Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.14.5 extracted from

  • Feng, J.; Zhang, Z.; Wallace, M.B.; Stafford, J.A.; Kaldor, S.W.; Kassel, D.B.; Navre, M.; Shi, L.; Skene, R.J.; Asakawa, T.; Takeuchi, K.; Xu, R.; Webb, D.R.; Gwaltney, S.L.
    Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV (2007), J. Med. Chem., 50, 2297-2300.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
2-([2-[(3R)-3-aminopiperidin-1-yl]-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-5-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-6,7-dimethoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-6,8-dichloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-chloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-methoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-7-chloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-7-fluoro-6-methoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-8-chloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3R)-3-aminopiperidin-1-yl]-8-methoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
2-([2-[(3S)-3-aminopiperidin-1-yl]-6-fluoro-7-morpholin-4-yl-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Rattus norvegicus
alogliptin potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
 Rattus norvegicus
DPP-4
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000004
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000004
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-7-fluoro-6-methoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000005
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000005
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-5-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000005
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-6-chloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000008
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-6-methoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000013
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000013
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-6,8-dichloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000015
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-7-chloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000018
-
-
 Rattus norvegicus 2-([2-[(3S)-3-aminopiperidin-1-yl]-6-fluoro-7-morpholin-4-yl-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000019
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-6,7-dimethoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000029
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-8-chloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.00003
-
-
 Rattus norvegicus 2-([2-[(3R)-3-aminopiperidin-1-yl]-8-methoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile