Literature summary for 3.4.14.5 extracted from

Longenecker, K.L.; Stewart, K.D.; Madar, D.J.; Jakob, C.G.; Fry, E.H.; Wilk, S.; Lin, C.W.; Ballaron, S.J.; Stashko, M.A.; Lubben, T.H.; Yong, H.; Pireh, D.; Pei, Z.; Basha, F.; Wiedeman, P.E.; von Geldern, T.W.; Trevillyan, J.M.; Stoll, V.S.
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors (2006), Biochemistry, 45, 7474-7482.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
vapor diffusion method, 2.8 A resolution	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
(1R,3S)-2-[(2S)-2-amino-2-cyclopentylacetyl]-3-ethynylcyclopentanecarbonitrile	-	Homo sapiens
(1R,3S)-2-[(2S)-2-amino-2-cyclopentylacetyl]-3-ethynylcyclopentanecarbonitrile	-	Rattus norvegicus
(2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile	-	Homo sapiens
(2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile	-	Rattus norvegicus
(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile	-	Homo sapiens
(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile	-	Rattus norvegicus
2-([8-(3-aminopiperidin-1-yl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl)benzonitrile	-	Homo sapiens
2-([8-(3-aminopiperidin-1-yl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl)benzonitrile	-	Rattus norvegicus
additional information	conformational flexibility of tyr548 is unique among protein family members and may be utilized in drug design to achieve peptidase selectivity	Homo sapiens
additional information	conformational flexibility of tyr548 is unique among protein family members and may be utilized in drug design to achieve peptidase selectivity	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	P14740	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
CD26	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000001	-	(2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile	-	Rattus norvegicus
0.000001	-	2-([8-(3-aminopiperidin-1-yl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl)benzonitrile	-	Homo sapiens
0.000002	-	(2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile	-	Homo sapiens
0.000003	-	2-([8-(3-aminopiperidin-1-yl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl)benzonitrile	-	Rattus norvegicus
0.000008	-	(1R,3S)-2-[(2S)-2-amino-2-cyclopentylacetyl]-3-ethynylcyclopentanecarbonitrile	-	Homo sapiens
0.000012	-	(1R,3S)-2-[(2S)-2-amino-2-cyclopentylacetyl]-3-ethynylcyclopentanecarbonitrile	-	Rattus norvegicus
0.00003	-	(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile	-	Homo sapiens
0.000056	-	(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile	-	Rattus norvegicus

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Release 2023.1 (January 2023)