Reference on EC 3.4.14.5 - dipeptidyl-peptidase IV and Organism(s) Rattus norvegicus and UniProt Accession P14740
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tiruppathi, C.; Miyamoto, Y.; Ganapathy, V.; Roesel, R.A.; Whitford, G.M.; Leibach, F.H.
Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains
J. Biol. Chem.
265
1476-1483
1990
Rattus norvegicus
Ogata, S.; Misumi, Y.; Ikehara, Y.
Primary structure of rat liver dipeptidyl peptidase IV deduced from its cDNA and identification of the NH2-terminal signal sequence as the membrane-anchoring domain
J. Biol. Chem.
264
3596-3601
1989
Rattus norvegicus
Reuter, W.; Hartel, S.; Hanski, C.; Huhle, T.; Zimmer, T.; Gossrau, R.
Biochemical properties of dipeptidyl peptidase IV in liver and hepatoma plasma membranes
Adv. Enzyme Regul.
28
253-269
1989
Rattus norvegicus
Hong, W.; Piazza, G.A.; Hixson, D.C.; Doyle, D.
Expression of enzymatically active rat dipeptidyl peptidase IV in Chinese hamster ovary cells after transfection
Biochemistry
28
8474-8479
1989
Rattus norvegicus
Piazza, G.A.; Callanan, H.M.; Mowery, J.; Hixson, D.C.
Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix
Biochem. J.
262
327-334
1989
Rattus norvegicus
Kikuchi, M.; Fukuyama, K.; Epstein, W.L.
Soluble dipeptidyl peptidase IV from terminal differentiated rat epidermal cells: purification and its activity on synthetic and natural peptides
Arch. Biochem. Biophys.
266
369-376
1988
Rattus norvegicus
Yamashita, K.; Tachibana, Y.; Matsuda, Y.; Katunuma, N.; Kochibe, N.; Kobata, A.
Comparative studies of the sugar chains of aminopeptidase N and dipeptidylpeptidase IV purified from rat kidney brush-border membrane
Biochemistry
27
5565-5573
1988
Rattus norvegicus
Hartel, S.; Hanski, C.; Kreisel, W.; Hoffmann, C.; Mauck, J.; Reutter, W.
Rapid purification of dipeptidyl peptidase IV from rat liver plasma membrane
Biochim. Biophys. Acta
924
543-547
1987
Rattus norvegicus
Hanski, C.; Zimmer, T.; Gossrau, R.; Reutter, W.
Increased activity of dipeptidyl peptidase IV in serum of hepatoma-bearing rats coincides with the loss of the enzyme from the hepatoma plasma membrane
Experientia
42
826-828
1986
Rattus norvegicus
Bartles, J.R.; Braiterman, L.T.; Hubbard, A.L.
Biochemical characterization of domain-specific glycoproteins of the rat hepatocyte plasma membrane
J. Biol. Chem.
260
12792-12802
1985
Rattus norvegicus
Umezawa, H.; Aoyagi, T.; Ogawa, K.; Naganawa, H.; Hamada, M.; Takeuchi, T.
Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria
J. Antibiot.
37
422-425
1984
Rattus norvegicus
Heins, J.; Neubert, K.; Barth, A.; Canizaro, P.C.; Behal, F.J.
Kinetic investigation of the hydrolysis of aminoacyl p-nitroanilides by dipeptidyl peptidase IV from human and pig kidney
Biochim. Biophys. Acta
785
30-35
1984
Homo sapiens, Rattus norvegicus, Sus scrofa
Miura, S.; Song, I.S.; Morita, A.; Erickson, R.H.; Kim, Y.S.
Distribution and biosynthesis of aminopeptidase N and dipeptidyl aminopeptidase IV in rat small intestine
Biochim. Biophys. Acta
761
66-75
1983
Rattus norvegicus
Erickson, R.H.; Bella, A.M.; Brophy, E.J.; Kobata, A.; Kim, Y.S.
Purification and molecular characterization of rat intestinal brush border membrane dipeptidyl aminopeptidase IV
Biochim. Biophys. Acta
756
258-265
1983
Rattus norvegicus
Bella, A.M.; Erickson, R.H.; Kim, Y.S.
Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV: kinetic properties and substrate specificities of the purified enzyme
Arch. Biochem. Biophys.
218
156-162
1982
Rattus norvegicus
Kyouden, T.; Himeno, M.; Ishikawa, T.; Ohsumi, Y.; Kato, K.
Purification and characterization of dipeptidyl peptidase IV in rat liver lysosomal membranes
J. Biochem.
111
770-777
1992
Rattus norvegicus
Volk, B.A.; Kreisel, W.; Kttgen, E.; Gerok, W.; Reutter, W.
Heterogeneous turnover of terminal and core sugars within the carbohydrate chain of dipeptidylaminopeptidase IV isolated from rat liver plasma membrane
FEBS Lett.
163
150-152
1983
Rattus norvegicus
Ikehara, Y.; Ogata, S.; Misumi, Y.
Dipeptidyl-peptidase IV from rat liver
Methods Enzymol.
244
215-227
1994
Rattus norvegicus
Cohen, M.; Fruitier-Arnaudin, I.; Piot, J.M.
Hemorphins: substrates and/or inhibitors of dipeptidyl peptidase IV. Hemorphins N-terminus sequence influence on the interaction between hemorphins and DPPIV
Biochimie
86
31-37
2004
Rattus norvegicus
Rosenblum, J.S.; Kozarich, J.W.
Prolyl peptidases: a serine protease subfamily with high potential for drug discovery
Curr. Opin. Chem. Biol.
7
496-504
2003
Homo sapiens, Mammalia, Mus musculus, Rattus norvegicus, Sus scrofa
Dobers, J.; Grams, S.; Reutter, W.; Fan, H.
Roles of cysteines in rat dipeptidyl peptidase IV/CD26 in processing and proteolytic activity
Eur. J. Biochem.
267
5093-5100
2000
no activity in Cricetulus griseus, Rattus norvegicus (P14740)
Ihara, T.; Tsujikawa, T.; Fujiyama, Y.; Ueyama, H.; Bamba, T.; Ohkubo, I.
Enhancement of brush border peptidase activity in rat jejunum during starvation
Int. Congr. Ser.
1218
389-393
2001
Rattus norvegicus
-
Longenecker, K.L.; Stewart, K.D.; Madar, D.J.; Jakob, C.G.; Fry, E.H.; Wilk, S.; Lin, C.W.; Ballaron, S.J.; Stashko, M.A.; Lubben, T.H.; Yong, H.; Pireh, D.; Pei, Z.; Basha, F.; Wiedeman, P.E.; von Geldern, T.W.; Trevillyan, J.M.; Stoll, V.S.
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors
Biochemistry
45
7474-7482
2006
Homo sapiens, Rattus norvegicus (P14740)
Abe, M.; Akiyama, T.; Umezawa, Y.; Yamamoto, K.; Nagai, M.; Yamazaki, H.; Ichikawa, Y.; Muraoka, Y.
Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem.
13
785-797
2005
Rattus norvegicus
Sakashita, H.; Akahoshi, F.; Kitajima, H.; Tsutsumiuchi, R.; Hayashi, Y.
[(S)-gamma-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors
Bioorg. Med. Chem.
14
3662-3671
2006
Homo sapiens, Rattus norvegicus
Kim, K.R.; Rhee, S.D.; Kim, H.Y.; Jung, W.H.; Yang, S.D.; Kim, S.S.; Ahn, J.H.; Cheon, H.G.
KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity
Eur. J. Pharmacol.
518
63-70
2005
Homo sapiens, Rattus norvegicus, Sus scrofa
Bilodeau, N.; Fiset, A.; Poirier, G.G.; Fortier, S.; Gingras, M.C.; Lavoie, J.N.; Faure, R.L.
Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src
FEBS J.
273
992-1003
2006
Rattus norvegicus (P14740)
Girardi, A.C.; Fukuda, L.E.; Rossoni, L.V.; Malnic, G.; Reboucas, N.A.
Dipeptidyl peptidase IV inhibition downregulates Na+ - H+ exchanger NHE3 in rat renal proximal tubule
Am. J. Physiol. Renal Physiol.
294
F414-F422
2008
Rattus norvegicus
Kondo, T.; Nekado, T.; Sugimoto, I.; Ochi, K.; Takai, S.; Kinoshita, A.; Tajima, Y.; Yamamoto, S.; Kawabata, K.; Nakai, H.; Toda, M.
Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration
Bioorg. Med. Chem.
15
2631-2650
2007
Homo sapiens, Rattus norvegicus
Kondo, T.; Sugimoto, I.; Nekado, T.; Ochi, K.; Ohtani, T.; Tajima, Y.; Yamamoto, S.; Kawabata, K.; Nakai, H.; Toda, M.
Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem.
15
2715-2735
2007
Homo sapiens, Rattus norvegicus
Sakashita, H.; Akahoshi, F.; Yoshida, T.; Kitajima, H.; Hayashi, Y.; Ishii, S.; Takashina, Y.; Tsutsumiuchi, R.; Ono, S.
Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors
Bioorg. Med. Chem.
15
641-655
2007
Rattus norvegicus, Homo sapiens (P27487)
Kondo, T.; Nekado, T.; Sugimoto, I.; Ochi, K.; Takai, S.; Kinoshita, A.; Hatayama, A.; Yamamoto, S.; Kawabata, K.; Nakai, H.; Toda, M.
Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem.
16
190-208
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Tsai, T.Y.; Coumar, M.S.; Hsu, T.; Hsieh, H.P.; Chien, C.H.; Chen, C.T.; Chang, C.N.; Lo, Y.K.; Wu, S.H.; Huang, C.Y.; Huang, Y.W.; Wang, M.H.; Wu, H.Y.; Lee, H.J.; Chen, X.; Chao, Y.S.; Jiaang, W.T.
Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
16
3268-3272
2006
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Kurukulasuriya, R.; Rohde, J.J.; Szczepankiewicz, B.G.; Basha, F.; Lai, C.; Jae, H.S.; Winn, M.; Stewart, K.D.; Longenecker, K.L.; Lubben, T.W.; Ballaron, S.J.; Sham, H.L.; von Geldern, T.W.
Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
16
6226-6230
2006
Homo sapiens, Rattus norvegicus (P14740)
Coumar, M.S.; Chang, C.N.; Chen, C.T.; Chen, X.; Chien, C.H.; Tsai, T.Y.; Cheng, J.H.; Wu, H.Y.; Han, C.H.; Wu, S.H.; Huang, Y.W.; Hsu, T.; Hsu, L.J.; Chao, Y.S.; Hsieh, H.P.; Jiaang, W.T.
3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes
Bioorg. Med. Chem. Lett.
17
1274-1279
2007
Rattus norvegicus
Backes, B.J.; Longenecker, K.; Hamilton, G.L.; Stewart, K.; Lai, C.; Kopecka, H.; von Geldern, T.W.; Madar, D.J.; Pei, Z.; Lubben, T.H.; Zinker, B.A.; Tian, Z.; Ballaron, S.J.; Stashko, M.A.; Mika, A.K.; Beno, D.W.; Kempf-Grote, A.J.; Black-Schaefer, C.; Sham, H.L.; Trevillyan, J.M.
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
Bioorg. Med. Chem. Lett.
17
2005-2012
2007
Rattus norvegicus (P14740), Homo sapiens (P27487)
Yoshida, T.; Sakashita, H.; Akahoshi, F.; Hayashi, Y.
[(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors
Bioorg. Med. Chem. Lett.
17
2618-2621
2007
Homo sapiens, Rattus norvegicus
Kim, D.; Kowalchick, J.E.; Edmondson, S.D.; Mastracchio, A.; Xu, J.; Eiermann, G.J.; Leiting, B.; Wu, J.K.; Pryor, K.D.; Patel, R.A.; He, H.; Lyons, K.A.; Thornberry, N.A.; Weber, A.E.
Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate)
Bioorg. Med. Chem. Lett.
17
3373-3377
2007
Rattus norvegicus
Biftu, T.; Scapin, G.; Singh, S.; Feng, D.; Becker, J.W.; Eiermann, G.; He, H.; Lyons, K.; Patel, S.; Petrov, A.; Sinha-Roy, R.; Zhang, B.; Wu, J.; Zhang, X.; Doss, G.A.; Thornberry, N.A.; Weber, A.E.
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin
Bioorg. Med. Chem. Lett.
17
3384-3387
2007
Canis lupus familiaris, Macaca mulatta, Rattus norvegicus
Koo, K.D.; Kim, M.J.; Kim, S.; Kim, K.H.; Hong, S.Y.; Hur, G.C.; Yim, H.J.; Kim, G.T.; Han, H.O.; Kwon, O.H.; Kwon, T.S.; Koh, J.S.; Lee, C.S.
Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones
Bioorg. Med. Chem. Lett.
17
4167-4172
2007
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Biftu, T.; Feng, D.; Qian, X.; Liang, G.B.; Kieczykowski, G.; Eiermann, G.; He, H.; Leiting, B.; Lyons, K.; Petrov, A.; Sinha-Roy, R.; Zhang, B.; Scapin, G.; Patel, S.; Gao, Y.D.; Singh, S.; Wu, J.; Zhang, X.; Thornberry, N.A.; Weber, A.E.
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg. Med. Chem. Lett.
17
49-52
2007
Canis lupus familiaris, Mus musculus, Rattus norvegicus
Chen, P.; Caldwell, C.G.; Mathvink, R.J.; Leiting, B.; Marsilio, F.; Patel, R.A.; Wu, J.K.; He, H.; Lyons, K.A.; Thornberry, N.A.; Weber, A.E.
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes
Bioorg. Med. Chem. Lett.
17
5853-5857
2007
Rattus norvegicus
Corbett, J.W.; Dirico, K.; Song, W.; Boscoe, B.P.; Doran, S.D.; Boyer, D.; Qiu, X.; Ammirati, M.; Vanvolkenburg, M.A.; McPherson, R.K.; Parker, J.C.; Cox, E.D.
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors
Bioorg. Med. Chem. Lett.
17
6707-6713
2007
Rattus norvegicus, Homo sapiens (P27487), Homo sapiens
Edmondson, S.D.; Wei, L.; Xu, J.; Shang, J.; Xu, S.; Pang, J.; Chaudhary, A.; Dean, D.C.; He, H.; Leiting, B.; Lyons, K.A.; Patel, R.A.; Patel, S.B.; Scapin, G.; Wu, J.K.; Beconi, M.G.; Thornberry, N.A.; Weber, A.E.
Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
18
2409-2413
2008
Rattus norvegicus
Jackson, E.K.; Dubinion, J.H.; Mi, Z.
Effects of dipeptidyl peptidase iv inhibition on arterial blood pressure
Clin. Exp. Pharmacol. Physiol.
35
29-34
2008
Rattus norvegicus
Raun, K.; von Voss, P.; Gotfredsen, C.F.; Golozoubova, V.; Rolin, B.; Knudsen, L.B.
Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not
Diabetes
56
8-15
2007
Rattus norvegicus
Drucker, D.J.
Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action
Diabetes Care
30
1335-1343
2007
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
McKennon, S.A.; Campbell, R.K.
The physiology of incretin hormones and the basis for DPP-4 inhibitors
Diabetes Educ.
33
55-66
2007
Homo sapiens, Rattus norvegicus
Augstein, P.; Berg, S.; Heinke, P.; Altmann, S.; Salzsieder, E.; Demuth, H.U.; Freyse, E.J.
Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance
Diabetes Obes. Metab.
10
850-861
2008
Rattus norvegicus
Beconi, M.G.; Reed, J.R.; Teffera, Y.; Xia, Y.Q.; Kochansky, C.J.; Liu, D.Q.; Xu, S.; Elmore, C.S.; Ciccotto, S.; Hora, D.F.; Stearns, R.A.; Vincent, S.H.
Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs
Drug Metab. Dispos.
35
525-532
2007
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Green, B.D.; Flatt, P.R.; Bailey, C.J.
Inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes
Expert. Opin. Emerg. Drugs
11
525-539
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Byrd, J.B.; Shreevatsa, A.; Putlur, P.; Foretia, D.; McAlexander, L.; Sinha, T.; Does, M.D.; Brown, N.J.
Dipeptidyl peptidase IV deficiency increases susceptibility to angiotensin-converting enzyme inhibitor-induced peritracheal edema
J. Allergy Clin. Immunol.
120
403-408
2007
Rattus norvegicus
Zhai, W.; Cardell, M.; De Meester, I.; Augustyns, K.; Hillinger, S.; Inci, I.; Arni, S.; Jungraithmayr, W.; Scharpe, S.; Weder, W.; Korom, S.
Intragraft DPP IV inhibition attenuates post-transplant pulmonary ischemia/reperfusion injury after extended ischemia
J. Heart Lung Transplant.
26
174-180
2007
Rattus norvegicus
Madar, D.J.; Kopecka, H.; Pireh, D.; Yong, H.; Pei, Z.; Li, X.; Wiedeman, P.E.; Djuric, S.W.; Von Geldern, T.W.; Fickes, M.G.; Bhagavatula, L.; McDermott, T.; Wittenberger, S.; Richards, S.J.; Longenecker, K.L.; Stewart, K.D.; Lubben, T.H.; Ballaron, S.J.; Stashko, M.A.; Long, M.A.; Wells, H.; Zinker, B.A.
Discovery of (2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes
J. Med. Chem.
49
6416-6420
2006
Canis lupus familiaris, Rattus norvegicus, Homo sapiens (P27487)
Feng, J.; Zhang, Z.; Wallace, M.B.; Stafford, J.A.; Kaldor, S.W.; Kassel, D.B.; Navre, M.; Shi, L.; Skene, R.J.; Asakawa, T.; Takeuchi, K.; Xu, R.; Webb, D.R.; Gwaltney, S.L.
Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV
J. Med. Chem.
50
2297-2300
2007
Rattus norvegicus
Eckhardt, M.; Langkopf, E.; Mark, M.; Tadayyon, M.; Thomas, L.; Nar, H.; Pfrengle, W.; Guth, B.; Lotz, R.; Sieger, P.; Fuchs, H.; Himmelsbach, F.
8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes
J. Med. Chem.
50
6450-6453
2007
Canis lupus familiaris, Macaca mulatta, Rattus norvegicus, Homo sapiens (P27487)
Kim, D.; Kowalchick, J.E.; Brockunier, L.L.; Parmee, E.R.; Eiermann, G.J.; Fisher, M.H.; He, H.; Leiting, B.; Lyons, K.; Scapin, G.; Patel, S.B.; Petrov, A.; Pryor, K.D.; Roy, R.S.; Wu, J.K.; Zhang, X.; Wyvratt, M.J.; Zhang, B.B.; Zhu, L.; Thornberry, N.A.; Weber, A.E.
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines
J. Med. Chem.
51
589-602
2008
Rattus norvegicus
Yamazaki, K.; Yasuda, N.; Inoue, T.; Yamamoto, E.; Sugaya, Y.; Nagakura, T.; Shinoda, M.; Clark, R.; Saeki, T.; Tanaka, I.
Effects of the combination of a dipeptidyl peptidase IV inhibitor and an insulin secretagogue on glucose and insulin levels in mice and rats
J. Pharmacol. Exp. Ther.
320
738-746
2007
Mus musculus, Rattus norvegicus
Jackson, E.K.; Zhang, M.; Liu, W.; Mi, Z.
Inhibition of renal dipeptidyl peptidase IV enhances peptide YY1-36-induced potentiation of angiotensin II-mediated renal vasoconstriction in spontaneously hypertensive rats
J. Pharmacol. Exp. Ther.
323
431-437
2007
Rattus norvegicus
Zhai, W.; Cardell, M.; De Meester, I.; Augustyns, K.; Hillinger, S.; Inci, I.; Arni, S.; Jungraithmayr, W.; Scharpe, S.; Weder, W.; Korom, S.
Ischemia/reperfusion injury: The role of CD26/dipeptidyl-peptidase-IV-inhibition in lung transplantation
Transplant. Proc.
38
3369-3371
2006
Rattus norvegicus
Matsuyama-Yokono, A.; Tahara, A.; Nakano, R.; Someya, Y.; Nagase, I.; Hayakawa, M.; Shibasaki, M.
ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity
Biochem. Pharmacol.
76
98-107
2008
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Jost, M.M.; Lamerz, J.; Tammen, H.; Menzel, C.; De Meester, I.; Lambeir, A.M.; Augustyns, K.; Scharpe, S.; Zucht, H.D.; Rose, H.; Juergens, M.; Schulz-Knappe, P.; Budde, P.
In vivo profiling of DPP4 inhibitors reveals alterations in collagen metabolism and accumulation of an amyloid peptide in rat plasma
Biochem. Pharmacol.
77
228-237
2009
Homo sapiens, Rattus norvegicus
Eckhardt, M.; Hauel, N.; Himmelsbach, F.; Langkopf, E.; Nar, H.; Mark, M.; Tadayyon, M.; Thomas, L.; Guth, B.; Lotz, R.
3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors
Bioorg. Med. Chem. Lett.
18
3158-3162
2008
Homo sapiens, Rattus norvegicus
Tsai, T.Y.; Hsu, T.; Chen, C.T.; Cheng, J.H.; Chiou, M.C.; Huang, C.H.; Tseng, Y.J.; Yeh, T.K.; Huang, C.Y.; Yeh, K.C.; Huang, Y.W.; Wu, S.H.; Wang, M.H.; Chen, X.; Chao, Y.S.; Jiaang, W.T.
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
19
1908-1912
2009
Rattus norvegicus
Tsai, T.Y.; Hsu, T.; Chen, C.T.; Cheng, J.H.; Yeh, T.K.; Chen, X.; Huang, C.Y.; Chang, C.N.; Yeh, K.C.; Hsieh, S.H.; Chien, C.H.; Chang, Y.W.; Huang, C.H.; Huang, Y.W.; Huang, C.L.; Wu, S.H.; Wang, M.H.; Lu, C.T.; Chao, Y.S.; Jiaang, W.T.
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem.
17
2388-2399
2009
Rattus norvegicus
Lee, B.; Shi, L.; Kassel, D.B.; Asakawa, T.; Takeuchi, K.; Christopher, R.J.
Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys
Eur. J. Pharmacol.
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Canis lupus familiaris, Macaca fascicularis, Homo sapiens, Rattus norvegicus
Forssmann, U.; Stoetzer, C.; Stephan, M.; Kruschinski, C.; Skripuletz, T.; Schade, J.; Schmiedl, A.; Pabst, R.; Wagner, L.; Hoffmann, T.; Kehlen, A.; Escher, S.E.; Forssmann, W.G.; Elsner, J.; von Hoersten, S.
Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo
J. Immunol.
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Homo sapiens, Rattus norvegicus
Connolly, B.A.; Sanford, D.G.; Chiluwal, A.K.; Healey, S.E.; Peters, D.E.; Dimare, M.T.; Wu, W.; Liu, Y.; Maw, H.; Zhou, Y.; Li, Y.; Jin, Z.; Sudmeier, J.L.; Lai, J.H.; Bachovchin, W.W.
Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety
J. Med. Chem.
51
6005-6013
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Homo sapiens, Mus musculus, Rattus norvegicus
Fuchs, H.; Tillement, J.P.; Urien, S.; Greischel, A.; Roth, W.
Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans
J. Pharm. Pharmacol.
61
55-62
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Thomas, L.; Eckhardt, M.; Langkopf, E.; Tadayyon, M.; Himmelsbach, F.; Mark, M.
(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with oth
J. Pharmacol. Exp. Ther.
325
175-182
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Michel, M.C.; Fliers, E.; Van Noorden, C.J.
Dipeptidyl peptidase IV inhibitors in diabetes: more than inhibition of glucagon-like peptide-1 metabolism?
Naunyn Schmiedebergs Arch. Pharmacol.
377
205-207
2008
Rattus norvegicus
Kirino, Y.; Kamimoto, T.; Sato, Y.; Kawazoe, K.; Minakuchi, K.; Nakahori, Y.
Increased plasma dipeptidyl peptidase IV (DPP IV) activity and decreased DPP IV activity of visceral but not subcutaneous adipose tissue in impaired glucose tolerance rats induced by high-fat or high-sucrose diet
Biol. Pharm. Bull.
32
463-467
2009
Rattus norvegicus
Nordhoff, S.; Cerezo-Galvez, S.; Deppe, H.; Hill, O.; Lopez-Canet, M.; Rummey, C.; Thiemann, M.; Matassa, V.G.; Edwards, P.J.; Feurer, A.
Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
19
4201-4203
2009
Rattus norvegicus
Gupta, R.C.; Chhipa, L.; Mandhare, A.B.; Zambad, S.P.; Chauthaiwale, V.; Nadkarni, S.S.; Dutt, C.
Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor
Bioorg. Med. Chem. Lett.
19
5021-5025
2009
Rattus norvegicus
Yeh, T.K.; Tsai, T.Y.; Hsu, T.; Cheng, J.H.; Chen, X.; Song, J.S.; Shy, H.S.; Chiou, M.C.; Chien, C.H.; Tseng, Y.J.; Huang, C.Y.; Yeh, K.C.; Huang, Y.L.; Huang, C.H.; Huang, Y.W.; Wang, M.H.; Tang, H.K.; Chao, Y.S.; Chen, C.T.; Jiaang, W.T.
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
20
3596-3600
2010
Homo sapiens, Rattus norvegicus
Krupina, N.A.; Kushnareva, E.Y.; Khlebnikova, N.N.; Zolotov, N.N.; Kryzhanovskii, G.N.
Behavioral changes in rats induced by a dipeptidyl peptidase IV inhibitor methionyl-2(S)-cyanopyrrolidine: experimental model of anxiety-depression disorder
Bull. Exp. Biol. Med.
147
285-290
2009
Rattus norvegicus
Luft, V.C.; Schmidt, M.I.; Pankow, J.S.; Hoogeveen, R.C.; Couper, D.; Heiss, G.; Duncan, B.B.; Duncan, B.B.
Dipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study
Diabetes Care
33
1109-1111
2010
Rattus norvegicus
Kiraly, K.; Szalay, B.; Szalai, J.; Barna, I.; Gyires, K.; Verbeken, M.; Ronai, A.Z.
Intrathecally injected Ile-Pro-Ile, an inhibitor of membrane ectoenzyme dipeptidyl peptidase IV, is antihyperalgesic in rats by switching the enzyme from hydrolase to synthase functional mode to generate endomorphin 2
Eur. J. Pharmacol.
620
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2009
Rattus norvegicus
Hung, T.T.; Wu, J.Y.; Liu, J.F.; Cheng, H.C.
Epitope analysis of the rat dipeptidyl peptidase IV monoclonal antibody 6A3 that blocks pericellular fibronectin-mediated cancer cell adhesion
FEBS J.
276
6548-6559
2009
Rattus norvegicus (P14740)
Kirino, Y.; Sato, Y.; Kamimoto, T.; Kawazoe, K.; Minakuchi, K.; Nakahori, Y.
Interrelationship of dipeptidyl peptidase IV (DPP4) with the development of diabetes, dyslipidaemia and nephropathy: A streptozotocin-induced model using wild-type and DPP4-deficient rats
J. Endocrinol.
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53-61
2009
Rattus norvegicus
Alponti, R.F.; Frezzatti, R.; Barone, J.M.; Alegre, V.D.; Silveira, P.F.
Dipeptidyl peptidase IV in the hypothalamus and hippocampus of monosodium glutamate obese and food-deprived rats
Metab. Clin. Exp.
60
234-242
2011
Rattus norvegicus (P14740)
Arscott, W.; LaBauve, A.; May, V.; Wesley, U.
Suppression of neuroblastoma growth by dipeptidyl peptidase IV: Relevance of chemokine regulation and caspase activation
Oncogene
28
479-491
2009
Rattus norvegicus
Ikuma, Y.; Hochigai, H.; Kimura, H.; Nunami, N.; Kobayashi, T.; Uchiyama, K.; Umezome, T.; Sakurai, Y.; Sawada, N.; Tadano, J.; Sugaru, E.; Ono, M.; Hirose, Y.; Nakahira, H.
Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: Use of a carboxylate prodrug to improve bioavailability
Bioorg. Med. Chem.
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779-790
2015
Rattus norvegicus
Gomez, H.; Chappe, M.; Valiente, P.A.; Pons, T.; Chavez, M.d.e..L.; Charli, J.L.; Pascual, I.
Effect of zinc and calcium ions on the rat kidney membrane-bound form of dipeptidyl peptidase IV
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461-469
2013
Rattus norvegicus
Rhnert, P.; Schmidt, W.; Emmerlich, P.; Goihl, A.; Wrenger, S.; Bank, U.; Nordhoff, K.; Tger, M.; Ansorge, S.; Reinhold, D.; Striggow, F.
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia
J. Neuroinflammation
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44
2012
Rattus norvegicus
