Protein Variants | Comment | Organism |
---|---|---|
C249S | catalytically inactive | Pseudomonas aeruginosa |
C249S | active-site Cys249 residue | Pseudomonas aeruginosa |
H162G | catalytically inactive | Pseudomonas aeruginosa |
H162G | mutation of the active-site histidine residue | Pseudomonas aeruginosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetamide | pH dependent DDAH inactivation, addition of 2.5 mM NG-methyl-L-arginine at pH 8.5 can prevent inactivation by idoacetamide, inactivation may be due to modification at the active site of DDAH, inactivation increases at higher pH values | Pseudomonas aeruginosa | |
L-lysine | competitive inhibitor; potential competitive inhibitor | Pseudomonas aeruginosa | |
Zinc acetate | - |
Pseudomonas aeruginosa | |
Zn2+ | - |
Pseudomonas aeruginosa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.026 | - |
S-methyl-L-thiocitrulline | at pH 8.0 | Pseudomonas aeruginosa | |
0.039 | - |
NG,NG-dimethyl-L-arginine | at pH 8.0 | Pseudomonas aeruginosa | |
0.044 | - |
NG-methyl-L-arginine | at pH 8.0 | Pseudomonas aeruginosa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30420 | - |
mass spectrometry, mutant H162G | Pseudomonas aeruginosa |
30500 | - |
electrospray ionization mass spectrometry | Pseudomonas aeruginosa |
30500 | - |
mass spectrometry, wilde type DDAH | Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Pseudomonas aeruginosa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NG,NG-dimethyl-L-arginine + H2O | - |
Pseudomonas aeruginosa | dimethylamine + L-citrulline | - |
? | |
NG,NG-dimethyl-L-arginine + H2O | - |
Pseudomonas aeruginosa | L-citrulline + dimethylamine | - |
? | |
NG-methyl-L-arginine + H2O | - |
Pseudomonas aeruginosa | L-citrulline + methylamine | - |
? | |
S-methyl-L-thiocitrulline + H2O | - |
Pseudomonas aeruginosa | methanethiol + L-citrulline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DDAH | - |
Pseudomonas aeruginosa |
dimethylarginine dimethylaminohydrolase | - |
Pseudomonas aeruginosa |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.59 | - |
NG-methyl-L-arginine | at pH 8.0 | Pseudomonas aeruginosa | |
1.27 | - |
NG,NG-dimethyl-L-arginine | at pH 8.0 | Pseudomonas aeruginosa | |
1.3 | - |
S-methyl-L-thiocitrulline | at pH 8.0 | Pseudomonas aeruginosa |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 9.5 | - |
Pseudomonas aeruginosa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.4 | - |
L-lysine | at pH 7.3 | Pseudomonas aeruginosa | |
4 | - |
L-lysine | at pH 7.3 | Pseudomonas aeruginosa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0088 | - |
- |
Pseudomonas aeruginosa | Zinc acetate |