Inhibitors | Comment | Organism | Structure |
---|---|---|---|
isoleucine thiazolidide | i.e. P32/98. Enhancement of incretin with the DPP-4 inhibitor P32/98 has therapeutic effects in hyperinsulinaemia, hyperglycaemia and impaired glucose toleranceIGT in Zucker rats with incipient impaired glucose tolerance and manifest impaired glucose tolerance. Apparently, administration of P32/98 in Zucker rats with incipient impaired glucose tolerance results in more efficient beta-cell function, which is associated with less need for insulin to cope with deterioration of glucose tolerance. P32/98 has a strong effect on dyslipidaemia in manifest impaired glucose tolerance. P32/98 has no side effect on intestinal growth. Daily intake of P32/98 is a promising strategy for treatment of glucose intolerance and has the potential to prevent type 2 diabetes | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Zucker rats | - |
Synonyms | Comment | Organism |
---|---|---|
DPP-4 | - |
Rattus norvegicus |