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Information on EC - uronate dehydrogenase

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
       uronate dehydrogenase
IUBMB Comments
Requires Mg2+. The enzyme, characterized from the bacterium Agrobacterium fabrum, participates in oxidative degradation pathways for galacturonate and glucuronate. The enzyme can only accept the beta anomeric form of the substrate . The 1,5-lactone product is rather stable at cytosolic pH and does not hydrolyse spontaneously at a substantial rate.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Atu3143, CsUDH, galacturonate acid reductase, GalUR, PfUDH, PmUDH, PnUDH, PSPTO_1053, PsUDH, Udh, more
beta-D-galacturonate + NAD+ = D-galactaro-1,5-lactone + NADH + H+
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beta-D-glucuronate + NAD+ = D-glucaro-1,5-lactone + NADH + H+
show the reaction diagram
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