Information on EC 2.6.1.42 - branched-chain-amino-acid transaminase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
2.6.1.42
-
RECOMMENDED NAME
GeneOntology No.
branched-chain-amino-acid transaminase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
branched-chain amino acid + 2-oxoglutarate = corresponding keto acid + L-glutamate, also acts on L-isoleucine and L-valine. Different from EC 2.6.1.66 valine-pyruvate transaminase
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
alanine metabolism
-
-
Biosynthesis of antibiotics
-
-
Biosynthesis of secondary metabolites
-
-
Cysteine and methionine metabolism
-
-
Glucosinolate biosynthesis
-
-
isoleucine metabolism
-
-
L-alanine biosynthesis I
-
-
L-isoleucine biosynthesis I (from threonine)
-
-
L-isoleucine biosynthesis II
-
-
L-isoleucine biosynthesis III
-
-
L-isoleucine biosynthesis IV
-
-
L-isoleucine biosynthesis V
-
-
L-isoleucine degradation I
-
-
L-isoleucine degradation II
-
-
L-leucine biosynthesis
-
-
L-leucine degradation I
-
-
L-leucine degradation III
-
-
L-valine biosynthesis
-
-
L-valine degradation I
-
-
L-valine degradation II
-
-
leucine degradation IV
-
-
leucine metabolism
-
-
Metabolic pathways
-
-
Pantothenate and CoA biosynthesis
-
-
valine metabolism
-
-
Valine, leucine and isoleucine biosynthesis
-
-
Valine, leucine and isoleucine degradation
-
-
SYSTEMATIC NAME
IUBMB Comments
branched-chain-amino-acid:2-oxoglutarate aminotransferase
Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine---pyruvate transaminase.
CAS REGISTRY NUMBER
COMMENTARY hide
9054-65-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
bovine
-
-
Manually annotated by BRENDA team
No.2247, ATCC 14067
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain W3110
-
-
Manually annotated by BRENDA team
IFO 3172, synonym Gluconobacter suboxydans
-
-
Manually annotated by BRENDA team
LM0230
-
-
Manually annotated by BRENDA team
macaque monkey
-
-
Manually annotated by BRENDA team
JJ, DSM 2067
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-
Manually annotated by BRENDA team
PS, DSM 1537
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
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-
Manually annotated by BRENDA team
strain BY4742
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
virus-induced gene silencing of BCAT results in abnormal leaf development and loss of apical dominance, suppressed expression of BCAT causes changes in various endogenous hormones and abnormal plant development that can be correlated with transcriptional induction of the KNOX genes, NTH15 and NTH23
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-alpha-methylbenzylamine + pyruvate
alpha-methylbenzaldehyde + L-alanine
show the reaction diagram
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid + L-glutamate
3-hydroxyadamantylglycine + 2-oxoglutarate
show the reaction diagram
2-oxo-6-hydroxyhexanoic acid + L-glutamate
L-6-hydroxynorleucine + 2-oxoglutarate
show the reaction diagram
-
-
-
-
?
2-oxoglutarate + L-isoleucine
L-glutamate + 3-methyl-2-oxopentanoate
show the reaction diagram
2-oxoglutarate + L-leucine
L-glutamate + 4-methyl-2-oxopentanoate
show the reaction diagram
2-oxoglutarate + L-valine
L-glutamate + 3-methyl-2-oxobutanoate
show the reaction diagram
3-methyl-2-oxobutanoic acid + L-glutamate
L-valine + 2-oxoglutarate
show the reaction diagram
3-methyl-2-oxobutyrate + L-glutamate
L-valine + 2-oxoglutarate
show the reaction diagram
3-methyl-2-oxobutyric acid + L-glutamate
L-valine + 2-oxoglutarate
show the reaction diagram
3-methyl-2-oxopentanoic acid + L-glutamate
L-isoleucine + 2-oxoglutarate
show the reaction diagram
3-methyl-2-oxovaleric acid + L-glutamate
L-isoleucine + 2-oxoglutarate
show the reaction diagram
4-methyl-2-oxopentanoic acid + L-glutamate
L-leucine + 2-oxoglutarate
show the reaction diagram
4-methyl-2-oxovaleric acid + L-glutamate
L-leucine + 2-oxoglutarate
show the reaction diagram
beta-chloro-L-alanine + ?
3-chloropyruvate + ?
show the reaction diagram
-
-
-
-
?
DL-2-aminoadipate + 2-oxoglutarate
3-oxohexanedioic acid + L-glutamate
show the reaction diagram
-
heart enzyme
-
-
r
DL-2-aminopimelate + 2-oxoglutarate
2-oxoheptanedioate + L-glutamate
show the reaction diagram
-
heart enzyme
-
-
r
DL-allo-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
heart enzyme
-
-
r
glycine + 2-oxoglutarate
glyoxylate + L-glutamate
show the reaction diagram
-
0.4% of the activity with L-isoleucine
-
?
glycine + 2-oxoglutarate
L-glutamic acid + glyoxylate
show the reaction diagram
L-2-aminobutanoate + 4-methylthio-2-oxo-butanoate
2-oxobutanoate + L-methionine
show the reaction diagram
-
-
-
-
r
L-2-aminobutyrate + 2-oxo-isopentanoate
2-oxobutanoate + L-valine
show the reaction diagram
-
-
-
-
r
L-2-aminobutyrate + 2-oxoglutarate
2-oxobutanoate + L-glutamate
show the reaction diagram
L-2-aminobutyrate + 4-methyl-2-oxopentanoate
2-oxobutanoate + L-leucine
show the reaction diagram
-
-
-
-
r
L-2-aminobutyrate + pyruvate
2-oxobutanoate + L-alanine
show the reaction diagram
-
-
-
-
r
L-alanine + 2-oxoglutarate
2-oxopropanoate + L-glutamate
show the reaction diagram
L-alanine + 2-oxoisohexanoate
pyruvate + L-leucine
show the reaction diagram
-
-
-
-
r
L-alanine + 2-oxoisopentanoate
pyruvate + L-valine
show the reaction diagram
-
-
-
-
r
L-alanine + 4-methyl-2-oxopentanoate
pyruvate + L-leucine
show the reaction diagram
L-alanine + pyruvate
pyruvate + L-alanine
show the reaction diagram
-
-
-
r
L-allo-isoleucine + 2-oxobutyrate
3-methyl-2-oxopentanoate + 2-aminobutyrate
show the reaction diagram
-
-
-
-
r
L-allo-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-allo-isoleucine + 2-oxohexanoate
3-methyl-2-oxopentanoate + 2-aminohexanoate
show the reaction diagram
-
-
-
-
r
L-allo-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
show the reaction diagram
-
-
-
-
r
L-allo-isoleucine + 2-oxoisopentanoate
3-methyl-2-oxopentanoate + L-valine
show the reaction diagram
-
-
-
-
r
L-allo-isoleucine + 2-oxooctanoate
3-methyl-2-oxopentanoate + 2-aminooctanoate
show the reaction diagram
-
-
-
-
r
L-arginine + 2-oxoglutarate
2-oxo-5-guanidinopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-asparagine + 2-oxoglutarate
2,4-dioxo-4-aminobutanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
show the reaction diagram
L-aspartate + 2-oxoisohexanoate
oxaloacetate + L-leucine
show the reaction diagram
-
-
-
-
r
L-aspartate + 2-oxoisopentanoate
oxaloacetate + L-valine
show the reaction diagram
-
-
-
-
r
L-cysteine + 2-oxoglutarate
2-oxo-3-thiobutyrate + L-glutamate
show the reaction diagram
L-glutamate + 2-oxo-3-methylpentanoate
2-oxoglutarate + L-isoleucine
show the reaction diagram
-
-
-
-
r
L-glutamate + 2-oxo-isohexanoate
2-oxoglutarate + L-leucine
show the reaction diagram
L-glutamate + 2-oxo-isopentanoate
2-oxoglutarate + L-valine
show the reaction diagram
L-glutamate + 2-oxobutyrate
2-oxoglutarate + 2-aminobutyrate
show the reaction diagram
-
-
-
-
r
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
show the reaction diagram
L-glutamate + 4-methyl-2-oxopentanoate
2-oxoglutarate + L-leucine
show the reaction diagram
-
-
-
-
r
L-glutamate + 4-methylthio-2-oxo-butanoate
2-oxoglutarate + L-methionine
show the reaction diagram
L-glutamate + pyruvate
2-oxoglutarate + L-alanine
show the reaction diagram
-
-
-
-
r
L-glutamine + 2-oxoglutarate
2,5-dioxo-5-aminopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-histidine + 2-oxoglutarate
2-oxo-3-imidazolpropanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-homomethionine + 2-oxoglutarate
5-methylthio-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
?
L-isoleucine + 2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
show the reaction diagram
-
-
-
-
r
L-isoleucine + 2-oxo-isopentanoate
2-oxoisohexanoate + L-valine
show the reaction diagram
L-isoleucine + 2-oxobutanoate
3-methyl-2-oxopentanoate + 2-aminobutanoate
show the reaction diagram
-
-
-
-
r
L-isoleucine + 2-oxobutyrate
2-oxoisohexanoate + 2-aminobutyrate
show the reaction diagram
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
L-isoleucine + 2-oxoglutarate
L-glutamate + 3-methyl-2-oxopentanoate
show the reaction diagram
L-isoleucine + 2-oxohexanoate
L-norleucine + 2-oxoisohexanoate
show the reaction diagram
-
-
-
-
r
L-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
show the reaction diagram
L-isoleucine + 2-oxooctanoate
2-oxoisohexanoate + 2-aminooctanoate
show the reaction diagram
-
-
-
-
r
L-isoleucine + 3-methyl-2-oxobutanoate
3-methyl-2-oxopentanoate + L-valine
show the reaction diagram
-
-
-
-
r
L-isoleucine + 3-methylthio-2-oxobutanoate
3-methyl-2-oxopentanoate + 2-amino-3-methylthiobutanoate
show the reaction diagram
-
-
-
-
r
L-isoleucine + 3-phenylpyruvate
2-oxoisohexanoate + L-phenylalanine
show the reaction diagram
-
-
-
r
L-isoleucine + 4-methylthio-2-oxo-butanoate
3-methyl-2-oxopentanoate + L-methionine
show the reaction diagram
L-isoleucine + 4-methylthio-2-oxobutyrate
3-methyl-2-oxopentanoate + L-methionine
show the reaction diagram
-
-
-
r
L-isoleucine + glyoxylate
2-oxoisohexanoate + glycine
show the reaction diagram
-
-
-
-
r
L-isoleucine + oxaloacetate
2-oxoisohexanoate + L-aspartate
show the reaction diagram
-
-
-
-
r
L-isoleucine + oxaloacetate
3-methyl-2-oxopentanoate + L-aspartate
show the reaction diagram
-
brain enzyme
-
-
r
L-isoleucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
L-leucine + 2-oxo-3-methiobutyrate
2-oxoisohexanoate + L-methionine
show the reaction diagram
-
-
-
-
r
L-leucine + 2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
show the reaction diagram
L-leucine + 2-oxo-butyrate
2-oxoisohexanoate + 2-aminobutyrate
show the reaction diagram
L-leucine + 2-oxo-hexanoate
2-oxoisohexanoate + 2-aminohexanoate
show the reaction diagram
-
-
-
-
r
L-leucine + 2-oxo-isohexanoate
2-oxoisohexanoate + L-leucine
show the reaction diagram
L-leucine + 2-oxo-pentanoate
2-oxoisohexanoate + 2-aminopentanoate
show the reaction diagram
-
-
-
-
r
L-leucine + 2-oxoglutarate
2-oxoisohexanoate + L-glutamate
show the reaction diagram
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
L-leucine + 2-oxoglutarate
L-glutamate + 4-methyl-2-oxopentanoate
show the reaction diagram
L-leucine + 2-oxohexanoate
2-oxoisohexanoate + 2-aminohexanoate
show the reaction diagram
-
-
-
-
r
L-leucine + 2-oxohexanoic acid
4-methyl-2-oxopentanoate + 2-aminohexanoic acid
show the reaction diagram
-
214% of the activity with 2-oxoglutarate
-
-
?
L-leucine + 2-oxoisohexanoate
2-oxoisohexanoate + L-leucine
show the reaction diagram
L-leucine + 2-oxoisopentanoate
2-oxoisohexanoate + L-valine
show the reaction diagram
L-leucine + 2-oxoisovaleric acid
4-methyl-2-oxopentanoate + 2-aminoisovaleric acid
show the reaction diagram
-
135% of the activity with 2-oxoglutarate
-
-
?
L-leucine + 2-oxooctanoate
2-oxoisohexanoate + 2-aminooctanoate
show the reaction diagram
-
-
-
-
r
L-leucine + 3-methyl-2-oxobutanoate
4-methyl-2-oxopentanoate + L-valine
show the reaction diagram
L-leucine + 3-methyl-2-oxopentanoate
2-oxo-4-methylpentanoate + L-isoleucine
show the reaction diagram
-
-
-
-
r
L-leucine + 3-methyl-2-oxopentanoate
4-methyl-2-oxopentanoate + L-isoleucine
show the reaction diagram
L-leucine + 4-methyl-2-oxopentanoate
L-glutamate + 2-oxoglutarate
show the reaction diagram
L-leucine + 4-methylthio-2-oxo-butanoate
4-methyl-2-oxopentanoate + L-methionine
show the reaction diagram
L-leucine + DL-2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
show the reaction diagram
L-leucine + glyoxylate
2-oxoisohexanoate + glycine
show the reaction diagram
-
-
-
-
r
L-leucine + oxaloacetate
2-oxoisohexanoate + L-asparagine
show the reaction diagram
-
-
-
-
r
L-leucine + p-hydroxyphenylpyruvate
2-oxoisohexanoate + L-tyrosine
show the reaction diagram
L-leucine + phenylpyruvate
2-oxoisohexanoate + L-phenylalanine
show the reaction diagram
L-leucine + prephenate
2-oxoisohexanoate + 1-(2-amino-2-carboxyethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid
show the reaction diagram
-
-
-
-
r
L-leucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
L-leucine + pyruvate
4-methyl-2-oxopentanoate + L-alanine
show the reaction diagram
L-lysine + 2-oxoglutarate
2-oxo-6-aminohexanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-methionine + 2-oxo-isohexanoate
4-methylsulfanyl-2-oxobutanoate + L-leucine
show the reaction diagram
-
-
-
-
r
L-methionine + 2-oxobutanoate
4-methylthio-2-oxobutanoate + L-2-aminobutanoate
show the reaction diagram
-
-
-
-
r
L-methionine + 2-oxobutyrate
4-methylsulfanyl-2-oxobutanoate + 2-aminobutyrate
show the reaction diagram
-
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
L-methionine + 2-oxoglutarate
4-methylthio-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
-
?
L-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
show the reaction diagram
-
-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
show the reaction diagram
L-norleucine + 4-methyl-2-oxopentanoate
2-oxohexanoate + L-leucine
show the reaction diagram
-
-
-
-
r
L-norvaline + 2-oxoglutarate
2-oxopentanoate + L-glutamate
show the reaction diagram
L-norvaline + 4-methyl-2-oxopentanoate
2-oxopentanoate + L-leucine
show the reaction diagram
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
L-phenylalanine + 4-methylthio-2-oxo-butanoate
phenylpyruvate + L-methionine
show the reaction diagram
L-serine + 2-oxoglutarate
3-hydroxy-2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-threo-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-threonine + 2-oxoglutarate
2-oxo-3-hydroxybutyrate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
show the reaction diagram
L-tryptophan + 2-oxoglutarate
L-glutamic acid + 3-indole-2-oxopropanoate
show the reaction diagram
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
L-valine + 2-oxo-3-methylpentanoate
3-methyl-2-oxobutanoate + L-isoleucine
show the reaction diagram
-
-
-
-
r
L-valine + 2-oxo-isohexanoate
2-oxoisopentanoate + L-leucine
show the reaction diagram
-
-
-
-
r
L-valine + 2-oxobutyrate
2-oxoisopentanoate + 2-aminobutanoate
show the reaction diagram
L-valine + 2-oxoglutarate
2-oxoisopentanoate + L-glutamate
show the reaction diagram
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
show the reaction diagram
L-valine + 2-oxoglutarate
L-glutamate + 3-methyl-2-oxobutanoate
show the reaction diagram
L-valine + 2-oxohexanoate
2-oxoisopentanoate + 2-aminohexanoate
show the reaction diagram
-
-
-
-
r
L-valine + 2-oxoisopentanoate
2-oxoisopentanoate + L-valine
show the reaction diagram
L-valine + 2-oxooctanoate
2-oxoisopentanoate + 2-aminooctanoate
show the reaction diagram
-
-
-
-
r
L-valine + 3-methyl-2-oxopentanoate
3-methyl-2-oxobutanoate + L-isoleucine
show the reaction diagram
-
-
-
-
r
L-valine + 4-methyl-2-oxopentanoate
2-oxoisopentanoate + L-leucine
show the reaction diagram
L-valine + 4-methylthio-2-oxo-butanoate
2-oxoisopentanoate + L-methionine
show the reaction diagram
-
-
-
-
?
L-valine + glyoxylate
2-oxoisopentanoate + glycine
show the reaction diagram
-
-
-
-
r
L-valine + oxaloacetate
2-oxoisopentanoate + L-aspartate
show the reaction diagram
-
-
-
-
r
L-valine + pyruvate
2-oxoisopentanoate + L-alanine
show the reaction diagram
L-valine + pyruvate
3-methyl-2-oxobutanoate + L-alanine
show the reaction diagram
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + ?
S-(1,1,2,2-tetrafluoroethyl)-2-oxo-3-thiobutyrate + ?
show the reaction diagram
-
-
-
-
?
S-(1,2-dichlorovinyl)-L-cysteine + ?
S-(1,2-dichlorovinyl)-2-oxo-3-thiobutyrate + ?
show the reaction diagram
-
-
-
-
?
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine + ?
S-(2-chloro-1,1,2-trifluoroethyl)-2-oxo-3-thiobutyrate + ?
show the reaction diagram
-
-
-
-
?
S-methyl-L-cysteine + 2-oxoglutarate
3-(methylthio)-2-oxopropanoic acid + L-glutamate
show the reaction diagram
-
heart enzyme
-
-
r
trimethylpyruvate + L-glutamate
L-tert-leucine + 2-oxoglutarate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3-methyl-2-oxobutyrate + L-glutamate
L-valine + 2-oxoglutarate
show the reaction diagram
-
the transamination of ketoisovalerate (KIV) to valine is carried out mainly by the transaminase B enzyme, with the transaminase C enzyme playing a minor role
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
L-leucine + 2-oxoglutarate
2-oxoisohexanoate + L-glutamate
show the reaction diagram
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
pyridoxamine 5'-phosphate
-
Km 0.00062 mM
additional information
-
pyridoxine 5'-phosphate, pyridoxal, pyridoxamine and pyridoxine are not effective as coenzymes
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
5 mM MgCl2 stimulates by 26%
Mn2+
-
5 mM MgCl2 stimulates by 34%
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-Ketoglutarate
2-oxo-3-methylvalerate
-
measured in the forward reaction, concentrations higher than 1.0 mM inhibits the enzyme
2-oxoglutarate
2-oxoisocaproate
2-oxoisovalerate
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measured in the forward reaction, concentrations higher than 1.0 mM inhibits the enzyme
4-methyl-2-oxopentanoate
-
-
5-bromo-N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
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IC50: 0.0025 mM
5-bromo-N'-(phenylsulfonyl)-1H-indole-2-carbohydrazide
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IC50: 0.015 mM
5-chloro-N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
-
IC50: 0.0042 mM
5-chloro-N'-[(2-chlorophenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
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IC50: 0.0057 mM
5-chloro-N'-[(2-methylphenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
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IC50: 0.00116 mM
5-chloro-N'-[(3-methylphenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
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IC50: 0.0012 mM
5-chloro-N'-[[2-(trifluoromethyl)phenyl]sulfonyl]-1-benzofuran-2-carbohydrazide
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IC50: 0.0008 mM, potent inhibitor
5-methoxy-N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
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IC50: 0.0128 mM
5-methoxy-N'-(phenylsulfonyl)-1H-indole-2-carbohydrazide
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IC50: 0.0568 mM
Aminooxyacetate
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aminooxyacetic acid
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benzothiazolyl-L-cysteine
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inhibits the L-leucine-2-oxoglutarate tranamination reaction of both isoenzymes
beta-chloro-L-alanine
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rapidly inactivated by the beta-lyase substrate
carboxymethoxylamine
cupric acetate
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diethyldicarbonate
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Fe2+
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1 mM, 34% residual activity
gabaculine
-
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gabapentin
Hg2+
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1 mM, 0% residual activity
hydrazine
hydroxylamine
iodoacetamide
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iodoacetic acid
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Isocaproic acid
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competitive inhibitor
isoleucine
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competitive inhibition of enzyme activity with leucine
L-cysteine
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10 mM, inhibits activity with isoleucine and tyrosine by 22 and 34%, respectively
L-isoleucine
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with 1 mM tyrosine as the substrate, 10 mM isoleucine inhibits activity by 94%
L-leucine
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with 1 mM tyrosine as the substrate, 10 mM leucine inhibits activity by 93%
L-methionine
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10 mM methionine inhibits the activity with 1 mM tyrosine and phenylalanine by 86 and 59%, respectively, but it has no effect on the isoleucine activity
L-phenylalanine
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with 2 mM isoleucine as the substrate, 10 mM phenylalanine inhibits activity by 46%
L-valine
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with 1 mM tyrosine as the substrate, 10 mM valine inhibits activity by 78%
Lead acetate
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Mersalyl
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N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
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IC50: 0.0183 mM
N'-(phenylsulfonyl)-1H-indole-2-carbohydrazide
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IC50: 0.036 mM
N'-(phenylsulfonyl)dibenzo[b,d]furan-2-carbohydrazide
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IC50: 0.00235 mM
N'-(phenylsulfonyl)quinoline-3-carbohydrazide
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IC50: 0.0333 mM
N'-(phenylsulfonyl)quinoline-6-carbohydrazide
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IC50: 0.0133 mM
N'-[(2-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
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IC50: 0.0129 mM
N'-[(2-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
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IC50: 0.0032 mM
N'-[(3-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
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IC50: above 0.035 mM
N'-[(3-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
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IC50: 0.0028 mM
N'-[(4-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
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IC50: 0.0372 mM
N'-[(4-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
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IC50: 0.051 mM
N-ethylmaleimide
O-(t-butyl)hydroxylamine
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mixed-type inhibition, acts also as growth inhibitor of organism
O-allylhydroxylamine
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mixed-type inhibition, acts also as growth inhibitor of organism
O-Benzylhydroxylamine
p-chloromercuribenzoate
phenylhydrazine
phenylpyruvate
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shows substrate inhibition at 4 mM
potassium cyanide
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S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
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rapidly inactivated by the beta-lyase substrate
S-(1,2-dichlorovinyl)-L-cysteine
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rapidly inactivated by the beta-lyase substrate
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
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rapidly inactivated by the beta-lyase substrate
Semicarbazide
silver acetate
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Sodium mersalyl
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Thiosemicarbazide
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Tris
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valine
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competitive inhibition of enzyme activity with leucine
Zinc acetate
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additional information