Literature summary for 3.4.14.5 extracted from

Ikuma, Y.; Hochigai, H.; Kimura, H.; Nunami, N.; Kobayashi, T.; Uchiyama, K.; Umezome, T.; Sakurai, Y.; Sawada, N.; Tadano, J.; Sugaru, E.; Ono, M.; Hirose, Y.; Nakahira, H.
Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: Use of a carboxylate prodrug to improve bioavailability (2015), Bioorg. Med. Chem., 23, 779-790.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-[(3R)-3-aminopiperidin-1-yl]-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylate	compound shows significantly high oral absorption and potent dipeptidyl peptidase IV inhibition in vivo and decreased Zucker fatty rats glucose levels in the oral glucose tolerance test	Rattus norvegicus
3H-imidazo[4,5-c]quinolin-4(5H)-one	inhibitor with potent dipeptidyl peptidase IV inhibitory activity that shows poor oral absorption can be improved by esterification of the carboxylic acid moiety	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

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Release 2023.1 (January 2023)