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Literature summary for 1.1.1.203 extracted from

  • Murugan, A.; Prathiviraj, R.; Mothay, D.; Chellapandi, P.
    Substrate-imprinted docking of Agrobacterium tumefaciens uronate dehydrogenase for increased substrate selectivity (2019), Int. J. Biol. Macromol., 140, 1214-1225 .
    View publication on PubMed
Search for more literature for 1.1.1.203

Protein Variants

Protein Variants Comment Organism
D34S the mutant shows a high selectivity of D-galacturonic acid and its substrate intermediates for D-galactaric acid production Agrobacterium tumefaciens
N112E the mutant shows a high selectivity of D-galacturonic acid and its substrate intermediates for D-galactaric acid production Agrobacterium tumefaciens
Q14F the mutant shows a high binding affinity to D-glucuronic acid and its substrate intermediates such as D-glucaro-1,4-lactone and D-glucaro-1,5-lactone. The mutant exhibits a low binding affinity to the substrate and cofactor required for D-galactaric acid production Agrobacterium tumefaciens
S165E the mutant shows a high selectivity of D-galacturonic acid and its substrate intermediates for D-galactaric acid production Agrobacterium tumefaciens
S36L the mutant shows a high binding affinity to D-glucuronic acid and its substrate intermediates such as D-glucaro-1,4-lactone and D-glucaro-1,5-lactone. The mutant exhibits a low binding affinity to the substrate and cofactor required for D-galactaric acid production Agrobacterium tumefaciens
S75T the mutant shows a high binding affinity to D-glucuronic acid and its substrate intermediates such as D-glucaro-1,4-lactone and D-glucaro-1,5-lactone. The mutant exhibits a low binding affinity to the substrate and cofactor required for D-galactaric acid production Agrobacterium tumefaciens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-D-galacturonate + NAD+ Agrobacterium tumefaciens
-
 D-galactaro-1,5-lactone + NADH + H+
-
 ?
beta-D-galacturonate + NAD+ Agrobacterium tumefaciens ATCC 33970
-
 D-galactaro-1,5-lactone + NADH + H+
-
 ?
beta-D-glucuronate + NAD+ Agrobacterium tumefaciens
-
 D-glucaro-1,5-lactone + NADH + H+
-
 ?
beta-D-glucuronate + NAD+ Agrobacterium tumefaciens ATCC 33970
-
 D-glucaro-1,5-lactone + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Agrobacterium tumefaciens Q7CRQ0
-
-
Agrobacterium tumefaciens ATCC 33970 Q7CRQ0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-galacturonate + NAD+
-
 Agrobacterium tumefaciens D-galactaro-1,5-lactone + NADH + H+
-
 ?
beta-D-galacturonate + NAD+
-
 Agrobacterium tumefaciens ATCC 33970 D-galactaro-1,5-lactone + NADH + H+
-
 ?
beta-D-glucuronate + NAD+
-
 Agrobacterium tumefaciens D-glucaro-1,5-lactone + NADH + H+
-
 ?
beta-D-glucuronate + NAD+
-
 Agrobacterium tumefaciens ATCC 33970 D-glucaro-1,5-lactone + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
Udh
-
 Agrobacterium tumefaciens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Agrobacterium tumefaciens