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Literature summary for 2.6.1.7 extracted from

  • Han, Q.; Li, J.
    Cysteine and keto acids modulate mosquito kynurenine aminotransferase catalyzed kynurenic acid production (2004), FEBS Lett., 577, 381-385.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.7

Activating Compound

Activating Compound Comment Organism Structure
L-cysteine at 1.25 mM, 3fold stimulation, at 10 mM, 70% inhibition Aedes aegypti

Inhibitors

Inhibitors Comment Organism Structure
L-cysteine at 1.25 mM, 3fold stimulation, at 10 mM, 70% inhibition Aedes aegypti

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.9
-
 L-tyrosine pH 8.5, 45°C Aedes aegypti
1.3
-
 L-cysteine pH 8.5, 45°C Aedes aegypti
1.4
-
 L-methionine pH 8.5, 45°C Aedes aegypti
1.5
-
 L-histidine pH 8.5, 45°C Aedes aegypti
3.5
-
 L-phenylalanine pH 8.5, 45°C Aedes aegypti
3.8
-
 L-glutamine pH 8.5, 45°C Aedes aegypti
4.3
-
 L-kynurenine pH 8.5, 45°C Aedes aegypti
6.1
-
 L-asparagine pH 8.5, 45°C Aedes aegypti
12.9
-
 L-tryptophan pH 8.5, 45°C Aedes aegypti
32.7
-
 L-serine pH 8.5, 45°C Aedes aegypti
34.5
-
 L-leucine pH 8.5, 45°C Aedes aegypti
92.7
-
 2-aminobutanoate pH 8.5, 45°C Aedes aegypti
246
-
 L-alanine pH 8.5, 45°C Aedes aegypti

Organism

Organism UniProt Comment Textmining
Aedes aegypti Q95VY4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine + 2-oxobutanoate
-
 Aedes aegypti pyruvate + 2-aminobutanoate
-
 ?
L-asparagine + 2-oxobutanoate
-
 Aedes aegypti 2-oxosuccinamic acid + 2-aminobutanoate
-
 ?
L-cysteine + 2-oxobutanoate
-
 Aedes aegypti ? + 2-aminobutanoate
-
 ?
L-glutamine + 2-oxobutanoate
-
 Aedes aegypti 2-oxoglutarate + 2-aminobutanoate
-
 ?
L-histidine + 2-oxobutanoate
-
 Aedes aegypti 3-(1H-imidazol-4-yl)-2-oxopropanoate + 2-aminobutanoate
-
 ?
L-kynurenine + 2-oxobutanoate
-
 Aedes aegypti 4-(2-aminophenyl)-2,4-dioxobutanoate + 2-aminobutanoate
-
 ?
L-leucine + 2-oxobutanoate
-
 Aedes aegypti alpha-ketoleucine + 2-aminobutanoate
-
 ?
L-methionine + 2-oxobutanoate
-
 Aedes aegypti 4-methylsulfanyl-2-oxobutanoate + 2-aminobutanoate
-
 ?
L-phenylalanine + 2-oxobutanoate
-
 Aedes aegypti phenylpyruvate + 2-aminobutanoate
-
 ?
L-serine + 2-oxobutanoate
-
 Aedes aegypti 3-hydroxy-2-oxopropanoate + 2-aminobutanoate
-
 ?
L-tryptophan + 2-oxobutanoate
-
 Aedes aegypti 3-indole-2-oxopropanoate + 2-aminobutanoate
-
 ?
L-tyrosine + 2-oxobutanoate
-
 Aedes aegypti 3-(4-hydroxyphenyl)-2-oxopropanoate + 2-aminobutanoate
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
139
-
 L-tyrosine pH 8.5, 45°C Aedes aegypti
163
-
 L-methionine pH 8.5, 45°C Aedes aegypti
168
-
 L-histidine pH 8.5, 45°C Aedes aegypti
172
-
 L-kynurenine pH 8.5, 45°C Aedes aegypti
206
-
 L-cysteine pH 8.5, 45°C Aedes aegypti
230
-
 L-asparagine pH 8.5, 45°C Aedes aegypti
283
-
 L-phenylalanine pH 8.5, 45°C Aedes aegypti
283
-
 L-tryptophan pH 8.5, 45°C Aedes aegypti
317
-
 2-aminobutanoate pH 8.5, 45°C Aedes aegypti
345
-
 L-serine pH 8.5, 45°C Aedes aegypti
561
-
 L-glutamine pH 8.5, 45°C Aedes aegypti
758
-
 L-leucine pH 8.5, 45°C Aedes aegypti
1540
-
 L-alanine pH 8.5, 45°C Aedes aegypti