase activity in different strains of experimental animals; variations in the levels of aldehyde oxidase activity in different strains of experimental animals; variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Gender-specific regulation of AOH1 by androgens and estrogens; variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Gender-specific regulation of AOX1 and AOH1 by androgens and estrogens; variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Gender-specific regulation of AOX1 by androgens and estrogens
Mus musculus
additional information
variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Rat strains with low aldehyde oxidase activity lack the ability to produce the catalytically active dimer and express only the monomeric form of the enzyme; variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Rat strains with low aldehyde oxidase activity lack the ability to produce the catalytically active dimer and express only the monomeric form of the enzyme; variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Rat strains with low aldehyde oxidase activity lack the ability to produce the catalytically active dimer and express only the monomeric form of the enzyme; variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Rat strains with low aldehyde oxidase activity lack the ability to produce the catalytically active dimer and express only the monomeric form of the enzyme; variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Rat strains with low aldehyde oxidase activity lack the ability to produce the catalytically active dimer and express only the monomeric form of the enzyme
Rattus norvegicus
Cloned(Commentary)
Commentary
Organism
AOX1 expressed in Escherichia coli
Mus musculus
Engineering
Amino acid exchange
Commentary
Organism
additional information
missense mutations in the coding exons of AOX1, reported in the population of the Churchill County of Nevada and in the Italian population, negatively affect catalytic activity of AOX1
Homo sapiens
additional information
AOH2 knock-out mice are viable and transmit the genetic deficit in a mendelian fashion
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
adiponectin
downregulates AOX1 expression by activating peroxisome proliferator-activated receptor-alpha
Rattus norvegicus
aspartate
neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
Mus musculus
beta-carboline
-
Homo sapiens
beta-carboline
a far better inhibitor of mouse AOH1 than AOX1; a far better inhibitor of mouse AOH1 than AOX1
Mus musculus
chlorpromazine
-
Homo sapiens
estradiol
-
Homo sapiens
estrogen
reduces liver aldehyde oxidase activity of male animals; reduces liver aldehyde oxidase activity of male animals; reduces liver aldehyde oxidase activity of male animals; reduces liver aldehyde oxidase activity of male animals; reduces liver aldehyde oxidase activity of male animals
Mus musculus
ethinyl estradiol
-
Homo sapiens
glutamate
neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
Mus musculus
menadione
-
Homo sapiens
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
Mus musculus
raloxifene
-
Homo sapiens
tamoxifen
-
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.031
-
all-trans retinaldehyde
-
Mus musculus
0.07
-
all-trans retinaldehyde
-
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Mus musculus
5829
-
cytosol
-
Oryctolagus cuniculus
5829
-
cytosol
-
Rattus norvegicus
5829
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
Q7G191
-
-
Arabidopsis thaliana
Q7G192
-
-
Arabidopsis thaliana
Q7G193
-
-
Bos taurus
P48034
-
-
Caenorhabditis elegans
O61198
-
-
Caenorhabditis elegans
Q960A1
-
-
Canis lupus familiaris
Q2QB47
-
-
Canis lupus familiaris
Q2QB48
-
-
Danio rerio
-
-
-
Drosophila melanogaster
-
-
-
Drosophila melanogaster
Q9VF53
-
-
Equus caballus
-
-
-
Gallus gallus
Q2QB49
-
-
Gallus gallus
Q2QB50
-
-
Homo sapiens
-
-
-
Macaca fascicularis
Q5FB27
-
-
Macaca mulatta
-
-
-
Mamestra brassicae
Q4VGM3
fragment
-
Monodelphis domestica
-
-
-
Mus musculus
-
DBA/2, CBA/2 C57Bl/6J and CD1 mice
-
Mus musculus
O54754
DBA/2, CBA/2 C57Bl/6J and CD1 mice
-
Mus musculus
Q5SGK3
DBA/2, CBA/2 C57Bl/6J and CD1 mice
-
Mus musculus
Q6V956
DBA/2, CBA/2 C57Bl/6J and CD1 mice
-
Mus musculus
Q8VJ15
DBA/2, CBA/2 C57Bl/6J and CD1 mice
-
no activity in Aspergillus nidulans
-
-
-
Oryctolagus cuniculus
P80456
-
-
Pan troglodytes
-
-
-
Pongo pygmaeus
-
-
-
Rattus norvegicus
Q5QE78
Wistar rats and Donryu rats
-
Rattus norvegicus
Q5QE79
Wistar rats and Donryu rats
-
Rattus norvegicus
Q5QE80
Wistar rats and Donryu rats
-
Rattus norvegicus
Q9Z0U5
Wistar rats and Donryu rats
-
Rattus norvegicus
-
Wistar rats and Donryu rats
-
Solanum lycopersicum
Q9FV23
-
-
Solanum lycopersicum
Q9FV24
-
-
Solanum lycopersicum
Q9FV25
-
-
Takifugu rubripes
-
-
-
Tetraodon nigroviridis
-
-
-
Xenopus laevis
Q6GMC5
-
-
Zea mays
O23887
-
-
Zea mays
O23888
-
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
-
Oryctolagus cuniculus
-
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
antenna
-
Mamestra brassicae
-
brain
AOH2 and AOH3 mRNAs are expressed in the brain at much lower levels than AOX1 and AOH1
Mus musculus
-
central nervous system
presence of the AOX1 transcript in the glial cell population of the spinal cord
Homo sapiens
-
central nervous system
-
Mus musculus
-
ear
richest source of AOH2 mRNA in the adult mouse is the inner ear
Mus musculus
-
esophagus
AOH2 is also present; AOX1 mRNA is particularly abundant in the epithelial layer
Mus musculus
-
eye
AOH2
Mus musculus
-
head
AOH2 and AOH3
Mus musculus
-
heart
-
Mus musculus
-
kidney
-
Homo sapiens
-
liver
AOX1 is expressed at high levels
Bos taurus
-
liver
-
Equus caballus
-
liver
only trace amounts of AOX1 activity
Gallus gallus
-
liver
high amounts
Homo sapiens
-
liver
AOH2 is also present. Aldehyde oxidase activity shows higher levels in male than female adult mice; the AOH1 transcript is already detectable in newborn mice; the AOX1 transcript takes time to appear and is measurable only in the fully developed animal
Mus musculus
-
liver
distribution of the activity is uneven, being seen mainly in the pericentral rather than the periportal area; distribution of the activity is uneven, being seen mainly in the pericentral rather than the periportal area; distribution of the activity is uneven, being seen mainly in the pericentral rather than the periportal area; distribution of the activity is uneven, being seen mainly in the pericentral rather than the periportal area; distribution of the activity is uneven, being seen mainly in the pericentral rather than the periportal area
Rattus norvegicus
-
liver
-
Oryctolagus cuniculus
-
lung
AOX1 is expressed at high levels
Bos taurus
-
lung
high amounts
Homo sapiens
-
lung
;
Mus musculus
-
lung
-
Rattus norvegicus
-
additional information
completely devoid of liver aldehyde oxidase activity; completely devoid of liver aldehyde oxidase activity
Canis lupus familiaris
-
additional information
AOH2 is abundant in the Harderian gland. AOH3 is restricted to the Bowman's gland
Mus musculus
-
neck
AOH2 and AOH3
Mus musculus
-
pancreas
AOH2
Mus musculus
-
respiratory system
-
Homo sapiens
-
skin
AOH2
Mus musculus
-
spleen
AOX1 is expressed at high levels
Bos taurus
-
testis
-
Mus musculus
-
zygote
very large amounts of AOH2 are predicted to be present during the early stages of development and specifically in the zygote
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(S)-RS-8359 + H2O + O2
Donryu rats show a dimorphic pattern for the 2-oxidation activity of RS-8359
691701
Rattus norvegicus
2-keto-(S)-RS-8359 + H2O2
-
-
-
?
1-nitropyrene + H2O + O2
-
691701
Oryctolagus cuniculus
?
-
-
-
?
6-deoxypenciclovir
is catalyzed by AOX1
691701
Homo sapiens
penciclovir
-
-
-
?
6-mercaptopurine + H2O + O2
-
691701
Homo sapiens
?
-
-
-
?
acetaldehyde + H2O + O2
is a poor substrate of AOH1
691701
Mus musculus
acetate + H2O2
-
-
-
?
acetaldehyde + H2O + O2
is a poor substrate of AOX1
691701
Mus musculus
acetate + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
-
691701
Oryctolagus cuniculus
all-trans retinoic acid + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
-
691701
Mus musculus
all-trans retinoic acid + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
AOH1 from the liver of CD1 mice is capable of oxidizing all-trans retinaldehyde
691701
Mus musculus
all-trans retinoic acid + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
AOH2 from the mouse Harderian gland and AOH3 from the mouse Bowman's gland are all capable of oxidizing all-trans retinaldehyde with equal efficiency
691701
Mus musculus
all-trans retinoic acid + H2O2
-
-
-
?
benzaldehyde + H2O + O2
-
691701
Homo sapiens
benzoate + H2O2
-
-
-
?
benzaldehyde + H2O + O2
-
691701
Rattus norvegicus
benzoate + H2O2
-
-
-
?
methotrexate + H2O + O2
-
691701
Rattus norvegicus
?
-
-
-
?
additional information
low and negligible quinine-oxidizing activity
691701
Rattus norvegicus
?
-
-
-
-
additional information
low and negligible quinine-oxidizing activity
691701
Canis lupus familiaris
?
-
-
-
-
additional information
pyridoxal is not recognized by mouse AOH2
691701
Mus musculus
?
-
-
-
-
N1-methylnicotinamide + H2O + O2
-
691701
Homo sapiens
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
-
691701
Rattus norvegicus
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
-
691701
Oryctolagus cuniculus
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
pyridoxal + H2O + O2
-
691701
Mus musculus
4-pyridoxic acid + H2O2
-
-
-
?
quinine + H2O + O2
-
691701
Oryctolagus cuniculus
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
dimer
-
Rattus norvegicus
monomer
-
Rattus norvegicus
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0000029
-
-
Homo sapiens
raloxifene
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
1-hydroxyphthalazine
administration to female rabbits causes an increase in the specific activity of liver aldehyde oxidase
Oryctolagus cuniculus
dioxin
induces AOX1 in mouse hepatoma cells
Mus musculus
methyl methanesulfonate
causes induction of liver aldehyde oxidase
Rattus norvegicus
additional information
aldehyde oxidase activity rapidly increases with age up to about one year after birth
Homo sapiens
additional information
fatty liver disease is associated with elevated hepatic AOX1
Rattus norvegicus
N-methyl-N'-nitro-N-nitrosoguanidine
causes induction of liver aldehyde oxidase
Rattus norvegicus
N-methyl-N-nitrosourea
causes induction of liver aldehyde oxidase
Rattus norvegicus
phenethyl isothiocyanate
induces AOX1 transcript through a transcriptional mechanism
Mus musculus
Phthalazine
administration to female rabbits causes an increase in the specific activity of liver aldehyde oxidase
Oryctolagus cuniculus
testosterone
significantly increases activity in castrated males and normal female mice
Mus musculus
Application (protein specific)
Application
Commentary
Organism
medicine
aldehyde oxidases represent an important drug-metabolizing system in the cytosol of the hepatic cell. AOX1 is potentially useful in the bioactivation of pro-drugs in human liver and lung, given that the two tissues are the only ones reported to express significant amounts of this enzymatic activity. Variability in the levels of liver aldehyde oxidase in the human population
Homo sapiens
additional information
aldehyde oxidase is involved in the chemo-reception of pheromonal stimuli in the antennae
Mamestra brassicae
additional information
variations in the levels of aldehyde oxidase activity in different strains of experimental animals
Mus musculus
additional information
variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Gender-specific regulation of AOX1 by androgens and estrogens
Mus musculus
additional information
variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Gender-specific regulation of AOH1 by androgens and estrogens
Mus musculus
additional information
variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Gender-specific regulation of AOX1 and AOH1 by androgens and estrogens
Mus musculus
additional information
variations in the levels of aldehyde oxidase activity in different strains of experimental animals. Rat strains with low aldehyde oxidase activity lack the ability to produce the catalytically active dimer and express only the monomeric form of the enzyme
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
AOX1 expressed in Escherichia coli
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
missense mutations in the coding exons of AOX1, reported in the population of the Churchill County of Nevada and in the Italian population, negatively affect catalytic activity of AOX1
Homo sapiens
additional information
AOH2 knock-out mice are viable and transmit the genetic deficit in a mendelian fashion
Mus musculus
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0000029
-
-
Homo sapiens
raloxifene
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
adiponectin
downregulates AOX1 expression by activating peroxisome proliferator-activated receptor-alpha
Rattus norvegicus
aspartate
neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
Mus musculus
beta-carboline
-
Homo sapiens
beta-carboline
a far better inhibitor of mouse AOH1 than AOX1
Mus musculus
chlorpromazine
-
Homo sapiens
estradiol
-
Homo sapiens
estrogen
reduces liver aldehyde oxidase activity of male animals
Mus musculus
ethinyl estradiol
-
Homo sapiens
glutamate
neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
Mus musculus
menadione
-
Homo sapiens
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
Mus musculus
raloxifene
-
Homo sapiens
tamoxifen
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.031
-
all-trans retinaldehyde
-
Mus musculus
0.07
-
all-trans retinaldehyde
-
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Mus musculus
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Oryctolagus cuniculus
5829
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
-
Oryctolagus cuniculus
-
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
antenna
-
Mamestra brassicae
-
brain
AOH2 and AOH3 mRNAs are expressed in the brain at much lower levels than AOX1 and AOH1
Mus musculus
-
brain
-
Mus musculus
-
central nervous system
presence of the AOX1 transcript in the glial cell population of the spinal cord
Homo sapiens
-
central nervous system
-
Mus musculus
-
ear
richest source of AOH2 mRNA in the adult mouse is the inner ear
Mus musculus
-
esophagus
AOH2 is also present
Mus musculus
-
esophagus
AOX1 mRNA is particularly abundant in the epithelial layer
Mus musculus
-
eye
AOH2
Mus musculus
-
head
AOH2 and AOH3
Mus musculus
-
heart
-
Mus musculus
-
kidney
-
Homo sapiens
-
liver
AOX1 is expressed at high levels
Bos taurus
-
liver
-
Equus caballus
-
liver
only trace amounts of AOX1 activity
Gallus gallus
-
liver
high amounts
Homo sapiens
-
liver
AOH2 is also present. Aldehyde oxidase activity shows higher levels in male than female adult mice
Mus musculus
-
liver
the AOX1 transcript takes time to appear and is measurable only in the fully developed animal
Mus musculus
-
liver
the AOH1 transcript is already detectable in newborn mice
Mus musculus
-
liver
distribution of the activity is uneven, being seen mainly in the pericentral rather than the periportal area
Rattus norvegicus
-
liver
-
Oryctolagus cuniculus
-
lung
AOX1 is expressed at high levels
Bos taurus
-
lung
high amounts
Homo sapiens
-
lung
-
Mus musculus
-
lung
-
Rattus norvegicus
-
additional information
completely devoid of liver aldehyde oxidase activity
Canis lupus familiaris
-
additional information
AOH2 is abundant in the Harderian gland. AOH3 is restricted to the Bowman's gland
Mus musculus
-
neck
AOH2 and AOH3
Mus musculus
-
pancreas
AOH2
Mus musculus
-
respiratory system
-
Homo sapiens
-
skin
AOH2
Mus musculus
-
spleen
AOX1 is expressed at high levels
Bos taurus
-
testis
-
Mus musculus
-
zygote
very large amounts of AOH2 are predicted to be present during the early stages of development and specifically in the zygote
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(S)-RS-8359 + H2O + O2
Donryu rats show a dimorphic pattern for the 2-oxidation activity of RS-8359
691701
Rattus norvegicus
2-keto-(S)-RS-8359 + H2O2
-
-
-
?
1-nitropyrene + H2O + O2
-
691701
Oryctolagus cuniculus
?
-
-
-
?
6-deoxypenciclovir
is catalyzed by AOX1
691701
Homo sapiens
penciclovir
-
-
-
?
6-mercaptopurine + H2O + O2
-
691701
Homo sapiens
?
-
-
-
?
acetaldehyde + H2O + O2
is a poor substrate of AOH1
691701
Mus musculus
acetate + H2O2
-
-
-
?
acetaldehyde + H2O + O2
is a poor substrate of AOX1
691701
Mus musculus
acetate + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
-
691701
Oryctolagus cuniculus
all-trans retinoic acid + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
-
691701
Mus musculus
all-trans retinoic acid + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
AOH1 from the liver of CD1 mice is capable of oxidizing all-trans retinaldehyde
691701
Mus musculus
all-trans retinoic acid + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
AOH2 from the mouse Harderian gland and AOH3 from the mouse Bowman's gland are all capable of oxidizing all-trans retinaldehyde with equal efficiency
691701
Mus musculus
all-trans retinoic acid + H2O2
-
-
-
?
benzaldehyde + H2O + O2
-
691701
Homo sapiens
benzoate + H2O2
-
-
-
?
benzaldehyde + H2O + O2
-
691701
Rattus norvegicus
benzoate + H2O2
-
-
-
?
methotrexate + H2O + O2
-
691701
Rattus norvegicus
?
-
-
-
?
additional information
low and negligible quinine-oxidizing activity
691701
Rattus norvegicus
?
-
-
-
-
additional information
low and negligible quinine-oxidizing activity
691701
Canis lupus familiaris
?
-
-
-
-
additional information
pyridoxal is not recognized by mouse AOH2
691701
Mus musculus
?
-
-
-
-
N1-methylnicotinamide + H2O + O2
-
691701
Homo sapiens
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
-
691701
Rattus norvegicus
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
-
691701
Oryctolagus cuniculus
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
pyridoxal + H2O + O2
-
691701
Mus musculus
4-pyridoxic acid + H2O2
-
-
-
?
quinine + H2O + O2
-
691701
Oryctolagus cuniculus
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
-
Rattus norvegicus
monomer
-
Rattus norvegicus
Other publictions for EC 1.2.3.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740850
Xu
Aldehyde oxidase mediated meta ...
Homo sapiens
J. Med. Chem.
60
2973-2982
2017
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741208
Srivastava
Aldehyde oxidase 4 plays a cri ...
Arabidopsis thaliana
Plant Physiol.
173
1977-1997
2017
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
11
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
11
1
-
-
-
-
-
-
-
-
1
1
1
1
-
-
740139
Siah
Inhibition of guinea pig aldeh ...
Cavia porcellus
Bioorg. Chem.
64
74-84
2016
-
-
-
-
-
-
2
1
-
-
-
-
-
4
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
2
2
2
1
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740025
Choughule
Interspecies differences in th ...
Homo sapiens, Oryctolagus cuniculus
Biochem. Pharmacol.
96
288-295
2015
-
-
2
1
6
-
-
2
-
-
-
-
-
8
-
-
-
-
-
2
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
1
6
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
2
-
-
-
-
-
2
2
-
-
-
740354
Barr
Inhibition of human aldehyde o ...
Homo sapiens
Drug Metab. Dispos.
43
34-41
2015
-
1
-
1
-
-
3
1
1
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
1
-
-
-
3
3
1
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740764
Cerqueira
Insights into the structural d ...
Mus musculus
J. Biol. Inorg. Chem.
20
209-217
2015
-
-
-
1
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740776
Yamada
A new aldehyde oxidase catalyz ...
Burkholderia sp. AIU 129
J. Biosci. Bioeng.
119
410-415
2015
-
-
-
-
-
-
7
7
-
-
4
-
-
2
-
-
-
-
-
-
-
-
8
1
1
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
7
-
-
4
-
-
-
-
-
-
-
-
-
8
1
1
-
1
-
1
1
-
-
-
-
-
-
-
-
740221
Li
NAD(+)-independent aldehyde ox ...
Pseudomonas sp., Pseudomonas sp. AIU 362
Biotechnol. Lett.
36
2215-2221
2014
-
1
1
-
-
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
2
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741471
Nirogi
Identification of a suitable a ...
Homo sapiens
Xenobiotica
44
197-204
2014
1
-
-
-
-
-
3
-
-
-
-
-
2
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
3
3
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723978
Rashidi
Aldehyde oxidase activity and ...
Oryctolagus cuniculus
Appl. Biochem. Biotechnol.
169
901-910
2013
-
-
-
-
-
-
1
8
-
-
-
-
5
2
-
-
1
-
-
1
1
-
1
-
-
2
3
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
8
-
-
-
-
5
-
-
1
-
1
1
-
1
-
-
2
3
-
2
1
-
-
-
-
-
-
-
-
724832
Barr
Evidence for substrate-depende ...
Homo sapiens
Drug Metab. Dispos.
41
24-29
2013
-
-
-
-
-
-
9
1
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
9
10
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
726341
Choo
Identification and characteriz ...
Amyelois transitella
PLoS ONE
8
e67794
2013
-
-
1
-
-
-
16
-
-
-
2
-
-
3
-
-
1
-
-
1
-
-
14
1
-
-
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
16
-
-
-
-
2
-
-
-
-
1
-
1
-
-
14
1
-
-
1
-
1
1
-
-
-
1
1
-
-
-
726542
Hamzeh-Mivehroud
Structure-based investigation ...
Rattus norvegicus, Rattus norvegicus Sprague–Dawley
Xenobiotica
43
661-670
2013
-
-
-
-
-
-
15
-
-
-
-
-
-
5
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
15
-
-
-
-
-
-
-
15
15
-
-
-
-
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741285
Mahro
Identification of crucial amin ...
Mus musculus
PLoS ONE
8
e82285
2013
-
-
1
-
8
-
-
27
-
1
-
-
-
3
-
-
-
-
-
-
-
-
5
-
-
-
-
25
-
-
-
1
-
-
-
-
-
1
1
-
8
-
-
-
-
27
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
25
-
-
-
-
-
-
-
-
26
26
724829
Hutzler
Characterization of aldehyde o ...
Homo sapiens
Drug Metab. Dispos.
40
267-275
2012
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725498
Coelho
The first mammalian aldehyde o ...
Mus musculus
J. Biol. Chem.
287
40690-40702
2012
-
-
-
1
4
-
4
22
-
-
-
-
-
2
-
-
1
-
-
1
-
-
4
1
-
-
-
21
-
-
-
3
5
-
-
-
-
-
3
1
4
-
-
4
5
22
-
-
-
-
-
-
-
1
-
1
-
-
4
1
-
-
-
21
-
-
-
-
-
-
-
-
21
21
724827
Mahro
Characterization and crystalli ...
Mus musculus
Drug Metab. Dispos.
39
1939-1945
2011
-
-
1
1
-
-
-
6
-
-
2
-
-
5
-
-
1
-
-
3
-
-
3
1
-
-
-
6
-
-
-
3
-
-
-
-
-
1
3
1
-
-
-
-
-
6
-
-
2
-
-
-
-
1
-
3
-
-
3
1
-
-
-
6
-
-
-
-
-
1
1
-
-
-
710735
Maeda
Crystallization and preliminar ...
Aspergillus oryzae, Aspergillus oryzae RIB 40
Acta Crystallogr. Sect. F
66
1064-1066
2010
-
-
1
1
-
-
-
-
-
-
-
-
-
8
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711490
Sorouraddin
Study of aldehyde oxidase-cata ...
Rattus norvegicus
Bioprocess Biosyst. Eng.
34
173-177
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711834
Zientek
In vitro-in vivo correlation f ...
Homo sapiens
Drug Metab. Dispos.
38
1322-1327
2010
-
-
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
1
-
-
11
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711838
Fukiya
A single amino acid substituti ...
Macaca fascicularis, Oryctolagus cuniculus
Drug Metab. Dispos.
38
302-307
2010
-
-
2
-
13
-
-
16
-
-
-
-
-
4
-
-
2
-
-
-
-
-
6
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
2
-
13
-
-
-
-
16
-
-
-
-
-
-
-
2
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711839
Dalvie
Cross-species comparison of th ...
Homo sapiens
Drug Metab. Dispos.
38
641-654
2010
-
-
-
-
-
-
2
1
1
-
-
-
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
2
-
1
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
713323
Zdunek-Zastocka
The activity pattern and gene ...
Pisum sativum
Plant Sci.
179
543-548
2010
-
-
-
-
-
-
-
-
-
1
-
-
-
5
-
-
-
-
-
8
-
-
9
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
29
-
-
9
-
-
-
-
-
-
-
-
-
1
1
4
3
-
-
696560
Itoh
Effects of selenium deficiency ...
Rattus norvegicus
Biol. Pharm. Bull.
32
190-194
2009
-
-
-
-
-
-
1
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696564
Itoh
Functional analysis of aldehyd ...
Macaca fascicularis, Rattus norvegicus
Biol. Pharm. Bull.
32
31-35
2009
-
-
-
-
2
-
-
9
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697588
Alfaro
Purification and mechanism of ...
Homo sapiens
Drug Metab. Dispos.
37
2393-2398
2009
-
-
1
-
-
-
-
4
-
-
1
-
-
3
-
-
-
-
-
-
-
-
5
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
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4
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1
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5
1
-
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-
-
699237
Pirouzpanah
Inhibitory effects of flavonoi ...
Cavia porcellus
J. Enzyme Inhib. Med. Chem.
24
14-21
2009
1
-
-
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10
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2
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1
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24
1
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24
10
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1
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1
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3
-
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700829
Ibdah
An aldehyde oxidase in develop ...
Arabidopsis thaliana
Plant Physiol.
150
416-423
2009
-
-
-
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1
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1
3
-
-
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3
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2
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8
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1
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3
1
1
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1
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1
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1
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1
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3
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2
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8
-
1
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-
3
1
1
-
-
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-
-
-
700901
Schumann
Site directed mutagenesis of a ...
Mus musculus
PLoS ONE
4
e5348
2009
-
-
1
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4
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10
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4
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1
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5
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10
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1
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4
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10
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5
-
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10
-
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712399
Li
Characterization of the magnit ...
Rattus norvegicus
J. Biol. Chem.
284
33850-33858
2009
-
-
-
-
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1
4
1
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1
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1
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3
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1
1
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1
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1
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1
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4
1
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1
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-
3
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
691701
Garattini
Mammalian aldehyde oxidases: g ...
Arabidopsis thaliana, Bos taurus, Caenorhabditis elegans, Canis lupus familiaris, Danio rerio, Drosophila melanogaster, Equus caballus, Gallus gallus, Homo sapiens, Macaca fascicularis, Macaca mulatta, Mamestra brassicae, Monodelphis domestica, Mus musculus, no activity in Aspergillus nidulans, Oryctolagus cuniculus, Pan troglodytes, Pongo pygmaeus, Rattus norvegicus, Solanum lycopersicum, Takifugu rubripes, Tetraodon nigroviridis, Xenopus laevis, Zea mays
Cell. Mol. Life Sci.
65
1019-1048
2008
10
4
1
-
2
-
13
2
3
-
-
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-
46
-
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3
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-
30
-
-
42
2
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-
-
-
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-
-
1
23
12
1
-
-
2
-
1
30
-
2
11
-
-
-
-
-
-
7
-
49
-
-
42
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693075
Li
Nitric oxide production from n ...
Rattus norvegicus
J. Biol. Chem.
283
17855-17863
2008
1
1
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2
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1
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1
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4
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1
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1
1
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1
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4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697933
Weigert
Small-interference RNA-mediate ...
Homo sapiens, Mus musculus
FEBS Lett.
582
2965-2972
2008
-
-
-
-
2
-
4
-
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3
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2
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2
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4
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698231
Kadam
Isolation of liver aldehyde ox ...
Cavia porcellus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Indian J. Pharm. Sci.
70
85-88
2008
-
-
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6
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10
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9
2
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4
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6
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9
2
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699045
Sasaki
Purification and characterizat ...
Pseudomonas sp., Pseudomonas sp. AIU 362
J. Biosci. Bioeng.
106
297-302
2008
1
-
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-
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4
9
-
1
2
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-
5
-
-
1
-
-
-
-
-
14
1
1
-
1
-
1
-
1
-
-
-
-
1
-
-
-
-
-
-
-
4
-
9
-
1
2
-
-
-
-
1
-
-
-
-
14
1
1
-
1
-
1
-
1
-
-
-
-
-
-
-
699722
Alfaro
Studies on the mechanism of al ...
synthetic construct
J. Org. Chem.
73
9469-9472
2008
-
-
-
-
-
-
-
-
-
1
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1
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-
-
1
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-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674374
Yamaguchi
Human Xanthine oxidase changes ...
Homo sapiens
J. Biochem.
141
513-524
2007
-
-
-
-
1
-
-
-
-
-
-
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4
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-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690612
Kundu
Characterization of superoxide ...
Rattus norvegicus
Arch. Biochem. Biophys.
460
113-121
2007
-
1
-
-
-
-
1
-
1
-
2
-
-
1
-
-
1
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-
1
2
-
1
1
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-
-
-
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-
-
-
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-
1
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-
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-
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-
1
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1
-
2
-
-
-
-
1
-
1
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691162
Hoshino
Cloning, expression, and chara ...
Macaca fascicularis, Rattus norvegicus
Biol. Pharm. Bull.
30
1191-1198
2007
-
1
1
-
-
-
-
3
2
-
4
-
-
7
-
-
1
-
-
4
2
-
2
1
-
-
-
-
-
-
-
-
-
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-
-
1
1
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-
-
-
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3
2
-
4
-
-
-
-
1
-
4
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691884
Tayama
Developmental changes of aldeh ...
Homo sapiens
Clin. Pharmacol. Ther.
81
567-572
2007
1
1
-
-
-
-
-
-
-
-
-
-
-
2
-
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-
-
1
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1
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1
1
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692051
Tayama
Developmental changes of aldeh ...
Rattus norvegicus
Drug Metab. Pharmacokinet.
22
119-124
2007
-
1
-
-
-
-
-
-
1
-
-
-
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2
-
-
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-
-
2
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3
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-
1
-
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-
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-
1
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-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692052
Rashidi
In vitro study of 6-mercaptopu ...
Cavia porcellus
Drug Metab. Pharmacokinet.
22
299-306
2007
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
1
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-
1
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
3
-
-
-
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-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692468
Pelletier
Identification of candidate al ...
Bombyx mori, Bombyx mori Nistari
Gene
404
31-40
2007
-
1
1
-
-
-
-
-
-
2
2
-
-
6
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
2
2
2
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692568
Graessler
The dual substrate specificity ...
Bos taurus, Gallus gallus, Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus
Horm. Metab. Res.
39
775-776
2007
-
1
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692569
Sigruener
Human aldehyde oxidase 1 inter ...
Homo sapiens
Horm. Metab. Res.
39
781-789
2007
-
1
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693533
Torres
Use of density functional calc ...
synthetic construct
J. Med. Chem.
50
4642-4647
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695270
Itoh
Lack of dimer formation abilit ...
Rattus norvegicus
Xenobiotica
37
709-716
2007
1
1
-
-
-
-
1
-
1
-
2
-
-
2
-
-
-
-
-
1
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
1
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671778
Neumeier
Aldehyde oxidase 1 is highly a ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
350
731-735
2006
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
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-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672548
Klecker
Zebularine metabolism by aldeh ...
Canis lupus familiaris, Homo sapiens, Macaca fascicularis, Mus musculus, Mus musculus CD-1, Rattus norvegicus
Bioorg. Med. Chem.
14
62-66
2006
-
-
-
-
-
-
8
6
10
-
-
-
-
15
-
-
-
-
-
10
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
6
10
-
-
-
-
-
-
-
-
10
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672629
Sasaki
Rat strain differences in ster ...
Rattus norvegicus
Biopharm. Drug Dispos.
27
247-255
2006
-
-
-
-
-
-
-
7
2
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
2
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673053
Saieed
-
Inhibitory effects of Ruta gra ...
Cavia porcellus
Chem. Pharm. Bull.
54
925
2006
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
4
5
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673063
Dick
Substrate specificity of rabbi ...
Rattus norvegicus
Chem. Res. Toxicol.
19
38-43
2006
-
-
-
-
-
-
-
6
-
-
-
-
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673297
Sugihara
Estimation of aldehyde oxidase ...
Rattus norvegicus
Drug Metab. Dispos.
34
208-212
2006
-
1
-
-
-
-
-
-
-
-
-
-
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2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674600
Terao
Avian and canine aldehyde oxid ...
Canis lupus familiaris, Gallus gallus
J. Biol. Chem.
281
19748-19761
2006
-
-
-
-
-
-
-
-
-
-
1
-
-
11
-
-
1
-
-
6
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
7
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675237
Thapper
Biochemical and spectroscopic ...
Desulfovibrio aminophilus
J. Inorg. Biochem.
100
44-50
2006
-
-
-
-
-
-
-
-
-
2
2
-
-
1
-
-
-
-
-
-
1
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
1
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677200
Honda
Neo-nicotinoid metabolic activ ...
Oryctolagus cuniculus
Toxicol. Lett.
161
108-114
2006
-
1
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10
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10
-
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-
677264
Uchida
Purification and some properti ...
Streptomyces rimosus, Streptomyces rimosus ATCC 10970
World J. Microbiol. Biotechnol.
22
469-474
2006
-
-
-
-
-
-
-
13
1
-
4
-
-
3
-
-
1
-
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-
1
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19
1
1
-
1
-
1
-
1
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13
1
-
4
-
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1
-
-
1
-
19
1
1
-
1
-
1
-
1
-
-
-
-
-
-
-
654321
Uchida
Characterization and potential ...
Pseudomonas stutzeri 12695, Pseudomonas stutzeri
Appl. Microbiol. Biotechnol.
68
53-56
2005
-
-
-
-
-
-
-
2
-
2
4
-
-
3
-
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1
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23
1
1
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3
-
1
1
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2
-
2
4
-
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1
-
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-
-
23
1
1
-
3
-
1
1
-
-
-
-
-
-
-
-
654379
Prabhu
Surgical stress-induced altera ...
Rattus norvegicus
Arch. Biochem. Biophys.
434
299-305
2005
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1
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-
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1
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1
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-
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-
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-
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-
-
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660183
Yesbergenova
The plant Mo-hydroxylases alde ...
Solanum lycopersicum
Plant J.
42
862-876
2005
-
-
-
-
-
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1
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-
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1
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5
-
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2
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6
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1
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1
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2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671699
Merlin
A new aldehyde oxidase selecti ...
Mamestra brassicae
Biochem. Biophys. Res. Commun.
332
4-10
2005
-
-
-
-
-
-
-
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1
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1
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4
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2
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1
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1
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1
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1
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1
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2
-
-
1
-
-
-
-
-
-
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-
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-
-
-
-
-
-
673058
Dick
Identification of aldehyde oxi ...
Gallus gallus, Homo sapiens, Macaca fascicularis, Oryctolagus cuniculus, Rattus norvegicus
Chem. Res. Toxicol.
18
317-323
2005
-
-
-
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5
-
5
-
-
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15
-
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5
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6
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5
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5
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5
-
-
6
-
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-
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674391
Yang
Effects of 2,3,7,8-tetrachloro ...
Mus musculus
J. Biochem. Mol. Toxicol.
19
327-335
2005
-
-
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1
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2
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674939
Al-Omar
-
Interaction of 2-thio-4-oxo-qu ...
Cavia porcellus
J. Biol. Sci.
5
370-378
2005
-
-
-
-
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25
-
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1
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1
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25
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-
-
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25
25
-
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674940
Al-Omar
-
Comparative effects of scopole ...
Cavia porcellus
J. Biol. Sci.
5
525-531
2005
-
-
-
-
-
-
3
-
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1
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1
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3
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-
3
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1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675324
Al-Omar
-
Effect of 2-hydroxy-1, 4-napht ...
Cavia porcellus
J. Med. Sci.
5
163-168
2005
-
-
-
-
-
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1
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1
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1
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1
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1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676103
Fedorova
Aldehyde oxidase (AO) in the r ...
Lupinus albus, Medicago truncatula
Mol. Plant Microbe Interact.
18
405-413
2005
-
-
-
-
-
-
-
-
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4
4
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6
-
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8
-
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8
2
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-
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4
4
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-
-
8
-
-
8
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677111
Al-Omar
-
In vitro inhibitory effect of ...
Cavia porcellus
Saudi Pharm. J.
13
164-170
2005
-
-
-
-
-
-
4
-
-
-
-
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1
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-
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1
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2
-
-
-
-
-
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2
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4
2
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-
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-
-
-
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-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677213
Rivera
Identification of aldehyde oxi ...
Mus musculus
Toxicology
207
401-409
2005
-
-
-
-
-
-
1
-
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-
-
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2
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2
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1
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
654034
Panoutsopoulos
Kinetics and specificity of gu ...
Cavia porcellus
Acta Biochim. Pol.
51
649-663
2004
-
-
-
-
-
-
8
8
-
-
-
-
-
4
-
-
1
-
-
3
-
-
11
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
8
2
8
-
-
-
-
-
-
-
1
-
3
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654035
Panoutsopoulos
Enzymatic oxidation of phthala ...
Cavia porcellus
Acta Biochim. Pol.
51
943-951
2004
-
-
-
-
-
-
1
-
-
-
-
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2
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1
-
-
2
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1
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-
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-
1
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1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656258
Kurosaki
The aldehyde oxidase gene clus ...
Mus musculus
J. Biol. Chem.
279
50482-50498
2004
-
-
1
-
-
-
-
-
-
-
1
-
-
6
-
-
1
-
-
6
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
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-
1
-
-
-
-
1
-
6
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656273
Vila
Regulation and biochemistry of ...
Mus musculus, Mus musculus CD-1, Mus musculus DBA/2
J. Biol. Chem.
279
8668-8683
2004
-
-
-
-
-
-
3
10
-
-
-
-
-
10
-
-
1
-
-
3
1
-
18
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
3
1
10
-
-
-
-
-
-
-
1
-
3
1
-
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656366
Obach
Human liver aldehyde oxidase: ...
Homo sapiens
J. Clin. Pharmacol.
44
7-19
2004
-
-
-
-
-
-
36
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
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-
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-
-
-
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-
-
-
-
-
-
-
36
-
-
1
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-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656630
Taylor
Xanthine dehydrogenase and ald ...
Persea americana
J. Plant Res.
117
121-130
2004
-
-
-
-
-
-
-
-
-
-
-
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-
3
-
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-
3
-
-
1
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-
-
-
-
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-
-
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-
-
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-
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-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
644705
Uchida
Purification and characterizat ...
Pseudomonas sp., Pseudomonas sp. KY 4690
FEMS Microbiol. Lett.
229
31-36
2003
-
-
-
-
-
-
-
8
-
2
4
-
-
3
-
-
1
-
-
-
1
-
18
1
-
-
2
-
-
-
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
8
-
2
4
-
-
-
-
1
-
-
1
-
18
1
-
-
2
-
-
-
1
-
-
-
-
-
-
-
656924
Omarov
Aldehyde oxidase isoforms and ...
Hordeum vulgare
Physiol. Plant.
117
337-342
2003
-
-
-
-
-
-
-
-
-
-
2
-
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3
-
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-
-
-
1
-
-
2
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348684
Coleman
Molecular characterization of ...
Culex quinquefasciatus
Eur. J. Biochem.
269
768-779
2002
-
-
1
-
-
-
1
-
-
1
2
-
-
4
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
2
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390370
Maia
Xanthine oxidase and aldehyde ...
Rattus norvegicus
Arch. Biochem. Biophys.
400
48-53
2002
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655278
Al-Salmy
Inter-strain variability in al ...
Mus musculus
Comp. Biochem. Physiol. C
132
341-347
2002
-
-
-
-
-
-
1
6
1
-
-
-
-
4
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
6
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656311
Yasuhara
Production of aldehyde oxidase ...
Methylobacillus sp., Pseudomonas sp., Streptomyces moderatus
J. Biosci. Bioeng.
94
124-129
2002
-
-
-
-
-
-
3
21
-
-
12
-
-
8
-
-
3
-
-
-
-
-
69
3
3
3
6
-
3
3
8
-
-
-
-
-
-
-
-
-
-
-
-
3
-
21
-
-
12
-
-
-
-
3
-
-
-
-
69
3
3
3
6
-
3
3
8
-
-
-
-
-
-
-
390371
Al-Salmy
Individual variation in hepati ...
Homo sapiens
IUBMB Life
51
249-253
2001
-
-
-
-
-
-
1
2
1
2
-
1
-
2
-
-
-
-
-
1
-
-
4
-
2
-
-
-
1
-
-
1
1
-
-
-
-
-
1
-
-
-
-
1
1
2
1
2
-
1
-
-
-
-
-
1
-
-
4
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
390372
Bittner
ABA3 is a molybdenum cofactor ...
Arabidopsis thaliana
J. Biol. Chem.
276
40381-40384
2001
-
-
1
-
-
1
-
-
-
-
-
1
-
2
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390373
Seo
The Arabidopsis aldehyde oxida ...
Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
97
12908-12913
2000
-
-
-
-
-
-
-
-
-
1
-
1
-
3
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
390374
Wroczynski
Aromatic aldehydes as fluoroge ...
Rattus norvegicus
Analyst
125
511-516
2000
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
8
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390375
Duarte
Biochemical/spectroscopic char ...
Desulfovibrio desulfuricans
Biochem. Biophys. Res. Commun.
268
745-749
2000
-
-
-
1
-
-
4
4
-
2
2
-
-
1
-
-
1
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1
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4
1
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1
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1
1
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1
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4
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4
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2
2
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1
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4
1
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1
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1
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-
-
-
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390376
Sugihara
Purification and some properti ...
Cavia porcellus, Mesocricetus auratus, Oryctolagus cuniculus
Biol. Pharm. Bull.
22
1246-1248
1999
-
-
-
-
-
-
14
2
3
6
2
1
-
4
-
-
1
-
-
3
1
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10
1
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3
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3
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14
-
2
3
6
2
1
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1
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3
1
-
10
1
-
-
-
-
-
-
-
-
-
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-
-
-
390377
Kurosaki
Molecular cloning of the cDNA ...
Mus musculus
Biochem. J.
341
71-80
1999
-
-
1
-
-
-
-
-
1
2
1
1
-
7
-
-
-
-
-
4
3
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2
1
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2
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1
2
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1
2
1
1
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4
3
-
2
1
-
-
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-
-
-
-
-
-
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-
-
390378
Wright
cDNA cloning, sequencing, and ...
Rattus norvegicus
J. Biol. Chem.
274
3878-3886
1999
-
-
-
-
-
-
-
5
-
2
1
2
-
3
-
-
1
-
-
2
-
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4
1
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1
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2
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2
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5
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2
1
2
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1
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2
-
-
4
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
390422
Huang
Molecular cloning of retinal o ...
Mus musculus, Oryctolagus cuniculus
Arch. Biochem. Biophys.
364
264-272
1999
-
-
1
-
-
-
-
2
2
-
2
2
-
5
-
-
2
-
-
20
1
-
4
2
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-
-
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-
1
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-
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2
2
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2
2
-
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-
2
-
20
1
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390379
Yoshihara
Purification and characterizat ...
Mus musculus
Arch. Biochem. Biophys.
338
29-34
1997
-
-
-
-
-
-
7
8
1
2
2
-
-
2
-
-
1
-
-
2
3
-
3
1
1
-
-
-
1
-
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2
-
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-
-
2
-
-
-
-
7
-
8
1
2
2
-
-
-
-
1
-
2
3
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
390380
Acheampong
Characterization of brimonidin ...
Canis lupus familiaris, Macaca fascicularis, Oryctolagus cuniculus, Rattus norvegicus
Xenobiotica
26
1035-1055
1996
-
-
-
-
-
-
1
-
2
-
-
4
-
9
-
-
-
-
-
7
-
-
4
-
-
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-
-
-
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-
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-
-
-
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-
-
-
-
-
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4
-
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7
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-
4
-
-
-
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-
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-
-
-
-
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-
-
-
390381
Koshiba
Purification and properties of ...
Zea mays
Plant Physiol.
110
781-789
1996
-
-
-
-
-
-
3
12
-
2
2
-
1
5
-
-
1
-
-
3
1
1
6
1
1
-
2
-
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
12
-
2
2
-
1
-
-
1
-
3
1
1
6
1
1
-
2
-
1
1
-
-
-
-
-
-
-
-
390382
Calzi
Purification, cDNA cloning, an ...
Bos taurus
J. Biol. Chem.
270
31037-31045
1995
-
-
-
-
-
-
1
-
-
2
2
1
-
3
-
-
1
-
-
5
1
-
2
1
1
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
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2
2
1
-
-
-
1
-
5
1
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
390423
Tomita
Retinal oxidase is identical t ...
Oryctolagus cuniculus
FEBS Lett.
336
272-274
1993
-
-
-
-
-
-
2
7
1
2
2
8
-
1
-
-
1
-
-
1
-
-
10
1
-
-
-
4
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
2
1
7
1
2
2
8
-
-
-
1
-
1
-
-
10
1
-
-
-
4
-
-
-
-
-
-
-
-
-
-
390424
Hupert
In vitro formation of retinoic ...
Rattus sp.
Biochem. Cell Biol.
69
509-514
1991
2
-
-
-
-
-
1
1
1
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
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-
-
2
-
-
-
-
-
-
-
1
-
1
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
390383
Tasayco
A specific affinity reagent to ...
Heliothis virescens
J. Biol. Chem.
265
3094-3101
1990
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390384
Tasayco
Aldehyde-oxidizing enzymes in ...
Heliothis virescens
Arch. Biochem. Biophys.
278
444-451
1990
-
-
-
-
-
-
1
-
1
-
-
-
-
3
-
-
-
-
-
3
-
-
9
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
3
-
-
9
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
390385
Stell
Purification of rabbit liver a ...
Oryctolagus cuniculus
J. Chromatogr.
475
363-372
1989
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
1
-
1
-
-
-
1
1
1
-
4
-
-
-
-
-
-
-
-
-
-
1
4
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
1
-
-
-
1
1
1
-
-
-
-
-
-
-
390425
Bhat
Properties of retinal-oxidizin ...
Rattus sp.
Biochim. Biophys. Acta
967
211-217
1988
-
-
-
-
-
-
8
-
1
-
-
2
-
2
-
-
-
-
-
1
-
1
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
8
-
-
1
-
-
2
-
-
-
-
-
1
-
1
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
390427
Bhat
Enzymatic oxidation of all-tra ...
Rattus sp.
Biochem. Cell Biol.
66
735-740
1988
4
-
-
-
-
-
-
1
-
-
-
1
-
2
-
-
-
-
-
3
-
-
1
-
1
-
-
-
-
-
-
-
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4
-
-
-
-
-
-
-
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1
-
-
-
1
-
-
-
-
-
3
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
390386
Turner
The molybdenum iron-sulphur pr ...
Desulfovibrio gigas
Biochem. J.
243
755-761
1987
-
-
-
-
-
-
-
-
-
2
-
-
-
3
-
-
-
-
-
-
-
-
3
-
1
-
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-
1
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-
-
-
-
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-
2
-
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-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
390387
Cabre
-
Purification and properties of ...
Bos taurus
Biochem. Soc. Trans.
15
882-883
1987
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
1
7
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
1
7
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
390388
Tatsumi
Oxime-metabolizing activity of ...
Cavia porcellus, Mesocricetus auratus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Arch. Biochem. Biophys.
253
413-418
1987
-
-
-
-
-
-
-
-
5
-
-
-
-
6
-
-
-
-
-
6
-
-
9
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
6
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390426
Mandal
Enzymic oxidation of vitamin A ...
Rattus sp.
Indian J. Exp. Biol.
25
796-797
1987
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
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1
-
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-
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390389
Banks
Tropylium tetrafluoroborate, a ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
140
609-615
1986
-
-
-
-
-
-
3
1
-
1
-
1
-
2
-
-
-
-
-
2
2
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
1
-
1
-
-
-
-
-
2
2
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
390390
Yoshihara
Kinetic and inhibition studies ...
Cavia porcellus
Arch. Biochem. Biophys.
249
8-14
1986
-
-
-
-
-
-
7
4
-
-
1
-
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
7
-
4
-
-
1
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390391
Banks
Chromate reduction by rabbit l ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
137
8-14
1986
-
-
-
-
-
-
2
-
-
1
-
-
-
2
-
-
-
-
-
2
2
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
2
2
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390393
Tatsumi
N-Hydroxy-2-acetylaminofluoren ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
138
312-317
1986
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
390394
Hall
Aldehyde oxidase from rabbit l ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
251
36-46
1986
-
-
-
-
-
-
1
2
-
-
-
-
-
3
-
-
1
-
-
2
-
-
6
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
1
-
2
-
-
6
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
390395
Chanteux
-
Ethanol metabolizing system in ...
Drosophila melanogaster
Experientia
41
1543-1546
1985
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390396
Yoshihara
Guinea pig liver aldehyde oxid ...
Cavia porcellus
Arch. Biochem. Biophys.
242
213-224
1985
-
-
-
-
-
-
4
-
2
2
2
-
-
3
-
-
1
-
-
3
2
-
12
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
4
-
-
2
2
2
-
-
-
-
1
-
3
2
-
12
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
390397
Thomas
Oxidation in H2O and D2O of 6- ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
241
649-655
1985
-
-
-
-
-
1
-
8
-
-
-
-
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
8
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
390398
Angelino
Purification and immobilizatio ...
Oryctolagus cuniculus
Biotechnol. Bioeng.
27
447-455
1985
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
7
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
7
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
390399
Kitamura
Involvement of liver aldehyde ...
Cavia porcellus, Mesocricetus auratus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Biochem. Biophys. Res. Commun.
120
602-606
1984
-
-
-
-
-
-
1
-
5
-
-
-
-
11
-
-
-
-
-
6
-
-
6
-
4
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
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6
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6
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4
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3
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390400
Kitamura
Reduction of tertiary amine N- ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
121
749-754
1984
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1
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390401
Taylor
Simultaneous formation of 2- a ...
Cavia porcellus, Oryctolagus cuniculus
Biochem. J.
220
67-74
1984
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10
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390402
Tatsumi
Sulfoxide reductase activity o ...
Cavia porcellus, Oryctolagus cuniculus
Biochim. Biophys. Acta
747
86-92
1983
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8
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2
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7
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8
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7
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390403
Gormley
An extremely potent anilinoacr ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
116
759-764
1983
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3
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3
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1
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390404
Barber
Properties of the prosthetic g ...
Oryctolagus cuniculus
Biochemistry
21
3561-3568
1982
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2
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390405
Badwey
Superoxide production by an un ...
Cavia porcellus
J. Biol. Chem.
256
3479-3486
1981
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5
1
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10
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5
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1
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1
10
-
1
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390406
Warner
Molybdenum hydroxylases in Dro ...
Drosophila melanogaster
Mol. Gen. Genet.
184
92-96
1981
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1
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1
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285726
Kishore
Enzymatic oxidation and reduct ...
Mus musculus
Biochem. Biophys. Res. Commun.
94
1381-1386
1980
2
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1
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1
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1
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390407
Brandänge
The enzyme aldehyde oxidase is ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
91
991-996
1979
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390408
Takahashi
Enzymatic improvement of food ...
Bos taurus
Agric. Biol. Chem.
43
2557-2561
1979
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1
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1
3
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390409
Kuhn
Aldehyde oxidase compartmental ...
Drosophila melanogaster
Science
196
875-877
1977
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3
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3
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390410
Andres
Aldehyde oxidase and xanthine ...
Drosophila melanogaster
Eur. J. Biochem.
62
591-600
1976
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2
2
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2
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1
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390411
Romeo
Absence of coenzyme Q10 as an ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
59
1286-1291
1974
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390412
Felsted
Purification and properties of ...
Oryctolagus cuniculus, Sus scrofa
J. Biol. Chem.
248
2580-2587
1973
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2
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2
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2
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2
2
5
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2
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2
2
5
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4
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390413
Massey
-
Iron-sulfur flavoprotein hydro ...
Oryctolagus cuniculus
Iron-Sulfur Proteins (Lovenberg, W. , ed. )
1
301-360
1973
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2
1
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1
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390414
Krenitsky
A comparison of the specificit ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
150
585-599
1972
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1
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390415
Stanulovic
Aldehyde oxidase: catalysis of ...
Mus musculus, Rattus norvegicus
Arch. Biochem. Biophys.
145
27-34
1971
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4
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2
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2
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-
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390416
Arneson
Substrate-induced chemilumines ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
136
352-360
1970
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1
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1
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390417
Rajagopalan
-
Aldehyde oxidase ...
Oryctolagus cuniculus
Methods Enzymol.
9
364-368
1968
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2
1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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-
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390418
Loo
-
Enzymic hydroxylation of 6-met ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
134
467-469
1967
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1
2
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1
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1
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1
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