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Literature summary for 3.4.14.5 extracted from
- Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action (2007), Diabetes Care, 30, 1335-1343.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Syrrx106124 | acutely lowers blood glucose and enhances glucose-stimulated insulin secretion in wild-type mice and in mice with targeted disruption of single incretin receptors | Mus musculus |  |
| TP8211 | acutely lowers blood glucose and enhances glucose-stimulated insulin secretion in wild-type mice and in mice with targeted disruption of single incretin receptors | Mus musculus | |
| valine pyrrolidide | - |
Sus scrofa | |
| vildagliptin | acutely lowers blood glucose and enhances glucose-stimulated insulin secretion in wild-type mice and in mice with targeted disruption of single incretin receptors | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | DPP-4 is an important determinant of incretin inactivation | ? | - |
? | |
| additional information | Mus musculus | DPP-4 plays a role in the control of immune function, inflammatory responses, and behavior | ? | - |
? | |
| additional information | Rattus norvegicus | DPP-4 plays a role in the control of immune function, inflammatory responses, and behavior | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| nose | levels of tissue DPP-4 are reduced in nasal tissue of human subjects with chronic rhinosinusitis | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucagon-like peptide-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| glucagon-like peptide-1 + H2O | - |
Sus scrofa | ? | - |
? | |
| glucose-dependent insulinotropic polypeptide + H2O | - |
Homo sapiens | ? | - |
? | |
| glucose-dependent insulinotropic polypeptide + H2O | - |
Sus scrofa | ? | - |
? | |
| additional information | DPP-4 is an important determinant of incretin inactivation | Homo sapiens | ? | - |
? | |
| additional information | DPP-4 plays a role in the control of immune function, inflammatory responses, and behavior | Mus musculus | ? | - |
? | |
| additional information | DPP-4 plays a role in the control of immune function, inflammatory responses, and behavior | Rattus norvegicus | ? | - |
? | |
| Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DPP-4 | - |
Mus musculus |
| DPP-4 | - |
Homo sapiens |
| DPP-4 | - |
Rattus norvegicus |
| DPP-4 | - |
Sus scrofa |
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