Information on EC 3.5.1.14 - N-acyl-aliphatic-L-amino acid amidohydrolase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY
3.5.1.14
-
RECOMMENDED NAME
GeneOntology No.
N-acyl-aliphatic-L-amino acid amidohydrolase
PATHWAY
KEGG Link
MetaCyc Link
Arginine and proline metabolism
-
Biosynthesis of secondary metabolites
-
Metabolic pathways
-
SYSTEMATIC NAME
IUBMB Comments
N-acyl-aliphatic-L-amino acid amidohydrolase (carboxylate-forming)
Contains Zn2+. The enzyme is found in animals and is involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). It acts on mercapturic acids (S-conjugates of N-acetyl-L-cysteine) and neutral aliphatic N-acyl-alpha-amino acids. Some bacterial aminoacylases demonstrate substrate specificity of both EC 3.5.1.14 and EC 3.5.1.114. cf. EC 3.5.1.15, aspartoacylase and EC 3.5.1.114, N-acyl-aromatic-L-amino acid amidohydrolase.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
AAIII
Q99JW2
-
ACY 1a
Q6AYS7
-
ACY 1b
P37111
-
ACY-1A
Q6AYS7
-
Acy1
-
-
Acy1
-
-
Acy1
-
-
acylase
-
-
-
-
acylase 1
Q6AYS7
-
acylase 1
P37111
-
acylase I
-
-
-
-
alpha-N-acylaminoacid hydrolase
-
-
-
-
amido acid deacylase
-
-
-
-
aminoacylase
G8EJ32
-
aminoacylase 1
-
-
aminoacylase 1
-
-
aminoacylase 1
Q6AYS7
-
aminoacylase 1
P37111
-
aminoacylase 1a
Q6AYS7
-
aminoacylase 3
-
-
aminoacylase 3
-
-
aminoacylase I
-
-
-
-
aminoacylase I
-
-
aminoacylase-1
-
-
aminoacylase-1A
Q6AYS7
-
aminoacylase-1B
P37111
-
benzamidase
-
-
-
-
D-AAse
-
-
D-Aminoacylase
-
-
dehydropeptidase II
-
-
-
-
fungus aminoacylase-1
-
-
hAcy1
-
-
hAcy1
Q03154
-
hippurase
-
-
-
-
hippuricase
-
-
-
-
histozyme
-
-
-
-
hog intestinal acylase I
-
-
hog kidney aminoacylase I
-
-
intestine acylase I
-
-
L-amido-acid acylase
-
-
-
-
L-aminoacylase
-
-
-
-
L-aminoacylase
-
-
lepidopteran aminoacylase 1
G8EJ32
-
long acyl amidoacylase
-
-
-
-
N-Acyl-D-aspartate amidohydrolase
-
-
N-acyl-L-amino acid amidohydrolase
P37111
-
N-acyl-L-amino acid hydrolase
-
-
N-acyl-L-amino acid hydrolase
P37111
-
N-acyl-L-amino-acid amidohydrolase
-
-
-
-
N-acyl-L-amino-acid amidohydrolase
Q6AYS7
-
N-acyl-L-amino-acid amidohydrolase
C9K2Z6
-
N-acyl-L-aminoacylase 1
P37111
-
N-acylase IA
-
-
N-formylmethionine deformylase
-
-
Nalpha-acyl-L-amino acid amidohydrolase
-
-
pAcy1
P37111
-
PhoACY
O58453
-
pig kidney aminoacylase
-
-
porcine kidney aminoacylase
-
-
short acyl amidoacylase
-
-
-
-
sphingosine kinase 1-interacting protein
-
-
additional information
-
the enzyme belongs to the M20 metallopeptidase family
additional information
Q6AYS7
the enzyme is a member of the metalloprotein family M20
additional information
C9K2Z6
the enzyme belongs to the peptidase M20 family
CAS REGISTRY NUMBER
COMMENTARY
9012-37-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
denitrificans DA181, M14; xylosoxydans subsp. xylosoxydans A-6
-
-
Manually annotated by BRENDA team
xylosoxydans subsp. xylosoxydans A-6
-
-
Manually annotated by BRENDA team
Aspergillus oryzae No.9
No.9
-
-
Manually annotated by BRENDA team
stearothermophilus
-
-
Manually annotated by BRENDA team
thermoglucosidicus, strain DSM 2542
-
-
Manually annotated by BRENDA team
Cercidium texanum
paloverde tree
-
-
Manually annotated by BRENDA team
Corynebacterium striatum AX20
strain Ax20
-
-
Manually annotated by BRENDA team
strain MG1363
-
-
Manually annotated by BRENDA team
Lactococcus lactis MG1363
strain MG1363
-
-
Manually annotated by BRENDA team
avium, smegmatis, phlei
-
-
Manually annotated by BRENDA team
no activity in Streptomyces olivaceus
-
-
-
Manually annotated by BRENDA team
no activity in Streptomyces olivaceus IFO 12805
-
-
-
Manually annotated by BRENDA team
strain SE83
-
-
Manually annotated by BRENDA team
Pyrococcus horikoshii OT-3
-
SwissProt
Manually annotated by BRENDA team
male Wistar rats
SwissProt
Manually annotated by BRENDA team
rat, male Sprague-Dawley
-
-
Manually annotated by BRENDA team
Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
Wistar rats, gene ACY1
SwissProt
Manually annotated by BRENDA team
gram-negative, motile, nonsporeforming rod-shaped bacterium, B1
-
-
Manually annotated by BRENDA team
i.e. Streptomyces luteoreticuli, strains NBRC/IFO 13819 and 13422
-
-
Manually annotated by BRENDA team
strain NBRC 13819; strain NBRC (IFO) 13819
UniProt
Manually annotated by BRENDA team
olivaeus 62 , tuirus
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Staphylococcus aureus (strain COL)