3.4.22.B60: cathepsin L2

This is an abbreviated version!
For detailed information about cathepsin L2, go to the full flat file.

Word Map on EC 3.4.22.B60

3.4.22.B60

fasciola

hepatica

proteinases

fluke

helminth

schistosome

trematode

l-like

excysted

collagenolytic

diagnostics

agriculture

Reaction

preference for Arg in the P1 position, Pro is accepted in the P2 position =

Synonyms

cathepsin L2, cathepsin L2 protease, CatL2, CL2, FhCatL2, FhCL2, FhpCL2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B60 cathepsin L2

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Results	in table
1	Activating Compound
4	AA Sequence
2	Application
5	Cloned(Commentary)
40	Disease/ Diagnostics
2	Expression
6	General Information
8	Inhibitors
8	kcat/KM [mM/s]
4	Ki Value [mM]
33	KM Value [mM]
4	Localization
4	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
155	Organism
1	pH Optimum
3	Posttranslational Modification
1	Protein Variants
6	Purification (Commentary)
1	Reaction
16	Reference
1	Renatured (Commentary)
10	Source Tissue
2	Specific Activity [micromol/min/mg]
48	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Temperature Optimum [°C]
33	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.22.B60 - cathepsin L2

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benzyloxycarbonyl-Phe-Ala-diazomethyl ketone

Fasciola hepatica

Q24940

FheCL2

680930

cathepsin K inhibitor II

2 entries

N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide

Mus musculus

SID, cathepsin L/V inhibitor SID attenuates vascular inflammation in hyperhomocysteinaemic mice, and SID decreases the number of leukocytes and the expression of interleukin-6, CXCL15 (human IL-8 homologous), and TNF-alpha in the thoracic arteries of hyperhomocysteinaemic mice

753117

Tetranitromethane

Fasciola hepatica

P80342

cathepsin L2 is completely inactivated by 4 mM tetranitromethane, cathepsin L1 is not inactivated

647701

Z-Phe-Ala-CHN2

Fasciola hepatica

718252

additional information

3 entries