Reference on EC 3.5.3.18 - dimethylargininase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Leiper, J.M.; Santa Maria, J.; Chubb, A.; MacAllister, R.J.; Charles, I.G.
Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases
Biochem. J.
343
209-214
1999
Homo sapiens (O95865), Homo sapiens
Kimoto, M.; Sasakawa, T.; Tsuji, H.; Miyatake, S.; Oka, T.
Cloning and sequencing of cDNA encoding NG,NG-dimethylarginine dimethylaminohydrolase from rat kidnes
Biochim. Biophys. Acta
1337
6-10
1997
BRENDA: Rattus norvegicus
Textmining: Rattus
Santa Maria, J.; Vallance, P.; Charles, I.G.; Leiper, J.M.
Identification of microbial dimethylarginine dimethylaminohydrolase enzymes
Mol. Microbiol.
33
1278-1279
1999
Homo sapiens, Mycobacterium tuberculosis, Mus musculus, Pseudomonas aeruginosa, Rattus norvegicus, Streptomyces coelicolor
Birdsey, G.M.; Leiper, J.M.; Vallance, P.
Intramolecular localization of dimethylarginine dimethylaminohydrolase overexpressed in an endothelial cell line
Acta Physiol. Scand.
168
73-79
2000
Homo sapiens
Bogumil, R.; Knipp, M.; Fundel, S.M.; Vasak, M.
Characterization of dimethylargininase from bovine brain: evidence for a zinc binding site
Biochemistry
37
4791-4798
1998
BRENDA: Bos taurus
Textmining: Rattus, Dialysis
MacAllister, R.J.; Parry, H.; Kimoto, M.; Ogawa, T.; Russell, R.J.; Hodson, H.; Whiteley, G.St.J.; Vallance, P.
Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase
Br. J. Pharmacol.
119
1533-1540
1996
BRENDA: Homo sapiens, Rattus norvegicus
Textmining: Rattus
Ogawa, T.; Kimoto, M.; Sasaoka, K.
Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase from rat kidney
J. Biol. Chem.
264
10205-10209
1989
BRENDA: Rattus norvegicus
Textmining: Rattus
Kimoto, M.; Whiteley, G.St.J.; Tsuji, H.; Ogawa, T.
Detection of NG,NG-dimethylarginine dimethylaminohydrolase in human tissue using a monoclonal antibody
J. Biochem.
117
237-238
1995
BRENDA: Homo sapiens
Textmining: Rattus
Kimoto, M.; Tsuji, H.; Ogawa, T.; Sasaoka, K.
Detection of NG,NG-dimethylarginine dimethylaminohydrolase in the nitric oxide-generating systems of rats using monoclonal antibody
Arch. Biochem. Biophys.
300
657-662
1993
BRENDA: Rattus norvegicus
Textmining: Mus musculus, Rattus
Knipp, M.; Charnock, J.M.; Garner, C.D.; Vasak, M.
Structural and functional characterization of the Zn(II) site in dimethylargininase-1 (DDAH-1) from bovine brain. Zn(II) release activates DDAH-1
J. Biol. Chem.
276
40449-40456
2001
BRENDA: Bos taurus
Textmining: Chelator
Knipp, M.; Braun, O.; Gehrig, P.M.; Sack, R.; Vasak, M.
Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylation
J. Biol. Chem.
278
3410-3416
2003
Bos taurus
Plevin, M.J.; Magalhaes, B.S.; Harris, R.; Sankar, A.; Perkins, S.J.; Driscoll, P.C.
Characterization and manipulation of the Pseudomonas aeruginosa dimethylarginine dimethylaminohydrolase monomer--dimer equilibrium
J. Mol. Biol.
341
171-184
2004
BRENDA: Pseudomonas aeruginosa (Q9I4E3), Pseudomonas aeruginosa
Textmining: Mammalia, bacterium
Leiper, J.; Murray-Rust, J.; McDonald, N.; Vallance, P.
S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase
Proc. Natl. Acad. Sci. USA
99
13527-13532
2002
Homo sapiens, Pseudomonas aeruginosa
Stone, E.M.; Schaller, T.H.; Bianchi, H.; Person, M.D.; Fast, W.
Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase
Biochemistry
44
13744-13752
2005
BRENDA: Pseudomonas aeruginosa (Q9I4E3), Pseudomonas aeruginosa
Textmining: Homo sapiens, Homo sapiens (Q9UM07)
Lu, X.; Li, L.; Wu, R.; Feng, X.; Li, Z.; Yang, H.; Wang, C.; Guo, H.; Galkin, A.; Herzberg, O.; Mariano, P.S.; Martin, B.M.; Dunaway-Mariano, D.
Kinetic analysis of Pseudomonas aeruginosa arginine deiminase mutants and alternate substrates provides insight into structural determinants of function
Biochemistry
45
1162-1172
2006
Pseudomonas aeruginosa, Pseudomonas aeruginosa (P13981)
Chen, Y.; Li, Y.; Zhang, P.; Traverse, J.H.; Hou, M.; Xu, X.; Kimoto, M.; Bache, R.J.
Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts
Am. J. Physiol. Heart Circ. Physiol.
289
H2212-2219
2005
Canis lupus familiaris, Homo sapiens
Billecke, S.S.; Kitzmiller, L.A.; Northrup, J.J.; Whitesall, S.E.; Kimoto, M.; Hinz, A.V.; D'Alecy, L.G.
Contribution of whole blood to the control of plasma asymmetrical dimethylarginine
Am. J. Physiol. Heart Circ. Physiol.
291
H1788-1796
2006
Rattus norvegicus
Hasegawa, K.; Wakino, S.; Tanaka, T.; Kimoto, M.; Tatematsu, S.; Kanda, T.; Yoshioka, K.; Homma, K.; Sugano, N.; Kurabayashi, M.; Saruta, T.; Hayashi, K.
Dimethylarginine dimethylaminohydrolase 2 increases vascular endothelial growth factor expression through Sp1 transcription factor in endothelial cells
Arterioscler. Thromb. Vasc. Biol.
26
1488-1494
2006
Bos taurus, Homo sapiens
Yin, Q.; Fu, S.; He, P.; Xiong, Y.
Dimethylarginine dimethylaminohydrolase inhibition and asymmetric dimethylarginine accumulation contribute to endothelial dysfunction in rats exposed to glycosylated protein: Effects of aminoguanidine
Atherosclerosis
190
53-61
2006
BRENDA: Rattus norvegicus
Textmining: Bos taurus, Rattus
Stone, E.M.; Person, M.D.; Costello, N.J.; Fast, W.
Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis
Biochemistry
44
7069 - 7078
2005
BRENDA: Pseudomonas aeruginosa (Q9I4E3), Pseudomonas aeruginosa
Textmining: Homo sapiens
Stone, E.M.; Costello, A.L.; Tierney, D.L.; Fast, W.
Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa
Biochemistry
45
5618-5630
2006
Pseudomonas aeruginosa
Mishima, T.; Hamada, T.; Ui-Tei, K.; Miyata, Y.; Imaki, J.; Suzuki, H.; Yamashita K.
Expression of DDAH1 in chick and rat embryos
Brain Res. Dev. Brain Res.
148
223-232
2004
BRENDA: Gallus gallus, Rattus norvegicus
Textmining: Rattus
Jiang, J.L.; Zhang, X.H.; Li, N.S.; Rang, W.Q; Feng-Ye, W.Q.; Hu, C.P.; Li, Y.J.; Deng, H.W.
Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity
Cardiovasc. Drugs Ther.
20
281-294
2006
Homo sapiens, Rattus norvegicus
Vallance, P.; Bush, H.D.; Mok, B.J.; Hurtado-Guerrero, R.; Gill, H.; Rossiter, S.; Wilden, J.D.; Caddick, S.
Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates
Chem. Commun. (Camb.)
2005
5563-5565
2005
Pseudomonas sp.
Wakino, S.; Hayashi, K.; Tatematsu, S.; Hasegawa, K.; Takamatsu, I.; Kanda, T.; Homma, K.; Yoshioka, K.; Sugano, N.; Saruta, T.
Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats
Hypertens. Res.
28
255-262
2005
BRENDA: Rattus norvegicus
Textmining: Rattus, Canis lupus familiaris
Scalera, F.; Kielstein, J.T.; Martens-Lobenhoffer, J.; Postel, S.C.; Tager, M.; Bode-Boger, S.M.
Erythropoietin increases asymmetric dimethylarginine in endothelial cells: role of dimethylarginine dimethylaminohydrolase
J. Am. Soc. Nephrol.
16
892-898
2005
BRENDA: Homo sapiens
Textmining: Metazoa
Rossiter, S.; Smith, C.L.; Malaki, M.; Nandi, M.; Gill, H.; Leiper, J.M.; Vallance, P.; Selwood, D.L.
Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase
J. Med. Chem.
48
4670-4678
2005
Rattus norvegicus
Frey, D.; Braun, O.; Briand, C.; Vaák, M.; Grütter, M.G.
Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: a basis for the design of specific inhibitors
Structure
14
901-911
2006
Bos taurus (P56965), Bos taurus
Braun, O.; Knipp, M.; Chesnov, S.; Vasak, M.
Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dimethylargininase-1 and CTP synthetase
Protein Sci.
16
1522-1534
2007
Bos taurus (P56965)
Sasaki, A.; Doi, S.; Mizutani, S.; Azuma, H.
Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats
Am. J. Physiol. Lung Cell Mol. Physiol.
292
L1480-L1487
2007
BRENDA: Rattus norvegicus
Textmining: Rattus
Forbes, S.P.; Druhan, L.J.; Guzman, J.E.; Parinandi, N.; Zhang, L.; Green-Church, K.B.; Cardounel, A.J.
Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation
Biochemistry
47
1819-1826
2008
Homo sapiens
Wang, J.; Sim, A.S.; Wang, X.L.; Wilcken, D.E.
L-arginine regulates asymmetric dimethylarginine metabolism by inhibiting dimethylarginine dimethylaminohydrolase activity in hepatic (HepG2) cells
Cell. Mol. Life Sci.
63
2838-2846
2006
Homo sapiens
Wang, D.; Gill, P.S.; Chabrashvili, T.; Onozato, M.L.; Raggio, J.; Mendonca, M.; Dennehy, K.; Li, M.; Modlinger, P.; Leiper, J.; Vallance, P.; Adler, O.; Leone, A.; Tojo, A.; Welch, W.J.; Wilcox, C.S.
Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO
Circ. Res.
101
627-635
2007
BRENDA: Rattus norvegicus (Q6MG60)
Textmining: Rattus
Siroen, M.P.; Teerlink, T.; Bolte, A.C.; van Elburg, R.M.; Richir, M.C.; Nijveldt, R.J.; van der Hoven, B.; van Leeuwen, P.A.
No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia
Gynecol. Obstet. Invest.
62
7-13
2006
Homo sapiens
Hong, L.; Fast, W.
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia
J. Biol. Chem.
282
34684-34692
2007
Homo sapiens
Slaghekke, F.; Dekker, G.; Jeffries, B.
Endogenous inhibitors of nitric oxide and preeclampsia: a review
J. Matern. Fetal. Neonatal. Med.
19
447-452
2006
Homo sapiens (O95865), Homo sapiens
Tain, Y.L.; Baylis, C.
Determination of dimethylarginine dimethylaminohydrolase activity in the kidney
Kidney Int.
72
886-889
2007
Rattus norvegicus
Mizuno, Y.; Isotani, E.; Ohno, K.; Nagai, A.; Imamura, M.; Azuma, H.
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit
Vascul. Pharmacol.
48
21-31
2008
BRENDA: Oryctolagus cuniculus
Textmining: Rattus, Metazoa
Dayal, S.; Rodionov, R.N.; Arning, E.; Bottiglieri, T.; Kimoto, M.; Murry, D.J.; Cooke, J.P.; Faraci, F.M.; Lentz, S.R.
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia
Am. J. Physiol. Heart Circ. Physiol.
295
H816-H825
2008
BRENDA: Mus musculus
Textmining: Mus sp.
Sydow, K.; Mondon, C.E.; Schrader, J.; Konishi, H.; Cooke, J.P.
Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity
Arterioscler. Thromb. Vasc. Biol.
28
692-697
2008
BRENDA: Homo sapiens
Textmining: Mus musculus, Mus sp.
Kotthaus, J.; Schade, D.; Muschick, N.; Beitz, E.; Clement, B.
Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads
Bioorg. Med. Chem.
16
10205-10209
2008
BRENDA: Homo sapiens
Textmining: Rattus
Xiao, J.; Xiao, Z.J.; Liu, Z.G.; Gong, H.Y.; Yuan, Q.; Wang, S.; Li, Y.J.; Jiang, D.J.
Involvement of dimethylarginine dimethylaminohydrolase-2 in visfatin-enhanced angiogenic function of endothelial cells
Diabetes Metab. Res. Rev.
25
242-249
2009
Homo sapiens
Ellger, B.; Richir, M.C.; van Leeuwen, P.A.; Debaveye, Y.; Langouche, L.; Vanhorebeek, I.; Teerlink, T.; Van den Berghe, G.
Glycemic control modulates arginine and asymmetrical-dimethylarginine levels during critical illness by preserving dimethylarginine-dimethylaminohydrolase activity
Endocrinology
149
3148-3157
2008
BRENDA: Oryctolagus cuniculus
Textmining: Homo sapiens, Metazoa, animal
Wadham, C.; Mangoni, A.A.
Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease
Expert. Opin. Drug Metab. Toxicol.
5
303-319
2009
Bos taurus, Bos taurus (Q3SX44), Oryctolagus cuniculus, Rattus norvegicus (O08557), Rattus norvegicus (Q6MG60), Homo sapiens (O94760), Homo sapiens (O95865), Mus musculus (Q99LD8), Mus musculus (Q9CWS0)
Sakurada, M.; Shichiri, M.; Imamura, M.; Azuma, H.; Hirata, Y.
Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells
Hypertension
52
903-909
2008
BRENDA: Homo sapiens, Mus musculus, Rattus norvegicus
Textmining: Rattus
Wang, S.; Hu, C.P.; Jiang, D.J.; Peng, J.; Zhou, Z.; Yuan, Q.; Nie, S.D.; Jiang, J.L.; Li, Y.J.; Huang, K.L.
All-trans retinoic acid inhibits cobalt chloride-induced apoptosis in PC12 cells: role of the dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine pathway
J. Neurosci. Res.
87
1938-1946
2009
Homo sapiens
Ueda, S.; Yamagishi, S.I.; Matsumoto, Y.; Kaida, Y.; Fujimi-Hayashida, A.; Koike, K.; Tanaka, H.; Fukami, K.; Okuda, S.
Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD)
Life Sci.
84
853-860
2009
BRENDA: Homo sapiens
Textmining: Rattus, Metazoa
Chen, G.F.; Wagner, L.; Sasser, J.M.; Zharikov, S.; Moningka, N.C.; Baylis, C.
Effects of angiotensin type 1 receptor blockade on arginine and ADMA synthesis and metabolic pathways in fawn-hooded hypertensive rats
Nephrol. Dial. Transplant.
25
3518-3525
2010
Rattus
Gray, G.A.; Patrizio, M.; Sherry, L.; Miller, A.A.; Malaki, M.; Wallace, A.F.; Leiper, J.M.; Vallance, P.
Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction
Acta Histochem.
112
413-423
2010
Rattus norvegicus
Lee, W.J.; Kim, S.H.; Kim, G.H.; Han, S.M.; Won, J.C.; Jung, C.H.; Park, H.S.; Choi, d.o..S.; Lee, K.U.; Park, J.Y.
Alpha-lipoic acid activates dimethylarginine dimethylaminohydrolase in cultured endothelial cells
Biochem. Biophys. Res. Commun.
398
653-658
2010
Mus musculus
Wang, Y.; Monzingo, A.F.; Hu, S.; Schaller, T.H.; Robertus, J.D.; Fast, W.
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide
Biochemistry
48
8624-8635
2009
Homo sapiens (O94760), Homo sapiens
Rodionov, R.N.; Dayoub, H.; Lynch, C.M.; Wilson, K.M.; Stevens, J.W.; Murry, D.J.; Kimoto, M.; Arning, E.; Bottiglieri, T.; Cooke, J.P.; Baumbach, G.L.; Faraci, F.M.; Lentz, S.R.
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia
Circ. Res.
106
551-558
2010
BRENDA: Homo sapiens
Textmining: Mus sp.
Breckenridge, R.A.; Kelly, P.; Nandi, M.; Vallance, P.J.; Ohun, T.J.; Leiper, J.
A role for dimethylarginine dimethylaminohydrolase 1 (DDAH1) in mammalian development
Int. J. Dev. Biol.
54
215-220
2010
BRENDA: Mus musculus
Textmining: Mus sp., Areas
Wang, Y.; Hu, S.; Fast, W.
A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase
J. Am. Chem. Soc.
131
15096-15097
2009
Homo sapiens
Pope, A.J.; Karrupiah, K.; Kearns, P.N.; Xia, Y.; Cardounel, A.J.
Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production
J. Biol. Chem.
284
35338-35347
2009
Bos taurus (P56965), Bos taurus (Q3SX44)
Li, J.; Wilson, A.; Gao, X.; Kuruba, R.; Liu, Y.; Poloyac, S.; Pitt, B.; Xie, W.; Li, S.
Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine
J. Pharmacol. Exp. Ther.
331
234-243
2009
BRENDA: Mus musculus
Textmining: Mus sp., Homo sapiens
Hu, X.; Atzler, D.; Xu, X.; Zhang, P.; Guo, H.; Lu, Z.; Fassett, J.; Schwedhelm, E.; Boeger, R.H.; Bache, R.J.; Chen, Y.
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine
Arterioscler. Thromb. Vasc. Biol.
31
1540-1546
2011
Mus musculus
Zhang, P.; Hu, X.; Xu, X.; Chen, Y.; Bache, R.J.
Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt
Arterioscler. Thromb. Vasc. Biol.
31
890-897
2011
Homo sapiens, Mus musculus
Cillero-Pastor, B.; Mateos, J.; Fernandez-Lopez, C.; Oreiro, N.; Ruiz-Romero, C.; Blanco, F.J.
Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes
Arthritis Rheum.
64
204-212
2012
Homo sapiens
Johnson, C.M.; Linsky, T.W.; Yoon, D.W.; Person, M.D.; Fast, W.
Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolase
J. Am. Chem. Soc.
133
1553-1562
2011
Pseudomonas aeruginosa
Kotthaus, J.; Schade, D.; Kotthaus, J.; Clement, B.
Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase
J. Enzyme Inhib. Med. Chem.
27
24-28
2012
Homo sapiens
Davids, M.; Richir, M.C.; Visser, M.; Ellger, B.; van den Berghe, G.; van Leeuwen, P.A.; Teerlink, T.
Role of dimethylarginine dimethylaminohydrolase activity in regulation of tissue and plasma concentrations of asymmetric dimethylarginine in an animal model of prolonged critical illness
Metab. Clin. Exp.
61
482-490
2012
BRENDA: Oryctolagus cuniculus
Textmining: animal, Homo sapiens
Ghebremariam, Y.T.; Erlanson, D.A.; Cooke, J.P.
A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide
J. Pharmacol. Exp. Ther.
348
69-76
2014
Homo sapiens (O94760), Homo sapiens
Sydow, K.; Schmitz, C.; von Leitner, E.C.; von Leitner, R.; Klinke, A.; Atzler, D.; Krebs, C.; Wieboldt, H.; Ehmke, H.; Schwedhelm, E.; Meinertz, T.; Blankenberg, S.; Boeger, R.H.; Magnus, T.; Baldus, S.; Wenzel, U.
Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension
PLoS ONE
7
e48150
2012
BRENDA: Homo sapiens (O94760)
Textmining: Mus musculus
Lambden, S.; Kelly, P.; Ahmetaj-Shala, B.; Wang, Z.; Lee, B.; Nandi, M.; Torondel, B.; Delahaye, M.; Dowsett, L.; Piper, S.; Tomlinson, J.; Caplin, B.; Colman, L.; Boruc, O.; Slaviero, A.; Zhao, L.; Oliver, E.; Khadayate, S.; Singer, M.; Arrigoni, F.; Leiper, J.
Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis
Arterioscler. Thromb. Vasc. Biol.
35
1382-1392
2015
Mus musculus (Q99LD8)
Yuan, Q.; Hu, C.P.; Gong, Z.C.; Bai, Y.P.; Liu, S.Y.; Li, Y.J.; Jiang, J.L.
Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine
Biochem. Biophys. Res. Commun.
458
869-876
2015
Homo sapiens (O95865), Homo sapiens
Dowsett, L.; Piper, S.; Slaviero, A.; Dufton, N.; Wang, Z.; Boruc, O.; Delahaye, M.; Colman, L.; Kalk, E.; Tomlinson, J.; Birdsey, G.; Randi, A.M.; Leiper, J.
Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis
Circulation
131
2217-2225
2015
BRENDA: Mus musculus (Q9CWS0), Mus musculus
Textmining: Mus sp.
Lundgren, B.; Bailey, F.; Moley, G.; Nomura, C.
DdaR (PA1196) regulates expression of dimethylarginine dimethylaminohydrolase for the metabolism of methylarginines in Pseudomonas aeruginosa PAO1
J. Bacteriol.
199
e00001-17
2017
BRENDA: Pseudomonas aeruginosa (Q9I4E3), Pseudomonas aeruginosa
Textmining: Pseudomonas aeruginosa PAO1
Chertow, J.H.; Alkaitis, M.S.; Nardone, G.; Ikeda, A.K.; Cunnington, A.J.; Okebe, J.; Ebonyi, A.O.; Njie, M.; Correa, S.; Jayasooriya, S.; Casals-Pascual, C.; Billker, O.; Conway, D.J.; Walther, M.; Ackerman, H.
Plasmodium infection is associated with impaired hepatic dimethylarginine dimethylaminohydrolase activity and disruption of nitric oxide synthase inhibitor/substrate homeostasis
PLoS Pathog.
11
e1005119
2015
BRENDA: Homo sapiens (O94760), Homo sapiens, Mus musculus (Q9CWS0), Mus musculus
Textmining: Plasmodium, Plasmodium berghei ANKA
Shiozawa, T.; Iyama, S.; Toshima, S.; Sakata, A.; Usui, S.; Minami, Y.; Sato, Y.; Hizawa, N.; Noguchi, M.
Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma
Virchows Arch.
468
179-190
2016
BRENDA: Homo sapiens (O95865), Homo sapiens
Textmining: Sus scrofa, Mus musculus
Ferrigno, A; Palladini, G; Bianchi, A; Rizzo, V; Di Pasqua, LG; Perlini, S; Richelmi, P; Vairetti, M
Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.
Biomed Res Int
2014
327537
2014
Rattus, Rattus norvegicus
Wójcicka, G; Jamroz-Wi?niewska, A; Czechowska, G; Korolczuk, A; Marciniak, S; Be?towski, J
The paraoxonase 1 (PON1), platelet-activating factor acetylohydrolase (PAF-AH) and dimethylarginine dimethylaminohydrolase (DDAH) activity in the metformin treated normal and diabetic rats.
Eur J Pharmacol
789
187-194
2016
Rattus
Trocha, M; Nowak, B; Merwid-L?d, A; Szuba, A; Dzi?giel, P; Pie?niewska, M; Gomu?kiewicz, A; Wi?niewski, J; Piasecki, T; Gziut, M; Szel?g, A; Soza?ski, T
The impact of sitagliptin, inhibitor of dipeptidyl peptidase-4 (DPP-4), on the ADMA-DDAH-NO pathway in ischemic and reperfused rat livers.
Adv Clin Exp Med
27
1483-1490
2018
Rattus
Loyaga-Rendon, RY; Sakamoto, S; Beppu, M; Aso, T; Ishizaka, M; Takahashi, R; Azuma, H
Accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, attenuated dimethylarginine dimethylaminohydrolase activity and intimal hyperplasia in premenopausal human uterine arteries.
Atherosclerosis
178
231-9
2005
Homo sapiens
Imamura, M; Waseda, Y; Marinova, GV; Ishibashi, T; Obayashi, S; Sasaki, A; Nagai, A; Azuma, H
Alterations of NOS, arginase, and DDAH protein expression in rabbit cavernous tissue after administration of cigarette smoke extract.
Am J Physiol Regul Integr Comp Physiol
293
R2081-9
2007
Oryctolagus cuniculus
HultstrĂśm, M; Helle, F; Iversen, BM
AT1 receptor activation regulates the mRNA expression of CAT-1, CAT-2, Arginase-1 and DDAH-2 in preglomerular vessels from angiotensin II hypertensive rats.
Am J Physiol Renal Physiol
2009
Metazoa, Rattus
Amrouni, D; Meiller, A; Gautier-Sauvigné, S; Piraud, M; Bouteille, B; Vincendeau, P; Buguet, A; Cespuglio, R
Cerebral Changes Occurring in Arginase and Dimethylarginine Dimethylaminohydrolase (DDAH) in a Rat Model of Sleeping Sickness.
PLoS One
6
e16891
2011
Rattus, Trypanosoma brucei, Homo sapiens, animal
López, V; Moraga, FA; Llanos, AJ; Ebensperger, G; Taborda, MI; Uribe, E
Plasmatic Concentrations of ADMA and Homocystein in Llama (Lama glama) and Regulation of Arginase Type II: An Animal Resistent to the Development of Pulmonary Hypertension Induced by Hypoxia.
Front Physiol
9
606
2018
Metazoa
López, V; Uribe, E; Moraga, FA
Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?
Hypertens Res
44
263-275
2021
Rattus
Wu, Y; Zhang, JJ; Li, TB; Liu, WQ; Li, LS; Luo, XJ; Jiang, JL; Ma, QL; Yang, ZC; Peng, J
Phosphorylation of Nonmuscle Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats Through a Mechanism Involving Downregulation of Dimethylarginine Dimethylaminohydrolase 2.
J Cardiovasc Pharmacol Ther
2016
Rattus
Kimoto, M; Miyatake, S; Sasagawa, T; Yamashita, H; Okita, M; Oka, T; Ogawa, T; Tsuji, H
Purification, cDNA cloning and expression of human NG,NG-dimethylarginine dimethylaminohydrolase.
Eur J Biochem
258
863-8
1998
Homo sapiens, Rattus, Escherichia coli
Nakagomi, S; Kiryu-Seo, S; Kimoto, M; Emson, PC; Kiyama, H
Dimethylarginine dimethylaminohydrolase (DDAH) as a nerve-injury-associated molecule: mRNA localization in the rat brain and its coincident up-regulation with neuronal NO synthase (nNOS) in axotomized motoneurons.
Eur J Neurosci
11
2160-6
1999
Rattus
Achan, V; Broadhead, M; Malaki, M; Whitley, G; Leiper, J; MacAllister, R; Vallance, P
Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase.
Arterioscler Thromb Vasc Biol
23
1455-9
2003
Homo sapiens
MagalhĂŁes, BS; Harris, R; Plevin, MJ; Driscoll, PC
Backbone 1H, 13C, and 15N resonance assignments for a 29 kD monomeric variant of Pseudomonas aeruginosa dimethylarginine dimethylaminohydrolase.
J Biomol NMR
29
463-4
2004
Pseudomonas aeruginosa
Leiper, J; Vallance, P
New tricks from an old dog: nitric oxide-independent effects of dimethylarginine dimethylaminohydrolase.
Arterioscler Thromb Vasc Biol
26
1419-20
2006
Canis lupus familiaris
Nonaka, S; Tsunoda, M; Aoyama, C; Funatsu, T
Determination of NG,NG-dimethyl-L-arginine in rat plasma and dimethylarginine dimethylaminohydrolase activity in rat kidney using a monolithic silica column.
J Chromatogr B Analyt Technol Biomed Life Sci
843
170-4
2006
Rattus
Maas, R; Tan-Andreesen, J; Schwedhelm, E; Schulze, F; BĂśger, RH
A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue.
J Chromatogr B Analyt Technol Biomed Life Sci
851
220-8
2007
Mus musculus, Mus sp.
Matsumoto, Y; Ueda, S; Yamagishi, S; Matsuguma, K; Shibata, R; Fukami, K; Matsuoka, H; Imaizumi, T; Okuda, S
Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.
J Am Soc Nephrol
18
1525-33
2007
Rattus
Hasegawa, K; Wakino, S; Tatematsu, S; Yoshioka, K; Homma, K; Sugano, N; Kimoto, M; Hayashi, K; Itoh, H
Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2.
Circ Res
101
e2-10
2007
Mus musculus, Mus sp.
Onozato, ML; Tojo, A; Leiper, J; Fujita, T; Palm, F; Wilcox, CS
Expression of NG,NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers.
Diabetes
57
172-80
2008
Rattus
Park, K; Lee, DG; Kim, SW; Paick, JS
Dimethylarginine dimethylaminohydrolase in rat penile tissue: reduced enzyme activity is responsible for erectile dysfunction in a rat model of atherosclerosis.
Int J Impot Res
21
228-34
0
Rattus
Schwedhelm, E; von Leitner, EC; Atzler, D; Schmitz, C; Jacobi, J; Meinertz, T; MĂźnzel, T; Baldus, S; Cooke, JP; BĂśger, RH; Maas, R; Sydow, K
Extensive characterization of the human DDAH1 transgenic mice.
Pharmacol Res
2009
Homo sapiens, Metazoa, Mus musculus, Mus sp.
Lu, CW; Guo, Z; Feng, M; Wu, ZZ; He, ZM; Xiong, Y
Ex vivo gene transferring of human dimethylarginine dimethylaminohydrolase-2 improved endothelial dysfunction in diabetic rat aortas and high glucose-treated endothelial cells.
Atherosclerosis
2009
Homo sapiens, Rattus, Cytomegalovirus
Caplin, B; Nitsch, D; Gill, H; Hoefield, R; Blackwell, S; MacKenzie, D; Cooper, JA; Middleton, RJ; Talmud, PJ; Veitch, P; Norman, J; Wheeler, DC; Leiper, JM
Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms.
Kidney Int
77
459-67
2010
Homo sapiens
Jacobi, J; Maas, R; Cardounel, AJ; Arend, M; Pope, AJ; Cordasic, N; Heusinger-Ribeiro, J; Atzler, D; Strobel, J; Schwedhelm, E; BĂśger, RH; Hilgers, KF
Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine.
Am J Pathol
176
2559-70
2010
Mus sp., Homo sapiens, Mus musculus, Rodentia
Feng, M; He, ZM; Zhu, YX; Liu, LH; Lu, CW; Xiong, Y
Improvement of endothelial dysfunction in atherosclerotic rabbit aortas by ex vivo gene transferring of dimethylarginine dimethylaminohydrolase-2.
Int J Cardiol
144
180-6
2010
Oryctolagus cuniculus, Homo sapiens, Cytomegalovirus
Lluis, M; Wang, Y; Monzingo, AF; Fast, W; Robertus, JD
Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1.
ChemMedChem
2010
Homo sapiens
Feng, J; Luo, H; Qiu, Y; Zhou, W; Yu, F; Wu, F
Down-regulation of DDAH2 and eNOS induces endothelial dysfunction in sinoaortic-denervated rats.
Eur J Pharmacol
661
86-91
2011
Rattus
Gad, MZ; Hassanein, SI; Abdel-Maksoud, SM; Shaban, GM; Abou-Aisha, K
Association of DDAH2 gene polymorphism with cardiovascular disease in Egyptian patients.
J Genet
90
161-3
2011
Homo sapiens
Linsky, T; Fast, W
A continuous, fluorescent, high-throughput assay for human dimethylarginine dimethylaminohydrolase-1.
J Biomol Screen
16
1089-97
2011
Homo sapiens
Lee, W; Chai, S; Lee, K; Park, H; Kim, J; Kim, B; Kim, N; Jeon, H; Kim, I; Choi, H; Song, H
Identification of the DDAH2 Protein in Pig Reproductive Tract Mucus: A Putative Oestrus Detection Marker.
Reprod Domest Anim
2012
Sus scrofa, Oestrus
Novella, S; Laguna-Fernández, A; Lázaro-Franco, M; Sobrino, A; Bueno-Betí, C; Tarín, JJ; Monsalve, E; Sanchís, J; Hermenegildo, C
Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells.
Mol Cell Endocrinol
2012
Homo sapiens
Bai, F; Makino, T; Kono, K; Nagatsu, A; Ono, T; Mizukami, H
Calycosin and formononetin from astragalus root enhance dimethylarginine dimethylaminohydrolase 2 and nitric oxide synthase expressions in Madin Darby Canine Kidney II cells.
J Nat Med
2013
Astragalus, Canis lupus familiaris, Rattus
Hasegawa, K; Wakino, S; Kimoto, M; Minakuchi, H; Fujimura, K; Hosoya, K; Komatsu, M; Kaneko, Y; Kanda, T; Tokuyama, H; Hayashi, K; Itoh, H
The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.
FASEB J
2013
Mus sp.
Sun, T; Zhou, JP; Kuang, DB; Li, MP; Xiong, Y; Tang, J; Xia, J; Bai, YP; Yang, GP; Li, YJ; Chen, XP
Correlations of DDAH1 Transcript Variants with Human Endothelial Asymmetric Dimethylarginine Metabolizing Activity.
Am J Hypertens
2013
Homo sapiens
Swärd, K; Sadegh, MK; Mori, M; Erjefält, JS; Rippe, C
Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.
Physiol Rep
1
e00008
2013
Mus sp.
Kinker, KG; Gibson, AM; Bass, SA; Day, BP; Deng, J; Medvedovic, M; Figueroa, JA; Hershey, GK; Chen, W
Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma.
PLoS One
9
e85148
2014
Mus musculus, Mus sp., Homo sapiens
Wang, Y; Hu, S; Gabisi, AM; Er, JA; Pope, A; Burstein, G; Schardon, CL; Cardounel, AJ; Ekmekcioglu, S; Fast, W
Developing an Irreversible Inhibitor of Human DDAH-1, an Enzyme Upregulated in Melanoma.
ChemMedChem
9
792-7
2014
Homo sapiens
Niu, PP; Cao, Y; Gong, T; Guo, JH; Zhang, BK; Jia, SJ
Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients.
J Transl Med
12
170
2014
Homo sapiens
Dimitroulas, T; Sandoo, A; Hodson, J; Smith, J; Panoulas, VF; Kitas, GD
Relationship between dimethylarginine dimethylaminohydrolase gene variants and asymmetric dimethylarginine in patients with rheumatoid arthritis.
Atherosclerosis
237
38-44
2014
Homo sapiens
Pérez-Hernández, N; Vargas-Alarcón, G; Arellano-Zapoteco, R; Martínez-Rodríguez, N; Fragoso, JM; Aptilon-Duque, G; Posadas-Sánchez, R; Posadas-Romero, C; Juárez-Cedillo, T; Domínguez-López, ML; Rodríguez-Pérez, JM
Protective role of DDAH2 (rs805304) gene polymorphism in patients with myocardial infarction.
Exp Mol Pathol
97
393-8
2014
Homo sapiens
Lumicisi, BA; Cartwright, JE; Leslie, K; Wallace, AE; Whitley, GS
Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL.
Hum Reprod
30
1813-9
2015
Homo sapiens
Menghini, R; Casagrande, V; Cardellini, M; Ballanti, M; Davato, F; Cardolini, I; Stoehr, R; Fabrizi, M; Morelli, M; Anemona, L; Bernges, I; Schwedhelm, E; Ippoliti, A; Mauriello, A; Böger, RH; Federici, M
FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis.
Atherosclerosis
242
230-5
2015
Homo sapiens
Tommasi, S; Zanato, C; Lewis, BC; Nair, PC; Dall'Angelo, S; Zanda, M; Mangoni, AA
Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1.
Org Biomol Chem
13
11315-30
2015
Homo sapiens
Minakuchi, H; Wakino, S; Hosoya, K; Sueyasu, K; Hasegawa, K; Shinozuka, K; Yoshifuji, A; Futatsugi, K; Komatsu, M; Kanda, T; Tokuyama, H; Hayashi, K; Itoh, H
The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.
Nephrol Dial Transplant
31
413-23
2016
Rattus, Mus sp.
Zhao, C; Li, T; Han, B; Yue, W; Shi, L; Wang, H; Guo, Y; Lu, Z
DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts.
Free Radic Biol Med
92
50-60
2016
Mus musculus
Lambden, S; Martin, D; Vanezis, K; Lee, B; Tomlinson, J; Piper, S; Boruc, O; Mythen, M; Leiper, J
Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia.
Nitric Oxide
58
59-66
2016
animal, Homo sapiens, Mus musculus
Li, T; Feng, R; Zhao, C; Wang, Y; Wang, J; Liu, S; Cao, J; Wang, H; Wang, T; Guo, Y; Lu, Z
Dimethylarginine dimethylaminohydrolase 1 protects against high fat diet induced hepatic steatosis and insulin resistance in mice.
Antioxid Redox Signal
2016
Mus sp.
Shoeibi, S; Mohammadi, S; Sadeghnia, HR; Mahdipour, E; Ghayour-Mobarhan, M
Determine exogenous human DDAH2 gene function in rabbit bone marrow-derived endothelial progenitor cells in vitro.
Cell Biochem Funct
35
69-76
2017
Homo sapiens, Oryctolagus cuniculus
Tommasi, S; Elliot, DJ; Hulin, JA; Lewis, BC; McEvoy, M; Mangoni, AA
Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance.
Sci Rep
7
2871
2017
Homo sapiens
Wang, T; Zhang, Y; Niu, K; Wang, L; Shi, Y; Liu, B
Association of the -449GC and -1151AC polymorphisms in the DDAH2 gene with asymmetric dimethylarginine and erythropoietin resistance in Chinese patients on maintenance hemodialysis.
Clin Exp Pharmacol Physiol
44
961-964
2017
Homo sapiens
Shi, L; Zhao, C; Wang, H; Lei, T; Liu, S; Cao, J; Lu, Z
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
Antioxid Redox Signal
2017
Mus sp.
Buijs, N; Oosterink, JE; Jessup, M; Schierbeek, H; Stolz, DB; Houdijk, AP; Geller, DA; van Leeuwen, PA
A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1.
Angiogenesis
2017
Homo sapiens
Xiao, HB; Sui, GG; Lu, XY; Sun, ZL
Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
Inflammation
41
299-306
2018
Rattus
Balasubramanian, V; Mehta, G; Jones, H; Sharma, V; Davies, NA; Jalan, R; Mookerjee, RP
Post-Transcriptional Regulation of Hepatic DDAH1 with TNF Blockade Leads to Improved eNOS Function and Reduced Portal Pressure In Cirrhotic Rats.
Sci Rep
7
17900
2017
Rattus
Bell, T; Araujo, M; Luo, Z; Tomlinson, J; Leiper, J; Welch, WJ; Wilcox, CS
Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine (ADMA) & dimethylarginine dimethylaminohydrolase (DDAH) 1.
Am J Physiol Renal Physiol
2018
Mus musculus, Rattus, Mus sp.
Zhu, ZD; Ye, JM; Fu, XM; Wang, XC; Ye, JY; Wu, XR; Hua, P; Liao, YQ; Xuan, W; Duan, JL; Li, WY; Fu, H; Xia, ZH; Zhang, X
DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats.
Int J Mol Med
43
749-760
2019
Rattus, Lentivirus
Trittmann, JK; Almazroue, H; Jin, Y; Nelin, LD
DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells.
Physiol Rep
7
e14150
2019
Homo sapiens
Brites-Anselmi, G; Azevedo, AMM; Miyazaki, AHL; Pinheiro, LC; Coeli-Lacchini, FB; de Andrade, MF; Molina, CAF; Tucci, S; Hirsch, E; Tanus-Santos, JE; Lacchini, R
DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls.
Nitric Oxide
92
11-17
2019
Homo sapiens
Wang, D; Li, H; Weir, EK; Xu, Y; Xu, D; Chen, Y
Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats.
Int J Cardiol
295
14-20
2019
Rattus
Mannino, GC; Pezzilli, S; Averta, C; Fuoco, A; Spiga, R; Mancuso, E; Di Fatta, C; Perticone, F; Prudente, S; Trischitta, V; Andreozzi, F; Sesti, G
A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients.
Cardiovasc Diabetol
18
102
2019
Homo sapiens
Matsuura, W; Nakamoto, K; Tokuyama, S
The Involvement of DDAH1 in the Activation of Spinal NOS Signaling in Early Stage of Mechanical Allodynia Induced by Exposure to Ischemic Stress in Mice.
Biol Pharm Bull
42
1569-1574
2019
Mus sp.
Wu, CC; Hsieh, MY; Lee, CK; Chuang, SY; Chung, MY; Lin, CC
Dimethylarginine Dimethylaminohydrolase 1 Polymorphisms and Venous Intimal Hyperplasia in Hemodialysis Patients.
Am J Nephrol
50
454-464
2019
Homo sapiens
Zhu, F; Zhou, C; Wen, Z; Wang, DW
DDAH1 promoter -396 4N insertion variant is associated with increased risk of type 2 diabetes in a gender-dependent manner.
Mol Genet Genomic Med
8
e1011
2020
insertion sequences
Zöllner, J; Lambden, S; Nasri, NM; Johnson, M; Leiper, J
Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Improves the Outcome of Sepsis in Pregnant Mice.
Shock
2019
Mus sp.
Lunk, I; Litty, FA; Hennig, S; Vetter, IR; Kotthaus, J; Altmann, KS; Ott, G; Havemeyer, A; Carrillo García, C; Clement, B; Schade, D
Discovery of N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1).
J Med Chem
63
425-432
2020
Homo sapiens
Hannemann, J; Glatzel, A; Hillig, J; Zummack, J; Schumacher, U; Lüneburg, N; Harbaum, L; Böger, R
Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice.
Front Physiol
11
597559
2020
Mus sp.
Chen, D; Xu, L; Wu, J; Liang, H; Liang, Y; Liu, G
Downregulating miR-96-5p promotes proliferation, migration, and invasion, and inhibits apoptosis in human trophoblast cells via targeting DDAH1.
Reprod Biol
21
100474
2021
Homo sapiens
Shoeibi, S; Mahdipour, E; Mohammadi, S; Moohebati, M; Ghayour-Mobarhan, M
Treatment of atherosclerosis through transplantation of endothelial progenitor cells overexpressing dimethylarginine dimethylaminohydrolase (DDAH) in rabbits.
Int J Cardiol
2021
Oryctolagus cuniculus
Kang, ES; Cates, TB; Harper, DN; Chiang, TM; Myers, LK; Acchiardo, SR; Kimoto, M
An enzyme hydrolyzing methylated inhibitors of nitric oxide synthase is present in circulating human red blood cells.
Free Radic Res
35
693-707
2001
Homo sapiens
Weis, M; Kledal, TN; Lin, KY; Panchal, SN; Gao, SZ; Valantine, HA; Mocarski, ES; Cooke, JP
Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.
Circulation
109
500-5
2004
Cytomegalovirus, Homo sapiens, Cucumber mosaic virus
Okuno, T; Masuda, H; Tsujii, T; Kihara, K; Yamauchi, Y; Azuma, H
Accumulated endogenous nitric oxide synthase inhibitors in inhibiting urethral relaxation following estrogen supplementation in ovariectomized rabbits.
J Urol
172
360-4
2004
Oryctolagus cuniculus
Luo, Z; Aslam, S; Welch, WJ; Wilcox, CS
Activation of Nuclear Factor Erythroid 2-Related Factor 2 Coordinates Dimethylarginine Dimethylaminohydrolase/PPAR-?/Endothelial Nitric Oxide Synthase Pathways That Enhance Nitric Oxide Generation in Human Glomerular Endothelial Cells.
Hypertension
65
896-902
2015
Homo sapiens
Sorrenti, V; Raffaele, M; Vanella, L; Acquaviva, R; Salerno, L; Pittalŕ, V; Intagliata, S; Di Giacomo, C
Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats.
Int J Mol Sci
20
2019
Rattus, Apis mellifera, Propolis
Tojo, A; Welch, WJ; Bremer, V; Kimoto, M; Kimura, K; Omata, M; Ogawa, T; Vallance, P; Wilcox, CS
Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney.
Kidney Int
52
1593-601
1997
Rattus, Electron
Laussmann, T; Janosi, RA; Fingas, CD; Schlieper, GR; Schlack, W; Schrader, J; Decking, UK
Myocardial proteome analysis reveals reduced NOS inhibition and enhanced glycolytic capacity in areas of low local blood flow.
FASEB J
16
628-30
2002
Areas, Canis lupus familiaris, Electron
Yokoro, M; Suzuki, M; Murota, K; Otsuka, C; Yamashita, H; Takahashi, Y; Tsuji, H; Kimoto, M
Asymmetric Dimethylarginine, an Endogenous NOS Inhibitor, Is Actively Metabolized in Rat Erythrocytes.
Biosci Biotechnol Biochem
76
1334-42
2012
Rattus
Gross, CM; Rafikov, R; Kumar, S; Aggarwal, S; Ham, PB; Meadows, ML; Cherian-Shaw, M; Kangath, A; Sridhar, S; Lucas, R; Black, SM
Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury.
PLoS One
10
e0119918
2015
Mus sp., Bacteria
Scalera, F; Fulge, B; Martens-Lobenhoffer, J; Heimburg, A; Bode-BĂśger, SM
Red wine decreases asymmetric dimethylarginine via SIRT1 induction in human endothelial cells.
Biochem Biophys Res Commun
2009
Homo sapiens, Areas
Tanaka, M; Osanai, T; Murakami, R; Sasaki, S; Tomita, H; Maeda, N; Satoh, K; Magota, K; Okumura, K
Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine.
J Hypertens
24
489-97
2006
Homo sapiens
Wei, T; Zhao, L; Jia, J; Xia, H; Du, Y; Lin, Q; Lin, X; Ye, X; Yan, Z; Gao, H
Metabonomic analysis of potential biomarkers and drug targets involved in diabetic nephropathy mice.
Sci Rep
5
11998
2015
Mus sp.
Kanzelmeyer, N; Tsikas, D; Chobanyan-Jürgens, K; Beckmann, B; Vaske, B; Illsinger, S; Das, AM; Lücke, T
Asymmetric dimethylarginine in children with homocystinuria or phenylketonuria.
Amino Acids
2011
Homo sapiens
Xu, X; Yang, XY; He, BW; Yang, WJ; Cheng, WW
Placental NRP1 and VEGF expression in pre-eclamptic women and in a homocysteine-treated mouse model of pre-eclampsia.
Eur J Obstet Gynecol Reprod Biol
196
69-75
2016
Mus sp.
Zeng, X; Liao, AJ; Tang, HL; Yi, L; Xie, N; Su, Q
[Screening Human Gastric Carcinoma-associated Antigens by Serologic Proteome Analysis.]
Ai Zheng
26
1080-4
2007
Homo sapiens
Prins, JM; Fu, L; Guo, L; Wang, Y
Cd(2+)-induced alteration of the global proteome of human skin fibroblast cells.
J Proteome Res
13
1677-87
2014
Homo sapiens
Tain, YL; Huang, LT; Lin, IC; Lau, YT; Lin, CY
Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats.
J Pineal Res
49
390-8
2010
Rattus
Shi, X; Luo, X; Xu, X
Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice.
Biosci Trends
14
115-122
2020
Mus sp.
Magné, J; Huneau, JF; Borderie, D; Mathé, V; Bos, C; Mariotti, F
Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia.
Amino Acids
47
1975-82
2015
Rattus
Gad, MZ; Abu el Maaty, MA; El-Maraghy, SA; Fahim, AT; Hamdy, MA
Investigating the cardio-protective abilities of supplemental L-arginine on parameters of endothelial function in a hypercholesterolemic animal model.
J Nutr Sci Vitaminol (Tokyo)
60
145-51
2014
animal, Oryctolagus cuniculus
Sobrino, A; Mata, M; Laguna-Fernandez, A; Novella, S; Oviedo, PJ; GarcĂa-PĂŠrez, MA; TarĂn, JJ; Cano, A; Hermenegildo, C
Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells.
PLoS One
4
e8242
2009
Homo sapiens
Bekpinar, S; Unlucerci, Y; Uysal, M; Gurdol, F
Propargylglycine aggravates liver damage in LPS-treated rats: Possible relation of nitrosative stress with the inhibition of H2S formation.
Pharmacol Rep
66
897-901
2014
Rattus, Rattus norvegicus, Metazoa
Hosoya, K; Minakuchi, H; Wakino, S; Fujimura, K; Hasegawa, K; Komatsu, M; Yoshifuji, A; Futatsugi, K; Shinozuka, K; Washida, N; Kanda, T; Tokuyama, H; Hayashi, K; Itoh, H
Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans.
Kidney Int
2014
Rattus, Homo sapiens
Palmfeldt, J; Vang, S; Stenbroen, V; Pavlou, E; Baycheva, M; Buchal, G; Monavari, AA; Augoustides-Savvopoulou, P; Mandel, H; Gregersen, N
Proteomics Reveals that Redox Regulation Is Disrupted in Patients with Ethylmalonic Encephalopathy.
J Proteome Res
2011
Homo sapiens
Nijveldt, RJ; Teerlink, T; Siroen, MP; van der Hoven, B; Prins, HA; Wiezer, MJ; Meijer, C; van der Sijp, JR; Cuesta, MA; Meijer, S; van Leeuwen, PA
Elevation of asymmetric dimethylarginine (ADMA) in patients developing hepatic failure after major hepatectomy.
JPEN J Parenter Enteral Nutr
28
382-7
0
Homo sapiens, Rattus
Deng, S; Deng, PY; Jiang, JL; Ye, F; Yu, J; Yang, TL; Deng, HD; Li, YJ
Aspirin protected against endothelial damage induced by LDL: role of endogenous NO synthase inhibitors in rats.
Acta Pharmacol Sin
25
1633-9
2004
Rattus
Yin, QF; Xiong, Y
Pravastatin restores DDAH activity and endothelium-dependent relaxation of rat aorta after exposure to glycated protein.
J Cardiovasc Pharmacol
45
525-32
2005
Rattus, Bos taurus, Rattus norvegicus
Monsalve, E; Oviedo, PJ; GarcĂa-PĂŠrez, MA; TarĂn, JJ; Cano, A; Hermenegildo, C
Estradiol counteracts oxidized LDL-induced asymmetric dimethylarginine production by cultured human endothelial cells.
Cardiovasc Res
73
66-72
2007
Homo sapiens
Eid, HM; Lyberg, T; Arnesen, H; Seljeflot, I
Insulin and adiponectin inhibit the TNFalpha-induced ADMA accumulation in human endothelial cells: the role of DDAH.
Atherosclerosis
194
e1-8
2007
Homo sapiens
Li, JX; Chen, J; Deng, ZH
[Effect of puerarin on ADMA-DDAH system in human umbilical vein endothelial cells cultured with oxidized free radical]
Zhongguo Zhong Xi Yi Jie He Za Zhi
26
1103-6
2006
Homo sapiens
Maas, R; Schulze, F; Baumert, J; LĂśwel, H; Hamraz, K; Schwedhelm, E; Koenig, W; BĂśger, RH
Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: prospective analysis from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Region Augsburg study and experimental data.
Clin Chem
53
693-701
2007
Homo sapiens, Nicotiana tabacum
Chobanyan, K; Thum, T; Suchy, MT; Zhu, B; Mitschke, A; Gutzki, FM; Beckmann, B; Stichtenoth, DO; Tsikas, D
GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): Evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in humans.
J Chromatogr B Analyt Technol Biomed Life Sci
858
32-41
2007
Homo sapiens, Rattus
Jacobi, J; Maas, R; Cordasic, N; Koch, K; Schmieder, RE; BĂśger, RH; Hilgers, KF
Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice.
Am J Physiol Heart Circ Physiol
294
H1058-66
2008
Homo sapiens, Mus musculus, Mus sp.
Desai, A; Zhao, Y; Warren, JS
Human recombinant erythropoietin augments serum asymmetric dimethylarginine concentrations but does not compromise nitric oxide generation in mice.
Nephrol Dial Transplant
23
1513-20
2008
Homo sapiens, Mus sp.
Thaha, M; Widodo, ; Pranawa, W; Yogiantoro, M; Tomino, Y
Intravenous N-acetylcysteine during hemodialysis reduces asymmetric dimethylarginine level in end-stage renal disease patients.
Clin Nephrol
69
24-32
2008
Homo sapiens
Chen, D; Lin, Y; Zhang, H
Characterization and expression of two amphioxus DDAH genes originating from an amphioxus-specific gene duplication.
Gene
410
75-81
2008
Branchiostoma lanceolatum, animal
Appolonova, SA; Dikunets, MA; Rodchenkov, GM
Possible indirect detection of rHuEPO administration in human urine by high-performance liquid chromatography tandem mass spectrometry.
Eur J Mass Spectrom (Chichester, Eng)
14
201-9
2008
Homo sapiens
Pasini, AF; Garbin, U; Stranieri, C; Boccioletti, V; Mozzini, C; Manfro, S; Pasini, A; Cominacini, M; Cominacini, L
Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients.
Am J Hypertens
21
1251-7
2008
Homo sapiens
Liu, H; Qu, X; Liang, Z; Chen, W; Xia, W; Song, Y
Variance of DDAH/PRMT/ADMA pathway in atrial fibrillation dogs.
Biochem Biophys Res Commun
377
884-8
2008
Canis lupus familiaris, Thrombus
Ito, E; Obayashi, S; Nagai, A; Imamura, M; Azuma, H
Regulation of myometrial contractivity during pregnancy in the rat: potential role for DDAH.
Mol Hum Reprod
15
507-12
2009
Rattus
Ahmad, T; Mabalirajan, U; Ghosh, B; Agrawal, A
Altered Assymetric Dimethyl Arginine Metabolism in Allergically Inflamed Mice Lungs.
Am J Respir Cell Mol Biol
2009
Mus sp., Mus musculus
Maas, R; BĂśger, R; LĂźneburg, N
ADMA and the role of the genes: Lessons from genetically modified animals and human gene polymorphisms.
Pharmacol Res
2009
Mus sp.
Leypoldt, F; Choe, CU; Gelderblom, M; von Leitner, EC; Atzler, D; Schwedhelm, E; Gerloff, C; Sydow, K; BĂśger, RH; Magnus, T
Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke.
PLoS One
4
e7337
2009
Mus musculus, Homo sapiens, Mus sp., Metazoa
Hu, X; Xu, X; Zhu, G; Atzler, D; Kimoto, M; Chen, J; Schwedhelm, E; LĂźneburg, N; BĂśger, RH; Zhang, P; Chen, Y
Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine.
Circulation
120
2222-9
2009
Mus sp., Mus musculus
Tain, YL; Hsieh, CS; Chen, CC; Sheen, JM; Lee, CT; Huang, LT
Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation.
J Pineal Res
48
212-21
2010
Rattus
MorĂĄn, JM; Ortiz-Ortiz, MA; Ruiz-Mesa, LM; Niso-Santano, M; Bravosanpedro, JM; SĂĄnchez, RG; GonzĂĄlez-Polo, RA; Fuentes, JM
Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells.
Nitric Oxide
2010
Rattus
Klein, E; Weigel, J; Buford, MC; Holian, A; Wells, SM
Asymmetric Dimethylarginine Potentiates Lung Inflammation in a Mouse Model of Allergic Asthma.
Am J Physiol Lung Cell Mol Physiol
2010
Mus musculus, Mus sp., Metazoa
Razny, U; Kiec-Wilk, B; Polus, A; Wator, L; Dyduch, G; Partyka, L; Bodzioch, M; Tomaszewska, R; Wybranska, I
The adipose tissue gene expression in mice with different nitric oxide availability.
J Physiol Pharmacol
61
607-18
2010
Mus sp., Homo sapiens, Metazoa
Vanella, L; Di Giacomo, C; Acquaviva, R; Santangelo, R; Cardile, V; Barbagallo, I; Abraham, NG; Sorrenti, V
The DDAH/NOS pathway in human prostatic cancer cell lines: Antiangiogenic effect of L-NAME.
Int J Oncol
2011
Homo sapiens
Speranza, L; Franceschelli, S; D'Orazio, N; Gaeta, R; Bucciarelli, T; Felaco, M; Grilli, A; Riccioni, G
The biological effect of pharmacological treatment on dimethylaminohydrolases (DDAH-1) and cationic amino acid transporter-1 (CAT-1) expression in patients with acute congestive heart failure.
Microvasc Res
2011
Homo sapiens
Balasubramaniyan, V; Wright, G; Sharma, V; Davies, NA; Sharifi, Y; Habtesion, A; Mookerjee, RP; Jalan, R
Ammonia reduction with ornithine phenylacetate restores brain eNOS activity via the DDAH-ADMA pathway in bile duct-ligated cirrhotic rats.
Am J Physiol Gastrointest Liver Physiol
302
G145-52
2012
Metazoa, Rattus
Lin, Y; Chen, D; Zhang, W; Cai, Z; Chen, Z; Zhang, N; Mao, B; Zhang, H
Characterization of the immune defense related tissues, cells, and genes in amphioxus.
Sci China Life Sci
54
999-1004
2011
Branchiostoma lanceolatum
Hsu, CN; Huang, LT; Lau, YT; Lin, CY; Tain, YL
The combined ratios of L-arginine and asymmetric and symmetric dimethylarginine as biomarkers in spontaneously hypertensive rats.
Transl Res
159
90-8
2012
Rattus
Bai, F; Makino, T; Ono, T; Mizukami, H
Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway.
J Nat Med
2012
Rattus, Rattus norvegicus, Homo sapiens, Astragalus, Angelica, Uncaria, Cnidium, Phellodendron, Rehmannia
Javadiyan, S; Burdon, KP; Whiting, MJ; Abhary, S; Straga, T; Hewitt, AW; Mills, RA; Craig, JE
Elevation of serum asymmetrical and symmetrical dimethylarginine in patients with advanced glaucoma.
Invest Ophthalmol Vis Sci
2012
Homo sapiens
Sukhovershin, RA; Gilinski?, MA
[The role of asymmetric dimethylarginine in the regulation of nitric oxide level in rats with acute renal injury].
Ross Fiziol Zh Im I M Sechenova
98
497-505
2012
Rattus, Indicator
Chen, P; Xia, K; Zhao, Z; Deng, X; Yang, T
Atorvastatin modulates the DDAH1/ADMA system in high-fat diet-induced insulin-resistant rats with endothelial dysfunction.
Vasc Med
17
416-23
2012
Rattus
Huang, CF; Hsu, CN; Chien, SJ; Lin, YJ; Huang, LT; Tain, YL
Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: the role of nitric oxide.
Eur J Pharmacol
699
233-40
2013
Rattus
He, H; Li, X; Wang, H; Zhang, W; Jiang, H; Wang, S; Yuan, L; Liu, Y; Liu, X
Effects of salvianolic acid A on plasma and tissues dimethylarginine levels in a rat model of myocardial infarction.
J Cardiovasc Pharmacol
2013
Rattus
Hirotsu, C; Matos, G; Tufik, S; Andersen, ML
Changes in gene expression in the frontal cortex of rats with pilocarpine-induced status epilepticus after sleep deprivation.
Epilepsy Behav
27
378-384
2013
Rattus, Felis catus, Rodentia
Merwid-L?d, A; Trocha, M; Chlebda-Sieragowska, E; Soza?ski, T; Magdalan, J; Ksi?dzyna, D; Szuba, A; Kopacz, M; Ku?niar, A; Nowak, D; Pie?niewska, M; Fereniec-Go??biewska, L; Szel?g, A
Effect of cyclophosphamide and morin-5'-sulfonic acid sodium salt, alone or in combination, on ADMA/DDAH pathway in rats.
Pharmacol Rep
65
201-7
2013
Rattus
Cao, Y; Mu, JJ; Fang, Y; Yuan, ZY; Liu, FQ
Impact of High Salt Independent of Blood Pressure on PRMT/ADMA/DDAH Pathway in the Aorta of Dahl Salt-Sensitive Rats.
Int J Mol Sci
14
8062-72
2013
Rattus
Ghebremariam, YT; Yamada, K; Lee, JC; Johnson, CL; Atzler, D; Anderssohn, M; Agrawal, R; Higgins, JP; Patterson, AJ; Böger, RH; Cooke, JP
FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats.
PLoS One
8
e60653
2013
Mus sp., Rattus
Chen, XM; Xia, J; Zhou, T; Yuan, Q; Zhang, WF; Hu, CP; Li, YJ; Jiang, JL
Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats.
Int Immunopharmacol
16
322-31
2013
Rattus, Homo sapiens, animal
Kim, HY; Kim, JH; Kim, HS
Effect of CCL5 on dimethylarginine dimethylaminohydrolase-1 production in vascular smooth muscle cells from spontaneously hypertensive rats.
Cytokine
64
227-33
2013
Rattus
Pacurari, M; Xing, D; Hilgers, RH; Guo, Y; Yang, Z; Hage, FG
Endothelial Cell Transfusion Ameliorates Endothelial Dysfunction in 5/6 Nephrectomized Rats.
Am J Physiol Heart Circ Physiol
2013
Rattus
Kimoto, M; Tsuji, H; Ogawa, T
N (G) ,N (G) -Dimethyl-L-arginine, a dominant precursor of endogenous dimethylamine in rats.
Amino Acids
6
273-82
1994
Rattus
May, M; Batkai, S; Zörner, AA; Tsikas, D; Jordan, J; Engeli, S
Clinical evaluation of extracellular ADMA concentrations in human blood and adipose tissue.
Int J Mol Sci
15
1189-200
2014
Homo sapiens
Fan, NC; Tsai, CM; Hsu, CN; Huang, LT; Tain, YL
N-acetylcysteine prevents hypertension via regulation of the ADMA-DDAH pathway in young spontaneously hypertensive rats.
Biomed Res Int
2013
696317
2013
Rattus, Metazoa
Sheen, JM; Chen, YC; Tain, YL; Huang, LT
Increased circulatory asymmetric dimethylarginine and multiple organ failure: bile duct ligation in rat as a model.
Int J Mol Sci
15
3989-4006
2014
Rattus
Kim, HY; Cha, HJ; Kim, HS
CCL5 upregulates activation of AMP-activated protein kinases in vascular smooth muscle cells of spontaneously hypertensive rats.
Cytokine
67
77-84
2014
Rattus
Jacobi, J; Maas, R; Arend, M; Cordasic, N; Hilgers, KF
Effect of Lowering Asymmetric Dimethylarginine (ADMA) on Vascular Pathology in Atherosclerotic ApoE-Deficient Mice with Reduced Renal Mass.
Int J Mol Sci
15
5522-35
2014
Mus sp., Mus musculus, Metazoa
Tsai, CM; Kuo, HC; Hsu, CN; Huang, LT; Tain, YL
Metformin reduces asymmetric dimethylarginine and prevents hypertension in spontaneously hypertensive rats.
Transl Res
164
452-9
2014
Rattus, Homo sapiens
Ferrigno, A; Rizzo, V; Bianchi, A; Di Pasqua, LG; Berardo, C; Richelmi, P; Vairetti, M
Changes in ADMA/DDAH pathway after hepatic ischemia/reperfusion injury in rats: the role of bile.
Biomed Res Int
2014
627434
2014
Rattus, Rattus norvegicus
Zhang, W; Zhang, J; Liu, YK; Liu, J; Wang, X; Xu, Q; Wang, Y; Xu, X; Dai, G
Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats.
Eur J Pharmacol
745
29-35
2014
Rattus
Milewski, K; Hilgier, W; Albrecht, J; Zieli?ska, M
The dimethylarginine (ADMA)/nitric oxide pathway in the brain and periphery of rats with thioacetamide-induced acute liver failure: Modulation by histidine.
Neurochem Int
2014
Rattus
Kim, HY; Cha, HJ; Kim, HS
CCL5 upregulates IL-10 expression and partially mediates the antihypertensive effects of IL-10 in the vascular smooth muscle cells of spontaneously hypertensive rats.
Hypertens Res
2015
Rattus
Wang, JH; Chen, D; Zhang, KQ; Zhang, H; Fu, Q
Effect of DDAH/ADMA/NOS regulation pathway on cavernae corporum cavernosorum rat penis of different age.
Andrologia
48
262-7
2016
Rattus, Homo sapiens, Electron
Greco, R; Ferrigno, A; Demartini, C; Zanaboni, A; Mangione, AS; Blandini, F; Nappi, G; Vairetti, M; Tassorelli, C
Evaluation of ADMA-DDAH-NOS axis in specific brain areas following nitroglycerin administration: study in an animal model of migraine.
J Headache Pain
16
560
2015
Areas, animal, Rattus
Kim, HY; Kim, HS
Dimethylarginine dimethylaminohydrolase-1 mediates inhibitory effect of interleukin-10 on angiotensin II-induced hypertensive effects in vascular smooth muscle cells of spontaneously hypertensive rats.
Cytokine
77
203-10
2016
Rattus
Zhang, Z; Zhu, LL; Jiang, HS; Chen, H; Chen, Y; Dai, YT
Demethylation treatment restores erectile function in a rat model of hyperhomocysteinemia.
Asian J Androl
18
763-8
0
Rattus
Lee, KH; Tsai, WJ; Chen, YW; Yang, WC; Lee, CY; Ou, SM; Chen, YT; Chien, CC; Lee, PC; Chung, MY; Lin, CC
Genotype polymorphisms of genes regulating nitric oxide synthesis determine long-term arteriovenous fistula patency in male hemodialysis patients.
Ren Fail
38
228-37
2016
Homo sapiens
Zhang, KQ; Chen, D; Sun, DQ; Zhang, H; Li, B; Fu, Q
Probucol Improves Erectile Function by Restoring Endothelial Function and Preventing Cavernous Fibrosis in Streptozotocin-induced Diabetic Rats.
Urology
2016
Rattus
Chen, D; Zhang, KQ; Li, B; Sun, DQ; Zhang, H; Fu, Q
Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway.
Asian J Androl
2016
Rattus
Quintana-Villamandos, B; Arnalich-Montiel, A; Arribas, S; Lüneburg, N; Böger, RH; Delgado-Martos, MJ; Fernández-Criado, C; Delgado-Baeza, E; González, MC
Early regression of coronary artery remodeling with esmolol and DDAH/ADMA pathway in hypertensive rats.
Hypertens Res
2016
Rattus
Gao, SL; Li, L; Zhai, XJ; Guo, RW; Gao, SS
[Effects and related mechanism of 5-aza-2'-deoxycytidine on endothelial function in rats with hyperhomocysteinemia].
Zhonghua Xin Xue Guan Bing Za Zhi
44
700-6
2016
Rattus
Zhou, R; Ma, P; Xiong, A; Xu, Y; Wang, Y; Xu, Q
Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway.
Cardiovasc Ther
35
2017
Rattus
Lin, Y; Feng, M; Lu, CW; Lei, YP; He, ZM; Xiong, Y
Preservation of vascular DDAH activity contributes to the protection of captopril against endothelial dysfunction in hyperlipidemic rabbits.
Eur J Pharmacol
798
43-48
2017
Oryctolagus cuniculus
Lu, CW; Lin, Y; Lei, YP; Wang, L; He, ZM; Xiong, Y
Pyrrolidine dithiocarbamate ameliorates endothelial dysfunction in thoracic aorta of diabetic rats by preserving vascular DDAH activity.
PLoS One
12
e0179908
2017
Rattus, Homo sapiens
Rodionov, RN; Heinrich, A; Brilloff, S; Jarzebska, N; Martens-Lobenhoffer, J; Bode-Böger, SM; Todorov, VT; Hugo, CPM; Weiss, N; Hohenstein, B
ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy.
Atheroscler Suppl
30
319-325
2017
Mus musculus, Metazoa, Mus sp.
Xiao, HB; Wang, YS; Luo, ZF; Lu, XY
SZSJ protects against insomnia by a decrease in ADMA level and an improvement in DDAH production in sleep-deprived rats.
Life Sci
209
97-102
2018
Rattus
Dai, G; Li, B; Xu, Y; Zeng, Z; Yang, H
Oxymatrine prevents the development of monocrotaline-induced pulmonary hypertension via regulation of the NG, NG-dimethyl-L-arginine metabolism pathways in rats.
Eur J Pharmacol
842
338-344
2019
Rattus
Azizi, F; Omrani, MD; Amiri, V; Mirfakhraie, R; Dodangeh, F; Shahmirzadi, SA; Gargari, SS
Altered methylation and expression patterns of genes regulating placental nitric oxide pathway in patients with severe preeclampsia.
Hum Antibodies
2018
Homo sapiens
Xiao, HB; Wang, YS; Liang, L; Lu, X; Sun, ZL
Procyanidin B2 from lotus seedpod regulate NO/ADMA/DDAH pathway to treat insomnia in rats.
Fundam Clin Pharmacol
33
549-557
2019
Rattus
Chen, WT; Shie, CB; Yang, CC; Lee, TM
Blockade of Cardiac Proton Pump Impairs Ventricular Remodeling Through a Superoxide-DDAH-Dependent Pathway in Infarcted Rats.
Acta Cardiol Sin
35
165-178
2019
Rattus
Rodionov, RN; Jarzebska, N; Schneider, A; Rexin, A; Sradnick, J; Brilloff, S; Martens-Lobenhoffer, J; Bode-Böger, SM; Todorov, V; Hugo, C; Weiss, N; Hohenstein, B
ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus.
Atheroscler Suppl
40
100-105
2019
Mus sp., Mus musculus
Garbincius, JF; Merz, LE; Cuttitta, AJ; Bayne, KV; Schrade, S; Armstead, EA; Converso-Baran, KL; Whitesall, SE; D'Alecy, LG; Michele, DE
Enhanced dimethylarginine degradation improves coronary flow reserve and exercise tolerance in Duchenne muscular dystrophy carrier mice.
Am J Physiol Heart Circ Physiol
319
H582-H603
2020
Mus sp.
Sezgin, D; Aslan, G; Sahin, K; Tuzcu, M; ?lhan, N; Sahna, E
The effects of melatonin against atherosclerosis-induced endothelial dysfunction and inflammation in hypercholesterolemic rats.
Arch Physiol Biochem
1-8
2020
Rattus
Mei, X; Zeng, J; Liu, DF; Zhao, Y; Yang, HL; Li, Y; Qiu, P; Tang, MW
Abnormalities of the PRMT1-ADMA-DDAH1 metabolism axis and probucol treatment in diabetic patients and diabetic rats.
Ann Palliat Med
10
3343-3353
2021
Felis catus, Homo sapiens, Rattus
P?oska, A; Cie?lik, P; Siekierzycka, A; Kalinowski, L; Wiero?ska, JM
Neurochemical changes underlying cognitive impairment in olfactory bulbectomized rats and the impact of the mGlu5-positive allosteric modulator CDPPB.
Brain Res
1768
147577
2021
Rattus, Metazoa, Hippocampus
Zou, Y; Zhou, Q; Zhang, Y
MicroRNA-21 released from mast cells-derived extracellular vesicles drives asthma in mice by potentiating airway inflammation and oxidative stress.
Am J Transl Res
13
7475-7491
2021
Mus sp.
Kim, YJ; Park, BH; Park, H; Jung, SC; Pang, MG; Ryu, HM; Lee, KS; Eom, SM; Park, HY
No association of the genetic polymorphisms of endothelial nitric oxide synthase, dimethylarginine dimethylaminohydrolase, and vascular endothelial growth factor with preeclampsia in Korean populations.
Twin Res Hum Genet
11
77-83
2008
Homo sapiens
Khor, GH; Froemming, GR; Zain, RB; Abraham, MT; Omar, E; Tan, SK; Tan, AC; Vincent-Chong, VK; Thong, KL
DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma.
Int J Med Sci
10
1727-39
2013
Transformation
Pullamsetti, SS; Savai, R; Schaefer, MB; Wilhelm, J; Ghofrani, HA; Weissmann, N; Schudt, C; Fleming, I; Mayer, K; Leiper, J; Seeger, W; Grimminger, F; Schermuly, RT
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
Circulation
123
1194-204
2011
Rattus
Sousse, LE; Yamamoto, Y; Enkhbaatar, P; Rehberg, SW; Wells, SM; Leonard, S; Traber, MG; Yu, YM; Cox, RA; Hawkins, HK; Traber, LD; Herndon, DN; Traber, DL
Acute Lung Injury-Induced Collagen Deposition is Associated with Elevated Asymmetric Dimethylarginine and Arginase Activity.
Shock
2010
Homo sapiens, Ovis aries
Yamamoto, Y; Sousse, LE; Enkhbaatar, P; Kraft, ER; Deyo, DJ; Wright, CL; Taylor, A; Traber, MG; Cox, RA; Hawkins, HK; Rehberg, SW; Traber, LD; Herndon, DN; Traber, DL
?-tocopherol nebulization decreases oxidative stress, arginase activity, and collagen deposition after burn and smoke inhalation in the ovine model.
Shock
38
671-6
2012
Ovis aries
Ito, A; Tsao, PS; Adimoolam, S; Kimoto, M; Ogawa, T; Cooke, JP
Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase.
Circulation
99
3092-5
1999
Homo sapiens, Oryctolagus cuniculus
Ribas, G; Neville, M; Wixon, JL; Cheng, J; Campbell, RD
Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region.
J Immunol
163
278-87
1999
Homo sapiens
Tran, CT; Fox, MF; Vallance, P; Leiper, JM
Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins.
Genomics
68
101-5
2000
Homo sapiens, Chondrichthyes
Achan, V; Tran, CT; Arrigoni, F; Whitley, GS; Leiper, JM; Vallance, P
all-trans-Retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylarginine dimethylaminohydrolase.
Circ Res
90
764-9
2002
Mus musculus
Lin, KY; Ito, A; Asagami, T; Tsao, PS; Adimoolam, S; Kimoto, M; Tsuji, H; Reaven, GM; Cooke, JP
Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.
Circulation
106
987-92
2002
Rattus, Homo sapiens
Kostourou, V; Robinson, SP; Cartwright, JE; Whitley, GS
Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesis.
Br J Cancer
87
673-80
2002
Homo sapiens, Rattus
Ueda, S; Kato, S; Matsuoka, H; Kimoto, M; Okuda, S; Morimatsu, M; Imaizumi, T
Regulation of cytokine-induced nitric oxide synthesis by asymmetric dimethylarginine: role of dimethylarginine dimethylaminohydrolase.
Circ Res
92
226-33
2003
Homo sapiens, Rattus
Smith, CL; Birdsey, GM; Anthony, S; Arrigoni, FI; Leiper, JM; Vallance, P
Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype.
Biochem Biophys Res Commun
308
984-9
2003
Homo sapiens, Mus musculus
Millatt, LJ; Whitley, GS; Li, D; Leiper, JM; Siragy, HM; Carey, RM; Johns, RA
Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
Circulation
108
1493-8
2003
Rattus
Holden, DP; Cartwright, JE; Nussey, SS; Whitley, GS
Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine.
Circulation
108
1575-80
2003
Homo sapiens, Mus musculus
Dayoub, H; Achan, V; Adimoolam, S; Jacobi, J; Stuehlinger, MC; Wang, BY; Tsao, PS; Kimoto, M; Vallance, P; Patterson, AJ; Cooke, JP
Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence.
Circulation
108
3042-7
2003
Mus musculus, animal, Homo sapiens
Akbar, F; Heinonen, S; Pirskanen, M; Uimari, P; Tuomainen, TP; Salonen, JT
Haplotypic association of DDAH1 with susceptibility to pre-eclampsia.
Mol Hum Reprod
11
73-7
2005
Homo sapiens
Jacobi, J; Sydow, K; von Degenfeld, G; Zhang, Y; Dayoub, H; Wang, B; Patterson, AJ; Kimoto, M; Blau, HM; Cooke, JP
Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis.
Circulation
111
1431-8
2005
Mus musculus, Mus sp., Metazoa
Tanaka, M; Sydow, K; Gunawan, F; Jacobi, J; Tsao, PS; Robbins, RC; Cooke, JP
Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease.
Circulation
112
1549-56
2005
Homo sapiens, Mus musculus, Mus sp.
Tomikawa, J; Fukatsu, K; Tanaka, S; Shiota, K
DNA methylation-dependent epigenetic regulation of dimethylarginine dimethylaminohydrolase 2 gene in trophoblast cell lineage.
J Biol Chem
281
12163-9
2006
Mus musculus
Lu, CW; Xiong, Y; He, P
Dimethylarginine dimethylaminohydrolase-2 overexpression improves impaired nitric oxide synthesis of endothelial cells induced by glycated protein.
Nitric Oxide
16
94-103
2007
Bos taurus
Konishi, H; Sydow, K; Cooke, JP
Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury.
J Am Coll Cardiol
49
1099-105
2007
Mus sp., Homo sapiens
Hartzoulakis, B; Rossiter, S; Gill, H; O'Hara, B; Steinke, E; Gane, PJ; Hurtado-Guerrero, R; Leiper, JM; Vallance, P; Rust, JM; Selwood, DL
Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.
Bioorg Med Chem Lett
17
3953-6
2007
Pseudomonas aeruginosa
Pope, AJ; Druhan, L; Guzman, JE; Forbes, SP; Murugesan, V; Lu, D; Xia, Y; Chicoine, LG; Parinandi, NL; Cardounel, AJ
Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.
Am J Physiol Cell Physiol
293
C1679-86
2007
Homo sapiens, Bos taurus
Palm, F; Onozato, ML; Luo, Z; Wilcox, CS
Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems.
Am J Physiol Heart Circ Physiol
293
H3227-45
2007
Homo sapiens, Mus sp., Rattus
Garbin, U; Pasini, AF; Stranieri, C; Manfro, S; Boccioletti, V; Cominacini, L
Nebivolol reduces asymmetric dimethylarginine in endothelial cells by increasing dimethylarginine dimethylaminohydrolase 2 (DDAH2) expression and activity.
Pharmacol Res
56
515-21
2007
Homo sapiens
Bai, Y; Hui, R
Dimethylarginine dimethylaminohydrolase (DDAH) - A critical regulator of hypertensive left ventricular hypertrophy?
Med Hypotheses
70
962-6
2008
Homo sapiens
Dayoub, H; Rodionov, R; Lynch, C; Cooke, JP; Arning, E; Bottiglieri, T; Lentz, SR; Faraci, FM
Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation.
Stroke
39
180-4
2008
Homo sapiens, Metazoa, Mus sp.
Zhang, JG; Liu, JX; Li, ZH; Wang, LZ; Jiang, YD; Wang, SR
Dysfunction of endothelial NO system originated from homocysteine-induced aberrant methylation pattern in promoter region of DDAH2 gene.
Chin Med J (Engl)
120
2132-7
2007
Homo sapiens
Feng, M; Liu, L; Guo, Z; Xiong, Y
Gene transfer of dimethylarginine dimethylaminohydrolase-2 improves the impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells induced by lysophosphatidylcholine.
Eur J Pharmacol
584
49-56
2008
Homo sapiens
Bai, Y; Chen, J; Sun, K; Xin, Y; Liu, J; Hui, R
Common genetic variation in DDAH2 is associated with intracerebral hemorrhage in Chinese population: a multicenter case-control study in China.
Clin Sci (Lond)
2009
Homo sapiens
Maas, R; Erdmann, J; LĂźneburg, N; Stritzke, J; Schwedhelm, E; Meisinger, C; Peters, A; Weil, J; Schunkert, H; BĂśger, RH; Lieb, W
Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension.
Pharmacol Res
2009
Homo sapiens
Ding, H; Wu, B; Wang, H; Lu, Z; Yan, J; Wang, X; Shaffer, JR; Hui, R; Wang, DW
A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.
Circ Res
106
1145-52
2010
insertion sequences, Homo sapiens
Abhary, S; Burdon, KP; Kuot, A; Javadiyan, S; Whiting, MJ; Kasmeridis, N; Petrovsky, N; Craig, JE
Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes.
PLoS One
5
e9462
2010
Homo sapiens
Frombaum, M; Therond, P; Djelidi, R; Beaudeux, JL; Bonnefont-Rousselot, D; Borderie, D
Piceatannol is more effective than resveratrol in restoring endothelial cell dimethylarginine dimethylaminohydrolase expression and activity after high-glucose oxidative stress.
Free Radic Res
45
293-302
2011
Bos taurus
Johnson, CM; Monzingo, AF; Ke, Z; Yoon, DW; Linsky, TW; Guo, H; Robertus, JD; Fast, W
On the mechanism of dimethylarginine dimethylaminohydrolase inactivation by 4-halopyridines.
J Am Chem Soc
133
10951-9
2011
Homo sapiens
Pullamsetti, SS; Savai, R; Dumitrascu, R; Dahal, BK; Wilhelm, J; Konigshoff, M; Zakrzewicz, D; Ghofrani, HA; Weissmann, N; Eickelberg, O; Guenther, A; Leiper, J; Seeger, W; Grimminger, F; Schermuly, RT
The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
Sci Transl Med
3
87ra53
2011
Homo sapiens, Mus musculus, Mus sp.
Chobanyan-Jürgens, K; Fuchs, AJ; Tsikas, D; Kanzelmeyer, N; Das, AM; Illsinger, S; Vaske, B; Jordan, J; Lücke, T
Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II.
Amino Acids
2011
Homo sapiens
Anderssohn, M; Maaß, LM; Diemert, A; Lüneburg, N; Atzler, D; Hecher, K; Böger, RH
Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia.
Eur J Obstet Gynecol Reprod Biol
2012
Homo sapiens
Seo, HA; Kim, SW; Jeon, EJ; Jeong, JY; Moon, SS; Lee, WK; Kim, JG; Lee, IK; Park, KG
Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension.
Diabetes Res Clin Pract
2012
Homo sapiens
Linsky, TW; Fast, W
Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
Bioorg Med Chem
20
5550-8
2012
Pseudomonas aeruginosa, Homo sapiens
Xu, AG; Xu, RM; Lu, CQ; Li, DD; Xu, QF; Guo, J; Fu, X; Zhao, W; Yao, MY
Association study of dimethylarginine dimethylaminohydrolase 2 gene polymorphisms and coronary heart disease.
Mol Med Report
6
1103-6
2012
Homo sapiens
Nandi, M; Kelly, P; Torondel, B; Wang, Z; Starr, A; Ma, Y; Cunningham, P; Stidwill, R; Leiper, J
Genetic and pharmacological inhibition of dimethylarginine dimethylaminohydrolase 1 is protective in endotoxic shock.
Arterioscler Thromb Vasc Biol
32
2589-97
2012
Homo sapiens
Janssen, W; Pullamsetti, SS; Cooke, J; Weissmann, N; Guenther, A; Schermuly, RT
The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis.
J Pathol
229
242-9
2013
Homo sapiens, Mus sp.
Serna, E; Mauricio, MD; Lluch, P; Segarra, G; Cortina, B; Lluch, S; Medina, P
Basal release of NO in the mesenteric artery in portal hypertension and cirrhosis: role of dimethylarginine dimethylaminohydrolase.
J Gastroenterol Hepatol
2013
Rattus
Jia, SJ; Lai, YQ; Zhao, M; Gong, T; Zhang, BK
Homocysteine-induced hypermethylation of DDAH2 promoter contributes to apoptosis of endothelial cells.
Pharmazie
68
282-6
2013
Homo sapiens
Zheng, J; Wang, K; Jin, P; Dong, C; Yuan, Q; Li, Y; Yang, Z
The association of adipose-derived dimethylarginine dimethylaminohydrolase-2 with insulin sensitivity in experimental type 2 diabetes mellitus.
Acta Biochim Biophys Sin (Shanghai)
45
641-8
2013
Homo sapiens, Rattus, animal
Aggarwal, S; Gross, CM; Kumar, S; Dimitropoulou, C; Sharma, S; Gorshkov, BA; Sridhar, S; Lu, Q; Bogatcheva, NV; Jezierska-Drutel, AJ; Lucas, R; Verin, AD; Catravas, JD; Black, SM
Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury.
Am J Respir Cell Mol Biol
50
614-25
2014
Mus sp., Homo sapiens
Zhang, BK; Lai, YQ; Niu, PP; Zhao, M; Jia, SJ
Epigallocatechin-3-gallate inhibits homocysteine-induced apoptosis of endothelial cells by demethylation of the DDAH2 gene.
Planta Med
79
1715-9
2013
Homo sapiens
Zhang, P; Xu, X; Hu, X; Wang, H; Fassett, J; Huo, Y; Chen, Y; Bache, RJ
DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis.
PLoS One
8
e79444
2013
Mus musculus, Mus sp.
Rasheed, M; Richter, C; Chisty, LT; Kirkpatrick, J; Blackledge, M; Webb, MR; Driscoll, PC
Ligand-dependent dynamics of the active-site lid in bacterial dimethylarginine dimethylaminohydrolase.
Biochemistry
53
1092-104
2014
Pseudomonas aeruginosa
Wang, Z; Lambden, S; Taylor, V; Sujkovic, E; Nandi, M; Tomlinson, J; Dyson, A; McDonald, N; Caddick, S; Singer, M; Leiper, J
Pharmacological inhibition of DDAH1 improves survival, hemodynamics and organ function in experimental septic shock.
Biochem J
2014
Homo sapiens, Rodentia, Metazoa
Bailey, K; Wyatt, T; Wells, S; Klein, E; Robinson, J; Romberger, D; Poole, J
Dimethylarginine dimethylaminohydrolase (DDAH) overexpression attenuates agricultural organic dust extract-induced inflammation.
J Environ Immunol Toxicol
2
72-78
2014
animal
Leo, MD; Kandasamy, K; Subramani, J; Tandan, SK; Kumar, D
Involvement of inducible nitric oxide synthase and dimethyl arginine dimethylaminohydrolase in N?-nitro-L-arginine methyl ester (L-NAME)-induced hypertension.
Cardiovasc Pathol
24
49-55
0
Rattus, Rattus norvegicus
Powers, R; Gefter, J
OS075. Endothelial-dependent vascular function is significantly impaired in obesity and restored by overexpression of DDAH1: Evidence for the role of ADMA.
Pregnancy Hypertens
2
218
2012
Mus musculus, Mus sp.
Liu, XJ; Hong, Q; Wang, Z; Yu, YY; Zou, X; Xu, LH
MicroRNA21 promotes interstitial fibrosis via targeting DDAH1: a potential role in renal fibrosis.
Mol Cell Biochem
411
181-9
2016
Homo sapiens
Trittmann, JK; Gastier-Foster, JM; Zmuda, EJ; Frick, J; Rogers, LK; Vieland, VJ; Chicoine, LG; Nelin, LD
A single nucleotide polymorphism in the dimethylarginine dimethylaminohydrolase gene is associated with lower risk of pulmonary hypertension in bronchopulmonary dysplasia.
Acta Paediatr
105
e170-5
2016
Homo sapiens
Wang, H; Guo, Y; Liu, L; Guan, L; Wang, T; Zhang, L; Wang, Y; Cao, J; Ding, W; Zhang, F; Lu, Z
DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells.
Biochim Biophys Acta
2016
Homo sapiens
Lange, C; Mowat, F; Sayed, H; Mehad, M; Duluc, L; Piper, S; Luhmann, U; Nandi, M; Kelly, P; Smith, A; Ali, R; Leiper, J; Bainbridge, J
Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis.
Exp Eye Res
147
148-55
2016
Mus sp.
Murphy, RB; Tommasi, S; Lewis, BC; Mangoni, AA
Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development.
Molecules
21
2016
Bacteria, Homo sapiens, Rodentia
Zhang, P; Fassett, JT; Zhu, G; Li, J; Hu, X; Xu, X; Chen, Y; Bache, RJ
Repetitive ischemia increases myocardial dimethylarginine dimethylaminohydrolase 1 expression.
Vasc Med
1358863X16681215
2017
Homo sapiens
Ye, J; Xu, J; Li, Y; Huang, Q; Huang, J; Wang, J; Zhong, W; Lin, X; Chen, W; Lin, X
DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/?-catenin signaling pathway.
Mol Oncol
11
1208-1224
2017
Homo sapiens
Chandra, D; Poole, JA; Bailey, KL; Staab, E; Sweeter, JM; DeVasure, JM; Romberger, DJ; Wyatt, TA
Dimethylarginine dimethylaminohydrolase (DDAH) overexpression enhances wound repair in airway epithelial cells exposed to agricultural organic dust.
Inhal Toxicol
30
133-139
2018
Mus musculus, Mus sp.
Hou, L; Guo, J; Xu, F; Weng, X; Yue, W; Ge, J
Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left-ventricular remodeling after acute myocardial infarction: involvement in oxidative stress and apoptosis.
Basic Res Cardiol
113
28
2018
Mus musculus, Mus sp.
Wang, Y; Wang, E; Zhang, Y; Madamsetty, VS; Ji, B; Radisky, DC; Grande, JP; Misra, S; Mukhopadhyay, D
Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II-induced hypertension.
FASEB J
fj201800499R
2018
Mus sp.
Lin, HH; Lee, TS; Lin, SJ; Yeh, YC; Lu, TM; Hsu, CP
DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase.
Clin Sci (Lond)
133
2361-2378
2019
Mus sp.
Zhao, Y; Zhou, Y; Ma, X; Liu, X; Zhao, Y; Liu, X
DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion.
Nitric Oxide
95
17-28
2020
Rattus
Wetzel, MD; Gao, T; Stanley, K; Cooper, TK; Morris, SM; Awad, AS
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy.
Am J Physiol Renal Physiol
318
F509-F517
2020
Homo sapiens, Mus sp.
Lee, Y; Mehrotra, P; Basile, D; Ullah, M; Singh, A; Skill, N; Younes, ST; Sasser, J; Shekhar, A; Singh, J
Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury.
J Pharmacol Exp Ther
376
181-189
2021
Rodentia
Hannemann, J; Appel, D; Seeberger-Steinmeister, M; Brüning, T; Zummack, J; Böger, R
Sequence Variation in the DDAH1 Gene Predisposes for Delayed Cerebral Ischemia in Subarachnoidal Hemorrhage.
J Clin Med
9
2020
Homo sapiens
Fan, Y; Gao, Q; Guan, JX; Liu, L; Hong, M; Jun, L; Wang, L; Ding, HF; Jiang, LH; Hou, BY; Li, M; Song, ZQ; Sun, DQ; Yan, CQ; Ma, L
DDAH2 (-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study.
Neural Regen Res
16
1592-1597
2021
Homo sapiens
Zhao, Y; Ma, X; Zhou, Y; Xie, J; Liu, X; Zhao, Y
DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage.
Lab Invest
101
808-823
2021
Rattus
Huang, S; Li, Z; Wu, Z; Liu, C; Yu, M; Wen, M; Zhang, L; Wang, X
DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission.
Sci Signal
14
2021
Homo sapiens, Mus musculus, Mus sp.
Kozlova, AA; Ragavan, VN; Jarzebska, N; Lukianova, IV; Bikmurzina, AE; Rubets, E; Suzuki-Yamamoto, T; Kimoto, M; Mangoni, AA; Gainetdinov, RR; Weiss, N; Bauer, M; Markov, AG; Rodionov, RN; Bernhardt, N
Divergent Dimethylarginine Dimethylaminohydrolase Isoenzyme Expression in the Central Nervous System.
Cell Mol Neurobiol
2021
Homo sapiens, Mus musculus
Uyeda, A; Quan, L; Kato, Y; Muramatsu, N; Tanabe, S; Sakai, K; Ichinohe, N; Kawahara, Y; Suzuki, T; Muramatsu, R
Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination.
Glia
69
2591-2604
2021
Mus musculus
Kopaliani, I; Jarzebska, N; Brilloff, S; Kolouschek, A; Martens-Lobenhoffer, J; Bornstein, SR; Bode-Böger, SM; Ragavan, VN; Weiss, N; Mangoni, AA; Deussen, A; Rodionov, RN
Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II - induced cardiac hypertrophy and vascular remodeling.
Am J Physiol Heart Circ Physiol
2021
Mus musculus, Metazoa
Zhang, GG; Shi, RZ; Jiang, DJ; Chen, YR; Jia-Chen, ; Tang, ZY; Bai, YP; Xiao, HB; Li, YJ
Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: The role of ALDH-2.
Life Sci
82
699-707
2008
Homo sapiens
Matsuoka, H; Itoh, S; Kimoto, M; Kohno, K; Tamai, O; Wada, Y; Yasukawa, H; Iwami, G; Okuda, S; Imaizumi, T
Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension.
Hypertension
29
242-7
1997
Rattus
StĂźhlinger, MC; Tsao, PS; Her, JH; Kimoto, M; Balint, RF; Cooke, JP
Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine.
Circulation
104
2569-75
2001
Homo sapiens, Sus scrofa
Yamagishi, S; Ueda, S; Okuda, S
A possible involvement of crosstalk between advanced glycation end products (AGEs) and asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor in accelerated atherosclerosis in diabetes.
Med Hypotheses
69
922-4
2007
Homo sapiens
Wang, L; Zhou, Y; Peng, J; Zhang, Z; Jiang, DJ; Li, YJ
Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury.
Can J Physiol Pharmacol
86
97-104
2008
Helicobacter pylori, Homo sapiens, Rattus
Huang, YY; Yao, XB; Lu, XH; Liu, HS; Chen, DJ
[Relationship between changes of endogenous nitric oxide synthase inhibitor and hydrolase and initiation of pre-eclampsia]
Zhonghua Fu Chan Ke Za Zhi
44
249-52
2009
Homo sapiens
Sharma, S; Smith, A; Kumar, S; Aggarwal, S; Rehmani, I; Snead, C; Harmon, C; Fineman, J; Fulton, D; Catravas, JD; Black, SM
Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: role of asymmetric dimethylarginine.
Vascul Pharmacol
52
182-90
0
Mus sp.
Luo, Z; Teerlink, T; Griendling, K; Aslam, S; Welch, WJ; Wilcox, CS
Angiotensin II and NADPH oxidase increase ADMA in vascular smooth muscle cells.
Hypertension
56
498-504
2010
Rattus
Tojo, A; Kimoto, M; Wilcox, CS
Renal expression of constitutive NOS and DDAH: separate effects of salt intake and angiotensin.
Kidney Int
58
2075-83
2000
Rattus
Jung, CS; Wispel, C; Zweckberger, K; Beynon, C; Hertle, D; Sakowitz, OW; Unterberg, AW
Endogenous nitric-oxide synthase inhibitor ADMA after acute brain injury.
Int J Mol Sci
15
4088-103
2014
Metazoa
Osanai, T; Saitoh, M; Sasaki, S; Tomita, H; Matsunaga, T; Okumura, K
Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells.
Hypertension
42
985-90
2003
Homo sapiens
Munjal, C; Givvimani, S; Qipshidze, N; Tyagi, N; Falcone, JC; Tyagi, SC
Mesenteric vascular remodeling in hyperhomocysteinemia.
Mol Cell Biochem
348
99-108
2011
Mus sp.
Wu, M; Yuan, M; Wang, Y; Tan, B; Huang, D; Wang, C; Zou, Y; Ye, C
Renal asymmetric dimethylarginine inhibits fibrosis.
FEBS Open Bio
2020
Mus musculus
Butterfield, DA; Gnjec, A; Poon, HF; Castegna, A; Pierce, WM; Klein, JB; Martins, RN
Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment.
J Alzheimers Dis
10
391-7
2006
Homo sapiens
Wang, H; Feng, L; Hu, JW; Xie, CL; Wang, F
Characterisation of the vitreous proteome in proliferative diabetic retinopathy.
Proteome Sci
10
15
2012
Homo sapiens
Krishna, MB; Joseph, A; Thomas, PL; Dsilva, B; Pillai, SM; Laloraya, M
Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome.
Cell Physiol Biochem
43
1880-1892
2017
Homo sapiens
Shibata, R; Ueda, S; Yamagishi, S; Kaida, Y; Matsumoto, Y; Fukami, K; Hayashida, A; Matsuoka, H; Kato, S; Kimoto, M; Okuda, S
Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy.
Nephrol Dial Transplant
24
1162-9
2009
Rattus, Areas
Chen, X; Niroomand, F; Liu, Z; Zankl, A; Katus, HA; Jahn, L; Tiefenbacher, CP
Expression of nitric oxide related enzymes in coronary heart disease.
Basic Res Cardiol
101
346-53
2006
Homo sapiens
Becker, T; Mevius, I; de Vries, DK; Schaapherder, AF; zu Vilsendorf, AM; Klempnauer, J; FrĂślich, JC; Tsikas, D
The L-arginine/NO pathway in end-stage liver disease and during orthotopic liver and kidney transplantation: biological and analytical ramifications.
Nitric Oxide
20
61-7
2009
Homo sapiens
Bekpinar, S; Develi-Is, S; Unlucerci, Y; Kusku-Kiraz, Z; Uysal, M; Gurdol, F
Modulation of arginine and asymmetric dimethylarginine concentrations in liver and plasma by exogenous hydrogen sulfide in LPS-induced endotoxemia.
Can J Physiol Pharmacol
91
1071-5
2013
Rattus, Rattus norvegicus, Metazoa
Bal, F; Bekpinar, S; Unlucerci, Y; Kusku-Kiraz, Z; Önder, S; Uysal, M; Gurdol, F
Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury.
Diabetes Res Clin Pract
106
295-302
2014
Metazoa, Rattus
Jiang, DJ; Jia, SJ; Yan, J; Zhou, Z; Yuan, Q; Li, YJ
Involvement of DDAH/ADMA/NOS pathway in nicotine-induced endothelial dysfunction.
Biochem Biophys Res Commun
349
683-93
2006
Rattus, Chelator
Tan, B; Jiang, DJ; Huang, H; Jia, SJ; Jiang, JL; Hu, CP; Li, YJ
Taurine protects against low-density lipoprotein-induced endothelial dysfunction by the DDAH/ADMA pathway.
Vascul Pharmacol
46
338-45
2007
Homo sapiens
He, H; Qiao, Y; Zhou, Q; Wang, Z; Chen, X; Liu, D; Yin, D; He, M
Iron Overload Damages the Endothelial Mitochondria via the ROS/ADMA/DDAHII/eNOS/NO Pathway.
Oxid Med Cell Longev
2019
2340392
2019
Homo sapiens
Watanabe, T; Kato, S; Sato, K; Nagata, K
Nitric oxide regulation system in degenerative lumbar disease.
Kurume Med J
52
39-47
2005
Homo sapiens, Stenosis
Hecker, M; Mitchell, JA; Harris, HJ; Katsura, M; Thiemermann, C; Vane, JR
Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine.
Biochem Biophys Res Commun
167
1037-43
1990
Rattus
Leiper, J; Vallance, P
Biological significance of endogenous methylarginines that inhibit nitric oxide synthases.
Cardiovasc Res
43
542-8
1999
Mammalia
BĂśger, RH
The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor.
Cardiovasc Res
59
824-33
2003
Homo sapiens
Selley, ML
Homocysteine increases the production of asymmetric dimethylarginine in cultured neurons.
J Neurosci Res
77
90-3
2004
Rattus
Fliser, D
Asymmetric dimethylarginine (ADMA): the silent transition from an 'uraemic toxin' to a global cardiovascular risk molecule.
Eur J Clin Invest
35
71-9
2005
Homo sapiens
Pullamsetti, S; Kiss, L; Ghofrani, HA; Voswinckel, R; Haredza, P; Klepetko, W; Aigner, C; Fink, L; Muyal, JP; Weissmann, N; Grimminger, F; Seeger, W; Schermuly, RT
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
FASEB J
19
1175-7
2005
Homo sapiens, Rattus
Achan, V; Ho, HK; Heeschen, C; Stuehlinger, M; Jang, JJ; Kimoto, M; Vallance, P; Cooke, JP
ADMA regulates angiogenesis: genetic and metabolic evidence.
Vasc Med
10
7-14
2005
Mus musculus, Mus sp.
Okubo, K; Hayashi, K; Wakino, S; Matsuda, H; Kubota, E; Honda, M; Tokuyama, H; Yamamoto, T; Kajiya, F; Saruta, T
Role of asymmetrical dimethylarginine in renal microvascular endothelial dysfunction in chronic renal failure with hypertension.
Hypertens Res
28
181-9
2005
Canis lupus familiaris, Metazoa
MĂźller, WE; Ushijima, H; Batel, R; Krasko, A; Borejko, A; MĂźller, IM; SchrĂśder, HC
Novel mechanism for the radiation-induced bystander effect: nitric oxide and ethylene determine the response in sponge cells.
Mutat Res
597
62-72
2006
Porifera, vertebrata, Metazoa, Suberites domuncula
Dayal, S; Lentz, SR
ADMA and hyperhomocysteinemia.
Vasc Med
10 Suppl 1
S27-33
2005
Mus musculus, animal
Valkonen, VP; Tuomainen, TP; Laaksonen, R
DDAH gene and cardiovascular risk.
Vasc Med
10 Suppl 1
S45-8
2005
Homo sapiens, animal
Matsuguma, K; Ueda, S; Yamagishi, S; Matsumoto, Y; Kaneyuki, U; Shibata, R; Fujimura, T; Matsuoka, H; Kimoto, M; Kato, S; Imaizumi, T; Okuda, S
Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease.
J Am Soc Nephrol
17
2176-83
2006
Homo sapiens, Rattus
Bulau, P; Zakrzewicz, D; Kitowska, K; Leiper, J; Gunther, A; Grimminger, F; Eickelberg, O
Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA.
Am J Physiol Lung Cell Mol Physiol
292
L18-24
2007
eukaryota, Mus musculus
Ryan, R; Thornton, J; Duggan, E; McGovern, E; O'Dwyer, MJ; Ryan, AW; Kelleher, D; McManus, R; Ryan, T
Gene polymorphism and requirement for vasopressor infusion after cardiac surgery.
Ann Thorac Surg
82
895-901
2006
Homo sapiens
Gates, PE; Boucher, ML; Silver, AE; Monahan, KD; Seals, DR
Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression.
J Appl Physiol
102
63-71
2007
Homo sapiens
O'dwyer, MJ; Dempsey, F; Crowley, V; Kelleher, D; McManus, R; Ryan, T
Septic shock correlates with ADMA levels which may be influenced by a polymorphism in DDAH II: a prospective observational study.
Crit Care
10
R139
2006
Homo sapiens
Hu, T; Chouinard, M; Cox, AL; Sipes, P; Marcelo, M; Ficorilli, J; Li, S; Gao, H; Ryan, TP; Michael, MD; Michael, LF
Farnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation.
J Biol Chem
281
39831-8
2006
Rattus
Leiper, J; Nandi, M; Torondel, B; Murray-Rust, J; Malaki, M; O'Hara, B; Rossiter, S; Anthony, S; Madhani, M; Selwood, D; Smith, C; Wojciak-Stothard, B; Rudiger, A; Stidwill, R; McDonald, NQ; Vallance, P
Disruption of methylarginine metabolism impairs vascular homeostasis.
Nat Med
13
198-203
2007
Homo sapiens, Mus sp.
Wojciak-Stothard, B; Torondel, B; Tsang, LY; Fleming, I; Fisslthaler, B; Leiper, JM; Vallance, P
The ADMA/DDAH pathway is a critical regulator of endothelial cell motility.
J Cell Sci
120
929-42
2007
Sus scrofa, Mus sp.
Xin, HY; Jiang, DJ; Jia, SJ; Song, K; Wang, GP; Li, YJ; Chen, FP
Regulation by DDAH/ADMA pathway of lipopolysaccharide-induced tissue factor expression in endothelial cells.
Thromb Haemost
97
830-8
2007
Homo sapiens
StĂźhlinger, MC; Conci, E; Haubner, BJ; Stocker, EM; Schwaighofer, J; Cooke, JP; Tsao, PS; Pachinger, O; Metzler, B
Asymmetric dimethyl L-arginine (ADMA) is a critical regulator of myocardial reperfusion injury.
Cardiovasc Res
75
417-25
2007
Mus musculus, Mus sp.
Zinellu, A; Pinna, A; Sotgia, S; Zinellu, E; Usai, MF; Carta, F; Gaspa, L; Deiana, L; Carru, C
Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease.
Clin Chem Lab Med
46
387-92
2008
Homo sapiens
Gini, B; Lovato, L; Cianti, R; Cecotti, L; Marconi, S; Anghileri, E; Armini, A; Moretto, G; Bini, L; Ferracci, F; Bonetti, B
Novel autoantigens recognized by CSF IgG from Hashimoto's encephalitis revealed by a proteomic approach.
J Neuroimmunol
196
153-8
2008
Homo sapiens, Mus musculus
Chen, M; Li, Y; Yang, T; Wang, Y; Bai, Y; Xie, X
ADMA induces monocyte adhesion via activation of chemokine receptors in cultured THP-1 cells.
Cytokine
43
149-59
2008
Homo sapiens
Liu, YZ; Zhou, Y; Li, D; Wang, L; Hu, GY; Peng, J; Li, YJ
Reduction of asymmetric dimethylarginine in the protective effects of rutaecarpine on gastric mucosal injury.
Can J Physiol Pharmacol
86
675-81
2008
Rattus
Wojciak-Stothard, B; Torondel, B; Zhao, L; RennĂŠ, T; Leiper, JM
Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function.
Mol Biol Cell
20
33-42
2009
Mus sp.
Kielstein, JT; Zoccali, C
Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease.
Curr Opin Nephrol Hypertens
17
609-615
2008
Homo sapiens
Yamagishi, S; Ueda, S; Nakamura, K; Matsui, T; Okuda, S
Role of asymmetric dimethylarginine (ADMA) in diabetic vascular complications.
Curr Pharm Des
14
2613-8
2008
Homo sapiens
Li Volti, G; Sorrenti, V; Acquaviva, R; Murabito, P; Gullo, A; Barcellona, ML; Galvano, F; Rodella, L; Rezzani, R; Vanella, L; Tringali, G; Caruso, M; Gazzolo, D; Di Giacomo, C
Effect of ischemia-reperfusion on renal expression and activity of N(G)-N(G)-dimethylarginine dimethylaminohydrolases.
Anesthesiology
109
1054-62
2008
Rattus
Xiao, HB; Jun-Fang, ; Lu, XY; Chen, XJ; Chao-Tan, ; Sun, ZL
Protective effects of kaempferol against endothelial damage by an improvement in nitric oxide production and a decrease in asymmetric dimethylarginine level.
Eur J Pharmacol
616
213-22
2009
Mus sp.
Teerlink, T; Luo, Z; Palm, F; Wilcox, CS
Cellular ADMA: Regulation and action.
Pharmacol Res
2009
Felis catus
Blackwell, S
The biochemistry, measurement and current clinical significance of asymmetric dimethylarginine.
Ann Clin Biochem
47
17-28
2010
Homo sapiens
Sasser, JM; Moningka, NC; Cunningham, MW; Croker, B; Baylis, C
Asymmetric dimethylarginine in angiotensin II-induced hypertension.
Am J Physiol Regul Integr Comp Physiol
298
R740-6
2010
Rattus
Becanovic, K; Pouladi, MA; Lim, RS; Kuhn, A; Pavlidis, P; Luthi-Carter, R; Hayden, MR; Leavitt, BR
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis.
Hum Mol Genet
19
1438-52
2010
Homo sapiens
Torondel, B; Nandi, M; Kelly, P; Wojciak-Stothard, B; Fleming, I; Leiper, J
Adenoviral-mediated overexpression of DDAH improves vascular tone regulation.
Vasc Med
2010
Homo sapiens, Mammalia, Mus sp.
Li, L; Luo, XJ; Liu, YZ; Zhang, YS; Yuan, Q; Tan, N; Xiang, DX; Peng, J
The role of the DDAH-ADMA pathway in the protective effect of resveratrol analog BTM-0512 on gastric mucosal injury.
Can J Physiol Pharmacol
88
562-7
2010
Rattus, plant
Tain, YL; Kao, YH; Hsieh, CS; Chen, CC; Sheen, JM; Lin, IC; Huang, LT
Melatonin blocks oxidative stress-induced increased asymmetric dimethylarginine.
Free Radic Biol Med
49
1088-98
2010
Rattus
Li, XH; Peng, J; Tan, N; Wu, WH; Li, TT; Shi, RZ; Li, YJ
Involvement of asymmetric dimethylarginine and Rho kinase in the vascular remodeling in monocrotaline-induced pulmonary hypertension.
Vascul Pharmacol
2010
Rattus
Gad, MZ; Hassanein, SI; Abdel-Maksoud, SM; Shaban, GM; Abou-Aisha, K; Elgabarty, HA
Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and l-arginine in coronary artery disease.
Biomarkers
2010
Homo sapiens
Whittle, N; Li, L; Chen, WQ; Yang, JW; Sartori, SB; Lubec, G; Singewald, N
Changes in brain protein expression are linked to magnesium restriction-induced depression-like behavior.
Amino Acids
40
1231-48
2011
Mus sp.
Tuygun, AK; Tuygun, A; Yurtseven, N; Sensöz, Y; Günay, R; Keser, M; Tuygun, UH; Ketenci, B; Sahin, S; Yekeler, I
Asymmetric Dimethylarginine Levels in Buerger's Disease.
Ann Vasc Surg
2011
Homo sapiens
Peng, ZY; Zhang, SD; Liu, S; He, BM
Protective effect of neferine on endothelial cell nitric oxide production induced by lysophosphatidylcholine: the role of the DDAH-ADMA pathway.
Can J Physiol Pharmacol
89
289-94
2011
Nelumbo nucifera, Homo sapiens
Pei, Y; Ma, P; Wang, X; Zhang, W; Zhang, X; Zheng, P; Yan, L; Xu, Q; Dai, G
Rosuvastatin attenuates monocrotaline-induced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism.
Eur J Pharmacol
666
165-72
2011
Rattus
Lee, TY; Chen, YJ; Lu, TC; Huang, HD; Chen, YJ
SNOSite: Exploiting Maximal Dependence Decomposition to Identify Cysteine S-Nitrosylation with Substrate Site Specificity.
PLoS One
6
e21849
2011
Homo sapiens, Bos taurus, Mus musculus
Lee, JH; Park, GH; Lee, YK; Park, JH
Changes in the arginine methylation of organ proteins during the development of diabetes mellitus.
Diabetes Res Clin Pract
2011
Mus sp.
Ishibashi, Y; Yamagishi, SI; Matsui, T; Ohta, K; Tanoue, R; Takeuchi, M; Ueda, S; Nakamura, KI; Okuda, S
Pravastatin inhibits advanced glycation end products (AGEs)-induced proximal tubular cell apoptosis and injury by reducing receptor for AGEs (RAGE) level.
Metabolism
2012
Homo sapiens
Saratsis, AM; Yadavilli, S; Magge, S; Rood, BR; Perez, J; Hill, DA; Hwang, E; Kilburn, L; Packer, RJ; Nazarian, J
Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid.
Neuro Oncol
14
547-60
2012
Homo sapiens
Iwasaki, H
Activities of asymmetric dimethylarginine-related enzymes in white adipose tissue are associated with circulating lipid biomarkers.
Diabetol Metab Syndr
4
17
2012
Rattus
Sorrenti, V; Di Giacomo, C; Acquaviva, R; Bognanno, M; Grilli, E; D'Orazio, N; Galvano, F
Dimethylarginine dimethylaminohydrolase/nitric oxide synthase pathway in liver and kidney: protective effect of cyanidin 3-O-?-D-glucoside on ochratoxin-A toxicity.
Toxins (Basel)
4
353-63
2012
Rattus
Rodríguez-Esparragón, F; Serna-Gómez, JA; Hernández-Velázquez, E; Buset-Ríos, N; Hernández-Trujillo, Y; García-Bello, MA; Rodríguez-Pérez, JC
Homocysteinylated protein levels in internal mammary artery (IMA) fragments and its genotype-dependence. S-Homocysteine-induced methylation modifications in IMA and aortic fragments.
Mol Cell Biochem
369
235-46
2012
Homo sapiens
Altmann, KS; Havemeyer, A; Beitz, E; Clement, B
Dimethylarginine-dimethylaminohydrolase-2 (DDAH-2) does not metabolize methylarginines.
Chembiochem
13
2599-604
2012
Sus scrofa
Marra, M; Marchegiani, F; Ceriello, A; Sirolla, C; Boemi, M; Franceschi, C; Spazzafumo, L; Testa, I; Bonfigli, AR; Cucchi, M; Testa, R
Chronic renal impairment and DDAH2-1151 A/C polymorphism determine ADMA levels in type 2 diabetic subjects.
Nephrol Dial Transplant
28
964-71
2013
Homo sapiens
Tanhäuserová, V; Tomandl, J; Pácal, L; Klepárník, M; Malúková, D; Bartáková, V; Kuricová, K; Reho?ová, J; St?pánková, S; Svojanovský, J; Olovský, J; B?lobrádková, J; Krusová, D; Jurajda, M; Muík, J; Pavlík, T; Ka?ková, K
ADMA, SDMA and L-arginine/ADMA Ratio but not DDAH Genetic Polymorphisms are Reliable Predictors of Diabetic Nephropathy Progression as Identified by Competing Risk Analysis.
Kidney Blood Press Res
36
200-8
2012
Homo sapiens
Defagó, MD; Gu, D; Hixson, JE; Shimmin, LC; Rice, TK; Gu, CC; Jaquish, CE; Liu, DP; He, J; Kelly, TN
Common Genetic Variants in the Endothelial System Predict Blood Pressure Response to Sodium Intake: The GenSalt Study.
Am J Hypertens
2013
Homo sapiens
Zhang, F; Chen, L; Liu, C; Qiu, P; Wang, A; Li, L; Wang, H
Up-regulation of protein tyrosine nitration in methamphetamine-induced neurotoxicity through DDAH/ADMA/NOS pathway.
Neurochem Int
62
1055-64
2013
Rattus
Park, SH; Hyun, SH; Ryu, HM; Ahn, JS; Oh, SH; Oh, EJ; Yoon, SH; Choi, JY; Cho, JH; Kim, CD; Kim, YL
Effects of losartan and pentoxifylline on renal dimethylarginine dimethylaminohydrolase-1 expression in proteinuric nephropathy.
Am J Nephrol
37
491-500
2013
Homo sapiens
Bakr, A; Pak, O; Taye, A; Hamada, F; Hemeida, R; Janssen, W; Gierhardt, M; Ghofrani, HA; Seeger, W; Grimminger, F; Schermuly, RT; Witzenrath, M; Brandes, RP; Huang, N; Cooke, JP; Weissmann, N; Sommer, N
Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia.
Am J Respir Cell Mol Biol
49
491-500
2013
Mus musculus, Mus sp.
Ando, R; Ueda, S; Yamagishi, S; Miyazaki, H; Kaida, Y; Kaifu, K; Yokoro, M; Nakayama, Y; Obara, N; Fukami, K; Takeuchi, M; Okuda, S
Involvement of advanced glycation end product-induced asymmetric dimethylarginine generation in endothelial dysfunction.
Diab Vasc Dis Res
10
436-41
2013
Homo sapiens
Sukhovershin, RA; Gilinsky, MA
The influence of acute renal injury on arginine and methylarginines metabolism.
Ren Fail
2013
Rattus
Nakayama, Y; Ueda, S; Yamagishi, S; Obara, N; Taguchi, K; Ando, R; Kaida, Y; Iwatani, R; Kaifu, K; Yokoro, M; Toyonaga, M; Kusumoto, T; Fukami, K; Okuda, S
Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury.
Kidney Int
85
570-8
2014
Mus musculus, Mus sp.
Wyatt, TA; Wells, SM; Alsaidi, ZA; DeVasure, JM; Klein, EB; Bailey, KL; Sisson, JH
Asymmetric dimethylarginine blocks nitric oxide-mediated alcohol-stimulated cilia beating.
Mediators Inflamm
2013
592892
2013
Mus musculus, Bos taurus, Mus sp.
Tsang, H; Leiper, J; Hou Lao, K; Dowsett, L; Delahaye, MW; Barnes, G; Wharton, J; Howard, L; Iannone, L; Lang, NN; Wilkins, MR; Wojciak-Stothard, B
Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function.
Pulm Circ
3
675-91
2013
Homo sapiens, Mus sp.
Iannone, L; Zhao, L; Dubois, O; Duluc, L; Rhodes, CJ; Wharton, J; Wilkins, MR; Leiper, J; Wojciak-Stothard, B
miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.
Biochem J
462
103-12
2014
Homo sapiens, Mus musculus, Mus sp.
Mookerjee, RP; Mehta, G; Balasubramaniyan, V; Mohamed, Fel Z; Davies, N; Sharma, V; Iwakiri, Y; Jalan, R
Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension.
J Hepatol
62
325-31
2015
Homo sapiens, Rattus, Metazoa
Lüneburg, N; Lieb, W; Zeller, T; Chen, MH; Maas, R; Carter, AM; Xanthakis, V; Glazer, NL; Schwedhelm, E; Seshadri, S; Ikram, MA; Longstreth, WT; Fornage, M; König, IR; Loley, C; Ojeda, FM; Schillert, A; Wang, TJ; Sticht, H; Kittel, A; König, J; Benjamin, EJ; Sullivan, LM; Bernges, I; Anderssohn, M; Ziegler, A; Gieger, C; Illig, T; Meisinger, C; Wichmann, HE; Wild, PS; Schunkert, H; Psaty, BM; Wiggins, KL; Heckbert, SR; Smith, N; Lackner, K; Lunetta, KL; Blankenberg, S; Erdmann, J; Munzel, T; Grant, PJ; Vasan, RS; Böger, RH
Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.
Circ Cardiovasc Genet
7
864-72
2014
Homo sapiens
Tomlinson, JA; Caplin, B; Boruc, O; Bruce-Cobbold, C; Cutillas, P; Dormann, D; Faull, P; Grossman, RC; Khadayate, S; Mas, VR; Nitsch, DD; Wang, Z; Norman, JT; Wilcox, CS; Wheeler, DC; Leiper, J
Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage.
J Am Soc Nephrol
26
3045-59
2015
Homo sapiens, Mus musculus, animal, Mus sp.
Pekarova, M; Koudelka, A; Kolarova, H; Ambrozova, G; Klinke, A; Cerna, A; Kadlec, J; Trundova, M; Sindlerova Svihalkova, L; Kuchta, R; Kuchtova, Z; Lojek, A; Kubala, L
Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha.
Vascul Pharmacol
73
138-48
2015
Homo sapiens
Zhao, L; Mao, Y; Zhang, Y; Shi, Y; Song, Y
[Ad-hVEGF165 reverses homocysteine-induced endothelial dysfunction by regulating nitric oxide system].
Zhonghua Xin Xue Guan Bing Za Zhi
43
432-6
2015
Homo sapiens
Nasibullin, TR; Timasheva, YR; Sadikova, RI; Tuktarova, IA; Erdman, VV; Nikolaeva, IE; Sabo, J; Kruzliak, P; Mustafina, OE
Genotype/allelic combinations as potential predictors of myocardial infarction.
Mol Biol Rep
43
11-6
2016
Homo sapiens
Quintana-Villamandos, B; Delgado-Baeza, E
Does the ADMA/DDAH/NO pathway modulate early regression of left ventricular hypertrophy with esmolol?
Med Hypotheses
87
44-7
2016
Homo sapiens, Rattus
Kuang, DB; Zhou, JP; Yu, LY; Zeng, WJ; Xiao, J; Zhu, GZ; Zhang, ZL; Chen, XP
DDAH1-V3 transcript might act as miR-21 sponge to maintain balance of DDAH1-V1 in cultured HUVECs.
Nitric Oxide
60
59-68
2016
Homo sapiens
Schardon, CL; Tuley, A; Er, JAV; Swartzel, JC; Fast, W
Selective Covalent Protein Modification by 4-Halopyridines through Catalysis.
Chembiochem
18
1551-1556
2017
Homo sapiens
Yokoro, M; Nakayama, Y; Yamagishi, SI; Ando, R; Sugiyama, M; Ito, S; Yano, J; Taguchi, K; Kaida, Y; Saigusa, D; Kimoto, M; Abe, T; Ueda, S; Fukami, K
Asymmetric Dimethylarginine Contributes to the Impaired Response to Erythropoietin in CKD-Anemia.
J Am Soc Nephrol
28
2670-2680
2017
Mus sp.
Winkler, MS; Kluge, S; Holzmann, M; Moritz, E; Robbe, L; Bauer, A; Zahrte, C; Priefler, M; Schwedhelm, E; Böger, RH; Goetz, AE; Nierhaus, A; Zoellner, C
Markers of nitric oxide are associated with sepsis severity: an observational study.
Crit Care
21
189
2017
Homo sapiens
Xu, X; Zhang, P; Kwak, D; Fassett, J; Yue, W; Atzler, D; Hu, X; Liu, X; Wang, H; Lu, Z; Guo, H; Schwedhelm, E; Böger, RH; Chen, P; Chen, Y
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Basic Res Cardiol
112
55
2017
Mus sp.
Liu, Z; Wang, J; Xing, W; Peng, Y; Huang, Y; Fan, X
Role of DDAH/ADMA pathway in TGF-?1-mediated activation of hepatic stellate cells.
Mol Med Rep
17
2549-2556
2018
Homo sapiens
Liu, YE; Tong, CC; Zhang, YB; Cong, PF; Shi, XY; Liu, Y; Shi, L; Tong, Z; Jin, HX; Hou, MX
Chitosan oligosaccharide ameliorates acute lung injury induced by blast injury through the DDAH1/ADMA pathway.
PLoS One
13
e0192135
2018
Mus musculus, Mus sp.
Magdy, YM; El-Kharashi, OA; El-Waseef, DAA; Nabih, ES; Abd El Samad, AA
Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy.
Exp Mol Pathol
105
293-310
2018
Rattus, Rattus norvegicus
Sun, GC; Wong, TY; Chen, HH; Ho, CY; Yeh, TC; Ho, WY; Tseng, CJ; Cheng, PW
Angiotensin II inhibits DDAH1-nNOS signaling via AT1R and ?OR dimerization to modulate blood pressure control in the central nervous system.
Clin Sci (Lond)
133
2401-2413
2019
Rattus
Li, S; Xiang, W; Tian, J; Wang, H; Hu, S; Wang, K; Chen, L; Huang, C; Zhou, J
Bone Marrow-Derived Mesenchymal Stem Cells Differentially Affect Glioblastoma Cell Proliferation, Migration, and Invasion: A 2D-DIGE Proteomic Analysis.
Biomed Res Int
2021
4952876
2021
Avena sp.
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