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Ligand glycine betaine

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

carnitine metabolism, glycine betaine biosynthesis, methionine metabolism

KEGG

ABC transporters, Glycine, serine and threonine metabolism

MetaCyc

(2-trimethylamino)ethylphosphonate degradation, choline degradation I, choline degradation II, choline degradation IV, D-carnitine degradation I, glycine betaine biosynthesis I (Gram-negative bacteria), glycine betaine biosynthesis II (Gram-positive bacteria), glycine betaine biosynthesis III (plants), glycine betaine biosynthesis IV (from glycine), glycine betaine biosynthesis V (from glycine), glycine betaine degradation I, glycine betaine degradation II (mammalian), glycine betaine degradation III, glycine betaine degradation IV, L-carnitine degradation III, L-methionine salvage from L-homocysteine, methanogenesis from glycine betaine more

Show all BRENDA pathways known for glycine betaine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

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Show Natural Substrate (10 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.17

glycine betaine + H2O2 = betaine aldehyde + O2 + H2O

739846

4mjw, 3D-view

1.14.13.251

glycine betaine + NADH + H+ + O2 = N,N-dimethylglycine + formaldehyde + NAD+ + H2O

763954

-

1.14.13.251

glycine betaine + NADPH + H+ + O2 = N,N-dimethylglycine + formaldehyde + NADP+ + H2O

763954

-

1.14.13.251

2 entries

1.21.4.4

N,N,N-trimethylglycine + phosphate + thioredoxin = acetyl phosphate + trimethylamine + thioredoxin disulfide

636280, 636281

-

2.1.1.376

glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] = N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein]

762268

-

2.1.1.376

glycine betaine + cob(I)alamin = N,N-dimethylglycine + methyl-cob(III)alamin

756781

-

2.1.1.376

glycine betaine + [Co(I) glycine betaine-specific corrinoid protein MV8465] = N,N-dimethylglycine + [methyl-Co(III) glycine betaine-specific corrinoid protein MV8465]

756781

-

2.1.1.5

L-homocysteine + betaine = L-methionine + dimethylglycine

658186, 658928

-

2.1.1.5

N,N,N-trimethylglycine + L-homocysteine = N,N-dimethylglycine + L-methionine

441244, 441233

-

2.1.1.376

3 entries

2.1.1.5

2 entries

7.6.2.9

ATP + H2O + glycine betaine/out = ADP + phosphate + glycine betaine/in

210318, 210321, 734090, 687343, 210319, 210323, 210322, 210324, 210325, 210320

-

In Vivo Product in Enzyme-catalyzed Reactions (21 results)

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Show Natural Product (21 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.17

betaine aldehyde + O2 + H2O = betaine + H2O2

0

4mjw, 3D-view

1.1.3.17

choline + 2 O2 + H2O = betaine + 2 H2O2

0

4mjw, 3D-view

1.1.3.17

choline + 2 O2 + H2O2 = betaine + 2 H2O2

0

4mjw, 3D-view

1.1.3.17

betaine aldehyde + O2 + H2O = glycine betaine + H2O2

0

4mjw, 3D-view

1.1.3.17

4 entries

1.1.99.1

choline + 2 acceptor + H2O = glycine-betaine + 2 reduced acceptor + H+

0

-

1.13.11.90

[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + phosphate

0

-

1.2.1.47

betaine aldehyde + NAD+ + H2O = betaine + NADH + H+

0

-

1.2.1.8

betaine aldehyde + NAD+ + H2O = betaine + NADH

0

-

1.2.1.8

betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+

0

-

1.2.1.8

betaine aldehyde + NAD+ + H2O = betaine + NADH + H+

0

-

1.2.1.8

betaine aldehyde + NADP+ + H2O = betaine + NADPH + H+

0

-

1.2.1.8

betaine aldehyde + NAD(P)+ + H2O = glycine betaine + NAD(P)H + 2 H+

0

-

1.2.1.8

betaine aldehyde + NAD(P)+ + H2O = glycine betaine + NAD(P)H + H+

0

-

1.2.1.8

betaine aldehyde + NAD+ + H2O = glycine betaine + NADH + 2 H+

0

-

1.2.1.8

betaine aldehyde + NAD+ + H2O = glycine betaine + NADH + H+

0

-

1.2.1.8

betaine aldehyde + NADP+ + H2O = glycine betaine + NADPH + H+

0

-

2.1.1.157

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine

0

-

2.1.1.157

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + N,N,N-trimethylglycine

0

-

1.2.1.8

9 entries

2.1.1.157

2 entries

2.1.1.161

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + N,N,N-trimethylglycine

0

-

2.1.1.162

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + N,N,N-trimethylglycine

0

-

7.6.2.9

ATP + H2O + glycine betaine/out = ADP + phosphate + glycine betaine/in

0, 210319, 210318

-

Substrate in Enzyme-catalyzed Reactions (21 results)

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Show Substrate (21 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.17

glycine betaine + H2O2 = betaine aldehyde + O2 + H2O

739846

4mjw, 3D-view

1.14.13.251

glycine betaine + NADH + H+ + O2 = N,N-dimethylglycine + formaldehyde + NAD+ + H2O

763954

-

1.14.13.251

glycine betaine + NADPH + H+ + O2 = N,N-dimethylglycine + formaldehyde + NADP+ + H2O

763954

-

1.14.13.251

2 entries

1.2.1.21

betaine + NADH = betaine aldehyde + NAD+ + H2O

390215

-

1.21.4.4

N,N,N-trimethylglycine + dithioerythritol = ?

636280

-

1.21.4.4

N,N,N-trimethylglycine + NADPH = ? + NADP+

636280

-

1.21.4.4

N,N,N-trimethylglycine + phosphate + thioredoxin = acetyl phosphate + trimethylamine + thioredoxin disulfide

636280, 636281

-

1.21.4.4

3 entries

2.1.1.10

betaine + L-homocysteine = dimethylglycine + L-methionine

756095

-

2.1.1.250

glycine betaine + cob(I)alamin = dimethylglycine + methylcob(III)alamin

737168

-

2.1.1.376

glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] = N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein]

762268

-

2.1.1.376

glycine betaine + cob(I)alamin = N,N-dimethylglycine + methyl-cob(III)alamin

756781, 762268

-

2.1.1.376

glycine betaine + [Co(I) glycine betaine-specific corrinoid protein MV8465] = N,N-dimethylglycine + [methyl-Co(III) glycine betaine-specific corrinoid protein MV8465]

756781

-

2.1.1.5

betaine + DL-homocysteine = dimethylglycine + L-methionine

675300

-

2.1.1.5

L-homocysteine + betaine = dimethylglycine + L-methionine

720080, 719035, 720040

-

2.1.1.5

L-homocysteine + betaine = L-methionine + dimethylglycine

676758, 684710, 687808, 703877, 658422, 673003, 675300, 689024, 701995, 705038, 671232, 702044, 705295, 658928, 735230, 657817, 671242, 441243, 658186, 671233

-

2.1.1.5

glycinebetaine + L-homocysteine = ? + L-methionine

441246, 441247

-

2.1.1.5

N,N,N-trimethylglycine + L-homocysteine = N,N-dimethylglycine + L-methionine

441232, 441234, 441233, 441235, 441236, 441237, 441244

-

2.1.1.376

3 entries

2.1.1.5

5 entries

2.1.1.B141

glycine betaine + [corrinoid-binding protein Co(I)-MtqC] = [methyl-corrinoid-protein Co(I)-MtqC] + N-dimethylglycine

763275

-

7.4.2.1

ATP + H2O + betaine/out = ADP + phosphate + betaine/in

246884

-

7.6.2.9

ATP + H2O + betaine/out = ADP + phosphate + betaine/in

656531, 210322, 656842, 671475

-

7.6.2.9

ATP + H2O + glycine betaine/out = ADP + phosphate + glycine betaine/in

210318, 210320, 210321, 210325, 673631, 675375, 675495, 734090, 734645, 210317, 210319, 210322, 655328, 655339, 210323, 210324, 687343, 674658, 720807, 656670, 680504, 734703

-

7.6.2.9

2 entries

Product in Enzyme-catalyzed Reactions (39 results)

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Show Product (39 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.17

betaine aldehyde + O2 + H2O = betaine + H2O2

0

4mjw, 3D-view

1.1.3.17

choline + 2 O2 + H2O = betaine + 2 H2O2

0

4mjw, 3D-view

1.1.3.17

choline + 2 O2 + H2O2 = betaine + 2 H2O2

0

4mjw, 3D-view

1.1.3.17

choline + O2 + H2O = betaine + 2 H2O2

0

4mjw, 3D-view

1.1.3.17

betaine aldehyde + O2 + H2O = glycine betaine + H2O2

0

4mjw, 3D-view

1.1.99.1

betaine aldehyde + phenazine methosulfate = glycine-betaine + ?

0

-

1.1.99.1

choline + 2 acceptor + H2O = glycine-betaine + 2 reduced acceptor + H+

0

-

1.1.3.17

5 entries

1.1.99.1

2 entries

1.13.11.90

[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + phosphate

0

-

1.2.1.19

betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+

0

-

1.2.1.19

betaine aldehyde + NAD+ + H2O = betaine + NADH + H+

288082

-

1.2.1.19

2 entries

1.2.1.24

betaine aldehyde + NAD+ + H2O = 2-trimethylammonioacetate + NADH

0

-

1.2.1.3

betaine aldehyde + NAD+ + H2O = betaine + NADH

0

-

1.2.1.3

betaine aldehyde + NAD+ + H2O = betaine + NADH + H+

0

-

1.2.1.47

betaine aldehyde + NAD+ + H2O = betaine + NADH + H+

0

-

1.2.1.47

betaine aldehyde + NAD+ = betaine + NADH

288255

-

1.2.1.8

betaine aldehyde + NAD(P)+ + H2O = betaine + NAD(P)H + H+

0

-

1.2.1.8

betaine aldehyde + NAD+ + H2O = betaine + NADH

0

-

1.2.1.8

betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+

0

-

1.2.1.8

betaine aldehyde + NAD+ + H2O = betaine + NADH + H+

0

-

1.2.1.8

betaine aldehyde + NADP+ + H2O = betaine + NADPH

0

-

1.2.1.8

betaine aldehyde + NADP+ + H2O = betaine + NADPH + H+

0

-

1.2.1.8

betaine aldehyde + NAD(P)+ + H2O = glycine betaine + NAD(P)H + 2 H+

0

-

1.2.1.8

betaine aldehyde + NAD(P)+ + H2O = glycine betaine + NAD(P)H + H+

0

-

1.2.1.8

betaine aldehyde + NAD+ + H2O = glycine betaine + NADH + 2 H+

0

-

1.2.1.8

betaine aldehyde + NAD+ + H2O = glycine betaine + NADH + H+

0

-

1.2.1.8

betaine aldehyde + NADP+ + H2O = glycine betaine + NADPH + H+

0

-

1.2.1.8

glycine betaine aldehyde + NAD+ + H2O = glycine betaine + NADH

0

-

1.2.1.8

glycine betaine aldehyde + NADP+ + H2O = glycine betaine + NADPH

0

-

2.1.1.157

2 S-adenosyl-L-methionine + sarcosine = 2 S-adenosyl-L-homocysteine + betaine

0

-

2.1.1.157

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine

0

-

2.1.1.157

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine + H+

0

-

2.1.1.157

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + N,N,N-trimethylglycine

0

-

1.2.1.3

2 entries

1.2.1.47

2 entries

1.2.1.8

13 entries

2.1.1.157

4 entries

2.1.1.161

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + N,N,N-trimethylglycine

0

-

2.1.1.162

3 S-adenosyl-L-methionine + glycine = 3 S-adenosyl-L-homocysteine + betaine

0

-

2.1.1.162

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine

0

-

2.1.1.162

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + N,N,N-trimethylglycine

0

-

2.1.1.162

3 entries

7.4.2.1

ATP + H2O + betaine/out = ADP + phosphate + betaine/in

246884

-

7.6.2.9

ATP + H2O + betaine/out = ADP + phosphate + betaine/in

0, 210322

-

7.6.2.9

ATP + H2O + glycine betaine/out = ADP + phosphate + glycine betaine/in

0, 210318, 210320, 210321, 210325, 210317, 210319, 210322, 210323, 210324

-

7.6.2.9

2 entries

Activator in Enzyme-catalyzed Reactions (20 results)

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Show Activating Compound (20 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.8

activates the wild-type enzyme but not the mutant enzyme

655947

-

1.5.3.10

-

724807

-

2.1.1.156

recombinant enzyme: 20% activation at 0.5 M with sarcosine, no activation with glycine

657578

5hij, 3D-view

2.1.1.17

attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, the effect is enhanced by ethanol, which alone has no effect on expression levels of the enzyme, overview

675185

-

2.1.1.5

-

673003

-

2.1.1.5

elevations in the liver activity

673003

-

2.1.1.5

only slightly increased homocysteine remethylation in response to addition of betaine to diets containing 0.07 and 0.24% supplemental methionine

676758

-

2.1.1.5

together with methionine restriction induces hepatic BHMT 4fold compared with methionine restriction alone, BHMT mRNAlevel is also increased by 3fold by betaine supplementation of methionine-replete diets

671855

-

2.1.1.5

4 entries

2.1.1.79

activity is extremely low in vitro in 100 mM buffers, 100fold stimulation by exogenous addition of 2-3 M glycinebetaine

485633

-

2.7.1.146

-

761158

-

2.7.1.146

activates at 0.1-1.5 M

761158

-

2.7.1.147

-

761158

-

2.7.1.147

activates at 0.1-1.5 M

761158

-

2.7.1.146

2 entries

2.7.1.147

2 entries

2.7.11.19

stimulates enzyme self-association and interaction with glycogen, prevents complex formation with phosphorylase b

662670

-

2.7.13.3

stimulates, stimulation pattern of MtrA is similar to that of MtrB

680813

-

3.1.1.79

it enhances the enzyme activity 2fold at 50°C and 3 M, and 1.5fold at 45°C and 1-3 M, while it reduces the enzyme activity at 35-40°C, by 20% at 40°C and 3 M, about 5% at 1 M, overview

729483

-

3.2.1.28

activates

136180

-

4.2.1.20

1 M betaine activates the enzyme 1.8fold in the absence of monovalent cations

729226

-

4.2.1.22

activates, effects on wild-type and mutant enzymes, overview

715808

-

6.3.1.2

0.4 M, 67.7% residual activity after 60°C heat treatment

667442

-

Inhibitor in Enzyme-catalyzed Reactions (28 results)

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Show Inhibitors (28 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.254

competitive inhibitor of (S)-carnitine oxidation; D-carnitine dehydrogenase, competitive inhibition

9589

-

1.1.3.17

-

654371

4mjw, 3D-view

1.1.3.17

binds to the active site, different binding of wild-type and mutant enzymes, overview

654773

4mjw, 3D-view

1.1.3.17

pH dependence of the kcat and kcat/Km values for glycine betaine inhibition shown, inhibition of H351A enzyme maximal at low pH and reduced with increasing pH

685260

4mjw, 3D-view

1.1.3.17

3 entries

1.13.11.55

25% inhibition at 1 M NaCl, below 10% activity at 3 M, inactive at 4 M NaCl

742795

-

1.14.15.7

300 mM betaine give 50% inhibition

285435

-

1.2.1.8

10 mM, 14% inhibition

390342

-

1.2.1.8

product inhibition

660944

-

1.2.1.8

-

390352, 390363

-

1.2.1.8

no inhibition up to 10 mM

390358

-

1.2.1.8

product inhibition

390353

-

2.1.1.156

feedback inhibition

720836, 758143

5hij, 3D-view

2.1.1.156

recombinant enzyme: poor inhibition, 60% inhibition at 2 M with glycine, and 70% inhibition at 2 M with sarcosine, synergistic with salts KCl and NaCl, overview

657578

5hij, 3D-view

2.1.1.157

above 1.0 M, no effect on sarcosine N-methyltransferase activity, 35% inhibition of N,N-dimethylglycine N-methyltransferase activity

695924

-

2.1.1.157

does not affect the SMT activity, but represses the DMT activity by 35% at 2 M

720836

-

2.1.1.157

recombinant enzyme: poor inhibition, 71% inhibition at 2 M with sarcosine, and 69% inhibition at 2 M with dimethylglycine, partially reversible by salts KCl and NaCl, overview

657578

-

1.2.1.8

5 entries

2.1.1.156

2 entries

2.1.1.157

3 entries

2.1.1.3

0.1 M

485244

-

2.7.1.32

-

641347, 641372

-

2.7.1.82

-

641347

-

2.7.1.82

not

642036, 642038

-

2.7.1.82

2 entries

2.7.11.19

stimulates enzyme self-association and interaction with glycogen, prevents complex formation with phosphorylase b

662670

-

3.1.1.79

it enhances the enzyme activity 2fold at 50°C and 3 M, and 1.5fold at 45°C and 1-3 M, while it reduces the enzyme activity at 35-40°C, by 20% at 40°C and 3 M,about % at 1 M, overview

729483

-

3.1.3.2

-

666336

-

3.1.3.75

-

714872

-

3.1.3.75

32% inhibition of wild-type enzyme in vivo at 5 mM, at lower concentrations betaine induces the enzyme expression in vivo

664697

-

3.1.3.75

2 entries

3.1.6.6

linear competitive inhibitor

135659

-

3.4.11.20

complete inhibition at 2 mM

665073

-

7.4.2.1

competitive inhibitor of His uptake

246884

-

Metals and Ions (1 result)

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Show Metals Ions (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.4.1.2

high concentrations of salt may be substituted with 30% DMSO or betaine with good stability and activity

724935

-

3D Structure of Enzyme-Ligand-Complex (PDB) (5 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (5 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.1.3.17

4mjw, 3D-view

2.1.1.156

5hij, 3D-view

3.4.21.4

3t27, 3D-view

3.4.21.64

6rve, 3D-view

3.4.24.27

3t2j, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (17 results)

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Show Turnover Number (17 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.1.1.5

0.000082

-

37°C, mutant enzyme E159K

657817

2.1.1.5

0.00023

-

37°C, mutant enzyme E159G

657817

2.1.1.5

0.001

-

37°C, mutant enzyme Y77A

657817

2.1.1.5

0.0021

-

37°C, mutant enzyme D26I

657817

2.1.1.5

0.0045

-

37°C, mutant enzym T73G

657817

2.1.1.5

0.0051

-

37°C, mutant enzyme D26A

657817

2.1.1.5

0.0058

-

37°C, mutant enzyme T184G

657817

2.1.1.5

0.006

-

37°C, mutant enzyme E21A

657817

2.1.1.5

0.006

-

37°C, mutant enzyme T186S

657817

2.1.1.5

0.0072

-

37°C, mutant enzyme F74A

657817

2.1.1.5

0.0075

-

37°C, mutant enzyme A119G

657817

2.1.1.5

0.0076

-

37°C, mutant enzyme C186A

657817

2.1.1.5

0.009

-

37°C, mutant enzyme E21K

657817

2.1.1.5

0.014

-

37°C, wild-type enzyme

657817

2.1.1.5

0.0298

-

wild-type, pH 7.5, 37°C

735230

2.1.1.5

0.0422

-

wild-type, presence of 150 mM KCl, pH 7.5, 37°C

735230

2.1.1.5

88

-

-

687808

2.1.1.5

17 entries

K_M Value (48 results)

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Show KM Value (48 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.21.4.4

9

-

pH 7.7, 30°C

636280

2.1.1.376

1.96

-

at pH 6.5 and 37°C

762268

2.1.1.5

0.002

-

recombinant enzyme

441241

2.1.1.5

0.012

-

mutant Arg239Gln

689024

2.1.1.5

0.0139

-

mutant Arg16Cys

689024

2.1.1.5

0.0139

-

mutant Gly199Ser

689024

2.1.1.5

0.0213

-

mutant Pro197Ser

689024

2.1.1.5

0.0227

-

wild-type

689024

2.1.1.5

0.023

-

-

441243

2.1.1.5

0.039

0.056

-

441233

2.1.1.5

0.059

-

wild-type, presence of 150 mM KCl, pH 7.5, 37°C

735230

2.1.1.5

0.075

-

wild-type, pH 7.5, 37°C

735230

2.1.1.5

0.1

-

-

441234, 673003

2.1.1.5

0.139

-

37°C, mutant enzyme E21A

657817

2.1.1.5

0.185

-

37°C, mutant enzyme C186A

657817

2.1.1.5

0.195

-

37°C, mutant enzyme E21K

657817

2.1.1.5

0.206

-

37°C, mutant enzyme T186S

657817

2.1.1.5

0.258

-

37°C, mutant enzym T73G

657817

2.1.1.5

0.305

-

37°C, mutant enzyme A119G

657817

2.1.1.5

0.333

-

37°C, wild-type enzyme

657817

2.1.1.5

0.548

-

37°C, mutant enzyme T184G

657817

2.1.1.5

0.969

-

37°C, mutant enzyme F74A

657817

2.1.1.5

1.17

-

37°C, mutant enzyme D26A

657817

2.1.1.5

2

-

-

675300

2.1.1.5

2.2

-

-

687808

2.1.1.5

2.4

-

-

673003

2.1.1.5

4.3

-

-

441247

7.6.2.9

0.0012

-

at 30°C in presence of 300 mM KCl

210323

7.6.2.9

0.0017

-

-

210322

7.6.2.9

0.0019

-

30ºC, pH 7.0, wild type/substrate binding domain-less mutant heterodimer

655339

7.6.2.9

0.0019

-

30ºC, pH 7.0, wild type/W484C heterodimer

655339

7.6.2.9

0.0024

-

OpuA

210325

7.6.2.9

0.0025

-

30ºC, pH 7.0, wild type enzyme

655339

7.6.2.9

0.0029

-

at 30°C in presence of 600 mM sucrose

210323

7.6.2.9

0.0037

-

kinetics of OpuC-mediated uptake, in 50 mM of phosphate buffer containing 0.5 M of NaCl, 0.2% glucose, pH 7, low-affinity transport of choline determined

680504

7.6.2.9

0.0051

-

OpuC, without NaCl

210325

7.6.2.9

0.006

-

OpuC, in presence of 0.4 M NaCl

210325

7.6.2.9

0.00832

-

Aphanothece halophytica cells supplemented with 0.5 M NaCl

671475

7.6.2.9

0.00941

-

Aphanothece halophytica cells supplemented with 2.0 M NaCl

671475

7.6.2.9

0.0095

-

OpuD, without NaCl

210325

7.6.2.9

0.013

-

OpuD, in presence of 0.4 M NaCl

210325

7.6.2.9

0.0157

-

at 4°C, no additions

210323

7.6.2.9

0.0608

-

at pH 8.5, Aphanothece halophytica cells

671475

7.6.2.9

0.0834

-

at pH 7.0, Aphanothece halophytica cells

671475

7.6.2.9

0.0919

-

at pH 8.5, BetTA.halophytica expressing MKH13 cells

671475

7.6.2.9

0.128

-

at pH 7.0, BetTA.halophytica expressing MKH13 cells

671475

7.6.2.9

0.143

-

at pH 5.5, Aphanothece halophytica cells

671475

7.6.2.9

0.272

-

at pH 5.5, BetTA.halophytica expressing MKH13 cells

671475

2.1.1.5

25 entries

7.6.2.9

21 entries

K_i Value (3 results)

top print hide

Show KI Value (3 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.3.17

15

-

pH 8.0, 25°C

654371

1.2.1.8

0.209

-

30°C, pH 8.0, cosubstrate NADP+

660944

1.2.1.8

0.289

-

30°C, pH 8.0, cosubstrate NAD+

660944

1.2.1.8

2 entries

References & Links

Literature References (111)

top print hide

Show Reference (111 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

9589

9003445

Purification and characterization of D(+)-carnitine dehydrogenase from Agrobacterium sp. - a new enzyme of carnitine metabolism

1997

Hanschmann, H.; Kleber, H.P.

Biochim. Biophys. Acta

1337

133-142

135659

4196744

Choline sulfatase of Pseudomonas aeruginosa

1972

Lucas, J.J.; Burchiel, S.W.; Segel, I.H.

Arch. Biochem. Biophys.

153

664-672

136180

-

Degradation of the compatible solute trehalose in Ectothiorhodospira halochloris: isolation and characterization of trehalase

1990

Herzog, R.M.; Galinski, E.A.; Trueper, H.G.

Arch. Microbiol.

153

600-606

210317

3305496

Purification and characterization of a glycine betaine binding protein from Escherichia coli

1987

Barron, A.; Jung, J.U.; Villarejo, M.

J. Biol. Chem.

262

11841-11846

210318

10860977

Osmoregulated ABC-transport system of Lactococcus lactis senses water stress via changes in the physical state of the membrane

2000

Van der Heide, T.; Poolman, B.

Proc. Natl. Acad. Sci. USA

97

7102-7106

210319

2949137

Binding protein dependent transport of glycine betaine and its osmotic regulation in Escherichia coli K12

1986

May, G.; Faatz, E.; Villarejo, M.; Bremer, E.

Mol. Gen. Genet.

205

225-233

210320

7622480

OpuA, an osmotically regulated binding protein-dependent transport system for the osmoprotectant glycine betaine in Bacillus subtilis

1995

Kempf, B.; Bremer, E.

J. Biol. Chem.

270

16701-16713

210321

9335265

Lipoprotein from the osmoregulated ABC transport system OpuA of Bacillus subtilis: purification of the glycine betaine binding protein and characterization of a functional lipidless mutant

1997

Kempf, B.; Gade, J.; Bremer, E.

J. Bacteriol.

179

6213-6220

210322

10515910

Genetic and biochemical characterization of a high-affinity betaine uptake system (BusA) in Lactococcus lactis reveals a new functional organization within bacterial ABC transporters

1999

Obis, D.; Guillot, A.; Gripon, J.C.; Renault, P.; Bolotin, A.; Mistou, M.Y.

J. Bacteriol.

181

6238-6246

210323

10762257

Osmotic and chill activation of glycine betaine porter II in Listeria monocytogenes membrane vesicles

2000

Gerhardt, P.N.; Tombras Smith, L.; Smith, G.M.

J. Bacteriol.

182

2544-2550

210324

10473414

Identification of an ATP-driven, osmoregulated glycine betaine transport system in Listeria monocytogenes

1999

Ko, R.; Smith, L.T.

Appl. Environ. Microbiol.

65

4040-4048

210325

8752321

Three transport systems for the osmoprotectant glycine betaine operate in Bacillus subtilis: characterization of OpuD

1996

Kappes, R.M.; Kempf, B.; Bremer, E.

J. Bacteriol.

178

5071-5079

246884

10850986

Characterization of a Sinorhizobium meliloti ATP-binding cassette histidine transporter also involved in betaine and proline uptake

2000

Boncompagni, E.; Dupont, L.; Mignot, T.; Osteraes, M.; Lambert, A.; Poggi, M.C.; Le Rudulier, D.

J. Bacteriol.

182

3717-3725

285435

16666757

Evidence for a ferredoxin-dependent choline monooxygenase from spinach chloroplast stroma

1989

Brouquisse, R.; Weigel, P.; Rhodes, D.; Yocum, C.F.; Hanson, A.D.

Plant Physiol.

90

322-329

288082

10467734

Aldehyde dehydrogenase from rat intestinal mucosa: purification and characterization of an isozyme with high affinity for gamma-aminobutyraldehyde

1999

Testore, G.; Cravanzola, C.; Bedino, S.

Int. J. Biochem. Cell Biol.

31

777-786

288255

10702312

Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis

2000

Vaz, F.M.; Fouchier, S.W.; Ofman, R.; Sommer, M.; Wanders, R.J.A.

J. Biol. Chem.

275

7390-7394

390215

-

Separation and characterization of glycolaldehyde dehydrogenase isozymes in Escherichia coli B

1978

Tani, Y.; Morita, H.; Nishise, H.; Ogata, K.

Agric. Biol. Chem.

42

63-68

390342

-

Purification and characterization of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa A-16

1976

Nagasawa, T.; Kawabata, Y.; Tani, Y.; Ogata, K.

Agric. Biol. Chem.

40

1743-1749

390352

9734333

Porcine kidney betaine aldehyde dehydrogenase: purification and properties

1998

Guzman-Partida, A.M.; Valenzuela-Soto, E.M.

Comp. Biochem. Physiol. B

119

485-491

390353

9059629

Effects of glycerol on the kinetic properties of betaine aldehyde dehydrogenase

1997

Munoz-Clares, R.A.; Vojtechova, M.; Mujica-Jimenez, C.; Rodriguez-Sotres, R.

Adv. Exp. Med. Biol.

414

261-268

390358

8226918

Betaine-aldehyde dehydrogenase from leaves of Amaranthus hypochondriacus L. exhibits an Iso Ordered Bi Bi steady state mechanism

1993

Valenzuela-Soto, E.M.; Munoz-Clares, R.A.

J. Biol. Chem.

268

23818-23823

390363

-

Characterization of partially purified betaine aldehyde dehydrogenase from horseshoe crab (Limulus polyphemus) cardiac mitochondria

1994

Dragolovich, J.; Pierce, S.K.

J. Exp. Zool.

270

417-425

441232

3657557

Betaine-homocysteine S-methyltransferase (human)

1987

Skiba, W.E.; Wells, M.S.; Mangum, J.H.; Awad, W.M.

Methods Enzymol.

143

384-388

441233

4650615

Methionine metabolism in mammals: kinetic study of betaine-homocysteine methyltransferase

1972

Finkelstein, J.D.; Harris, B.J.; Kyle, W.E.

Arch. Biochem. Biophys.

153

320-324

441234

7174675

Human hepatic methionine biosynthesis. Purification and characterization of betaine:homocysteine S-methyltransferase

1982

Skiba, W.E.; Taylor, M.P.; Wells, M.S.; Mangum, J.H.; Awad, W.M.

J. Biol. Chem.

257

14944-14948

441235

1370132

Betaine:homocysteine methyltransferase from rat liver: purification and inhibition by a boronic acid substrate analog

1992

Lee, K.H.; Cava, M.; Amiri, P.; Ottoboni, T.; Lindquist, R.N.

Arch. Biochem. Biophys.

292

77-86

441236

6696751

Inactivation of betaine-homocysteine methyltransferase by adenosylmethionine and adenosylethionine

1984

Finkelstein, J.D.; Martin, J.J.

Biochem. Biophys. Res. Commun.

118

14-19

441237

6630207

Evidence for direct methyl transfer in betaine: homocysteine S-methyl-transferase

1983

Awad, W.M.; Whitney, P.L.; Skiba, W.E.; Mangum, J.H.; Wells, M.S.

J. Biol. Chem.

258

12790-12792

441241

9681996

Human betaine-homocysteine methyltransferase is a zinc metalloenzyme

1998

Millian, N.S.; Garrow, T.A.

Arch. Biochem. Biophys.

356

93-98

441243

8798461

Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase

1996

Garrow, T.A.

J. Biol. Chem.

271

22831-22838

441244

9804840

Betaine-homocysteine methyltransferase is a developmentally regulated enzyme crystallin in rhesus monkey lens

1998

Rao, P.V.; Garrow, T.A.; John, F.; Garland, D.; Millian, N.S.; Zigler, J.S., Jr.

J. Biol. Chem.

273

30669-30674

441246

10977887

Degradation of glycinebetaine by betaine-homocysteine methyltransferase in Aphanothece halophytica: effect of salt downshock and starvation

2000

Incharoensakdi, A.; Waditee, R.

Curr. Microbiol.

41

227-231

441247

11391473

Purification and kinetic properties of betaine-homocysteine methyltransferase from Aphanothece halophytica

2001

Waditee, R.; Incharoensakdi, A.

Curr. Microbiol.

43

107-111

485244

13584318

Thetin-homocysteine transmethylase: some further characteristics of the enzyme from rat liver

1958

Maw, G.A.

Biochem. J.

70

168-173

485633

-

Glycinebetaine stimulates, but NaCl inhibits, fatty acid biosynthesis in the moderately halophilic eubacterium HX

1994

Kuchta, T.; Russell, N.

Arch. Microbiol.

161

234-238

636280

-

Reductive cleavage of sarcosine and betaine by Eubacterium acidaminophilum via enzyme systems different from glycine reductase

1989

Hormann, K.; Andreesen, J.R.

Arch. Microbiol.

153

50-59

636281

8529639

Purification and characterization of protein PB of betaine reductase and its relationship to the corresponding proteins glycine reductase and sarcosine reductase from Eubacterium acidaminophilum

1995

Meyer, M.; Granderath, K.; Andreesen, J.R.

Eur. J. Biochem.

234

184-191

641347

199433

Choline kinase and ethanolamine kinase are separate, soluble enzymes in rat liver

1977

Brophy, P.J.; Choy, P.C.; Toone, J.R.; Vance, D.E.

Eur. J. Biochem.

78

491-495

641372

1323025

Choline/ethanolamine kinase from rat kidney

1992

Ishidate, K.; Nakazawa, Y.

Methods Enzymol.

209

121-134

642036

5626092

Phosphorylation of choline and ethanolamine in Ehrlich ascites-carcinoma cells

1967

Sung, C.P.; Johnstone, R.M.

Biochem. J.

105

497-503

642038

5047700

Ethanolamine phosphokinase: activity and properties during liver development

1972

Weinhold, P.A.; Rethy, V.B.

Biochim. Biophys. Acta

276

143-154

654371

15369826

The trimethylammonium headgroup of choline is a major determinant for substrate binding and specificity in choline oxidase

2004

Gadda, G.; Powell, N.L.; Menon, P.

Arch. Biochem. Biophys.

430

264-273

654773

15654745

On the catalytic role of the conserved active site residue His466 of choline oxidase

2005

Ghanem, M.; Gadda, G.

Biochemistry

44

893-904

655328

11742979

On the osmotic signal and osmosensing mechanism of an ABC transport system for glycine betaine

2001

van der Heide, T.; Stuart, M.C.A.; Poolman, B.

EMBO J.

20

7022-7032

655339

14609945

On the role of the two extracytoplasmic substrate-binding domains in the ABC transporter OpuA

2003

Biemans-Oldehinkel, E.; Poolman, B.

EMBO J.

22

5983-5993

655947

12186739

Glu103Gln site-directed mutation causes an alteration in physical properties of spinach betaine aldehyde dehydrogenase

2002

Incharoensakdi, A.; Hibino, T.; Takabe, T.

J. Biochem. Mol. Biol. Biophys.

6

243-248

656531

14623183

Nucleotide dependent monomer/dimer equilibrium of OpuAA, the nucleotide-binding protein of the osmotically regulated ABC transporter OpuA from Bacillus subtilis

2003

Horn, C.; Bremer, E.; Schmitt, L.

J. Mol. Biol.

334

403-419

656670

12766159

The ATP/substrate stoichiometry of the ATP-binding cassette (ABC) transporter OpuA

2003

Patzlaff, J.S.; van der Heide, T.; Poolman, B.

J. Biol. Chem.

278

29546-29551

656842

12581365

Osmoregulation in Lactococcus lactis: BusR, a transcriptional repressor of the glycine betaine uptake system BusA

2003

Romeo, Y.; Obis, D.; Bouvier, J.; Guillot, A.; Fourçans, A.; Bouvier, I.; Gutierrez, C.; Mistou, MY.

Mol. Microbiol.

47

1135-1147

657578

11319079

Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase

2001

Nyyssola, A.; Reinikainen, T.; Leisola, M.

Appl. Environ. Microbiol.

67

2044-2050

657817

12487625

Active-site-mutagenesis study of rat liver betaine-homocysteine S-methyltransferase

2003

Gonzalez, B.; Campillo, N.; Garrido, F.; Gasset, M.; Sanz-Aparicio, J.; Pajares, M.A.

Biochem. J.

370

945-952

658186

12757931

Betaine homocysteine methyltransferase: gene cloning and expression analysis in rat liver cirrhosis

2003

Forestier, M.; Banninger, R.; Reichen, J.; Solioz, M.

Biochim. Biophys. Acta

1638

29-34

658422

12618183

Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase

2003

Collinsova, M.; Castro, C.; Garrow, T.A.; Yiotakis, A.; Dive, V.; Jiracek, J.

Chem. Biol.

10

113-122

658928

15203112

In vitro modification of betaine-homocysteine S-methyltransferase by tissue-type transglutaminase

2004

Ichikawa, A.; Ohashi, Y.; Terada, S.; Natsuka, S.; Ikura, K.

Int. J. Biochem. Cell Biol.

36

1981-1992

660944

11104673

Steady-state kinetic mechanism of the NADP+- and NAD+-dependent reactions catalysed by betaine aldehyde dehydrogenase from Pseudomonas aeruginosa

2000

Velasco-Garcia, R.; Gonzalez-Segura, L.; Munoz-Clares, R.A.

Biochem. J.

352

675-683

662670

15362101

Effect of molecular crowding on self-association of phosphorylase kinase and its interaction with phosphorylase b and glycogen

2004

Chebotareva, N.A.; Andreeva, I.E.; Makeeva, V.F.; Livanova, N.B.; Kurganov, B.I.

J. Mol. Recognit.

17

426-432

664697

15886911

Identification, cloning, and expression of Pseudomonas aeruginosa phosphorylcholine phosphatase gene

2005

Massimelli, M.J.; Beassoni, P.R.; Forrellad, M.A.; Barra, J.L.; Garrido, M.N.; Domenech, C.E.; Lisa, A.T.

Curr. Microbiol.

50

251-256

665073

-

Aminopeptidase Ey

2004

Ichishima, E.

Handbook of Proteolytic Enzymes (2nd Edition)

1

294-296

666336

6436682

Pseudomonas aeruginosa acid phosphatase and cholinesterase induced by choline and its metabolic derivatives may contain a similar anionic peripheral site

1984

Lisa, T.A.; Garrido, M.N.; Domenech, C.E.

Mol. Cell. Biochem.

63

113-118

667442

16701563

Cyclitols protect glutamine synthetase and malate dehydrogenase against heat induced deactivation and thermal denaturation

2006

Jaindl, M.; Popp, M.

Biochem. Biophys. Res. Commun.

345

761-765

671232

16352668

Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver

2006

Ratnam, S.; Wijekoon, E.P.; Hall, B.; Garrow, T.A.; Brosnan, M.E.; Brosnan, J.T.

Am. J. Physiol. Endocrinol. Metab.

290

E933-E939

671233

16835399

Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats

2006

Nieman, K.M.; Hartz, C.S.; Szegedi, S.S.; Garrow, T.A.; Sparks, J.D.; Schalinske, K.L.

Am. J. Physiol. Endocrinol. Metab.

291

E1235-E1242

671242

17218476

Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells

2007

Schaefer, C.; Hoffmann, L.; Heldt, K.; Lornejad-Schaefer, M.R.; Brauers, G.; Gehrmann, T.; Garrow, T.A.; Haeussinger, D.; Mayatepek, E.; Schwahn, B.C.; Schliess, F.

Am. J. Physiol. Gastrointest. Liver Physiol.

292

G1089-G1098

671475

16957224

Halotolerant cyanobacterium Aphanothece halophytica contains a betaine transporter active at alkaline pH and high salinity

2006

Laloknam, S.; Tanaka, K.; Buaboocha, T.; Waditee, R.; Incharoensakdi, A.; Hibino, T.; Tanaka, Y.; Takabe, T.

Appl. Environ. Microbiol.

72

6018-6026

671855

16396637

Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase

2006

Sparks, J.D.; Collins, H.L.; Chirieac, D.V.; Cianci, J.; Jokinen, J.; Sowden, M.P.; Galloway, C.A.; Sparks, C.E.

Biochem. J.

395

363-371

673003

17086380

Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?

2006

Pajares, M.A.; Perez-Sala, D.

Cell. Mol. Life Sci.

63

2792-2803

673631

16225868

Functional overexpression and in vitro re-association of OpuA, an osmotically regulated ABC-transport complex from Bacillus subtilis

2005

Horn, C.; Bremer, E.; Schmitt, L.

FEBS Lett.

579

5765-5768

674658

16844687

Ion specificity and ionic strength dependence of the osmoregulatory ABC transporter OpuA

2006

Mahmood, N.A.; Biemans-Oldehinkel, E.; Patzlaff, J.S.; Schuurman-Wolters, G.K.; Poolman, B.

J. Biol. Chem.

281

29830-29839

675185

17156888

Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway

2007

Kharbanda, K.K.; Mailliard, M.E.; Baldwin, C.R.; Beckenhauer, H.C.; Sorrell, M.F.; Tuma, D.J.

J. Hepatol.

46

314-321

675300

16789755

S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase

2006

Jiracek, J.; Collinsova, M.; Rosenberg, I.; Budesinsky, M.; Protivinska, E.; Netusilova, H.; Garrow, T.A.

J. Med. Chem.

49

3982-3989

675375

16445940

Molecular determinants for substrate specificity of the ligand-binding protein OpuAC from Bacillus subtilis for the compatible solutes glycine betaine and proline betaine

2006

Horn, C.; Sohn-Boesser, L.; Breed, J.; Welte, W.; Schmitt, L.; Bremer, E.

J. Mol. Biol.

357

592-606

675495

16645306

Biochemical and structural analysis of the Bacillus subtilis ABC transporter OpuA and its isolated subunits

2005

Horn, C.; Jenewein, S.; Sohn-Boesser, L.; Bremer, E.; Schmitt, L.

J. Mol. Microbiol. Biotechnol.

10

76-91

676758

16493950

Homocysteine remethylation in young broilers fed varying levels of methionine, choline, and betaine

2006

Pillai, P.B.; Fanatico, A.C.; Beers, K.W.; Blair, M.E.; Emmert, J.L.

Poult. Sci.

85

90-95

680504

17660277

Characterization of the osmoprotectant transporter OpuC from Pseudomonas syringae and demonstration that cystathionine-beta-synthase domains are required for its osmoregulatory function

2007

Chen, C.; Beattie, G.A.

J. Bacteriol.

189

6901-6912

680813

17650500

Osmosensing properties of the histidine protein kinase MtrB from Corynebacterium glutamicum

2007

Moeker, N.; Reihlen, P.; Kraemer, R.; Morbach, S.

J. Biol. Chem.

282

27666-27677

684710

18262489

Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc

2008

Castro, C.; Millian, N.S.; Garrow, T.A.

Arch. Biochem. Biophys.

472

26-33

685260

18540638

On the role of histidine 351 in the reaction of alcohol oxidation catalyzed by choline oxidase

2008

Rungsrisuriyachai, K.; Gadda, G.

Biochemistry

47

6762-6769

687343

17976173

Glycine betaine improves Listeria monocytogenes tolerance to desiccation on parsley leaves independent of the osmolyte transporters BetL, Gbu and OpuC

2008

Dreux, N.; Albagnac, C.; Sleator, R.D.; Hill, C.; Carlin, F.; Morris, C.E.; Nguyen-the, C.

J. Appl. Microbiol.

104

1221-1227

687808

18230605

Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase

2008

Szegedi, S.S.; Castro, C.C.; Koutmos, M.; Garrow, T.A.

J. Biol. Chem.

283

8939-8945

689024

18457970

Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization

2008

Li, F.; Feng, Q.; Lee, C.; Wang, S.; Pelleymounter, L.L.; Moon, I.; Eckloff, B.W.; Wieben, E.D.; Schaid, D.J.; Yee, V.; Weinshilboum, R.M.

Mol. Genet. Metab.

94

326-335

695924

19693490

Characterization of osmolyte betaine synthesizing sarcosine dimethylglycine N-methyltransferase from Methanohalophilus portucalensis

2009

Chen, S.; Lai, M.; Lai, S.; Lee, Y.

Arch. Microbiol.

191

735-743

701995

18059170

Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization

2008

Mercer, C.; Kaliappan, A.; Dennis, P.

Autophagy

4

185-194

702044

19239903

Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats

2009

Kharbanda, K.K.; Vigneswara, V.; McVicker, B.L.; Newlaczyl, A.U.; Bailey, K.; Tuma, D.; Ray, D.E.; Carter, W.G.

Biochem. Biophys. Res. Commun.

381

523-527

703877

19923254

An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity

2010

Liu, H.H.; Lu, P.; Guo, Y.; Farrell, E.; Zhang, X.; Zheng, M.; Bosano, B.; Zhang, Z.; Allard, J.; Liao, G.; Fu, S.; Chen, J.; Dolim, K.; Kuroda, A.; Usuka, J.; Cheng, J.; Tao, W.; Welch, K.; Liu, Y.; Pease, J.; de Keczer, S.A.; Masjedizadeh, M.; Hu, J.S.; Weller, P.; Garrow, T.; Peltz, G.

Genome Res.

20

28-35

705038

19534555

Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase

2009

Vanek, V.; Budesinsky, M.; Kabeleova, P.; Sanda, M.; Kozisek, M.; Hanclova, I.; Mladkova, J.; Brynda, J.; Rosenberg, I.; Koutmos, M.; Garrow, T.A.; Jiracek, J.

J. Med. Chem.

52

3652-3665

705295

19436145

Hepatic cystathionine beta-synthase activity does not increase in response to methionine supplementation in rats fed a low casein diet: association with plasma homocysteine concentrations

2009

Ohuchi, S.; Morita, T.; Mori, M.; Sugiyama, K.

J. Nutr. Sci. Vitaminol.

55

178-185

714872

21915373

Phosphorylcholine phosphatase: A peculiar enzyme of Pseudomonas aeruginosa

2011

Domenech, C.E.; Otero, L.H.; Beassoni, P.R.; Lisa, A.T.

Enzyme Res.

2011

561841

715808

20490928

Restoring assembly and activity of cystathionine beta-synthase mutants by ligands and chemical chaperones

2011

Kopecka, J.; Krijt, J.; Rakova, K.; Kozich, V.

J. Inherit. Metab. Dis.

34

39-48

719035

22653757

Quantification of homocysteine-related metabolites and the role of betaine-homocysteine S-methyltransferase in HepG2 cells

2013

Korinek, M.; Sistek, V.; Mladkova, J.; Mikes, P.; Jiracek, J.; Selicharova, I.

Biomed. Chromatogr.

27

111-121

720040

22847001

Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development

2012

Lee, M.B.; Kooistra, M.; Zhang, B.; Slow, S.; Fortier, A.L.; Garrow, T.A.; Lever, M.; Trasler, J.M.; Baltz, J.M.

J. Biol. Chem.

287

33094-33103

720080

22357209

Corticoadrenal activity in rat regulates betaine-homocysteine S-methyltransferase expression with opposite effects in liver and kidney

2012

Fridman, O.; Morales, A.V.; Bortoni, L.E.; Turk-Noceto, P.C.; Prieto, E.A.

J. Biosci.

37

115-123

720807

20454456

Ligand binding and crystal structures of the substrate-binding domain of the ABC transporter OpuA

2010

Wolters, J.; Ronnie, P.; Gul, N.; Karasawa, A.; Andy-Mark, W.; Slotboom, D.; Poolman, B.

PLoS ONE

5

e10361

720836

21949863

Characterization and regulation of the osmolyte betaine synthesizing enzymes GSMT and SDMT from halophilic methanogen Methanohalophilus portucalensis

2011

Lai, S.J.; Lai, M.C.

PLoS ONE

6

e25090

724807

21188587

Studies of dimethylglycine oxidase isoenzymes in Arthrobacter globiformis cells

2011

Casaite, V.; Poviloniene, S.; Meskiene, R.; Rutkiene, R.; Meskys, R.

Curr. Microbiol.

62

1267-1273

724935

22527040

Overexpression in a non-native halophilic host and biotechnological potential of NAD+-dependent glutamate dehydrogenase from Halobacterium salinarum strain NRC-36014

2012

Munawar, N.; Engel, P.C.

Extremophiles

16

463-476

729226

23088292

Effects of pressure and osmolytes on the allosteric equilibria of Salmonella typhimurium tryptophan synthase

2012

Phillips, R.S.; Wang, A.K.; Marchal, S.; Lange, R.

Biochemistry

51

9354-9363

729483

22718288

Thermal stabilization of psychrophilic enzymes: a case study of the cold-active hormone-sensitive lipase from Psychrobacter sp. TA144

2012

De Santi, C.; Durante, L.; Vecchio, P.D.; Tutino, M.L.; Parrilli, E.; de Pascale, D.

Biotechnol. Prog.

28

946-952

734090

23175650

Osmotic control of opuA expression in Bacillus subtilis and its modulation in response to intracellular glycine betaine and proline pools

2013

Hoffmann, T.; Wensing, A.; Brosius, M.; Steil, L.; Voelker, U.; Bremer, E.

J. Bacteriol.

195

510-522

734645

25012968

Plant-derived compatible solutes proline betaine and betonicine confer enhanced osmotic and temperature stress tolerance to Bacillus subtilis

2014

Bashir, A.; Hoffmann, T.; Kempf, B.; Xie, X.; Smits, S.; Bremer, E.

Microbiology

160

2283-2294

734703

23249124

Functional reconstitution and osmoregulatory properties of the ProU ABC transporter from Escherichia coli

2013

Gul, N.; Poolman, B.

Mol. Membr. Biol.

30

138-148

735230

24895213

Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase

2014

Mladkova, J.; Hladilkova, J.; Diamond, C.E.; Tryon, K.; Yamada, K.; Garrow, T.A.; Jungwirth, P.; Koutmos, M.; Jiracek, J.

Proteins

82

2552-2564

737168

25313086

A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase

2014

Ticak, T.; Kountz, D.J.; Girosky, K.E.; Krzycki, J.A.; Ferguson, D.J.

Proc. Natl. Acad. Sci. USA

111

E4668-E4676

739846

27956151

Enzymatic methods for choline-containing water soluble phospholipids based on fluorescence of choline oxidase: Application to lyso-PAF

2017

Sanz-Vicente, I.; Dominguez, A.; Ferrandez, C.; Galban, J.

Anal. Biochem.

519

30-37

742795

27920296

A sulfur oxygenase from the haloalkaliphilic bacterium Thioalkalivibrio paradoxus with atypically low reductase Activity

2017

Ruehl, P.; Poell, U.; Braun, J.; Klingl, A.; Kletzin, A.

J. Bacteriol.

199

e00675

756095

28288879

Betaine homocysteine S-methyltransferase emerges as a new player of the nuclear methionine cycle

2017

Perez-Miguelsanz, J.; Vallecillo, N.; Garrido, F.; Reytor, E.; Perez-Sala, D.; Pajares, M.A.

Biochim. Biophys. Acta

1864

1165-1182

756781

31787957

Examination of the glycine betaine-dependent methylotrophic methanogenesis pathway insights into anaerobic quaternary amine methylotrophy

2019

Creighbaum, A.J.; Ticak, T.; Shinde, S.; Wang, X.; Ferguson, D.J.

Front. Microbiol.

10

2572

758143

28036340

Comparison of enzymatic traits between native and recombinant Glycine Sarcosine N-Methyltransferase from Methanohalophilus portucalensis FDF1T

2016

Lai, S.J.; Deng, Y.C.; Lai, M.C.

PLoS ONE

11

e0168666

761158

29997580

ADP-dependent kinases from the archaeal order Methanosarcinales adapt to salt by a non-canonical evolutionarily conserved strategy

2018

Gonzalez-Ordenes, F.; Cea, P.A.; Fuentes-Ugarte, N.; Munoz, S.M.; Zamora, R.A.; Leonardo, D.; Garratt, R.C.; Castro-Fernandez, V.; Guixe, V.

Front. Microbiol.

9

1305

762268

25313086

A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase

2014

Ticak, T.; Kountz, D.J.; Girosky, K.E.; Krzycki, J.A.; Ferguson, D.J.

Proc. Natl. Acad. Sci. USA

111

E4668-E4676

763275

34688665

The MttB superfamily member MtyB from the human gut symbiont Eubacterium limosum is a cobalamin-dependent gamma-butyrobetaine methyltransferase

2021

Ellenbogen, J.; Jiang, R.; Kountz, D.; Zhang, L.; Krzycki, J.

J. Biol. Chem.

297

101327

763954

29703733

Glycine betaine monooxygenase, an unusual Riesketype oxygenase system, catalyzes the oxidative N-demethylation of glycine betaine in Chromohalobacter salexigens DSM 3043

2018

Shao, Y.; Guo, L.; Zhang, Y.; Yu, H.; Zhao, B.; Pang, H.; Lu, W.

Appl. Environ. Microbiol.

84

e00377-18

Links to other databases for glycine betaine

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