Information on EC 2.6.1.7 - kynurenine-oxoglutarate transaminase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
2.6.1.7
-
RECOMMENDED NAME
GeneOntology No.
kynurenine-oxoglutarate transaminase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Metabolic pathways
-
tryptophan degradation XI (mammalian, via kynurenine)
-
Tryptophan metabolism
-
SYSTEMATIC NAME
IUBMB Comments
L-kynurenine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
aminoadipate aminotransferase
Q9WVM8
-
aminotransferase, kynurenine
-
-
-
-
aspartate aminotransferase
P05202
-
cysteine conjugate beta-lyase 1
Q8BTY1
-
cysteine conjugate beta-lyase 2
Q71RI9
-
glutamic-oxaloacetic transaminase 2
P05202
-
glutamine transaminase K
Q8BTY1
-
KAT
Q08415
-
KAT
Q64602
-
KAT I
-
also called GTK or CCBL1
KAT I
Q16773
-
KAT I
-
also called GTK or CCBL1
KAT I
-
also called GTK or CCBL1
KAT II
-
also called AADAT
KAT II
-
identical with alpha-aminoadipate aminotransferase
KAT II
Q8N5Z0
-
KAT II
-
also called AADAT
KAT II
-
also called AADAT
KAT II
-
identical with alpha-aminoadipate aminotransferase
KAT III
-
also called CCBL2
KAT III
Q71RI9
-
KAT III
-
also called CCBL2
KAT IV
-
also called mitochondrial ASAT or GOT2
KAT-1
Q16773
-
KAT-I
-
-
KAT-I
Q08415
-
KAT-II
-
isoform
kynurenine 2-oxoglutarate transaminase
-
-
-
-
kynurenine aminotransferase
-
-
-
-
kynurenine aminotransferase
-
-
kynurenine aminotransferase I
-
-
kynurenine aminotransferase I
Q8BTY1
-
kynurenine aminotransferase I
-
-
kynurenine aminotransferase II
-
-
kynurenine aminotransferase II
Q8N5Z0
-
kynurenine aminotransferase II
Q9WVM8
-
kynurenine aminotransferase II
-
-
kynurenine aminotransferase II
-
-
kynurenine aminotransferase III
Q6YP21
-
kynurenine aminotransferase III
Q71RI9
-
kynurenine aminotransferase III
Q58FK9
-
kynurenine aminotransferase IV
P05202
-
kynurenine aminotransferase-1
Q16773
-
kynurenine aminotransferase-I
-
-
kynurenine aminotransferase-I
Q08415
-
kynurenine aminotransferase-IV
P05202
-
kynurenine aminotransferases I
Q08415
-
kynurenine aminotransferases II
Q64602
-
kynurenine pyruvate aminotransferase
-
i.e. KAT-I
kynurenine transaminase (cyclizing)
-
-
-
-
kynurenine-2-oxoglutarate aminotransferase
-
i.e. KAT-II
L-kynurenine aminotransferase
-
-
-
-
PhKAT
O57946
-
type II kynurenine aminotransferase
-
-
mitochondrial aspartate aminotransferase
P05202
-
additional information
-
brain KAT I is identical with glutamine transferase K
additional information
-
enzyme from mitochondria may be identical with EC 2.6.1.39
additional information
-
identical to kidney soluble cysteine conjugate beta-lyase, EC 2.6.1.64, also referred to as glutamine transaminase K, EC 2.6.1.15, K stands for kidney
additional information
-
not identical with EC 2.6.1.39
additional information
Rattus norvegicus Wistar
-
enzyme from mitochondria may be identical with EC 2.6.1.39
-
CAS REGISTRY NUMBER
COMMENTARY
9030-38-0
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
yellow fever mosquito
SwissProt
Manually annotated by BRENDA team
low activity
-
-
Manually annotated by BRENDA team
low activity
-
-
Manually annotated by BRENDA team
Debaryomyces globosus
low activity
-
-
Manually annotated by BRENDA team
Hansenula schneggii
yeast
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
expression in Sf9 system
-
-
Manually annotated by BRENDA team
isoform KAT II
-
-
Manually annotated by BRENDA team
isoform KAT II
SwissProt
Manually annotated by BRENDA team
kynurenine aminotransferase I and II, i.e. KAT I and KAT II, in elderly Down syndrome patients
-
-
Manually annotated by BRENDA team
isoforms KAT I and KAT II, no change of enzyme activity 24 and 72 h after transient global ischemia episode
-
-
Manually annotated by BRENDA team
black tiger prawn
-
-
Manually annotated by BRENDA team
strain OT3, expression in Escherichia coli
-
-
Manually annotated by BRENDA team
Pyrococcus horikoshii OT-3
strain OT3, expression in Escherichia coli
-
-
Manually annotated by BRENDA team
adult albino
-
-
Manually annotated by BRENDA team
adult albino; male
-
-
Manually annotated by BRENDA team
brain KAT I
SwissProt
Manually annotated by BRENDA team
brain KAT I
-
-
Manually annotated by BRENDA team
cytosolic KAT I
SwissProt
Manually annotated by BRENDA team
Donryu; isoenzyme 2
-
-
Manually annotated by BRENDA team
identical to kidney soluble cysteine conjugate beta-lyase also referred to as glutamine transaminase K, K stands for kidney
-
-
Manually annotated by BRENDA team
isoforms KAT I and KAT II
-
-
Manually annotated by BRENDA team
KAT I and KAT II
-
-
Manually annotated by BRENDA team
KAT II accounts for more than 70% of kynurenate production under physiological conditiones
-
-
Manually annotated by BRENDA team
male Wistar
-
-
Manually annotated by BRENDA team
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Donryu
Donryu
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
isoform Bna3 is not an formyl kynurenine formamidase, but kynurenine aminotransferase
UniProt
Manually annotated by BRENDA team
Saccharomyces fragilis
low activity
-
-
Manually annotated by BRENDA team
Saccharomyces marxianus
-
-
-
Manually annotated by BRENDA team
low activity
-
-
Manually annotated by BRENDA team
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.4
-
B1B6U5
calculated from amino acid sequence
PDB
SCOP
CATH
ORGANISM
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
EXPRESSION
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
protein expression levels increase during the blood-feeding course
B1B6U5
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
medicine
-
isoforms KAT I and KAT II, no change of enzyme activity 24 and 72 h after transient global ischemia episode