Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme expression silencing in HCT-116 cells using a small interfering RNA | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q03154 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | enzyme overexpression | Homo sapiens | - |
epithelial cell | neoplastic | Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
additional information | enzyme expression patterns in tumor cells, overview. No expression in stroma cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Acy1 | - |
Homo sapiens |
aminoacylase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of aminoacylase 1 is associated with colorectal cancer progression. Enzyme knockdown inhibits cell proliferation and causes cell cycle perturbation | Homo sapiens |
additional information | strong ACY1 immunoreactivity is an adverse prognostic indicator compared with combined negative and weak ACY 1 expression | Homo sapiens |
physiological function | the enzyme is responsible for amino acid deacylation during intracellular protein degradation, it is implicated in a number of human tumor types. Strong expression of the enzyme is significantly associated with more advanced TNM stage, lymph node metastasis, positive vascular invasion, and shorter cancer-specific survival | Homo sapiens |