Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.14.5 extracted from

  • Kirino, Y.; Sato, Y.; Kamimoto, T.; Kawazoe, K.; Minakuchi, K.; Nakahori, Y.
    Interrelationship of dipeptidyl peptidase IV (DPP4) with the development of diabetes, dyslipidaemia and nephropathy: A streptozotocin-induced model using wild-type and DPP4-deficient rats (2009), J. Endocrinol., 200, 53-61.
    View publication on PubMed
Search for more literature for 3.4.14.5

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Rattus norvegicus
-
blood plasma
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
pancreas
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro-4-nitroanilide + H2O
-
 Rattus norvegicus Gly-L-Pro + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Rattus norvegicus
dipeptidyl peptidase IV
-
 Rattus norvegicus
DPP4
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus plasma DPP4 activity increases progressively with time after streptozotocin treatment in wild type rats, the kidney of wild type rats show decreased DPP4 activity with increased Dpp4 mRNA after streptozotocin treatment up

General Information

General Information Comment Organism
malfunction DPP4-deficient rats are resistant to developing diabetes, while susceptible to dyslipidaemia and reduction of glomerular filtration rate by streptozotocin Rattus norvegicus
physiological function DPP4 activation may be responsible for hyperglycaemia, lipid metabolism and preservation of renal function Rattus norvegicus