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Literature summary for 3.4.14.5 extracted from

  • Röhnert, P.; Schmidt, W.; Emmerlich, P.; Goihl, A.; Wrenger, S.; Bank, U.; Nordhoff, K.; Täger, M.; Ansorge, S.; Reinhold, D.; Striggow, F.
    Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia (2012), J. Neuroinflammation, 9, 44.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine mRNA expression in ipsilateral and contralateral cortices. At day 3 post-ischemia, dipeptidyl peptidase IV, 8 and aminopeptidase N are identified in activated microglia and macrophages in the ipsilateral cortex. Seven days post artery occlusion, dipeptidyl peptidase IV immunoreactivity is found in the perikarya of surviving cortical neurons of the ipsilateral hemisphere. At the same time point, dipeptidyl peptidase IV, 8 and aminopeptidase N are targeted in astroglial cells. Total dipeptidyl peptidase IV, 8 and 9 activities remain constant in both hemispheres until day 3 post experimental ischemia, but are increased to 165% in the ipsilateral cortex at day 7. Dipeptidyl peptidase II and aminopeptidase N are up-regulated ipsilaterally from 6 h to 7 days post ischemia. IPC1755, a non-selective protease inhibitor, reveals a significant reduction of cortical lesions after transient cerebral ischemia Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
cerebellar cortex mRNA expression in ipsilateral and contralateral cortices. At day 3 post-ischemia, dipeptidyl peptidase IV, 8 and aminopeptidase N are identified in activated microglia and macrophages in the ipsilateral cortex. Seven days post artery occlusion, dipeptidyl peptidase IV immunoreactivity is found in the perikarya of surviving cortical neurons of the ipsilateral hemisphere. At the same time point, dipeptidyl peptidase IV, 8 and aminopeptidase N are targeted in astroglial cells. Total dipeptidyl peptidase IV, 8 and 9 activities remain constant in both hemispheres until day 3 post experimental ischemia, but are increased to 165% in the ipsilateral cortex at day 7 Rattus norvegicus
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