2.3.1.304: poly[(R)-3-hydroxyalkanoate] polymerase

This is an abbreviated version!
For detailed information about poly[(R)-3-hydroxyalkanoate] polymerase, go to the full flat file.

Reaction

Synonyms

BP-M-CPF4, broad-range class I PhaCAc, CLAOCE_21140, CLAOCE_21150, CLAOCE_21150/21140, class I PHA synthase, Class I PhaC, class I PhaCRe, class I PHB synthase, Class I poly(R)-hydroxyalkanoic acid synthase, class I polyhydroxyalkanoate synthase, class I polyhydroxybutyrate synthase, Class I synthase, Class II PHA polymerizing enzyme, class II PHA synthase, Class II PhaC, class II PhaC1, class III PHA synthase, class III PHB synthase, class III polyhydroxyalkanoate synthase, class III polyhydroxybutyrate synthase, class III synthase, class IV PHA synthase, H16_A1437, HPTL0263, HPTL0635, HPTL1376, intracellular polyhydroxyalkanoate synthase, P(3HB) synthase, PHA polymerase, PHA synthase, PHA synthase 1, PHA synthase I, PHA synthase II, PHA synthase III, PhaC, PhaC type II, PhaC-II, PhaC1, PhaC1P-5, PhaC1Pp, PhaC1Ps, PhaC1SG, PhaC2, PhaC2P-5, PhaC2Ps, PhaC2SG, PhaCAc, PhaCAv, phaCBP-M-CPF4, PhaCCc, PhaCCn-CAT, PhaCCs, PhaCCs-CAT, phaCCv, PhaCPhaEAv, PhaCRe, PhaE, PhaEC, PhaECAv, PhaRCBm, PhaRCYB4, PHB synthase, PhbC, PhbCRe, phbC_2, phbE, poly(3-hydroxybutyrate) synthase, poly(hydroxyalkanoic acid) synthase, poly-3-hydroxybutyrate synthase, poly-beta-hydroxybutyrate synthase, polyhydroxyalkanoate (PHA) synthase, polyhydroxyalkanoate synthase, polyhydroxyalkanoate synthase 1, polyhydroxyalkanoate synthase synthase, polyhydroxyalkanoic acids synthase, polyhydroxyalkanoic synthase I, polyhydroxyalkanoic synthase II, polyhydroxyalkanoic synthase III, polyhydroxybutyrate synthase, Q667_12980, TH-1_PHB synthase_HPTL_0263, TH-1_PHB synthase_HPTL_0635, TH-1_PHB synthase_HPTL_1376, type I PHA synthase, type I polyhydroxyalkanoate synthase, type II PHA synthase, type II PhaC1, type II polyhydroxyalkanoate synthase, type II Pseudomonas PHA synthase 1, type III PHA synthase, type-III PHA synthase, YdcS

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.304 poly[(R)-3-hydroxyalkanoate] polymerase

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Results	in table
10	Activating Compound
35	AA Sequence
36	Application
87	Cloned(Commentary)
1	Crystallization (Commentary)
3	Expression
98	General Information
1	General Stability
1	IC50 Value
8	Inhibitors
10	kcat/KM [mM/s]
3	Ki Value [mM]
30	KM Value [mM]
13	Localization
4	Metals/Ions
13	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
304	Organism
4	Pathway
12	pH Optimum
2	pH Range
1	pI Value
2	Posttranslational Modification
236	Protein Variants
21	Purification (Commentary)
5	Reaction
167	Reference
8	Source Tissue
10	Specific Activity [micromol/min/mg]
183	Substrates and Products (Substrate)
47	Subunits
406	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
21	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 2.3.1.304 - poly[(R)-3-hydroxyalkanoate] polymerase

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

390000

Allochromatium vinosum

-

non-denaturing PAGE

686489

39320

Bacillus subtilis

I4EBJ0

x * 39320, calculated

735837

400000

Allochromatium vinosum

-

gel filtration

686489

40600

2 entries

41700

2 entries

62300

Pseudomonas sp.

C0KTZ0

x * 62300, about, sequence calculation

719746

64000

2 entries

66000

Cupriavidus necator

-

x * 66000, (His)6-tagged wild-type and G4D mutant PhaCRe, SDS-PAGE

688783

73000

Caulobacter vibrioides

Q9F4K5

x * 73000, SDS-PAGE

688851

80000

Halopiger aswanensis

-

x * 80000, SDS-PAGE

684663

40600

Ectothiorhodospira shaposhnikovii

Q9F5P8; Q9F5P9, Q9F5P9

3 * 41700 (PhaE) + 3 * 40600 (PhaC), two major complexes are identified in preparations of purified PHA synthase. The large complex appears to be composed of 12 PhaC subunits and 12 PhaE subunits (dodecamer). The small complex appears to be composed of 6 PhaC and 6 PhaE subunits (hexamer). In dilute aqueous solution, the synthase is predominantly composed of hexamer and has low activity accompanied with a significant lag period at the initial stage of reaction. The percentage of dodecameric complex increases with increasing salt concentration. The dodecameric complex has a greatly increased specific activity for the polymerization of (R)-3-hydroxybutyryl-CoA and a negligible lag period. The PHA synthase from Ectothiorhodospira shaposhnikoVii may catalyze a living polymerization and two PhaC and two PhaE subunits may comprise a single catalytic site in the synthase complex, SDS-PAGE

685488

40600

Ectothiorhodospira shaposhnikovii

Q9F5P8; Q9F5P9, Q9F5P9

6 * 41700 (PhaE) + 6 * 40600 (PhaC), two major complexes are identified in preparations of purified PHA synthase. The large complex appears to be composed of 12 PhaC subunits and 12 PhaE subunits (dodecamer). The small complex appears to be composed of 6 PhaC and 6 PhaE subunits (hexamer). In dilute aqueous solution, the synthase is predominantly composed of hexamer and has low activity accompanied with a significant lag period at the initial stage of reaction. The percentage of dodecameric complex increases with increasing salt concentration. The dodecameric complex has a greatly increased specific activity for the polymerization of (R)-3-hydroxybutyryl-CoA and a negligible lag period. The PHA synthase from Ectothiorhodospira shaposhnikoVii may catalyze a living polymerization and two PhaC and two PhaE subunits may comprise a single catalytic site in the synthase complex, SDS-PAGE

685488

41700

Ectothiorhodospira shaposhnikovii

Q9F5P8; Q9F5P9, Q9F5P9

3 * 41700 (PhaE) + 3 * 40600 (PhaC), two major complexes are identified in preparations of purified PHA synthase. The large complex appears to be composed of 12 PhaC subunits and 12 PhaE subunits (dodecamer). The small complex appears to be composed of 6 PhaC and 6 PhaE subunits (hexamer). In dilute aqueous solution, the synthase is predominantly composed of hexamer and has low activity accompanied with a significant lag period at the initial stage of reaction. The percentage of dodecameric complex increases with increasing salt concentration. The dodecameric complex has a greatly increased specific activity for the polymerization of (R)-3-hydroxybutyryl-CoA and a negligible lag period. The PHA synthase from Ectothiorhodospira shaposhnikoVii may catalyze a living polymerization and two PhaC and two PhaE subunits may comprise a single catalytic site in the synthase complex, SDS-PAGE

685488

41700

Ectothiorhodospira shaposhnikovii

Q9F5P8; Q9F5P9, Q9F5P9

6 * 41700 (PhaE) + 6 * 40600 (PhaC), two major complexes are identified in preparations of purified PHA synthase. The large complex appears to be composed of 12 PhaC subunits and 12 PhaE subunits (dodecamer). The small complex appears to be composed of 6 PhaC and 6 PhaE subunits (hexamer). In dilute aqueous solution, the synthase is predominantly composed of hexamer and has low activity accompanied with a significant lag period at the initial stage of reaction. The percentage of dodecameric complex increases with increasing salt concentration. The dodecameric complex has a greatly increased specific activity for the polymerization of (R)-3-hydroxybutyryl-CoA and a negligible lag period. The PHA synthase from Ectothiorhodospira shaposhnikoVii may catalyze a living polymerization and two PhaC and two PhaE subunits may comprise a single catalytic site in the synthase complex, SDS-PAGE

685488

64000

Cupriavidus necator

-

1 * 64000, PhaC, SDS-PAGE

718922

64000

Cupriavidus necator

-

2 * 64000, PhaC, SDS-PAGE

718922