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3.4.22.B60: cathepsin L2

This is an abbreviated version!
For detailed information about cathepsin L2, go to the full flat file.

Word Map on EC 3.4.22.B60

Reaction

preference for Arg in the P1 position, Pro is accepted in the P2 position =

Synonyms

cathepsin L2, cathepsin L2 protease, CatL2, CL2, FhCatL2, FhCL2, FhpCL2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B60 cathepsin L2

Turnover Number

Turnover Number on EC 3.4.22.B60 - cathepsin L2

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.06
benzoyl-Phe-Val-Arg-4-methylcoumarinyl-7-amide
pH 7.0, 37°C, cathepsin L2
0.09
benzyloxycarbonyl-Arg-4-methylcoumarinyl-7-amide
pH 7.0, 37°C, cathepsin L2
0.02
benzyloxycarbonyl-Arg-Arg-4-methylcoumarinyl-7-amide
pH 7.0, 37°C, cathepsin L2
1.62
benzyloxycarbonyl-L-Leu-L-Arg-4-methylcoumarinyl-7-amide
FheCL2
1.7
benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarinyl-7-amide
FheCL2
2.64
benzyloxycarbonyl-L-Pro-L-Arg-4-methylcoumarinyl-7-amide
FheCL2
1.6 - 3.2
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin
0.56
benzyloxycarbonyl-Phe-Arg-4-methylcoumarinyl-7-amide
pH 7.0, 37°C, cathepsin L2
0.4 - 50
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
1.9 - 2.6
benzyloxycarbonyl-Pro-Arg-7-amido-4-methylcoumarin
0.55
Boc-AGPR-7-amido-4-methylcoumarin
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37°C
0.07
Boc-VLK-7-amido-4-methylcoumarin
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37°C
0.23
Boc-VPR-7-amido-4-methylcoumarin
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37°C
0.21
Leu-Val-Tyr-4-methylcoumarinyl-7-amide
pH 7.0, 37°C, cathepsin L2
0.14
succinyl-Ala-Phe-Lys-4-methylcoumarinyl-7-amide
pH 7.0, 37°C, cathepsin L2
0.08
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarinyl-7-amide
pH 7.0, 37°C, cathepsin L2
2.48
tert-butoxycarbonyl-Gly-Pro-Arg-4-methylcoumarinyl-7-amide
FheCL2
3.75
tert-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarinyl-7-amide
pH 7.0, 37°C, cathepsin L2
1.19
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumarinyl-7-amide
pH 7.0, 37°C, cathepsin L2
26.3
tosyl-Gly-Phe-Arg-7-amido-4-methylcoumarin
-
FhCatL2
1.17 - 1.93
tosyl-Gly-Pro-Arg-4-methylcoumarinyl-7-amide
440
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin
-
FhCatL2
1.37
tosyl-Gly-Pro-Lys-4-methylcoumarinyl-7-amide
pH 7.0, 37°C, cathepsin L2
0.18
tosyl-GPK-7-amido-4-methylcoumarin
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37°C
0.26
tosyl-GPR-7-amido-4-methylcoumarin
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37°C
0.95
Z-Leu-Arg-NHMe
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37°C
0.09
Z-Phe-Arg-NHMe
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37°C
0.014
Z-VVR-7-amido-4-methylcoumarin
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37°C