3.4.22.B60: cathepsin L2

This is an abbreviated version!
For detailed information about cathepsin L2, go to the full flat file.

Reaction

preference for Arg in the P1 position, Pro is accepted in the P2 position =

Synonyms

cathepsin L2, cathepsin L2 protease, CatL2, CL2, FhCatL2, FhCL2, FhpCL2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B60 cathepsin L2

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
4	AA Sequence
2	Application
5	Cloned(Commentary)
40	Disease/ Diagnostics
2	Expression
6	General Information
8	Inhibitors
8	kcat/KM [mM/s]
4	Ki Value [mM]
33	KM Value [mM]
4	Localization
4	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
155	Organism
1	pH Optimum
3	Posttranslational Modification
1	Protein Variants
6	Purification (Commentary)
1	Reaction
16	Reference
1	Renatured (Commentary)
10	Source Tissue
2	Specific Activity [micromol/min/mg]
48	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Temperature Optimum [°C]
33	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Natural Substrates Products on EC 3.4.22.B60 - cathepsin L2

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Boc-AGPR-7-amido-4-methylcoumarin + H2O

?

Fasciola hepatica

-

-

718252

-

-

?

Boc-VLK-7-amido-4-methylcoumarin + H2O

?

Fasciola hepatica

-

-

718252

-

-

?

Boc-VPR-7-amido-4-methylcoumarin + H2O

?

Fasciola hepatica

-

-

718252

-

-

?

Collagen type I + H2O

?

Fasciola hepatica

-

cathepsin L2 cleaves collagen type I at 43 sites within the alpha1 chain and 26 sites within the alpha2 chain

718252

-

-

?

collagen type II + H2O

?

Fasciola hepatica

-

cathepsin L2 exhibits collagenase activity by cleaving at multiple sites within the alpha1 and alpha2 triple helix regions (Col domains)

718252

-

-

?

tosyl-GPK-7-amido-4-methylcoumarin + H2O

?

Fasciola hepatica

-

-

718252

-

-

?

tosyl-GPR-7-amido-4-methylcoumarin + H2O

?

Fasciola hepatica

-

-

718252

-

-

?

Z-Gly-Pro-Gly-Gly-Pro-Ala + H2O

Z-Gly-Pro + Gly-Gly + L-Pro-L-Ala

Fasciola hepatica

-

-

718252

-

-

?

Z-Gly-Pro-Leu-Gly-Pro + H2O

Z-Gly-Pro + L-Leu + Gly + L-Pro

Fasciola hepatica

-

-

718252

-

-

?

Z-Leu-Arg-NHMe + H2O

?

Fasciola hepatica

-

-

718252

-

-

?

Z-Phe-Arg-NHMe + H2O

?

Fasciola hepatica

-

-

718252

-

-

?

Z-VVR-7-amido-4-methylcoumarin + H2O

?

Fasciola hepatica

-

-

718252

-

-

?

additional information

?

-

2 entries

additional information

?

-

Fasciola hepatica

-

cathepsin L2 readily cleaves substrates with Pro in the P2 position and peptide substrates mimicking the repeating Gly-Pro-Xaa motifs

718252

-

-

?

additional information

?

-

Fasciola hepatica

-

the cathepsin L zymogen is autocatalytically activated and processed to mature enzyme by incubation for 2 h at 37°C in 0.1 M sodium citrate buffer (pH 5.0) containing 2 mM dithiothreitol and 2.5 mM EDTA

718252

-

-

?