3.4.22.B60: cathepsin L2
This is an abbreviated version!
For detailed information about cathepsin L2, go to the full flat file.
Word Map on EC 3.4.22.B60
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3.4.22.B60
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fasciola
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hepatica
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proteinases
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fluke
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helminth
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schistosome
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trematode
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l-like
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excysted
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collagenolytic
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diagnostics
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agriculture
- 3.4.22.B60
- fasciola
- hepatica
- proteinases
- fluke
-
helminth
-
schistosome
-
trematode
-
l-like
-
excysted
-
collagenolytic
- diagnostics
- agriculture
Reaction
preference for Arg in the P1 position, Pro is accepted in the P2 position =
Synonyms
cathepsin L2, cathepsin L2 protease, CatL2, CL2, FhCatL2, FhCL2, FhpCL2
ECTree
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General Information
General Information on EC 3.4.22.B60 - cathepsin L2
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evolution
adult flukes produce three different clades of cathepsin Ls: FhCL1, FhCL2, and FhCL5
metabolism
physiological function
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effects of cathepsin V on the dual-specificity protein phosphatases (DUSPs) and MAPK pathways
metabolism
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effects of cathepsin V on the dual-specificity protein phosphatases (DUSPs) and MAPK pathways
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although no direct anticoagulant effect of the peptidases is observed, cathepsin peptidases from Fasciola are able to degrade purified fibrinogen, with FhCL1 having the highest fibrinogenolytic activity. FhCL1 and FhCL2 also both efficiently degraded fibrin, but FhCL3 does not. FhCL1 has a larger fibrinogenolytic activity than FhCL2 and FhCL3 and is capable of degradation of the fibrinogen alpha-chain, beta-chain, and gamma-chain. FhCL2 and FhCL3 demonstrate only minor cleavage of the gamma-chain and slower cleavage of the alpha-chain and beta-chain compared to FhCL1
physiological function
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L-homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. Cathepsin V, specifically expressed in humans, is involved in vascular diseases through its elastolytic and collagenolytic activities
physiological function
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L-homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. Cathepsin V, specifically expressed in humans, is involved in vascular diseases through its elastolytic and collagenolytic activities
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