print visible entries

print all entries

Ligand choline

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

degradation of sugar alcohols, glycine betaine biosynthesis, phosphatidylethanolamine bioynthesis

KEGG

ABC transporters, Bile secretion, Choline metabolism in cancer, Cholinergic synapse, Glycerophospholipid metabolism, Glycine, serine and threonine metabolism, Teichoic acid biosynthesis more

MetaCyc

cell-surface glycoconjugate-linked phosphocholine biosynthesis, choline biosynthesis I, choline biosynthesis II, choline biosynthesis III, choline degradation I, choline degradation II, choline degradation III, choline-O-sulfate degradation, glycine betaine biosynthesis I (Gram-negative bacteria), glycine betaine biosynthesis II (Gram-positive bacteria), glycine betaine biosynthesis III (plants), phosphatidate metabolism, as a signaling molecule, phosphatidylcholine biosynthesis I, phosphatidylcholine biosynthesis VI, phosphatidylcholine resynthesis via glycerophosphocholine, phosphatidylserine biosynthesis I, phospholipases, plasmalogen biosynthesis I (aerobic), plasmalogen degradation, sinapate ester biosynthesis, type IV lipoteichoic acid biosynthesis (S. pneumoniae) more

Show all BRENDA pathways known for choline

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (21 results)

top print hide

Show Natural Substrate (21 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.17

choline + 2 O2 + H2O = betaine + 2 H2O2

724282, 724368, 739846, 724598

-

1.1.3.17

choline + 2 O2 + H2O2 = betaine + 2 H2O2

724047, 724108, 724284

-

1.1.3.17

choline + O2 = betaine aldehyde + H2O2

389723, 287801, 740194, 689522, 389716, 389718, 389719, 389720, 389721, 389724, 389727, 654773, 671605, 672136, 389722, 740932, 740937, 675130, 389717, 685162, 685213, 685260, 689966, 739787, 740068, 740077, 740986, 741133, 741453, 684421, 686373, 688879, 655800, 674159, 677058, 672121, 724598

-

1.1.99.1

choline + 2 acceptor + H2O = glycine-betaine + 2 reduced acceptor + H+

654268

-

1.1.99.1

choline + acceptor = betaine aldehyde + reduced acceptor

741756, 686202, 688563, 741800, 654440

-

1.1.99.1

choline + coenzyme Q1 = betaine aldehyde + reduced coenzyme Q1

389886

-

1.14.15.7

choline + O2 + 2 reduced ferredoxin + 2 H+ = betaine aldehyde hydrate + H2O + 2 oxidized ferredoxin

726250

-

1.14.15.7

choline + O2 + reduced ferredoxin + H+ = betaine aldehyde hydrate + H2O + oxidized ferredoxin

699804, 700840, 700129, 689239, 688086, 689515

-

1.14.15.7

choline + O2 + reduced ferredoxin = betaine aldehyde hydrate + H2O + oxidized ferredoxin

658414, 660154, 660075, 659186, 671340

-

2.3.1.6

acetyl-CoA + choline = acetylcholine + CoA

487277, 487279, 487300, 487302, 658416, 658358, 657464, 660006, 660007, 658417, 659848, 659816, 660442, 658548

2fy3, 3D-view

2.3.1.6

acetyl-CoA + choline = CoA + O-acetylcholine

702958, 703135, 704830, 705281, 705905, 705919, 705922, 735409, 735874, 735984, 737113, 735909, 736062, 736678, 705317, 705279, 702964

2fy3, 3D-view

1.1.3.17

3 entries

1.1.99.1

3 entries

1.14.15.7

3 entries

2.3.1.6

2 entries

2.3.1.91

1-O-sinapoyl-beta-D-glucose + choline = D-glucose + sinapoylcholine

487711, 716651, 487709, 706265, 487708, 659208

-

2.7.1.32

ATP + choline = ADP + O-phosphocholine

641379, 641374, 641365, 641368, 663274, 662203, 661736, 663273

4r7b, 3D-view

2.7.1.32

ATP + choline = ADP + phosphocholine

738968, 739447, 737751, 737834, 738832, 738851, 739185, 739680, 758809, 760183, 739407, 759237, 760133, 759595, 759713, 759857, 759092

4r7b, 3D-view

2.7.1.32

choline + ATP = O-phosphocholine + ADP

685011

4r7b, 3D-view

2.7.1.32

choline + ATP = phosphocholine + ADP

671362, 688743, 687709, 671383, 685337, 687686

4r7b, 3D-view

2.7.1.32

4 entries

2.7.8.24

CDP-diacylglycerol + choline = CMP + phosphatidylcholine

738208, 394955, 394956, 662776, 662001, 691697, 738417

-

2.8.2.6

3'-phosphoadenylylsulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate

643827, 643829, 643828, 643830

-

4.3.99.4

choline = trimethylamine + acetaldehyde

728855, 747482

5fau, 3D-view

4.3.99.4

choline = trimethylamine + acetaldehyde

728855, 747482

5faw, 3D-view

4.3.99.4

choline = trimethylamine + acetaldehyde

728855, 747482

5fay, 3D-view

4.3.99.4

3 entries

In Vivo Product in Enzyme-catalyzed Reactions (38 results)

top print hide

Show Natural Product (38 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.29

L-1-phosphatidylcholine + L-serine = L-1-phosphatidylserine + choline

0

-

3.1.1.49

O-sinapoylcholine + H2O = choline + sinapate

0

-

3.1.1.49

sinapoylcholine + H2O = sinapic acid + choline

0

-

3.1.1.7

acetylcholine + H2O = acetate + choline

0

2ha3, 3D-view

3.1.1.7

acetylcholine + H2O = choline + acetate

0, 651529, 651586, 652016, 653365, 650380, 649499, 651505

2ha3, 3D-view

3.1.1.8

acetylcholine + H2O = choline + acetate

0

1p0m, 3D-view

3.1.1.8

benzoylcholine + H2O = benzoic acid + choline

0

1p0m, 3D-view

3.1.1.8

butyrylcholine + H2O = butyrate + choline

0

1p0m, 3D-view

3.1.1.8

butyrylcholine + H2O = choline + butyrate

653365, 0, 649453

1p0m, 3D-view

3.1.3.75

O-phosphocholine + H2O = choline + phosphate

0

-

3.1.3.75

phosphocholine + H2O = choline + phosphate

0

-

3.1.4.2

sn-glycero-3-phosphocholine + H2O = choline + sn-glycerol 3-phosphate

0

-

3.1.4.2

sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline

0

-

3.1.1.49

2 entries

3.1.1.7

2 entries

3.1.1.8

4 entries

3.1.3.75

2 entries

3.1.4.2

2 entries

3.1.4.38

lysophosphatidylcholine + H2O = choline + 2-lysophosphatidate

0

-

3.1.4.39

1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycerol 3-phosphate + choline

0

-

3.1.4.39

1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-2-lyso-sn-glycero-3-phosphate + choline

208402

-

3.1.4.39

lysophosphatidyl choline + H2O = lysophosphatidic acid + choline

0

-

3.1.4.39

lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0

-

3.1.4.39

sphingosylphosphorylcholine + H2O = sphingosine 1-phosphate + choline

0

-

3.1.4.4

phosphatidylcholine + H2O = 1,2-diacylglycerophosphate + choline

0

-

3.1.4.4

phosphatidylcholine + H2O = choline + phosphatidate

0

-

3.1.4.4

phosphatidylcholine + H2O = choline + phosphatidic acid

0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = 2-lysophosphatidate + choline

0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = choline + 2-lysophosphatidate

0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0

-

3.1.4.41

lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0

-

3.1.4.41

N-lauroyl-D-erythro-sphingosylphosphorylcholine + H2O = lauroyl ceramide-1-phosphate + choline

0

-

3.1.4.41

sphingomyelin + H2O = ceramide 1-phosphate + choline

0

-

3.1.4.41

sphingomyelin + H2O = ceramide phosphate + choline

0

-

3.1.4.41

sphingomyelin + H2O = choline + ceramide 1-phosphate

0

-

3.1.4.46

glycerophosphocholine + H2O = choline + glycerol-3-phosphate

0

-

3.1.4.46

glycerophosphocholine + H2O = sn-glycerol 3-phosphate + choline

646457, 0

-

3.1.4.46

L-alpha-glycerophosphocholine + H2O = choline + sn-glycerol-3-phosphate

0

-

3.1.4.46

sn-glycero-3-phosphocholine + H2O = choline + sn-glycerol 3-phosphate

0

-

3.1.6.6

choline sulfate + H2O = choline + sulfate

0

6g60, 3D-view

3.1.6.6

choline sulfate + H2O = choline + sulfate

0

7pth, 3D-view

3.1.6.6

choline-O-sulfate + H2O = choline + sulfate

0

6g60, 3D-view

3.1.6.6

choline-O-sulfate + H2O = choline + sulfate

0

7pth, 3D-view

3.1.4.39

5 entries

3.1.4.4

3 entries

3.1.4.41

8 entries

3.1.4.46

4 entries

3.1.6.6

4 entries

Substrate in Enzyme-catalyzed Reactions (47 results)

top print hide

Show Substrate (47 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.1

choline + NAD+ = ? + NADH + H+

678779

-

1.1.3.17

choline + 2 O2 + H2O = betaine + 2 H2O2

724282, 724368, 739846, 724598

-

1.1.3.17

choline + 2 O2 + H2O2 = betaine + 2 H2O2

724047, 724108, 724284

-

1.1.3.17

choline + O2 + H2O = betaine + 2 H2O2

762910

-

1.1.3.17

choline + O2 = betaine aldehyde + H2O2

389723, 287801, 740194, 689522, 389716, 389718, 389719, 389720, 389721, 389724, 389727, 654371, 654773, 654860, 655800, 671605, 672121, 672136, 695885, 389722, 695307, 712974, 740932, 740937, 675130, 389717, 654364, 685162, 685213, 685260, 689966, 696242, 696243, 698905, 739787, 740068, 740077, 740986, 741133, 741453, 711016, 684421, 686373, 688879, 674159, 677058, 724282, 724598

-

1.1.99.1

choline + 2 acceptor + H2O = glycine-betaine + 2 reduced acceptor + H+

654268

-

1.1.99.1

choline + 2,6-dichlorophenolindophenol = betaine aldehyde + reduced 2,6-dichlorophenolindophenol

389885

-

1.1.99.1

choline + acceptor + phenazine methosulfate = betaine aldehyde + ?

654268

-

1.1.99.1

choline + acceptor = betaine aldehyde + reduced acceptor

711962, 699705, 389891, 389888, 654440, 741756, 686202, 688563, 741800, 389885, 389886, 389887, 389884, 389889, 389883, 389890

-

1.1.99.1

choline + coenzyme Q1 = betaine aldehyde + reduced coenzyme Q1

389886

-

1.1.99.1

choline + p-benzoquinone = betaine aldehyde + reduced p-benzoquinone

389885

-

1.1.99.1

choline + phenazine methosulfate = betaine aldehyde + reduced phenazine methosulfate

389885, 389886, 389887, 725104, 726473

-

1.14.15.7

choline + O2 + 2 reduced ferredoxin + 2 H+ = betaine aldehyde hydrate + H2O + 2 oxidized ferredoxin

726149, 726250

-

1.14.15.7

choline + O2 + reduced ferredoxin + H+ = betaine aldehyde hydrate + H2O + oxidized ferredoxin

689515, 699804, 688086, 700840, 700129, 689239

-

1.14.15.7

choline + O2 + reduced ferredoxin = betaine aldehyde hydrate + H2O + oxidized ferredoxin

671340, 658414, 660154, 660075, 659186

-

1.14.15.7

choline + O2 + reduced ferredoxin = betaine aldehyde hydrate + oxidized ferredoxin

285434, 285435, 285436

-

1.1.3.17

4 entries

1.1.99.1

7 entries

1.14.15.7

4 entries

2.1.1.B141

choline + [corrinoid-binding protein Co(I)-MtqC] = [methyl-corrinoid-protein Co(I)-MtqC] + 2-(dimethylamino)ethan-1-ol

763275

-

2.3.1.137

choline + L-carnitine = ?

486306, 486303

-

2.3.1.6

acetyl-CoA + choline = acetylcholine + CoA

487277, 487293, 487319, 487321, 487279, 658416, 487278, 487284, 487292, 487318, 487287, 487306, 487325, 658358, 487290, 487294, 487303, 487315, 487320, 487330, 487300, 487302, 660442, 487285, 487288, 487295, 487297, 487301, 487305, 487310, 487316, 487322, 487323, 487324, 487329, 487331, 487328, 657464, 660006, 660007, 487281, 487280, 487283, 487304, 487307, 487314, 487326, 487309, 487291, 487289, 487296, 487308, 487312, 658417, 487282, 487298, 487299, 487327, 659848, 487286, 487311, 658548, 659816, 487313

2fy3, 3D-view

2.3.1.6

acetyl-CoA + choline = CoA + O-acetylcholine

702958, 705279, 702964, 705317, 703135, 704830, 705281, 705905, 705919, 705922, 735409, 735874, 735984, 737113, 735909, 736062, 736678

2fy3, 3D-view

2.3.1.7

acetyl-CoA + choline = acetylcholine + CoA

672172

-

2.3.1.7

acetyl-CoA + choline = acetylcholine + CoASH

487399

-

2.3.1.91

1,2-di-O-sinapoyl-beta-D-glucose + choline = 2-O-sinapoyl-beta-D-glucose + sinapoylcholine

487708

-

2.3.1.91

1-feruloyl-beta-D-glucose + choline = D-glucose + feruloylcholine

487708, 487710, 487709

-

2.3.1.91

1-O-caffeoyl-beta-D-glucose + choline = beta-D-glucose + caffeoylcholine

659208

-

2.3.1.91

1-O-feruloyl-beta-D-glucose + choline = beta-D-glucose + feruloylcholine

659208

-

2.3.1.91

1-O-sinapoyl-beta-D-glucose + choline = beta-D-glucose + sinapoylcholine

659208

-

2.3.1.91

1-O-sinapoyl-beta-D-glucose + choline = D-glucose + sinapoylcholine

487711, 716651, 487709, 706265, 689684, 487710, 487708, 659208

-

2.3.1.91

1-p-coumaroyl-beta-D-glucose + choline = D-glucose + p-coumaroylcholine

487708, 487710, 487709

-

2.3.1.91

caffeoyl-beta-D-glucose + choline = D-glucose + caffeoylcholine

487710

-

2.3.1.91

p-coumaroyl-beta-D-glucose + choline = beta-D-glucose + coumaroylcholine

659208

-

2.7.1.32

ATP + choline = ADP + O-phosphocholine

641346, 641356, 641365, 641367, 663274, 672371, 673201, 641353, 641373, 672898, 673093, 673202, 673447, 674066, 641345, 641347, 641348, 641349, 641352, 641359, 641360, 641366, 641368, 641370, 641371, 641372, 641351, 641361, 641363, 641374, 641376, 674456, 641377, 641354, 641357, 661736, 641375, 662203, 641364, 672361, 641369, 641355, 641350, 641358, 641362, 663273, 675410, 641385, 641379, 760908

4r7b, 3D-view

2.7.1.32

ATP + choline = ADP + phosphocholine

721704, 671362, 722242, 722904, 738968, 641380, 721292, 671383, 722754, 722672, 739447, 721743, 722191, 723311, 737751, 737834, 738832, 738851, 739185, 739680, 758809, 760183, 739407, 759237, 760133, 759595, 759713, 759857, 759092

4r7b, 3D-view

2.7.1.32

choline + ATP = O-phosphocholine + ADP

702145, 685011

4r7b, 3D-view

2.7.1.32

choline + ATP = phosphocholine + ADP

671362, 688743, 706447, 687709, 671383, 685337, 687686

4r7b, 3D-view

2.7.1.32

choline + ATP = phosphorylcholine + ADP

705538

4r7b, 3D-view

2.7.1.32

CTP + choline = CDP + choline phosphate

641371

4r7b, 3D-view

2.7.1.32

GTP + choline = GDP + choline phosphate

641371, 641372, 641362

4r7b, 3D-view

2.7.1.32

UTP + choline = UDP + choline phosphate

641371, 641372, 641362

4r7b, 3D-view

2.7.1.82

ATP + choline = ADP + ?

641379, 642053, 642052

-

2.7.1.82

ATP + choline = ADP + choline phosphate

685011

-

2.7.1.82

choline + ATP = ADP + O-phosphocholine

641348

-

2.3.1.6

2 entries

2.3.1.7

2 entries

2.3.1.91

9 entries

2.7.1.32

8 entries

2.7.1.82

3 entries

2.7.8.24

CDP-diacylglycerol + choline = CMP + phosphatidylcholine

662776, 721740, 723125, 721725, 662785, 721960, 723115, 738208, 738417, 394955, 394956, 662001, 691697

-

2.8.2.6

3'-phosphoadenylylsulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate

643827, 643829, 643828, 643830

-

4.3.99.4

choline = trimethylamine + acetaldehyde

728855, 747482, 748194, 720938

5fau, 3D-view

4.3.99.4

choline = trimethylamine + acetaldehyde

728855, 747482, 748194, 720938

5faw, 3D-view

4.3.99.4

choline = trimethylamine + acetaldehyde

728855, 747482, 748194, 720938

5fay, 3D-view

4.3.99.4

3 entries

Product in Enzyme-catalyzed Reactions (202 results)

top print hide

Show Product (202 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.29

L-1-phosphatidylcholine + L-serine = L-1-phosphatidylserine + choline

0

-

3.1.1.49

3-phenylpropionylcholine + H2O = 3-phenylpropionate + choline

0

-

3.1.1.49

4-coumaroylcholine + H2O = coumaric acid + choline

0

-

3.1.1.49

benzoylcholine + H2O = benzoate + choline

0

-

3.1.1.49

caffeoylcholine = caffeic acid + choline

80961, 0

-

3.1.1.49

cinnamoylcholine + H2O = cinnamic acid + choline

80961, 0

-

3.1.1.49

feruloylcholine + H2O = ferulic acid + choline

80961, 0

-

3.1.1.49

isoferuloylcholine + H2O = isoferulic acid + choline

0

-

3.1.1.49

O-sinapoylcholine + H2O = choline + sinapate

0

-

3.1.1.49

p-coumaroylcholine = p-coumaric acid + choline

0, 80961

-

3.1.1.49

sinapoylcholine + H2O = sinapic acid + choline

0, 80960

-

3.1.1.49

10 entries

3.1.1.5

1-O-hexadecyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O = 1-(1-hexadecyl)-sn-glycero-3-phosphate + choline

0

-

3.1.1.7

succinyldicholine + H2O = 2 choline + succinate

0

2ha3, 3D-view

3.1.1.7

acetylcholine + H2O = acetate + choline

0

2ha3, 3D-view

3.1.1.7

acetylcholine + H2O = choline + acetate

0, 651529, 651586, 652016, 652645, 653355, 653365, 650380, 649499, 651505, 649755, 650098

2ha3, 3D-view

3.1.1.7

butyryl choline + H2O = butyrate + choline

0

2ha3, 3D-view

3.1.1.8

acetoacetylcholine + H2O = acetoacetate + choline

0

1p0m, 3D-view

3.1.1.8

acetyl choline + H2O = acetate + choline

654021

1p0m, 3D-view

3.1.1.8

acetylcholine + H2O = acetate + choline

0

1p0m, 3D-view

3.1.1.8

acetylcholine + H2O = choline + acetate

653355, 0

1p0m, 3D-view

3.1.1.8

adipyldicholine + H2O = adipic acid + choline

0

1p0m, 3D-view

3.1.1.8

benzoylcholine + H2O = benzoate + choline

0

1p0m, 3D-view

3.1.1.8

benzoylcholine + H2O = benzoic acid + choline

0

1p0m, 3D-view

3.1.1.8

benzoylcholine + H2O = choline + benzoate

651173, 652971, 649795, 653775, 0, 650956

1p0m, 3D-view

3.1.1.8

beta-hydroxybutyrylcholine + H2O = 3-hydroxybutanoate + choline

0

1p0m, 3D-view

3.1.1.8

butyryl choline + H2O = butyrate + choline

654021

1p0m, 3D-view

3.1.1.8

butyrylcholine + H2O = butanoate + choline

0

1p0m, 3D-view

3.1.1.8

butyrylcholine + H2O = butyrate + choline

0

1p0m, 3D-view

3.1.1.8

butyrylcholine + H2O = choline + butyrate

653365, 0, 649453

1p0m, 3D-view

3.1.1.8

crotonylcholine + H2O = crotonate + choline

0

1p0m, 3D-view

3.1.1.8

propionyl choline + H2O = propionate + choline

654021

1p0m, 3D-view

3.1.1.8

propionylcholine + H2O = propanoate + choline

0

1p0m, 3D-view

3.1.1.8

sebacyldicholine + H2O = sebacic acid + choline

0

1p0m, 3D-view

3.1.1.8

succinylcholine + H2O = succinate + choline

0

1p0m, 3D-view

3.1.1.8

succinylmonocholine + H2O = succinate + choline

0

1p0m, 3D-view

3.1.3.1

phosphocholine + H2O = choline + phosphate

0

-

3.1.3.1

phosphorylcholine + H2O = phosphate + choline

0

-

3.1.3.2

choline O-phosphate + H2O = choline + phosphate

0

-

3.1.3.2

phosphocholine + H2O = choline + phosphate

0

-

3.1.3.2

phosphorylcholine + H2O = choline + phosphate

0

-

3.1.3.75

O-phosphocholine + H2O = choline + phosphate

0

-

3.1.3.75

phosphocholine + H2O = choline + phosphate

0

-

3.1.4.2

choline lysoplasmalogen + H2O = choline + 1-(1-alkenyl)-sn-glycero-3-phosphate

0

-

3.1.4.2

glycerophosphocholine + H2O = glycerol 1,2-cyclic phosphate + choline

81114, 0

-

3.1.4.2

glycerophosphocholine + H2O = sn-glycerol 3-phosphate + choline

0

-

3.1.4.2

sn-glycero 3-phosphorylcholine + H2O = sn-glycerol 3-phosphate + choline

95138, 95133, 653105, 95136, 646468, 95152, 95142, 95139, 81114, 95130, 95132, 95134, 95135, 95137, 95141, 95144, 95146, 95147, 95148, 95149, 95150, 95151, 95131, 95129

-

3.1.4.2

sn-glycero-3-phosphocholine + H2O = choline + sn-glycerol 3-phosphate

0

-

3.1.4.2

sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline

0

-

3.1.1.7

4 entries

3.1.1.8

19 entries

3.1.3.1

2 entries

3.1.3.2

3 entries

3.1.3.75

2 entries

3.1.4.2

6 entries

3.1.4.3

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O = 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate + choline

0

-

3.1.4.38

lysophosphatidylcholine + H2O = choline + 2-lysophosphatidate

0

-

3.1.4.39

1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphate + choline

650814

-

3.1.4.39

1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycerol 3-phosphate + choline

0

-

3.1.4.39

1-heptadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycerol 3-phosphate + choline

0

-

3.1.4.39

1-linoleoyl-2-lyso-glycerophoshorylcholine + H2O = 1-linoleoyl-sn-glycerol-3-phosphate + choline

0

-

3.1.4.39

1-linoleoyl-sn-glycero-3-phosphocholine + H2O = 1-linoleoyl-sn-glycerol 3-phosphate + choline

0

-

3.1.4.39

1-myristoyl-lysophosphatidylcholine + H2O = 1-myristoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-2-lyso-sn-glycero-3-phosphate + choline

208402

-

3.1.4.39

1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycerol 3-phosphate + choline

0

-

3.1.4.39

1-O-hexadecyl-2-lyso-glycerophosphorylcholine + H2O = 1-O-hexadecyl-sn-glycerol-3-phosphate + choline

0

-

3.1.4.39

1-O-hexadecyl-2-lyso-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-2-lyso-sn-glycero-3-phosphate + choline

208394, 208396, 208397, 208398, 208399, 208400, 208401, 208402, 208395

-

3.1.4.39

1-O-octadecyl-2-lyso-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-2-lyso-sn-glycero-3-phosphate + choline

208400

-

3.1.4.39

1-palmitoyl-2-lyso-glycerophoshorylcholine + H2O = 1-palmitoyl-sn-glycerol-3-phosphate + choline

0

-

3.1.4.39

1-palmitoyl-sn-glycero-3-phosphocholine + H2O = 1-palmitoyl-sn-glycerol 3-phosphate + choline

0

-

3.1.4.39

1-stearoyl-2-lyso-glycerophoshorylcholine + H2O = 1-stearoyl-sn-glycerol-3-phosphate + choline

0

-

3.1.4.39

arachidoyl-lysophosphatidylcholine + H2O = 1-arachidoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

behenoyl-lysophosphatidylcholine + H2O = 1-behenoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

caproyl-lysophosphatidylcholine + H2O = 1-hexanoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

capryl-lysophosphatidylcholine + H2O = 1-decanoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

caprylyl-lysophosphatidylcholine + H2O = 1-octanoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

decanoyl-lysophosphatidylcholine + H2O = 1-decanoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

hexanoyl-lysophosphatidylcholine + H2O = 1-hexanoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

lauroyl-lysophosphatidylcholine + H2O = 1-lauroyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

lyso-phosphatidylcholine + H2O = lyso-phosphatidic acid + choline

0

-

3.1.4.39

lysophosphatidyl choline + H2O = lysophosphatidic acid + choline

0

-

3.1.4.39

lysophosphatidylcholine + H2O = lysophosphatic acid + choline

0

-

3.1.4.39

lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0

-

3.1.4.39

myristoyl-lysophosphatidylcholine + H2O = 1-myristoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

octanoyl-lysophosphatidylcholine + H2O = 1-octanoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

oleoyl-lysophosphatidylcholine + H2O = 1-oleoyl-sn-gycerol 3-phosphate + choline

0

-

3.1.4.39

palmitoyl-lysophosphatidylcholine + H2O = 1-palmitoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.39

platelet-activating factor + H2O = ? + choline

0

-

3.1.4.39

sphingosylphosphorylcholine + H2O = sphingosine 1-phosphate + choline

0

-

3.1.4.39

sphingosylphosphorylcholine + H2O = sphingosine-1-phosphate + choline

0

-

3.1.4.39

stearoyl-lysophosphatidylcholine + H2O = 1-stearoyl-sn-gycerol-3-phosphate + choline

0

-

3.1.4.4

2 1,2-dioleoyl-sn-glycerophosphocholine + diethanolamine = 2 choline + bis(1,2-dioleoyl-sn-glycerophospho)-diethanolamine

0

-

3.1.4.4

2 1,2-dioleoyl-sn-glycerophosphocholine + serinol = 2 choline + bis(1,2-dioleoyl-sn-glycerophospho)-serinol

0

-

3.1.4.4

2 1,2-dioleoyl-sn-glycerophosphocholine + triethanolamine = 2 choline + bis(1,2-dioleoyl-sn-glycerophospho)-triethanolamine

0

-

3.1.4.4

2 1,2-dioleoyl-sn-glycerophosphocholine + tris(hydroxymethyl)-aminomethane = 2 choline + bis(1,2-dioleoyl-sn-glycerophospho)-tris(hydroxymethyl)-aminomethane

0

-

3.1.4.4

(7R)-4-hydroxy-N,N,N-trimethyl-7-({12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoyl}oxy)-10-oxo-3,5,9-trioxa-4-phosphatricosan-1-aminium 4-oxide + H2O = choline + (2R)-2-({12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoyl}oxy)-3-(phosphonooxy)propyl tetradecanoate

0

-

3.1.4.4

1,2-dibutyl-sn-glycero-3-phosphocholine + H2O = choline + ?

653805

-

3.1.4.4

1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexanoyl-sn-glycero-3-phosphatidate + choline

0

-

3.1.4.4

1,2-dioleoyl-sn-glycero-3-phosphocholine + glycerol = 1,2-dioleoyl-sn-glycero-3-phospho-3'-sn-glycerol + 1,2-dioleoyl-sn-glycero-3-phospho-1'-sn-glycerol + choline

0

-

3.1.4.4

1,2-dioleoyl-sn-glycerophosphocholine + 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol = choline + 1,2-dioleoyl-sn-glycerophospho-2-[bis(2-hydroxyethyl)imino]-2-(hydroxymethyl)-1,3-propanediol

0

-

3.1.4.4

1,2-dioleoyl-sn-glycerophosphocholine + diethanolamine = choline + 1,2-dioleoyl-sn-glycerophospho-diethanolamine

0

-

3.1.4.4

1,2-dioleoyl-sn-glycerophosphocholine + H2O = choline + 1,2-dioleoyl-sn-glycero-3-phosphatidic acid

0

-

3.1.4.4

1,2-dioleoyl-sn-glycerophosphocholine + serinol = choline + 1,2-dioleoyl-sn-glycerophospho-serinol

0

-

3.1.4.4

1,2-dioleoyl-sn-glycerophosphocholine + triethanolamine = choline + 1,2-dioleoyl-sn-glycerophospho-triethanolamine

0

-

3.1.4.4

1,2-dioleoyl-sn-glycerophosphocholine + tris(hydroxymethyl)-aminomethane = choline + 1,2-dioleoyl-sn-glycerophospho-tris(hydroxymethyl)-aminomethane

0

-

3.1.4.4

1,2-dioleoylphosphatidylcholine + inositol = 1,2-dioleoylphosphatidylinositol + choline

0

-

3.1.4.4

1-O-alkyl-2-lyso-phosphatidylcholine + H2O = choline + 1-O-alkyl-2-lyso-phosphatidate

0

-

3.1.4.4

1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphatidate + choline

0

-

3.1.4.4

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O = 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate + choline

0

-

3.1.4.4

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O = 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidate + choline

0

-

3.1.4.4

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O = 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidic acid + choline

0, 653086

-

3.1.4.4

2-decanoyl-1-(O-[(11-(4,4-difluoro-5,7-dimethyl)-4-bora-3a,4a-diaza-s-indacene-3-propionyl)amino]-undecyl)-phosphatidylcholine + H2O = 2-decanoyl-1-(O-[(11-(4,4-difluoro-5,7-dimethyl)-4-bora-3a,4a-diaza-s-indacene-3-propionyl)amino]-undecyl)-phosphatidic acid + choline

0

-

3.1.4.4

dibutyroylphosphatidylcholine + H2O = dibutyroylglycerophosphate + choline

0

-

3.1.4.4

diheptanoylphosphatidylcholine + H2O = diheptanoylglycerophosphate + choline

0

-

3.1.4.4

dihexanoylphosphatidylcholine + H2O = dihexanoylglycerophosphate + choline

0

-

3.1.4.4

dioleoyl-phosphatidylcholine + cyclohexane-1,2,3-triol = choline + dioleoyl-phosphatidylcyclohexane-2,3-diol

0

-

3.1.4.4

dioleoyl-phosphatidylcholine + cyclohexane-1,2,5-triol = choline + dioleoyl-phosphatidylcyclohexane-2,5-diol

0

-

3.1.4.4

dioleoyl-phosphatidylcholine + cyclohexane-1,2-diol = choline + dioleoyl-phosphatidylcyclohexane-2-ol

0

-

3.1.4.4

dioleoyl-phosphatidylcholine + cyclohexane-1,3-diol = choline + dioleoyl-phosphatidylcyclohexane-3-ol

0

-

3.1.4.4

dioleoyl-phosphatidylcholine + cyclohexane-1,4-diol = choline + dioleoyl-phosphatidylcyclohexane-4-ol

0

-

3.1.4.4

dioleoyl-phosphatidylcholine + cyclohexanol = choline + dioleoyl-phosphatidylcyclohexane

0

-

3.1.4.4

dioleoyl-phosphatidylcholine + H2O = choline + dioleoyl-phosphatidate

0

-

3.1.4.4

dioleoyl-phosphatidylcholine + myo-inositol = phosphatidylinositol + choline

0

-

3.1.4.4

dioleoylphosphatidylcholine + H2O = choline + 1,2-dioleoyl-sn-glycero-3-phosphatidic acid

0

-

3.1.4.4

dioleoylphosphatidylcholine + myo-inositol = choline + dioleoylphosphatidylinositol

0

-

3.1.4.4

dipalmitoyl phosphatidylcholine + H2O = choline + phosphatidate

0

-

3.1.4.4

dipalmitoylphosphatidylcholine + H2O = 1,2-dipalmitoylglycerophosphate + choline

0

-

3.1.4.4

dipalmitoylphosphatidylcholine + H2O = choline + dipalmitoylphosphatidate

0

-

3.1.4.4

dipalmitoylphosphatidylcholine + H2O = dipalmitoylglycerophosphate + choline

0

-

3.1.4.4

docosahexanoylphosphatidylcholine + D-serine = docosahexanoylphosphatidylserine + choline

0

-

3.1.4.4

lysophosphatidylcholine + H2O = choline + lysophosphatidate

650848

-

3.1.4.4

lysophosphatidylcholine + H2O = choline + lysophosphatidic acid

0

-

3.1.4.4

lysophosphatidylcholine + H2O = monoacylglycerophosphate + choline

0

-

3.1.4.4

n-butanol + phosphatidylcholine = phosphatidylbutanol + choline

0

-

3.1.4.4

octadecylphosphocholine + L-serine = octadecylphospho-L-serine + choline

650690

-

3.1.4.4

phosphatidylcholine + butanol = phosphatidylbutanol + choline

0

-

3.1.4.4

phosphatidylcholine + D-arabinose = phosphatidylarabinose + choline

0

-

3.1.4.4

phosphatidylcholine + D-fructose = phosphatidylfructose + choline

0

-

3.1.4.4

phosphatidylcholine + D-galactose = phosphatidylgalactose + choline

0

-

3.1.4.4

phosphatidylcholine + D-glucose = phosphatidylglucose + choline

0

-

3.1.4.4

phosphatidylcholine + D-mannose = phosphatidylmannose + choline

0

-

3.1.4.4

phosphatidylcholine + D-serine = phosphatidylserine + choline

0

-

3.1.4.4

phosphatidylcholine + D-xylose = phosphatidylxylose + choline

0

-

3.1.4.4

phosphatidylcholine + diethyleneglycol = phosphatidyldiethyleneglycol + choline

0

-

3.1.4.4

phosphatidylcholine + diethyleneglycol monomethyl ester = diethyleneglycol dimethyl phosphatidic acid + choline

0

-

3.1.4.4

phosphatidylcholine + ethanol = choline + phosphatidyl ethanol

0

-

3.1.4.4

phosphatidylcholine + ethanol = choline + phosphatidylethanol

0

-

3.1.4.4

phosphatidylcholine + ethanol = phosphatidylethanol + choline

0

-

3.1.4.4

phosphatidylcholine + ethanolamine = phosphatidylethanolamine + choline

0

-

3.1.4.4

phosphatidylcholine + ethyleneglycol = phosphatidylethyleneglycol + choline

0

-

3.1.4.4

phosphatidylcholine + ethyleneglycol monomethyl ester = ethyleneglycol monomethyl phosphatidic acid + choline

0

-

3.1.4.4

phosphatidylcholine + glycerol = phosphatidylglycerol + choline

0

-

3.1.4.4

phosphatidylcholine + H2O = 1,2-diacylglycerophosphate + choline

0, 652769

-

3.1.4.4

phosphatidylcholine + H2O = choline + ?

650337, 653703

-

3.1.4.4

phosphatidylcholine + H2O = choline + a phosphatidate

0

-

3.1.4.4

phosphatidylcholine + H2O = choline + phosphatidate

0, 650910, 650848, 653523, 652644

-

3.1.4.4

phosphatidylcholine + H2O = choline + phosphatidic acid

0

-

3.1.4.4

phosphatidylcholine + H2O = phosphatidate + choline

0

-

3.1.4.4

phosphatidylcholine + H2O = phosphatidic acid + choline

0

-

3.1.4.4

phosphatidylcholine + heptanol = phosphatidylheptanol + choline

0

-

3.1.4.4

phosphatidylcholine + hexanol = phosphatidylhexanol + choline

0

-

3.1.4.4

phosphatidylcholine + inositol = phosphatidylinositol + choline

0

-

3.1.4.4

phosphatidylcholine + L-serine = phosphatidyl-L-serine + choline

0

-

3.1.4.4

phosphatidylcholine + L-serine = phosphatidylserine + choline

0

-

3.1.4.4

phosphatidylcholine + L-sorbose = phosphatidylsorbose + choline

0

-

3.1.4.4

phosphatidylcholine + methanol = phosphatidylmethanol + choline

0

-

3.1.4.4

phosphatidylcholine + myo-inositol = phosphatidylinositol + choline

0

-

3.1.4.4

phosphatidylcholine + N,N,N-triethyl-N-2-hydroxyethylammonium bromide = choline + ?

0

-

3.1.4.4

phosphatidylcholine + pentanol = phosphatidylpentanol + choline

0

-

3.1.4.4

phosphatidylcholine + propanol = phosphatidylpropanol + choline

0

-

3.1.4.4

phosphatidylcholine + triethyleneglycol = phosphatidyltriethyleneglycol + choline

0

-

3.1.4.4

phosphatidylcholine + triethyleneglycol monomethyl ester = triethyleneglycol trimethyl phosphatidic acid + choline

0

-

3.1.4.4

sphingomyelin + H2O = N-acylsphingosylphosphate + choline

0

-

3.1.4.41

1-O-hexadecylglycero-3-phosphocholine + H2O = choline + 1-O-hexadecylglycero-3-phosphate

652516

-

3.1.4.41

1-octanoyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O = 1-octanoyl-sn-glycero-2,3-cyclic-phosphate + choline

0

-

3.1.4.41

1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O = 1-palmitoyl-sn-glycero-2,3-cyclic-phosphate + choline

0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = 2-lysophosphatidate + choline

135481, 0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = choline + 2-lysophosphatidate

0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0

-

3.1.4.41

lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0, 135478, 652516

-

3.1.4.41

N-lauroyl-D-erythro-sphingosylphosphorylcholine + H2O = lauroyl ceramide-1-phosphate + choline

0

-

3.1.4.41

phosphatidylcholine + H2O = phosphatidic acid + choline

0

-

3.1.4.41

sphingomyelin + H2O = ceramide 1-phosphate + choline

0

-

3.1.4.41

sphingomyelin + H2O = ceramide phosphate + choline

653121, 652708, 0, 650896

-

3.1.4.41

sphingomyelin + H2O = ceramide-1-phosphate + choline

0

-

3.1.4.41

sphingomyelin + H2O = choline + ceramide 1-phosphate

0

-

3.1.4.41

sphingomyelin + H2O = choline + ceramide phosphate

652516, 0

-

3.1.4.41

sphingomyelin + H2O = N-acylsphingosylphosphate + choline

135483, 135485, 135478, 135479, 135481, 135486, 135480, 135482, 135487, 135484

-

3.1.4.41

trinitrophenylaminolauric acid sphingomyelin + H2O = choline + ?

0

-

3.1.4.39

34 entries

3.1.4.4

82 entries

3.1.4.41

16 entries

3.1.4.44

glycerophosphocholine + H2O = choline + glycerolphosphate

653592

-

3.1.4.46

1-lysophosphatidylcholine + H2O = choline + 1-lysophosphatidate

0

-

3.1.4.46

2-lysophosphatidylcholine + H2O = choline + 2-lysophosphatidate

0

-

3.1.4.46

glycerophosphocholine + H2O = choline + glycerol-3-phosphate

0

-

3.1.4.46

glycerophosphocholine + H2O = sn-glycerol 3-phosphate + choline

646457, 0

-

3.1.4.46

glycerophosphorylcholine + H2O = sn-glycerol 3-phosphate + choline

0

-

3.1.4.46

L-alpha-glycerophosphocholine + H2O = choline + sn-glycerol-3-phosphate

0

-

3.1.4.46

L-alpha-glycerophosphorylcholine + H2O = sn-glycerol 3-phosphate + choline

0

-

3.1.4.46

sn-glycero-3-phosphocholine + H2O = choline + sn-glycerol 3-phosphate

0

-

3.1.4.46

8 entries

3.1.4.56

O-(4-nitrophenylphosphoryl)choline + H2O = 4-nitrophenyl phosphate + choline

0

-

3.1.6.6

choline O-sulfate + H2O = choline + sulfate

0

6g60, 3D-view

3.1.6.6

choline O-sulfate + H2O = choline + sulfate

0

7pth, 3D-view

3.1.6.6

choline sulfate + H2O = choline + sulfate

0, 135665

6g60, 3D-view

3.1.6.6

choline sulfate + H2O = choline + sulfate

0, 135665

7pth, 3D-view

3.1.6.6

choline-O-sulfate + H2O = choline + sulfate

0

6g60, 3D-view

3.1.6.6

choline-O-sulfate + H2O = choline + sulfate

0

7pth, 3D-view

3.1.6.6

phosphoryl choline + H2O = choline + phosphate

0

6g60, 3D-view

3.1.6.6

phosphoryl choline + H2O = choline + phosphate

0

7pth, 3D-view

3.1.6.6

phosphorylcholine + H2O = choline + phosphate

0

6g60, 3D-view

3.1.6.6

phosphorylcholine + H2O = choline + phosphate

0

7pth, 3D-view

3.1.6.6

10 entries

Activator in Enzyme-catalyzed Reactions (21 results)

top print hide

Show Activating Compound (21 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.5

-

673003

-

2.1.1.5

elevations in the liver activity, whereas it has no effect in the renal enzyme

673003

-

2.1.1.5

liver BHMT activity is 1.3fold higher in rats fed the methionine deficient diet containing choline than in rats fed the methionine-adequate diet containing supplemental choline

675565

-

2.1.1.5

3 entries

2.3.1.6

extracellular choline increases acetylcholine contents in the cell

705279

2fy3, 3D-view

2.4.1.17

required as phospholipid with a polar head group for maximal activity

488765

-

3.1.1.7

the activity gradually increases from 100% at 0.1 mM to around 120% at 10-20 mM

715396

2ha3, 3D-view

3.1.4.12

required for enzyme activity, and probably to prevent enzyme dissociation from the membranes

678434

-

3.1.6.6

formation of the enzyme is induced by

135665

6g60, 3D-view

3.1.6.6

formation of the enzyme is induced by

135665

7pth, 3D-view

3.2.1.17

the cell wall binding module is intrinsically unstable, and the ultimate folding and stabilization of the active, monomeric form of the enzyme relies on choline binding. Complex formation proceeds in a rather slow way, and all sites behave as equivalent. Coupling between choline binding and folding indicates a high conformational plasticity that could correlate with the unusual alternation of short and long choline-binding repeats present in this enzyme. It can contribute to regulate enzymic activity

698818

1oba, 3D-view

3.2.1.17

the cell wall binding module is intrinsically unstable, and the ultimate folding and stabilization of the active, monomeric form of the enzyme relies on choline binding. Complex formation proceeds in a rather slow way, and all sites behave as equivalent. Coupling between choline binding and folding indicates a high conformational plasticity that could correlate with the unusual alternation of short and long choline-binding repeats present in this enzyme. It can contribute to regulate enzymic activity

698818

2ww5, 3D-view

3.2.1.17

the cell wall binding module is intrinsically unstable, and the ultimate folding and stabilization of the active, monomeric form of the enzyme relies on choline binding. Complex formation proceeds in a rather slow way, and all sites behave as equivalent. Coupling between choline binding and folding indicates a high conformational plasticity that could correlate with the unusual alternation of short and long choline-binding repeats present in this enzyme. It can contribute to regulate enzymic activity

698818

2wwc, 3D-view

3.2.1.17

the cell wall binding module is intrinsically unstable, and the ultimate folding and stabilization of the active, monomeric form of the enzyme relies on choline binding. Complex formation proceeds in a rather slow way, and all sites behave as equivalent. Coupling between choline binding and folding indicates a high conformational plasticity that could correlate with the unusual alternation of short and long choline-binding repeats present in this enzyme. It can contribute to regulate enzymic activity

698818

2wwd, 3D-view

3.2.1.17

the cell wall binding module is intrinsically unstable, and the ultimate folding and stabilization of the active, monomeric form of the enzyme relies on choline binding. Complex formation proceeds in a rather slow way, and all sites behave as equivalent. Coupling between choline binding and folding indicates a high conformational plasticity that could correlate with the unusual alternation of short and long choline-binding repeats present in this enzyme. It can contribute to regulate enzymic activity

698818

4aga, 3D-view

3.2.1.17

the cell wall binding module is intrinsically unstable, and the ultimate folding and stabilization of the active, monomeric form of the enzyme relies on choline binding. Complex formation proceeds in a rather slow way, and all sites behave as equivalent. Coupling between choline binding and folding indicates a high conformational plasticity that could correlate with the unusual alternation of short and long choline-binding repeats present in this enzyme. It can contribute to regulate enzymic activity

698818

7b9j, 3D-view

3.2.1.17

the cell wall binding module is intrinsically unstable, and the ultimate folding and stabilization of the active, monomeric form of the enzyme relies on choline binding. Complex formation proceeds in a rather slow way, and all sites behave as equivalent. Coupling between choline binding and folding indicates a high conformational plasticity that could correlate with the unusual alternation of short and long choline-binding repeats present in this enzyme. It can contribute to regulate enzymic activity

698818

7baz, 3D-view

3.2.1.17

the cell wall binding module is intrinsically unstable, and the ultimate folding and stabilization of the active, monomeric form of the enzyme relies on choline binding. Complex formation proceeds in a rather slow way, and all sites behave as equivalent. Coupling between choline binding and folding indicates a high conformational plasticity that could correlate with the unusual alternation of short and long choline-binding repeats present in this enzyme. It can contribute to regulate enzymic activity

698818

7bb1, 3D-view

3.2.1.96

0.1%, activates

171673

7pl2, 3D-view

3.2.1.96

0.1%, activates

171673

7pl5, 3D-view

3.1.6.6

2 entries

3.2.1.17

8 entries

3.2.1.96

2 entries

3.4.21.62

increases the enzyme activity

708884

-

3.6.1.15

activates at concentration below 20 mM

209886

-

Inhibitor in Enzyme-catalyzed Reactions (60 results)

top print hide

Show Inhibitors (60 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.254

competitive inhibitor of (S)-carnitine oxidation; D-carnitine dehydrogenase, competitive inhibition

9589

-

1.2.1.8

-

390358, 390361

4v3f, 3D-view

1.2.1.8

-

390358, 390361

5a2d, 3D-view

1.2.1.8

10 mM, 23% inhibition

390342

4v3f, 3D-view

1.2.1.8

10 mM, 23% inhibition

390342

5a2d, 3D-view

1.2.1.8

100 mM, 78% inhibition

390329

4v3f, 3D-view

1.2.1.8

100 mM, 78% inhibition

390329

5a2d, 3D-view

1.2.1.8

competitive against betaine aldehyde and uncompetitive with respect to NAD+

390355

4v3f, 3D-view

1.2.1.8

competitive against betaine aldehyde and uncompetitive with respect to NAD+

390355

5a2d, 3D-view

1.2.1.8

mutant enzyme shows stronger inhibition compared to wild-type enzyme

655947

4v3f, 3D-view

1.2.1.8

mutant enzyme shows stronger inhibition compared to wild-type enzyme

655947

5a2d, 3D-view

1.3.8.13

200 mM, about 50% residual activity

739868

-

1.3.8.13

350 mM, 74% residual activity

740464

-

1.2.1.8

10 entries

1.3.8.13

2 entries

2.1.1.5

60% inhibition at 5 mM

441247

-

2.3.1.6

-

487302

2fy3, 3D-view

2.3.1.7

-

487398

-

2.3.1.7

competitively inhibits formation of acetylcarnitine

487399

-

2.7.1.32

-

641370, 673201

4r7b, 3D-view

2.7.1.32

-

641355

4r7b, 3D-view

2.7.1.32

several compounds tested and found to be inhibitory

663273

4r7b, 3D-view

2.7.1.81

-

642035

-

2.7.1.81

40 mM, weak inhibition

642034

-

2.7.1.82

-

641354, 642036, 642038

-

2.7.1.82

ethanolamine kinase I not inhibited, ethanolamine kinase II strongly inhibited

641348

-

2.7.1.82

mixed type

641347

-

2.7.1.82

not

641350, 642039, 642041

-

2.7.1.82

very strong

641345

-

2.3.1.7

2 entries

2.7.1.32

3 entries

2.7.1.81

2 entries

2.7.1.82

5 entries

2.8.2.6

substrate inhibitor

643829

-

3.1.1.7

-

114133

2ha3, 3D-view

3.1.1.7

product inhibition

708730

2ha3, 3D-view

3.1.1.7

product inhibition, binding structure analysis

680690

2ha3, 3D-view

3.1.1.7

the activity decreases to 40% at 200 mM

715396

2ha3, 3D-view

3.1.1.7

4 entries

3.1.1.8

competitive

653036

1p0m, 3D-view

3.1.3.2

-

666336

-

3.1.3.75

-

714872, 714874

-

3.1.3.75

12% inhibition of wild-type enzyme in vivo at 5 mM, at lower concentrations choline induces the enzyme expression in vivo

664697

-

3.1.3.75

2 entries

3.1.4.2

-

95151

-

3.1.4.38

competitive inhibitor

95160, 95161

-

3.1.4.39

-

715631

-

3.1.6.6

competitive with respect to choline sulfate

749790

6g60, 3D-view

3.1.6.6

competitive with respect to choline sulfate

749790

7pth, 3D-view

3.1.6.6

partial competitive inhibitor

135659

6g60, 3D-view

3.1.6.6

partial competitive inhibitor

135659

7pth, 3D-view

3.1.6.6

uncompetitive inhibitor

135659

6g60, 3D-view

3.1.6.6

uncompetitive inhibitor

135659

7pth, 3D-view

3.1.6.6

6 entries

3.2.1.33

very poor inhibitor

171379

-

3.2.1.96

2%, activates

171673

7pl2, 3D-view

3.2.1.96

2%, activates

171673

7pl5, 3D-view

3.2.1.96

2 entries

3.4.21.6

positively linked to Na+ binding

649987

-

3.5.1.28

-

172018

1gvm, 3D-view

3.5.1.28

-

172018

1h8g, 3D-view

3.5.1.28

-

172018

1hcx, 3D-view

3.5.1.28

-

172018

4x36, 3D-view

3.5.1.28

IC50: 0.4 mM; IC50: 2 mM

669091

1gvm, 3D-view

3.5.1.28

IC50: 0.4 mM; IC50: 2 mM

669091

1h8g, 3D-view

3.5.1.28

IC50: 0.4 mM; IC50: 2 mM

669091

1hcx, 3D-view

3.5.1.28

IC50: 0.4 mM; IC50: 2 mM

669091

4x36, 3D-view

3.5.1.28

8 entries

3.6.1.15

at concentration above 20 mM

209886

-

5.5.1.4

slight inhibition

661510

-

7.6.2.9

slightly inhibits betaine uptake

671475

-

3D Structure of Enzyme-Ligand-Complex (PDB) (133 results)

top print hide

Show 3D Structure of Enzyme-Ligand-Complex (PDB) (133 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.2.1.8

4v3f, 3D-view

1.2.1.8

5a2d, 3D-view

1.2.1.8

4v3f, 3D-view

1.2.1.8

5a2d, 3D-view

1.2.1.8

4v3f, 3D-view

1.2.1.8

5a2d, 3D-view

1.2.1.8

4v3f, 3D-view

1.2.1.8

5a2d, 3D-view

1.2.1.8

4v3f, 3D-view

1.2.1.8

5a2d, 3D-view

1.2.1.8

4v3f, 3D-view

1.2.1.8

5a2d, 3D-view

1.2.1.8

12 entries

2.1.1.37

5nvo, 3D-view

2.3.1.6

2fy3, 3D-view

2.7.1.32

4r7b, 3D-view

2.7.7.15

4zcq, 3D-view

3.1.1.7

2ha3, 3D-view

3.1.1.8

1p0m, 3D-view

3.1.6.6

6g60, 3D-view

3.1.6.6

7pth, 3D-view

3.1.6.6

6g60, 3D-view

3.1.6.6

7pth, 3D-view

3.1.6.6

6g60, 3D-view

3.1.6.6

7pth, 3D-view

3.1.6.6

6g60, 3D-view

3.1.6.6

7pth, 3D-view

3.1.6.6

6g60, 3D-view

3.1.6.6

7pth, 3D-view

3.1.6.6

6g60, 3D-view

3.1.6.6

7pth, 3D-view

3.2.1.17

1oba, 3D-view

3.2.1.17

2ww5, 3D-view

3.2.1.17

2wwc, 3D-view

3.2.1.17

2wwd, 3D-view

3.2.1.17

4aga, 3D-view

3.2.1.17

7b9j, 3D-view

3.2.1.17

7baz, 3D-view

3.2.1.17

7bb1, 3D-view

3.2.1.17

1oba, 3D-view

3.2.1.17

2ww5, 3D-view

3.2.1.17

2wwc, 3D-view

3.2.1.17

2wwd, 3D-view

3.2.1.17

4aga, 3D-view

3.2.1.17

7b9j, 3D-view

3.2.1.17

7baz, 3D-view

3.2.1.17

7bb1, 3D-view

3.2.1.17

1oba, 3D-view

3.2.1.17

2ww5, 3D-view

3.2.1.17

2wwc, 3D-view

3.2.1.17

2wwd, 3D-view

3.2.1.17

4aga, 3D-view

3.2.1.17

7b9j, 3D-view

3.2.1.17

7baz, 3D-view

3.2.1.17

7bb1, 3D-view

3.2.1.17

1oba, 3D-view

3.2.1.17

2ww5, 3D-view

3.2.1.17

2wwc, 3D-view

3.2.1.17

2wwd, 3D-view

3.2.1.17

4aga, 3D-view

3.2.1.17

7b9j, 3D-view

3.2.1.17

7baz, 3D-view

3.2.1.17

7bb1, 3D-view

3.2.1.17

1oba, 3D-view

3.2.1.17

2ww5, 3D-view

3.2.1.17

2wwc, 3D-view

3.2.1.17

2wwd, 3D-view

3.2.1.17

4aga, 3D-view

3.2.1.17

7b9j, 3D-view

3.2.1.17

7baz, 3D-view

3.2.1.17

7bb1, 3D-view

3.2.1.17

1oba, 3D-view

3.2.1.17

2ww5, 3D-view

3.2.1.17

2wwc, 3D-view

3.2.1.17

2wwd, 3D-view

3.2.1.17

4aga, 3D-view

3.2.1.17

7b9j, 3D-view

3.2.1.17

7baz, 3D-view

3.2.1.17

7bb1, 3D-view

3.2.1.96

7pl2, 3D-view

3.2.1.96

7pl5, 3D-view

3.2.1.96

7pl2, 3D-view

3.2.1.96

7pl5, 3D-view

3.2.1.96

7pl2, 3D-view

3.2.1.96

7pl5, 3D-view

3.2.1.96

7pl2, 3D-view

3.2.1.96

7pl5, 3D-view

3.2.1.96

7pl2, 3D-view

3.2.1.96

7pl5, 3D-view

3.2.1.96

7pl2, 3D-view

3.2.1.96

7pl5, 3D-view

3.5.1.28

1gvm, 3D-view

3.5.1.28

1h8g, 3D-view

3.5.1.28

1hcx, 3D-view

3.5.1.28

4x36, 3D-view

3.5.1.28

1gvm, 3D-view

3.5.1.28

1h8g, 3D-view

3.5.1.28

1hcx, 3D-view

3.5.1.28

4x36, 3D-view

3.5.1.28

1gvm, 3D-view

3.5.1.28

1h8g, 3D-view

3.5.1.28

1hcx, 3D-view

3.5.1.28

4x36, 3D-view

3.5.1.28

1gvm, 3D-view

3.5.1.28

1h8g, 3D-view

3.5.1.28

1hcx, 3D-view

3.5.1.28

4x36, 3D-view

3.5.1.28

1gvm, 3D-view

3.5.1.28

1h8g, 3D-view

3.5.1.28

1hcx, 3D-view

3.5.1.28

4x36, 3D-view

3.5.1.28

1gvm, 3D-view

3.5.1.28

1h8g, 3D-view

3.5.1.28

1hcx, 3D-view

3.5.1.28

4x36, 3D-view

4.3.99.4

5fau, 3D-view

4.3.99.4

5faw, 3D-view

4.3.99.4

5fay, 3D-view

4.3.99.4

5fau, 3D-view

4.3.99.4

5faw, 3D-view

4.3.99.4

5fay, 3D-view

4.3.99.4

5fau, 3D-view

4.3.99.4

5faw, 3D-view

4.3.99.4

5fay, 3D-view

4.3.99.4

5fau, 3D-view

4.3.99.4

5faw, 3D-view

4.3.99.4

5fay, 3D-view

4.3.99.4

5fau, 3D-view

4.3.99.4

5faw, 3D-view

4.3.99.4

5fay, 3D-view

4.3.99.4

5fau, 3D-view

4.3.99.4

5faw, 3D-view

4.3.99.4

5fay, 3D-view

3.1.6.6

12 entries

3.2.1.17

48 entries

3.2.1.96

12 entries

3.5.1.28

24 entries

4.3.99.4

18 entries

4.6.1.13

4i90, 3D-view