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Ligand D-galactaro-1,5-lactone

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for D-galactaro-1,5-lactone

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.4.1.4

D-galactaro-1,5-lactone = D-galactaro-1,4-lactone

747077

-

5.5.1.27

D-galactarolactone = 3-deoxy-2-dehydro-L-threo-hexarate

734177

-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.203

beta-D-galacturonate + NAD+ = D-galactaro-1,5-lactone + NADH + H+

0

3rfv, 3D-view

1.1.1.203

D-galacturonate + NAD+ = D-galactaro-1,5-lactone + NADH + H+

0

3rfv, 3D-view

1.1.1.203

2 entries

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.4.1.4

D-galactaro-1,5-lactone = D-galactaro-1,4-lactone

747077

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5.5.1.27

D-galactarolactone = 3-deoxy-2-dehydro-L-threo-hexarate

734177

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.203

beta-D-galacturonate + NAD+ = D-galactaro-1,5-lactone + NADH + H+

0

3rfv, 3D-view

1.1.1.203

D-galacturonate + NAD+ = D-galactaro-1,5-lactone + NADH + H+

0

3rfv, 3D-view

1.1.1.203

2 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.203

noncompetitve versus NAD+ and beta-D-glucuronate

740393

3rfv, 3D-view

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

1.1.1.203

3rfv, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

5.4.1.4

16

-

mutant enzyme N240D, pH and temperature not specified in the publication

747077

References & Links

Literature References (3)

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Show Reference (3 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

734177

22493433

Characterization of a novel Agrobacterium tumefaciens galactarolactone cycloisomerase enzyme for direct conversion of D-galactarolactone to 3-deoxy-2-keto-L-threo-hexarate

2012

Andberg, M.; Maaheimo, H.; Boer, H.; Penttilae, M.; Koivula, A.; Richard, P.

J. Biol. Chem.

287

17662-17671

740393

25640726

Biochemical characterization of uronate dehydrogenases from three pseudomonads, Chromohalobacter salixigens, and Polaromonas naphthalenivorans

2015

Wagschal, K.; Jordan, D.B.; Lee, C.C.; Younger, A.; Braker, J.D.; Chan, V.J.

Enzyme Microb. Technol.

69

62-68

747077

24450804

Galactaro delta-lactone isomerase Lactone isomerization by a member of the amidohydrolase superfamily

2014

Bouvier, J.; Groninger-Poe, F.; Vetting, M.; Almo, S.; Gerlt, J.

Biochemistry

53

614-616

Links to other databases for D-galactaro-1,5-lactone

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Show Links (1 entry)

ChEBI

PubChem