1.12.1.2: hydrogen dehydrogenase This is an abbreviated version! For detailed information about hydrogen dehydrogenase, go to the full flat file .
Reaction
H2 +
NAD+ =
H+ +
NADH
Synonyms bidirectional hydrogenase, bidirectional Ni-Fe hydrogenase, bidirectional NiFe-hydrogenase, bidirectional [NiFe] hydrogenase, dehydrogenase, hydrogen, FeHyd, H2:NAD+ oxidoreductase, H2ase, Hox, Hox hydrogenase, Hox type hydrogenase, HoxE, HoxEFUYH, HoxF, HoxFUYHI2, HoxH, HoxS, HoxU, HoxY, hydrogen-evolving enzyme, hydrogenase, Hyn, iron-hydrogenase, NAD+-reducing hydrogenase, NAD+-reducing NiFe hydrogenase, NAD+-reducing [NiFe]-hydrogenase, NAD-dependent hydrogenase, NAD-reducing hydrogenase, NADH-dependent Fe-only hydrogenase, NiFe hydrogenase, NiFe-type reversible hydrogenase, SH, soluble hydrogenase, soluble [NiFe]-hydrogenase, [FeFe] hydrogenase, [FeFe]-hydrogenase, [NiFe] H2ase, [NiFe] hydrogenase, [NiFe]-hydrogenase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 1.12.1.2 - hydrogen dehydrogenase
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H+ + NADH
H2 + NAD+
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?
H+ + NADPH
H2 + NADP+
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-
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?
H2 + oxidized methyl viologen
H+ + reduced methyl viologen
the artificial electron donor is accepted by the cells for H2 production when added to the culture medium
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r
additional information
?
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H2 + NAD+
H+ + NADH
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-
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r
H2 + NAD+
H+ + NADH
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-
-
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?
H2 + NAD+
H+ + NADH
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-
-
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r
H2 + NAD+
H+ + NADH
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-
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?
H2 + NAD+
H+ + NADH
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utilization of H2 as energy source during autotrophic growth on hydrogen and CO2
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r
H2 + NAD+
H+ + NADH
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utilization of H2 as energy source during autotrophic growth on hydrogen and CO2
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r
H2 + NAD+
H+ + NADH
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enzyme provides reducing equivalents for CO2 fixation
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r
H2 + NAD+
H+ + NADH
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key enzyme in H2 metabolism
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r
H2 + NAD+
H+ + NADH
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the enzyme catalyzes electron transfer from molecular hydrogen to NAD+, thereby producing reducing equivalents for CO2 fixation in the form of NADH
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?
H2 + NAD+
H+ + NADH
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?
H2 + NAD+
H+ + NADH
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utilization of H2 as energy source during autotrophic growth on hydrogen and CO2
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r
H2 + NAD+
H+ + NADH
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key enzyme in H2 metabolism
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r
H2 + NAD+
H+ + NADH
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physiological function of the enzyme in Frankia strains, overview
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r
H2 + NAD+
H+ + NADH
H2 producing activity is not dependent on NAD+ reduction
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r
H2 + NAD+
H+ + NADH
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enzyme delivers hydrogen-driven reducing power for methane oxidation
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r
H2 + NAD+
H+ + NADH
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?
H2 + NAD+
H+ + NADH
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r
H2 + NAD+
H+ + NADH
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?
H2 + NAD+
H+ + NADH
in vivo H2 evolution under nitrogenase-repressed conditions
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r
additional information
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at high H2 partial pressure enzyme activity is reduced and fermentation is partially shifted to ethanol production
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?
additional information
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activity is equally high in atmosperes of 20% O2, 20% N2, or 100% H2, the latter being slightly preferred
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?
additional information
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enzyme regulation involves a regulatory hydrogenase RH which acts as a sensor for H2 content, interaction via signal cascade
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additional information
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the organism can grow on H2 as sole energy source in an oxic environment
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?
additional information
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the organism can grow on H2 as sole energy source in an oxic environment
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?
additional information
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enzyme is the key enzyme in hydrogen metabolism, no activity in strain R43 under aerobic nitrogen-limited conditions
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?
additional information
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enzyme is the key enzyme in hydrogen metabolism, no activity in strain R43 under aerobic nitrogen-limited conditions
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?
additional information
?
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enzyme is the key enzyme in hydrogen metabolism, no activity in strain R43 under aerobic nitrogen-limited conditions
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?
additional information
?
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enzyme is the key enzyme in hydrogen metabolism, no activity in strain R43 under aerobic nitrogen-limited conditions
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?
additional information
?
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physiological role of the hydrogenase seems to be equally associated with both formation and uptake of H2, depending on the redox state of the intracellular medium
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?
additional information
?
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physiological role of the hydrogenase seems to be equally associated with both formation and uptake of H2, depending on the redox state of the intracellular medium
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?