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Literature summary for 2.6.1.7 extracted from

  • Buchli, R.; Alberati-Giani, D.; Malherbe, P.; Kohler, C.; Broger, C.; Cesura, A.M.
    Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney (1995), J. Biol. Chem., 270, 29330-29335.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient expression in HEK-293 cells Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.045
-
2-oxoglutarate pH 8.0, 37°C, recombinant enzyme, cosubstrate L-kyrunenine Rattus norvegicus
0.95
-
L-kynurenine pH 8.0, 37°C, recombinant enzyme Rattus norvegicus
1.36
-
L-3-hydroxykynurenine pH 8.0, 37°C, recombinant enzyme Rattus norvegicus
5.6
-
L-glutamate pH 8.0, 37°C, alpha-aminoadipate aminotransferase activity Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
2 * 45000, SDS-PAGE Rattus norvegicus
90000 100000 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q64602
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate, DEAE-Sepharose, phenyl-Sepharose, Mono Q, Mono P Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.56
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-3-hydroxykynurenine + 2-oxoglutarate
-
Rattus norvegicus xanthurenic acid + L-glutamate
-
?
L-kynurenine + 2-oxoadipate 91% of activity with 2-oxoglutarate Rattus norvegicus kynurenic acid + 2-aminoadipate + H2O
-
?
L-kynurenine + 2-oxobutyrate 28% of activity with 2-oxoglutarate Rattus norvegicus kynurenic acid + 2-aminobutanoate + H2O
-
?
L-kynurenine + 2-oxoglutarate enzyme has both kynurenine aminotransferase and alpha-aminoadipate aminotransferase activity Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
?
L-kynurenine + 4-methyl-2-oxovalerate 5.9% of activity with 2-oxoglutarate Rattus norvegicus kynurenic acid + 2,4-dimethylvalerate + H2O
-
?
L-kynurenine + phenylpyruvate 43% of activity with 2-oxoglutarate Rattus norvegicus 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine
-
?
L-kynurenine + pyruvate 3% of activity with 2-oxoglutarate Rattus norvegicus kynurenic acid + L-alanine + H2O
-
?

Subunits

Subunits Comment Organism
dimer 2 * 45000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
KAT
-
Rattus norvegicus