Cloned (Comment) | Organism |
---|---|
expressed in Mus musculus | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Nomega,Nomega'-dimethyl-L-arginine + H2O | Homo sapiens | - |
dimethylamine + L-citrulline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O94760 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Nomega,Nomega'-dimethyl-L-arginine + H2O | - |
Homo sapiens | dimethylamine + L-citrulline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DDAH1 | - |
Homo sapiens |
dimethylarginine dimethylaminohydrolase1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | human DDAH1 overexpression does not protect against hypertension-induced cardiac fibrosis and hypertrophy. In addition, the hypertension-induced impairment of the endothelium-dependent vasorelaxation of aortic segments ex vivo is not significantly attenuated by DDAH1 overexpression. However, human DDAH1 overexpressing mice display an attenuated hypertensive inflammatory response in renal tissue, resulting in less hypertensive renal injury | Homo sapiens |