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Information on EC 1.1.3.17 - choline oxidase

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.3 With oxygen as acceptor
                1.1.3.17 choline oxidase
IUBMB Comments
A flavoprotein (FAD). In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyse the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine. In plants, the first reaction is catalysed by EC 1.14.15.7, choline monooxygenase, whereas in animals and many bacteria, it is catalysed by either membrane-bound choline dehydrogenase (EC 1.1.99.1) or soluble choline oxidase (EC 1.1.3.17) . The enzyme involved in the second step, EC 1.2.1.8, betaine-aldehyde dehydrogenase, appears to be the same in those plants, animals and bacteria that use two separate enzymes.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
alkaliphilic choline oxidase, An_CodA, APChO-syn, CHO, choline oxidase, choline-oxygen 1-oxidoreductase, choline:oxygen 1-reductase, ChOx, ChOx protein, codA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
betaine aldehyde + O2 + H2O = betaine + H2O2
show the reaction diagram
choline + 2 O2 + H2O = betaine + 2 H2O2
show the reaction diagram
choline + O2 = betaine aldehyde + H2O2
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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