Information on EC 2.6.1.42 - branched-chain-amino-acid transaminase

New: Word Map on EC 2.6.1.42
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
2.6.1.42
-
RECOMMENDED NAME
GeneOntology No.
branched-chain-amino-acid transaminase
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
branched-chain amino acid + 2-oxoglutarate = corresponding keto acid + L-glutamate, also acts on L-isoleucine and L-valine. Different from EC 2.6.1.66 valine-pyruvate transaminase
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-alanine biosynthesis I
-
-
L-isoleucine biosynthesis I (from threonine)
-
-
L-isoleucine biosynthesis II
-
-
L-isoleucine biosynthesis III
-
-
L-isoleucine biosynthesis IV
-
-
L-isoleucine biosynthesis V
-
-
L-isoleucine degradation I
-
-
L-isoleucine degradation II
-
-
L-leucine biosynthesis
-
-
L-leucine degradation I
-
-
L-leucine degradation III
-
-
L-valine biosynthesis
-
-
L-valine degradation I
-
-
L-valine degradation II
-
-
alanine metabolism
-
-
isoleucine metabolism
-
-
leucine metabolism
-
-
valine metabolism
-
-
Valine, leucine and isoleucine degradation
-
-
Valine, leucine and isoleucine biosynthesis
-
-
Pantothenate and CoA biosynthesis
-
-
Glucosinolate biosynthesis
-
-
Metabolic pathways
-
-
Biosynthesis of secondary metabolites
-
-
Biosynthesis of antibiotics
-
-
SYSTEMATIC NAME
IUBMB Comments
branched-chain-amino-acid:2-oxoglutarate aminotransferase
Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine---pyruvate transaminase.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
BCAA aminotransferase
-
-
BCAA-AT
-
-
BCAATase
Saccharomyces cerevisiae BY4742
-
-
-
BcaT
Escherichia coli W3110
-
;
-
BcaT
Helicobacter pylori NCTC 11637
-
-
-
BcaT
-
-
BcaT
-
-
BCATc
-
cytosolic isoform
BCATc
-
-
branched chain amino acid: 2-oxoglutarate aminotransferase EC 2.6.1
-
formerly
branched chain aminotransferase
-
-
branched chain aminotransferase
Enterobacter sp. TL3
-
-
-
branched chain aminotransferase
-
-
branched chain aminotransferase
-
-
branched chain aminotransferase
-
-
branched chain aminotransferase, cytosolic isoform
-
branched chain aminotransferase, mitochondrial isoform
-
branched-chain amino acid aminotransferase
-
-
-
-
branched-chain amino acid aminotransferase
-
-
branched-chain amino acid aminotransferase
Helicobacter pylori NCTC 11637
-
-
-
branched-chain amino acid aminotransferase
-
-
branched-chain amino acid aminotransferase
-
branched-chain amino acid aminotransferase
-
-
branched-chain amino acid aminotransferase
-
-
-
branched-chain amino acid aminotransferase 1
-
-
branched-chain amino acid aminotransferase 2
-
-
branched-chain amino acid aminotransferase 3
-
-
branched-chain amino acid aminotransferase 4
-
-
branched-chain amino acid aminotransferase 5
-
-
branched-chain amino acid aminotransferase 6
-
-
branched-chain amino acid transaminase
-
-
branched-chain amino acid transaminase
-
-
branched-chain amino acid transaminase
Saccharomyces cerevisiae BY4742
-
-
-
branched-chain amino acid-glutamate transaminase
-
-
-
-
branched-chain amino-acid aminotransferase
-
-
branched-chain amino-acid transaminase
-
branched-chain amino-acid transaminase
-
-
branched-chain aminotransferase
-
-
-
-
branched-chain aminotransferase
-
branched-chain aminotransferase
-
-
branched-chain aminotransferase
-
-
branched-chain aminotransferase
-
-
branched-chain aminotransferase
-
-
branched-chain aminotransferase
-
branched-chain aminotransferase
-
-
branched-chain aminotransferase
-
branched-chain aminotransferase
-
-
branched-chain aminotransferase
-
branched-chain aminotransferase
-
-
branched-chain aminotransferase 7
-
-
branched-chain aminotransferase4
-
-
EC 2.6.1.6
-
related
glutamate-branched-chain amino acid transaminase
-
-
-
-
hBCATm
-
-
L-branched chain amino acid aminotransferase
-
-
-
-
L-leucine-alpha-ketoglutarate transaminase
-
-
leucine aminotransferase
-
-
leucine transaminase
-
-
transaminase B
-
-
-
-
transaminase B
-
-
CAS REGISTRY NUMBER
COMMENTARY
9054-65-3
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
AtBCAT-1
SwissProt
Manually annotated by BRENDA team
AtBCAT-2
SwissProt
Manually annotated by BRENDA team
AtBCAT-3
SwissProt
Manually annotated by BRENDA team
AtBCAT-4
SwissProt
Manually annotated by BRENDA team
AtBCAT-5
SwissProt
Manually annotated by BRENDA team
AtBCAT-6
SwissProt
Manually annotated by BRENDA team
six isoforms
-
-
Manually annotated by BRENDA team
bovine
-
-
Manually annotated by BRENDA team
No.2247, ATCC 14067
-
-
Manually annotated by BRENDA team
Enterobacter sp. TL3
-
-
-
Manually annotated by BRENDA team
strain W
-
-
Manually annotated by BRENDA team
strain W3110
-
-
Manually annotated by BRENDA team
Escherichia coli W3110
strain W3110
-
-
Manually annotated by BRENDA team
IFO 3172, synonym Gluconobacter suboxydans
-
-
Manually annotated by BRENDA team
strain NCTC 11637
-
-
Manually annotated by BRENDA team
strain NCTC 11637
UniProt
Manually annotated by BRENDA team
Helicobacter pylori NCTC 11637
strain NCTC 11637
-
-
Manually annotated by BRENDA team
Helicobacter pylori NCTC 11637
strain NCTC 11637
UniProt
Manually annotated by BRENDA team
cytosolic and mitochondrial isoforms
SwissProt
Manually annotated by BRENDA team
human, BCATm DNA sequence
SwissProt
Manually annotated by BRENDA team
barley, L. cv. Ingrid
-
-
Manually annotated by BRENDA team
cultivar Georgie
UniProt
Manually annotated by BRENDA team
subsp. paracasei CHCC 2115
-
-
Manually annotated by BRENDA team
subsp. cremoris NCDO 763 and TIL 46
-
-
Manually annotated by BRENDA team
subsp. cremoris NCDO 763 and TIL 46, same nucleotide sequence accession number in DDBJ and EMBL >
SwissProt
Manually annotated by BRENDA team
Lactococcus lactis LM0230
LM0230
-
-
Manually annotated by BRENDA team
macaque monkey
-
-
Manually annotated by BRENDA team
JJ, DSM 2067
-
-
Manually annotated by BRENDA team
PS, DSM 1537
-
-
Manually annotated by BRENDA team
sheep, BCATc amino acid sequence
SwissProt
Manually annotated by BRENDA team
sheep, BCATm cDNA
SwissProt
Manually annotated by BRENDA team
sheep, BCATm cDNA
SwissProt
Manually annotated by BRENDA team
cytosolic and mitochondrial enzyme
-
-
Manually annotated by BRENDA team
cytosolic isoform
-
-
Manually annotated by BRENDA team
mitochondrial isoform
-
-
Manually annotated by BRENDA team
rat, strain Wistar
-
-
Manually annotated by BRENDA team
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
strain BY4742
-
-
Manually annotated by BRENDA team
strains MD101, 22, 133, 124, 138 and AE55, 16, 25 and 89
-
-
Manually annotated by BRENDA team
YR6a, YPH501, Bat1p, amino acid sequence accession number
SwissProt
Manually annotated by BRENDA team
YR6a, YPH501, Bat2p, amino acid sequence accession number
SwissProt
Manually annotated by BRENDA team
Saccharomyces cerevisiae BY4742
strain BY4742
-
-
Manually annotated by BRENDA team
strains BioCarna Ferment S1, PSM213, PSM215
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
virus-induced gene silencing of BCAT results in abnormal leaf development and loss of apical dominance, suppressed expression of BCAT causes changes in various endogenous hormones and abnormal plant development that can be correlated with transcriptional induction of the KNOX genes, NTH15 and NTH23
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid + L-glutamate
3-hydroxyadamantylglycine + 2-oxoglutarate
show the reaction diagram
Escherichia coli, Enterobacter sp., Enterobacter sp. TL3
-
-
-
?
2-oxo-6-hydroxyhexanoic acid + L-glutamate
L-6-hydroxynorleucine + 2-oxoglutarate
show the reaction diagram
-
-
-
?
2-oxoglutarate + L-isoleucine
L-glutamate + 3-methyl-2-oxopentanoate
show the reaction diagram
-
-
-
?
2-oxoglutarate + L-leucine
L-glutamate + 4-methyl-2-oxopentanoate
show the reaction diagram
-
-
-
?
2-oxoglutarate + L-valine
L-glutamate + 3-methyl-2-oxobutanoate
show the reaction diagram
-
-
-
?
3-methyl-2-oxobutanoic acid + L-glutamate
L-valine + 2-oxoglutarate
show the reaction diagram
-
-
-
?
3-methyl-2-oxobutyrate + L-glutamate
L-valine + 2-oxoglutarate
show the reaction diagram
-
the transamination of ketoisovalerate (KIV) to valine is carried out mainly by the transaminase B enzyme, with the transaminase C enzyme playing a minor role
-
?
3-methyl-2-oxobutyric acid + L-glutamate
L-valine + 2-oxoglutarate
show the reaction diagram
Escherichia coli, Enterobacter sp., Enterobacter sp. TL3
-
-
-
?
3-methyl-2-oxopentanoic acid + L-glutamate
L-isoleucine + 2-oxoglutarate
show the reaction diagram
-
-
-
?
3-methyl-2-oxovaleric acid + L-glutamate
L-isoleucine + 2-oxoglutarate
show the reaction diagram
Escherichia coli, Enterobacter sp., Enterobacter sp. TL3
-
-
-
?
4-methyl-2-oxopentanoic acid + L-glutamate
L-leucine + 2-oxoglutarate
show the reaction diagram
-
-
-
?
4-methyl-2-oxovaleric acid + L-glutamate
L-leucine + 2-oxoglutarate
show the reaction diagram
Escherichia coli, Enterobacter sp., Enterobacter sp. TL3
-
-
-
?
beta-chloro-L-alanine + ?
3-chloropyruvate + ?
show the reaction diagram
-
-
-
?
DL-2-aminoadipate + 2-oxoglutarate
3-oxohexanedioic acid + L-glutamate
show the reaction diagram
-
heart enzyme
-
r
DL-2-aminopimelate + 2-oxoglutarate
2-oxoheptanedioate + L-glutamate
show the reaction diagram
-
heart enzyme
-
r
DL-allo-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
heart enzyme
-
r
DL-allo-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
heart enzyme
-
r
glycine + 2-oxoglutarate
glyoxylate + L-glutamate
show the reaction diagram
-
0.4% of the activity with L-isoleucine
?
glycine + 2-oxoglutarate
L-glutamic acid + glyoxylate
show the reaction diagram
-
-
?
L-2-aminobutanoate + 4-methylthio-2-oxo-butanoate
2-oxobutanoate + L-methionine
show the reaction diagram
-
-
-
r
L-2-aminobutyrate + 2-oxo-isopentanoate
2-oxobutanoate + L-valine
show the reaction diagram
-
-
-
r
L-2-aminobutyrate + 2-oxoglutarate
2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-2-aminobutyrate + 2-oxoglutarate
2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-2-aminobutyrate + 2-oxoglutarate
2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-2-aminobutyrate + 2-oxoglutarate
2-oxobutanoate + L-glutamate
show the reaction diagram
-
heart enzyme
-
r
L-2-aminobutyrate + 4-methyl-2-oxopentanoate
2-oxobutanoate + L-leucine
show the reaction diagram
-
-
-
r
L-2-aminobutyrate + pyruvate
2-oxobutanoate + L-alanine
show the reaction diagram
-
-
-
r
L-alanine + 2-oxoglutarate
2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-alanine + 2-oxoglutarate
2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-alanine + 2-oxoglutarate
2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-alanine + 2-oxoglutarate
2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-alanine + 2-oxoisohexanoate
pyruvate + L-leucine
show the reaction diagram
-
-
-
r
L-alanine + 2-oxoisopentanoate
pyruvate + L-valine
show the reaction diagram
-
-
-
r
L-alanine + 4-methyl-2-oxopentanoate
pyruvate + L-leucine
show the reaction diagram
-
-
-
r
L-alanine + pyruvate
pyruvate + L-alanine
show the reaction diagram
-
-
r
L-allo-isoleucine + 2-oxobutyrate
3-methyl-2-oxopentanoate + 2-aminobutyrate
show the reaction diagram
-
-
-
r
L-allo-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-allo-isoleucine + 2-oxohexanoate
3-methyl-2-oxopentanoate + 2-aminohexanoate
show the reaction diagram
-
-
-
r
L-allo-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
show the reaction diagram
-
-
-
r
L-allo-isoleucine + 2-oxoisopentanoate
3-methyl-2-oxopentanoate + L-valine
show the reaction diagram
-
-
-
r
L-allo-isoleucine + 2-oxooctanoate
3-methyl-2-oxopentanoate + 2-aminooctanoate
show the reaction diagram
-
-
-
r
L-arginine + 2-oxoglutarate
2-oxo-5-guanidinopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-asparagine + 2-oxoglutarate
2,4-dioxo-4-aminobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
show the reaction diagram
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
show the reaction diagram
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
show the reaction diagram
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
show the reaction diagram
-
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
show the reaction diagram
-
1.7% of the activity with L-isoleucine
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
show the reaction diagram
Helicobacter pylori NCTC 11637
-
1.7% of the activity with L-isoleucine
?
L-aspartate + 2-oxoisohexanoate
oxaloacetate + L-leucine
show the reaction diagram
-
-
-
r
L-aspartate + 2-oxoisopentanoate
oxaloacetate + L-valine
show the reaction diagram
-
-
-
r
L-cysteine + 2-oxoglutarate
2-oxo-3-thiobutyrate + L-glutamate
show the reaction diagram
-
-
-
r
L-cysteine + 2-oxoglutarate
2-oxo-3-thiobutyrate + L-glutamate
show the reaction diagram
-
-
r
L-glutamate + 2-oxo-3-methylpentanoate
2-oxoglutarate + L-isoleucine
show the reaction diagram
-
-
-
r
L-glutamate + 2-oxo-isohexanoate
2-oxoglutarate + L-leucine
show the reaction diagram
-
-
-
r
L-glutamate + 2-oxo-isohexanoate
2-oxoglutarate + L-leucine
show the reaction diagram
-
-
-
r
L-glutamate + 2-oxo-isopentanoate
2-oxoglutarate + L-valine
show the reaction diagram
-
-
-
r
L-glutamate + 2-oxo-isopentanoate
2-oxoglutarate + L-valine
show the reaction diagram
-
-
-
r
L-glutamate + 2-oxobutyrate
2-oxoglutarate + 2-aminobutyrate
show the reaction diagram
-
-
-
r
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
show the reaction diagram
-
-
-
r
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
show the reaction diagram
-
-
r
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
show the reaction diagram
-
-
-
r
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
show the reaction diagram
-
-
-
r
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
show the reaction diagram
-
mitochondrial enzyme
-
r
L-glutamate + 4-methyl-2-oxopentanoate
2-oxoglutarate + L-leucine
show the reaction diagram
-
-
-
r
L-glutamate + 4-methylthio-2-oxo-butanoate
2-oxoglutarate + L-methionine
show the reaction diagram
-
-
-
?
L-glutamate + pyruvate
2-oxoglutarate + L-alanine
show the reaction diagram
-
-
-
r
L-glutamine + 2-oxoglutarate
2,5-dioxo-5-aminopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-histidine + 2-oxoglutarate
2-oxo-3-imidazolpropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-homomethionine + 2-oxoglutarate
5-methylthio-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxo-isopentanoate
2-oxoisohexanoate + L-valine
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxo-isopentanoate
2-oxoisohexanoate + L-valine
show the reaction diagram
-
-
r
L-isoleucine + 2-oxo-isopentanoate
2-oxoisohexanoate + L-valine
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxo-isopentanoate
2-oxoisohexanoate + L-valine
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxobutanoate
3-methyl-2-oxopentanoate + 2-aminobutanoate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxobutyrate
2-oxoisohexanoate + 2-aminobutyrate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxobutyrate
2-oxoisohexanoate + 2-aminobutyrate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
mitochondrial enzyme
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
lower reactivity than other origins
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
biosynthesis of L-isoleucine
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Lactococcus lactis LM0230
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Helicobacter pylori NCTC 11637
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoglutarate
L-glutamate + 3-methyl-2-oxopentanoate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
L-glutamate + 3-methyl-2-oxopentanoate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
L-glutamate + 3-methyl-2-oxopentanoate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxohexanoate
L-norleucine + 2-oxoisohexanoate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
show the reaction diagram
-
-
r
L-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxooctanoate
2-oxoisohexanoate + 2-aminooctanoate
show the reaction diagram
-
-
-
r
L-isoleucine + 3-methyl-2-oxobutanoate
3-methyl-2-oxopentanoate + L-valine
show the reaction diagram
-
-
-
r
L-isoleucine + 3-methylthio-2-oxobutanoate
3-methyl-2-oxopentanoate + 2-amino-3-methylthiobutanoate
show the reaction diagram
-
-
-
r
L-isoleucine + 3-phenylpyruvate
2-oxoisohexanoate + L-phenylalanine
show the reaction diagram
-
-
r
L-isoleucine + 4-methylthio-2-oxo-butanoate
3-methyl-2-oxopentanoate + L-methionine
show the reaction diagram
-
-
-
?
L-isoleucine + 4-methylthio-2-oxobutyrate
3-methyl-2-oxopentanoate + L-methionine
show the reaction diagram
-
-
r
L-isoleucine + glyoxylate
2-oxoisohexanoate + glycine
show the reaction diagram
-
-
-
r
L-isoleucine + oxaloacetate
3-methyl-2-oxopentanoate + L-aspartate
show the reaction diagram
-
brain enzyme
-
r
L-isoleucine + oxaloacetate
2-oxoisohexanoate + L-aspartate
show the reaction diagram
-
-
-
r
L-isoleucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
-
-
-
r
L-isoleucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
-
-
r
L-isoleucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxo-3-methiobutyrate
2-oxoisohexanoate + L-methionine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
show the reaction diagram
-
-
r
L-leucine + 2-oxo-butyrate
2-oxoisohexanoate + 2-aminobutyrate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxo-butyrate
2-oxoisohexanoate + 2-aminobutyrate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxo-butyrate
2-oxoisohexanoate + 2-aminobutyrate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxo-hexanoate
2-oxoisohexanoate + 2-aminohexanoate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxo-isohexanoate
2-oxoisohexanoate + L-leucine
show the reaction diagram
-
-
r
L-leucine + 2-oxo-isohexanoate
2-oxoisohexanoate + L-leucine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxo-pentanoate
2-oxoisohexanoate + 2-aminopentanoate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
70.1% of the activity with L-isoleucine
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
key enzyme on the biosynthetic pathway of hydrophobic amino acids
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
biosynthesis of branched-chain amino acids
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
last step of the synthesis or initial step of the degradation of branched chain amino acids
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
mitochondrial isoenzyme functions in the biosynthesis of L-isoleucine, L-leucine and L-valine, cytoplasmic isoenzyme functions in amino acid catabolism
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
biosynthesis of the branched-chain amino acids L-valine, L-isoleucine and L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
biosynthesis of L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
first step in the metabolism of branched-chain amino acids
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
sole transaminase in fetal rat liver
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
involved in production of fusel alcohols during fermentation
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
82% of the activity with L-isoleucine
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Saccharomyces cerevisiae BY4742
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Lactococcus lactis LM0230
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Helicobacter pylori NCTC 11637
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Helicobacter pylori NCTC 11637
-
70.1% of the activity with L-isoleucine
?
L-leucine + 2-oxoglutarate
2-oxoisohexanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
2-oxoisohexanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
2-oxoisohexanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
2-oxoisohexanoate + L-glutamate
show the reaction diagram
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-leucine + 2-oxoglutarate
L-glutamate + 4-methyl-2-oxopentanoate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxohexanoate
2-oxoisohexanoate + 2-aminohexanoate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxohexanoic acid
4-methyl-2-oxopentanoate + 2-aminohexanoic acid
show the reaction diagram
-
214% of the activity with 2-oxoglutarate
-
?
L-leucine + 2-oxoisohexanoate
2-oxoisohexanoate + L-leucine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoisohexanoate
2-oxoisohexanoate + L-leucine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoisohexanoate
2-oxoisohexanoate + L-leucine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoisohexanoate
2-oxoisohexanoate + L-leucine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoisohexanoate
2-oxoisohexanoate + L-leucine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoisohexanoate
2-oxoisohexanoate + L-leucine
show the reaction diagram
-
-
r
L-leucine + 2-oxoisopentanoate
2-oxoisohexanoate + L-valine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoisopentanoate
2-oxoisohexanoate + L-valine
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoisovaleric acid
4-methyl-2-oxopentanoate + 2-aminoisovaleric acid
show the reaction diagram
-
135% of the activity with 2-oxoglutarate
-
?
L-leucine + 2-oxooctanoate
2-oxoisohexanoate + 2-aminooctanoate
show the reaction diagram
-
-
-
r
L-leucine + 3-methyl-2-oxobutanoate
4-methyl-2-oxopentanoate + L-valine
show the reaction diagram
-
-
-
r
L-leucine + 3-methyl-2-oxobutanoate
4-methyl-2-oxopentanoate + L-valine
show the reaction diagram
-
-
-
r
L-leucine + 3-methyl-2-oxobutanoate
4-methyl-2-oxopentanoate + L-valine
show the reaction diagram
-
-
-
r
L-leucine + 3-methyl-2-oxobutanoate
4-methyl-2-oxopentanoate + L-valine
show the reaction diagram
-
-
-
-
L-leucine + 3-methyl-2-oxobutanoate
4-methyl-2-oxopentanoate + L-valine
show the reaction diagram
-
-
r
L-leucine + 3-methyl-2-oxopentanoate
4-methyl-2-oxopentanoate + L-isoleucine
show the reaction diagram
-
-
-
r
L-leucine + 3-methyl-2-oxopentanoate
4-methyl-2-oxopentanoate + L-isoleucine
show the reaction diagram
-
-
-
r
L-leucine + 3-methyl-2-oxopentanoate
2-oxo-4-methylpentanoate + L-isoleucine
show the reaction diagram
-
-
-
r
L-leucine + 4-methyl-2-oxopentanoate
L-glutamate + 2-oxoglutarate
show the reaction diagram
-
-
-
r
L-leucine + 4-methyl-2-oxopentanoate
L-glutamate + 2-oxoglutarate
show the reaction diagram
-
-
-
r
L-leucine + 4-methyl-2-oxopentanoate
L-glutamate + 2-oxoglutarate
show the reaction diagram
-
-
-
r
L-leucine + 4-methylthio-2-oxo-butanoate
4-methyl-2-oxopentanoate + L-methionine
show the reaction diagram
-
-
-
?
L-leucine + DL-2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
show the reaction diagram
-
-
-
r
L-leucine + DL-2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
show the reaction diagram
-
-
-
r
L-leucine + glyoxylate
2-oxoisohexanoate + glycine
show the reaction diagram
-
-
-
r
L-leucine + oxaloacetate
2-oxoisohexanoate + L-asparagine
show the reaction diagram
-
-
-
r
L-leucine + p-hydroxyphenylpyruvate
2-oxoisohexanoate + L-tyrosine
show the reaction diagram
-
-
-
r
L-leucine + p-hydroxyphenylpyruvate
2-oxoisohexanoate + L-tyrosine
show the reaction diagram
-
-
-
r
L-leucine + phenylpyruvate
2-oxoisohexanoate + L-phenylalanine
show the reaction diagram
-
-
-
r
L-leucine + phenylpyruvate
2-oxoisohexanoate + L-phenylalanine
show the reaction diagram
-
-
-
r
L-leucine + phenylpyruvate
2-oxoisohexanoate + L-phenylalanine
show the reaction diagram
-
2-oxo-isohexanoic acid 100%, BCATm relative rate 4%, BCATc 6%
-
r
L-leucine + prephenate
2-oxoisohexanoate + 1-(2-amino-2-carboxyethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid
show the reaction diagram
-
-
-
r
L-leucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
-
-
-
r
L-leucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
-
-
-
r
L-leucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
-
-
r
L-leucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
-
slight activity
-
r
L-leucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
-
2-oxoglutarate 100%, relative rate 1%
-
r
L-leucine + pyruvate
2-oxoisohexanoate + L-alanine
show the reaction diagram
-
2-oxo-isohexanoic acid 100%, BCATm and BCATc, relative rate 6%
-
r
L-lysine + 2-oxoglutarate
2-oxo-6-aminohexanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxo-isohexanoate
4-methylsulfanyl-2-oxobutanoate + L-leucine
show the reaction diagram
-
-
-
r
L-methionine + 2-oxobutanoate
4-methylthio-2-oxobutanoate + L-2-aminobutanoate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxobutyrate
4-methylsulfanyl-2-oxobutanoate + 2-aminobutyrate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
2.9% of the activity with L-isoleucine
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
transaminated extremely poorly
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
transaminated extremely poorly
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
higher reactivity than other origins
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
cytoplasmic isoenzyme
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
6% of the activity with L-isoleucine
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
-
-
-
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
Lactococcus lactis LM0230
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
Helicobacter pylori NCTC 11637
-
2.9% of the activity with L-isoleucine
?
L-methionine + 2-oxoglutarate
4-methylthio-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
show the reaction diagram
-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
show the reaction diagram
-
brain enzyme
-
r
L-norleucine + 4-methyl-2-oxopentanoate
2-oxohexanoate + L-leucine
show the reaction diagram
-
-
-
r
L-norvaline + 2-oxoglutarate
2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norvaline + 2-oxoglutarate
2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norvaline + 2-oxoglutarate
2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norvaline + 2-oxoglutarate
2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norvaline + 2-oxoglutarate
2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-norvaline + 2-oxoglutarate
2-oxopentanoate + L-glutamate
show the reaction diagram
-
brain enzyme
-
r
L-norvaline + 2-oxoglutarate
2-oxopentanoate + L-glutamate
show the reaction diagram
-
heart enzyme
-
r
L-norvaline + 4-methyl-2-oxopentanoate
2-oxopentanoate + L-leucine
show the reaction diagram
-
-
-
-
L-norvaline + 4-methyl-2-oxopentanoate
2-oxopentanoate + L-leucine
show the reaction diagram
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
0.9% of the activity with L-isoleucine
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
-
cytoplasmic isoenzyme
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
Lactococcus lactis LM0230
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
Helicobacter pylori NCTC 11637
-
0.9% of the activity with L-isoleucine
?
L-phenylalanine + 4-methylthio-2-oxo-butanoate
phenylpyruvate + L-methionine
show the reaction diagram
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxy-2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-threo-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-threonine + 2-oxoglutarate
2-oxo-3-hydroxybutyrate + L-glutamate
show the reaction diagram
-
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
show the reaction diagram
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-tryptophan + 2-oxoglutarate
L-glutamic acid + 3-indole-2-oxopropanoate
show the reaction diagram
-
-
-
?
L-tryptophan + 2-oxoglutarate
L-glutamic acid + 3-indole-2-oxopropanoate
show the reaction diagram
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
-
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-
cytoplasmic isoenzyme
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
-
-
-
L-valine + 2-oxo-3-methylpentanoate
3-methyl-2-oxobutanoate + L-isoleucine
show the reaction diagram
-
-
-
r
L-valine + 2-oxo-isohexanoate
2-oxoisopentanoate + L-leucine
show the reaction diagram
-
-
-
r
L-valine + 2-oxobutyrate
2-oxoisopentanoate + 2-aminobutanoate
show the reaction diagram
-
-
-
r
L-valine + 2-oxobutyrate
2-oxoisopentanoate + 2-aminobutanoate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
47.9% of the activity with L-isoleucine
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
mitochondrial enzyme
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
biosynthesis of L-valine
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
86% of the activity with L-isoleucine
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
Saccharomyces cerevisiae BY4742
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
Helicobacter pylori NCTC 11637
-
-
?
L-valine + 2-oxoglutarate
2-oxoisopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-valine + 2-oxoglutarate
2-oxoisopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
show the reaction diagram
-
-
r
L-valine + 2-oxoglutarate
L-glutamate + 3-methyl-2-oxobutanoate
show the reaction diagram
-
-
-
?
L-valine + 2-oxohexanoate
2-oxoisopentanoate + 2-aminohexanoate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoisopentanoate
2-oxoisopentanoate + L-valine
show the reaction diagram
-
-
-
r
L-valine + 2-oxoisopentanoate
2-oxoisopentanoate + L-valine
show the reaction diagram
-
-
r
L-valine + 2-oxooctanoate
2-oxoisopentanoate + 2-aminooctanoate
show the reaction diagram
-
-
-
r
L-valine + 3-methyl-2-oxopentanoate
3-methyl-2-oxobutanoate + L-isoleucine
show the reaction diagram
-
-
-
r
L-valine + 4-methyl-2-oxopentanoate
2-oxoisopentanoate + L-leucine
show the reaction diagram
-
-
-
r
L-valine + 4-methyl-2-oxopentanoate
2-oxoisopentanoate + L-leucine
show the reaction diagram
-
-
-
r
L-valine + 4-methylthio-2-oxo-butanoate
2-oxoisopentanoate + L-methionine
show the reaction diagram
-
-
-
?
L-valine + glyoxylate
2-oxoisopentanoate + glycine
show the reaction diagram
-
-
-
r
L-valine + oxaloacetate
2-oxoisopentanoate + L-aspartate
show the reaction diagram
-
-
-
r
L-valine + pyruvate
2-oxoisopentanoate + L-alanine
show the reaction diagram
-
-
-
r
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + ?
S-(1,1,2,2-tetrafluoroethyl)-2-oxo-3-thiobutyrate + ?
show the reaction diagram
-
-
-
?
S-(1,2-dichlorovinyl)-L-cysteine + ?
S-(1,2-dichlorovinyl)-2-oxo-3-thiobutyrate + ?
show the reaction diagram
-
-
-
?
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine + ?
S-(2-chloro-1,1,2-trifluoroethyl)-2-oxo-3-thiobutyrate + ?
show the reaction diagram
-
-
-
?
S-methyl-L-cysteine + 2-oxoglutarate
3-(methylthio)-2-oxopropanoic acid + L-glutamate
show the reaction diagram
-
heart enzyme
-
r
trimethylpyruvate + L-glutamate
L-tert-leucine + 2-oxoglutarate
show the reaction diagram
-
-
-
?
trimethylpyruvate + L-glutamate
L-tert-leucine + 2-oxoglutarate
show the reaction diagram
Escherichia coli, Enterobacter sp., Enterobacter sp. TL3
-
-
-
?
L-valine + pyruvate
2-oxoisopentanoate + L-alanine
show the reaction diagram
-
-
-
r
additional information
?
-
-
purified mitochondrial enzyme is not active with L-phenylalanine
-
-
-
additional information
?
-
-
no significant activity with glycine
-
-
-
additional information
?
-
-
purified enzyme has no measurable L-aspartate-2-oxoglutarate activity
-
-
-
additional information
?
-
-
B6-vitamin-dependent enzyme
-
-
-
additional information
?
-
-
L-aspartic acid, L-arginine, L-citrulline, L-lysine, L-ornithine, L-alanine, beta-alanine and gamma-aminobutyrate are not amino donors, oxalaceteate and glyoxylate are not amino acceptors, pyruvate is a weak amino acceptor, relative activity 1%
-
-
-
additional information
?
-
-
glycine and D-leucine are no substrates, oxaloacetate, pyruvate and glyoxylate are not amino acceptors
-
-
-
additional information
?
-
-
recombinant human BCATm and BCATc have beta-lyase activity towards 3 toxic L-cysteine S-conjugates, S-(1,1,2,2-tetrafluoroethyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-cysteine and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine and toward 3-chloro-L-alanine, BCATm is also active toward benzothiazolyl-L-cysteine, pyruvate formed from beta-lyase substrates
-
-
-
additional information
?
-
-
no activity towards L-aspartate
-
-
-
additional information
?
-
-
transamination activity with oxaloacetate is too low to be evaluated, DL-aminoadipate, glycine, L-phenylalanine, L-tyrosine and L-methionine are no substrates
-
-
-
additional information
?
-
-
L-glutamine is no substrate
-
-
-
additional information
?
-
-
L-citrulline and L-methionine are poor amino donors
-
-
-
additional information
?
-
-
only little or no activity with L-tryptophan, L-phenylalanine, L-glutamine, L-alanine and L-aspartate, KIC, KIV, DL-2oxo-3-methylpentanoate, 2-oxoglutarate, 2-oxohexanoate, 2-oxopentanoate, 2-oxobutyrate, 2-oxo-3-methiobutyrate, pyruvate or phenylpyruvate are acceptors
-
-
-
additional information
?
-
with 2-oxoglutarate as acceptor L-alanine is no substrate, with L-aspartate as amino donor, oxaloacetate is no amino acceptor
-
-
-
additional information
?
-
-
activity less than 3% with glycine, L-alanine, L-lysine, L-phenylalanine, L-tryptophan, D-alloisoleucine, D-valine, D-leucine, L-threonine, L-histidine, L-arginine, L-cysteine, DL-homocyteine, beta-aminoisobutyrate, gamma-aminobutyrate, alpha-aminoisobutyrate, DL-alpha-aminocaprylate, L-serine, DL-homoserine, DL-beta-aminobutyrate, DL-N-hydroxyleucine, DL-N-hydroxyvaline, L-aspartate, L-tyrosine, L-kynurenine, L-ornithine, DL-proline, L-glutamine, L-peniclliamine, DL-methionine sulfone, DL-methionine sulfoxide and DL-beta-hydroxy-leucine
-
-
-
additional information
?
-
-
L-isoleucine is the best substrate for the heart enzyme, L-alanine, aspartic, alpha-amino-butyric acid and gamma-aminobutyric acid, epsilon-aminocaproic acid, L-ornithine, L-methionine and L-phenylalanine are no substrates, pyruvate is not a good acceptor
-
-
-
additional information
?
-
-
L-leucine is the best substrate for the heart enzyme
-
-
-
additional information
?
-
novel co-repressor for thyroid hormone nuclear receptors
-
-
-
additional information
?
-
-
specific for L-leucine, L-isoleucine or L-valine, no other amino acid would serve as an amino donor
-
-
-
additional information
?
-
-
enzyme may influence methionine levels and play an important role in the metabolism of the nonprotein amino acid alpha-aminobutanoate, isoform Atbcat-1 is able to initiate degradation of all branched-chain amino acids
-
-
-
additional information
?
-
-
no substrate: phenylalanine, tyrosine, tryptophan, aspartic acid, asparagine
-
-
-
additional information
?
-
-
little or no activity is detected with L-isoleucine, no activity is observed with 6-methylthio-2-oxohexanoate, 3-methyl-2-oxopentanoate, or 3-methyl-2-oxobutyrate
-
-
-
additional information
?
-
no or very weak activity is shown toward L-methionine, L-aspartate, L-phenylalanine, glycine and the D-enantiomers of leucine, isoleucine and valine
-
-
-
additional information
?
-
no substrate: L-asparagine, L-histidine, and L-lysine, D-isoleucine, D-leucine, D-valine, as well as both enantiomers of alanine, proline, and serine
-
-
-
additional information
?
-
Escherichia coli W3110
-
no activity towards L-aspartate
-
-
-
additional information
?
-
Helicobacter pylori NCTC 11637
no or very weak activity is shown toward L-methionine, L-aspartate, L-phenylalanine, glycine and the D-enantiomers of leucine, isoleucine and valine
-
-
-
additional information
?
-
Helicobacter pylori NCTC 11637
no substrate: L-asparagine, L-histidine, and L-lysine, D-isoleucine, D-leucine, D-valine, as well as both enantiomers of alanine, proline, and serine
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3-methyl-2-oxobutyrate + L-glutamate
L-valine + 2-oxoglutarate
show the reaction diagram
-
the transamination of ketoisovalerate (KIV) to valine is carried out mainly by the transaminase B enzyme, with the transaminase C enzyme playing a minor role
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
P47176
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
O97932
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
P24288, P54687, P54690, Q9GKM4
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Q7BPX6
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Q93Y32, Q9FYA6, Q9LE06, Q9LPM9, Q9M401, Q9M439
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
B6RFK8
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
biosynthesis of L-isoleucine
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Lactococcus lactis LM0230
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
O97932
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
P24288, P54687, P54690, Q9GKM4
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Q7BPX6
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
key enzyme on the biosynthetic pathway of hydrophobic amino acids
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
biosynthesis of branched-chain amino acids
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Q93Y32, Q9FYA6, Q9LE06, Q9LPM9, Q9M401, Q9M439
last step of the synthesis or initial step of the degradation of branched chain amino acids
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
mitochondrial isoenzyme functions in the biosynthesis of L-isoleucine, L-leucine and L-valine, cytoplasmic isoenzyme functions in amino acid catabolism
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
biosynthesis of the branched-chain amino acids L-valine, L-isoleucine and L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
biosynthesis of L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
first step in the metabolism of branched-chain amino acids
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
-
sole transaminase in fetal rat liver
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
P47176
involved in production of fusel alcohols during fermentation
-
r
L-leucine + 2-oxoglutarate
2-oxoisohexanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-leucine + 2-oxoglutarate
2-oxoisohexanoate + L-glutamate
show the reaction diagram
B6RFK8
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Escherichia coli W3110
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
Lactococcus lactis LM0230
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
P47176
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
O97932
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
P24288, P54687, P54690, Q9GKM4
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
Q7BPX6
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
Q93Y32, Q9FYA6, Q9LE06, Q9LPM9, Q9M401, Q9M439
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
B6RFK8
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
biosynthesis of L-valine
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
r
additional information
?
-
-
specific for L-leucine, L-isoleucine or L-valine, no other amino acid would serve as an amino donor
-
-
-
additional information
?
-
-
enzyme may influence methionine levels and play an important role in the metabolism of the nonprotein amino acid alpha-aminobutanoate
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
Km 0.067 mM
pyridoxal 5'-phosphate
-
Km 0.025 mM
pyridoxal 5'-phosphate
-
Km 0.0065 mM
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
Km 0.00053 mM
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
Km 0.0065
pyridoxal 5'-phosphate
BCATc
pyridoxal 5'-phosphate
-
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
required
pyridoxal 5'-phosphate
-
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
pyridoxal 5'-phosphate
-
pyridoxal 5'-phosphate
-
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
pyridoxamine 5'-phosphate
-
Km 0.00062 mM
additional information
-
pyridoxine 5'-phosphate, pyridoxal, pyridoxamine and pyridoxine are not effective as coenzymes
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
-
5 mM MgCl2 stimulates by 26%
Mn2+
-
5 mM MgCl2 stimulates by 34%
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-Ketoglutarate
-
-
2-Ketoglutarate
-
17.5% activity in the presence of 10 mM
2-oxo-3-methylvalerate
-
measured in the forward reaction, concentrations higher than 1.0 mM inhibits the enzyme
2-oxoglutarate
-
5 mM 2-oxoglutarate inhibits the transamination of the 6.3-fold purified enzyme, of valine and isoleucine by about 50%, but the leucine activity is less affected. Inhibition is competitive with respect to valine
2-oxoisocaproate
-
-
2-oxoisocaproate
-
measured in the forward reaction, concentrations higher than 1.0 mM inhibits the enzyme
2-oxoisocaproate
-
-
2-oxoisovalerate
-
measured in the forward reaction, concentrations higher than 1.0 mM inhibits the enzyme
4-methyl-2-oxopentanoate
-
-
5-bromo-N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
-
IC50: 0.0025 mM
5-bromo-N'-(phenylsulfonyl)-1H-indole-2-carbohydrazide
-
IC50: 0.015 mM
5-chloro-N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
-
IC50: 0.0042 mM
5-chloro-N'-[(2-chlorophenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
-
IC50: 0.0057 mM
5-chloro-N'-[(2-methylphenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
-
IC50: 0.00116 mM
5-chloro-N'-[(3-methylphenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
-
IC50: 0.0012 mM
5-chloro-N'-[[2-(trifluoromethyl)phenyl]sulfonyl]-1-benzofuran-2-carbohydrazide
-
IC50: 0.0008 mM, potent inhibitor
5-methoxy-N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
-
IC50: 0.0128 mM
5-methoxy-N'-(phenylsulfonyl)-1H-indole-2-carbohydrazide
-
IC50: 0.0568 mM
Aminooxyacetate
-
-
aminooxyacetic acid
-
-
benzothiazolyl-L-cysteine
-
inhibits the L-leucine-2-oxoglutarate tranamination reaction of both isoenzymes
beta-chloro-L-alanine
-
rapidly inactivated by the beta-lyase substrate
carboxymethoxylamine
-
mixed-type inhibition, acts also as growth inhibitor of organism
carboxymethoxylamine
-
1 mM, 20% residual activity
Co2+
-
1 mM, 49% residual activity
Cu2+
-
1 mM, 39% residual activity
cupric acetate
-
-
diethyldicarbonate
-
-
Fe2+
-
1 mM, 34% residual activity
gabaculine
-
-
gabapentin
-
structural analogue of leucine, competitive inhibitor of BCATc, does not inhibit BCATm
gabapentin
inhibition is isoform-specific
gabapentin
-
inhibitor of the cytosolic enzyme
Hg2+
-
1 mM, 0% residual activity
HgCl2
-
-
hydroxylamine
-
-
hydroxylamine
-
-
hydroxylamine
-
-
hydroxylamine
-
hydroxylamine
-
1 mM, 3% residual activity
hydroxylamine
-
-
iodoacetamide
-
iodoacetic acid
-
Isocaproic acid
-
competitive inhibitor
isoleucine
-
competitive inhibition of enzyme activity with leucine
L-cysteine
-
10 mM, inhibits activity with isoleucine and tyrosine by 22 and 34%, respectively
L-isoleucine
-
with 1 mM tyrosine as the substrate, 10 mM isoleucine inhibits activity by 94%
L-leucine
-
with 1 mM tyrosine as the substrate, 10 mM leucine inhibits activity by 93%
L-methionine
-
10 mM methionine inhibits the activity with 1 mM tyrosine and phenylalanine by 86 and 59%, respectively, but it has no effect on the isoleucine activity
L-phenylalanine
-
with 2 mM isoleucine as the substrate, 10 mM phenylalanine inhibits activity by 46%
L-valine
-
with 1 mM tyrosine as the substrate, 10 mM valine inhibits activity by 78%
Lead acetate
-
-
N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
-
IC50: 0.0183 mM
N'-(phenylsulfonyl)-1H-indole-2-carbohydrazide
-
IC50: 0.036 mM
N'-(phenylsulfonyl)dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.00235 mM
N'-(phenylsulfonyl)quinoline-3-carbohydrazide
-
IC50: 0.0333 mM
N'-(phenylsulfonyl)quinoline-6-carbohydrazide
-
IC50: 0.0133 mM
N'-[(2-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.0129 mM
N'-[(2-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.0032 mM
N'-[(3-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: above 0.035 mM
N'-[(3-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.0028 mM
N'-[(4-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.0372 mM
N'-[(4-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.051 mM
N-ethylmaleimide
-
-
N-ethylmaleimide
-
-
O-(t-butyl)hydroxylamine
-
mixed-type inhibition, acts also as growth inhibitor of organism
O-allylhydroxylamine
-
mixed-type inhibition, acts also as growth inhibitor of organism
O-Benzylhydroxylamine
-
mixed-type inhibition, acts also as growth inhibitor of organism
O-Benzylhydroxylamine
-
O-Benzylhydroxylamine
-
-
p-chloromercuribenzoate
-
0.1 mM, complete inhibition
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
isoenzyme I, complete inhibition, isoenzyme III only partially inhibited
p-chloromercuribenzoate
-
5 mM, complete inhibition
p-chloromercuribenzoate
-
-
phenylhydrazine
-
-
phenylhydrazine
-
-
phenylhydrazine
-
-
phenylhydrazine
-
phenylhydrazine
-
1 mM, 0% residual activity
phenylpyruvate
-
shows substrate inhibition at 4 mM
potassium cyanide
-
-
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
rapidly inactivated by the beta-lyase substrate
S-(1,2-dichlorovinyl)-L-cysteine
-
rapidly inactivated by the beta-lyase substrate
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
rapidly inactivated by the beta-lyase substrate
Semicarbazide
-
isoenzyme II is somewhat sensitive, isoenzyme I is not
Semicarbazide
-
-
silver acetate
-
-
Sodium mersalyl
-
-
Thiosemicarbazide
-
-
Tris
-
-
valine
-
competitive inhibition of enzyme activity with leucine
Zinc acetate
-
-
ZnCl2
-
5 mM, 50% inhibition
Mersalyl
-
-
additional information
-
not inhibited by 5 mM KCI, NaCl, CuCl2, NiCl2, CoCl2, or FeCl2. No of activity with tyrosine by 10 mM aspartate, arginine, asparagine, glutamine, glycine, histidine, lysine, proline, serine, threonine or alanine
-
additional information
-
less than 10% inhibition with iodoacetamide, iodoacetate, sodium arsenite, oxidized glutathione, potassium ferricyanide, stannous chloride, ceric sulfate, aluminium chloride, cobalt chloride, ferric chloride, manganese chloride, magnesium chloride, calcium chloride or ferrous ammonium sulfate
-
additional information
-
no inhibition with isonicotinic acid hydrazide or KCN
-
additional information
-
not inhibited by isonicotinic acid and semicarbazide
-
additional information
-
no inhibition with isonicotinic acid hydrazide or KCN
-
additional information
-
not inhibitory: 4% NaCl, 1 mM iodoacetamide, 1 mM phenylmethylsulfonylfluoride
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-mercaptoethanol
-
-
2-mercaptoethanol
-
1.0 mM, relative activity 101%
2-mercaptoethanol
-
-
alpha,alpha'-dipyridyl
-
1.0 mM, relative activity 103%
EDTA
-
1.0 mM, relative activity 108%
glutathione
-
1.0 mM, relative activity 109%
neocuproin
-
1.0 mM, relative activity 106%
o-phenanthroline
-
1.0 mM, relative activity 108%
thioglycolate
-
1.0 mM, relative activity 101%
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.06
(R)-3-methyl-2-oxopentanoate
-
pH 8.0, 25C, substrate L-glutamate
0.07
(R,S)-3-methyl-2-oxopentanoate
-
pH 8.3, 25C
0.09
(S)-3-methyl-2-oxopentanoate
-
pH 8.3, 37C, leucine as amino group donor
0.17
(S)-3-methyl-2-oxopentanoate
-
pH 8.0, 25C, substrate L-glutamate
7.38
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid
-
pH 8.0, 37C
9.52
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid
-
pH 8.0, 37C
35.8
2-aminobutyrate
-
pH 8.3, 37C, 4-methyl-2-oxopentanoate as amino group acceptor
0.2
2-oxo-3-methylpentanoate
-
pH 8.4, 30C
2.5
2-oxo-3-methylpentanoate
-
pH 8.0, 37C
3.62
2-oxobutyrate
-
pH 8.3, 37C, leucine as amino group donor
0.085
2-oxoglutarate
in 50mM Tris-HCl buffer, pH 8.0, at 37C; pH 8.0, 37C
0.1
2-oxoglutarate
-
pH and temperature not specified in the publication, cosubstrate: L-phenylalanine; pH and temperature not specified in the publication, cosubstrate: L-tryptophan; pH and temperature not specified in the publication, cosubstrate: L-tyrosine
0.24
2-oxoglutarate
-
pH 8.0, 25C, substrate L-tyrosine
0.26
2-oxoglutarate
-
pH 8.0, 25C, substrate L-phenylalanine
0.3
2-oxoglutarate
-
pH and temperature not specified in the publication, cosubstrate: L-isoleucine; pH and temperature not specified in the publication, cosubstrate: L-valine
0.3
2-oxoglutarate
-
pH 8.0, 30C
0.56
2-oxoglutarate
-
pH 8.0, 25C, substrate L-tryptophan
0.57
2-oxoglutarate
-
pH 8.2, 37C, brain enzyme
0.6
2-oxoglutarate
-
pH and temperature not specified in the publication, cosubstrate: L-leucine
0.63
2-oxoglutarate
-
pH 8.6, 25C, heart enzyme
0.68
2-oxoglutarate
-
pH 8.4, 25C, L-leucine as amino group donor
0.77
2-oxoglutarate
-
pH 8.0, 37C, leucine as amino group donor
0.8
2-oxoglutarate
-
pH 8.4, 30C, L-valine as amino group donor
1
2-oxoglutarate
-
pH 8.2, 37C
1
2-oxoglutarate
-
pH 8.0, 25C, substrate L-methionine
1
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme III, isoleucine as amino group donor
1
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme III, leucine as amino group donor
1
2-oxoglutarate
-
pH 8.0, 25C, substrate L-methionine
1.1
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme III, isoleucine as amino group donor
1.28
2-oxoglutarate
-
pH 8.0, 37C
1.4
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme III, leucine as amino group donor
1.5
2-oxoglutarate
-
pH 8.4, 30C, leucine as amino group donor
1.52
2-oxoglutarate
-
pH 8.3, 37C, leucine as amino group donor
1.7
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme III, valine as amino group donor
1.7
2-oxoglutarate
-
pH 8.0, 25C, substrate L-valine
1.8
2-oxoglutarate
-
pH 8.4, 30C, isoleucine as amino group donor
2.1
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme I, leucine as amino group donor
2.4
2-oxoglutarate
-
pH 8.0, 25C, substrate L-isoleucine
2.4
2-oxoglutarate
-
pH 8.4, 25C, substrate L-alloisoleucine
2.7
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme I, valine as amino group donor
4
2-oxoglutarate
-
pH 8.0, 37C, leucine as amino group donor
4
2-oxoglutarate
-
pH 8.4, 25C, valine as amino group donor
4.57
2-oxoglutarate
-
pH 8.0, 37C, leucine as amino group donor
4.8
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme I, isoleucine as amino group donor
5
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme I, valine as amino group donor
5.5
2-oxoglutarate
-
pH 8.4, 25C, isoleucine as amino group donor
5.72
2-oxoglutarate
-
pH 8.0, 37C, valine as amino group donor
6.6
2-oxoglutarate
-
pH 8.0, 25C, substrate L-leucine
6.67
2-oxoglutarate
-
pH 8.0, 37C, isoleucine as amino group donor
6.95
2-oxoglutarate
-
cosubstrate L-leucine, pH 7.4, 37C
7.6
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme I, leucine as amino group donor
10
2-oxoglutarate
-
pH 8.0, 37C, isoenzyme I, isoleucine as amino group donor
12.5
2-oxoglutarate
-
pH 8.0, 37C, valine as amino group donor
14.2
2-oxoglutarate
-
pH 8.0, 37C, isoleucine as amino group donor
0.41
2-Oxohexanoate
-
pH 8.3, 37C, leucine as amino group donor
0.1
2-Oxoisohexanoate
-
pH 8.4, 30C, glutamate as amino group donor
0.21
2-Oxoisohexanoate
-
pH 8.3, 37C, leucine as amino group donor
0.37
2-Oxoisohexanoate
-
pH 7.5, 25C
0.56
2-Oxoisohexanoate
-
pH 8.0, 37C
0.91
2-Oxoisohexanoate
-
pH 8.0, 37C
1.1
2-Oxoisohexanoate
-
pH 8.0, 30C
0.33
2-oxoisopentanoate
-
pH 8.0, 37C
0.34
2-oxoisopentanoate
-
pH 7.5, 25C
0.37
2-oxoisopentanoate
-
pH 8.3, 37C, leucine as amino group donor
0.4
2-oxoisopentanoate
-
pH 8.4, 30C
0.56
2-oxoisopentanoate
-
pH 8.0, 37C
1.54
2-oxooctanoate
-
pH 8.3, 37C, leucine as amino group donor
0.64
2-oxovalerate
-
pH 8.3, 37C, L-leucine as amino group donor
0.11
3-methyl-2-oxobutanoate
-
pH 8.3, 25C
0.61
3-methyl-2-oxobutanoate
-
pH 8.0, 25C, substrate L-isoleucine
0.15
3-methyl-2-oxobutanoic acid
-
SlBCAT6, pH not specified in the publication, 25C
0.37
3-methyl-2-oxobutanoic acid
-
SlBCAT4, pH not specified in the publication, 25C
0.65
3-methyl-2-oxobutanoic acid
-
SlBCAT3, pH not specified in the publication, 25C
1.2
3-methyl-2-oxobutanoic acid
-
SlBCAT5, pH not specified in the publication, 25C
5.5
3-methyl-2-oxobutanoic acid
-
SlBCAT2, pH not specified in the publication, 25C
5.57
3-methyl-2-oxobutanoic acid
-
SlBCAT1, pH not specified in the publication, 25C
5.58
3-methyl-2-oxobutanoic acid
-
pH not specified in the publication, 25C
7.09
3-methyl-2-oxobutanoic acid
-
pH not specified in the publication, 25C
0.78
3-methyl-2-oxobutyric acid
-
pH 8.0, 37C
1.64
3-methyl-2-oxobutyric acid
-
pH 8.0, 37C
0.14
3-methyl-2-oxopentanoic acid
-
SlBCAT4, pH not specified in the publication, 25C
0.16
3-methyl-2-oxopentanoic acid
-
SlBCAT6, pH not specified in the publication, 25C
0.19
3-methyl-2-oxopentanoic acid
-
SlBCAT3, pH not specified in the publication, 25C; SlBCAT5, pH not specified in the publication, 25C
5.52
3-methyl-2-oxopentanoic acid
-
pH not specified in the publication, 25C
7.9
3-methyl-2-oxopentanoic acid
-
pH not specified in the publication, 25C
11.65
3-methyl-2-oxopentanoic acid
-
SlBCAT1, pH not specified in the publication, 25C
12.4
3-methyl-2-oxopentanoic acid
-
SlBCAT2, pH not specified in the publication, 25C
0.63
3-methyl-2-oxovaleric acid
-
pH 8.0, 37C
0.99
3-methyl-2-oxovaleric acid
-
pH 8.0, 37C
0.14
4-methyl-2-oxopentanoate
-
pH 8.3, 25C
0.53
4-methyl-2-oxopentanoate
-
pH 8.0, 25C, substrate L-isoleucine
0.22
4-methyl-2-oxopentanoic acid
-
SlBCAT6, pH not specified in the publication, 25C
0.34
4-methyl-2-oxopentanoic acid
-
SlBCAT5, pH not specified in the publication, 25C
0.35
4-methyl-2-oxopentanoic acid
-
SlBCAT3, pH not specified in the publication, 25C
0.41
4-methyl-2-oxopentanoic acid
-
SlBCAT4, pH not specified in the publication, 25C
4.92
4-methyl-2-oxopentanoic acid
-
pH not specified in the publication, 25C
7.09
4-methyl-2-oxopentanoic acid
-
SlBCAT1, pH not specified in the publication, 25C; SlBCAT2, pH not specified in the publication, 25C
11.65
4-methyl-2-oxopentanoic acid
-
pH not specified in the publication, 25C
0.42
4-methyl-2-oxovaleric acid
-
pH 8.0, 37C
0.97
4-methyl-2-oxovaleric acid
-
pH 8.0, 37C
0.045
4-methylsulfanyl-2-oxobutanoate
-
-
4.2
4-methylthio-2-oxo-butanoate
-
cosubstrate leucine, pH 7.4, 37C
0.6
beta-chloro-L-alanine
-
pH 7.4, 23C, recombinant BCATm
0.2
DL-2-oxo-3-methyl-n-pentanoate
-
pH 8.0, 37C
0.21
DL-2-oxo-3-methylpentanoate
-
pH 7.5, 25C
16.7
glutamate
-
pH 8.0, 37C, leucine as amino group donor
0.56
isoleucine
-
pH 8.4, 25C, 2-oxoglutarate as amino group acceptor
1.54
L-alloisoleucine
-
pH 8.4, 25C, 2-oxoglutarate as amino group acceptor
10
L-aspartate
-
pH 8.3, 37C, 4-methyl-2-oxopentanoate as amino group acceptor
0.56
L-glutamate
-
pH 8.0, 37C
1.3
L-glutamate
-
pH 8.4, 30C, 2-oxoisocaproate as amino group acceptor
2.45
L-glutamate
-
pH 8.3, 25C, (R,S)-3-methyl-2-oxopentanoate as amino group acceptor
3.2
L-glutamate
-
pH 8.0, 30C
3.6
L-glutamate
-
pH 8.3, 25C, 3-methyl-2-oxobutanoate as amino group acceptor
4.5
L-glutamate
-
pH 8.0, 25C, (R)-3-methyl-2-oxopentanoate as amino group acceptor
6.65
L-glutamate
-
pH 8.3, 25C, 4-methyl-2-oxopentanoate as amino group acceptor
9.53
L-glutamate
-
cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37C
10.4
L-glutamate
-
pH 8.0, 25C, 3-methyl-2-oxobutanoate as amino group acceptor
18.1
L-glutamate
-
pH 8.3, 37C, 4-methyl-2-oxopentanoate as amino group acceptor
18.2
L-glutamate
-
pH 8.0, 37C, isoleucine as amino group donor
21.3
L-glutamate
-
pH 8.0, 25C, (S)-3-methyl-2-oxopentanoate as amino group acceptor
24
L-glutamate
-
pH 7.5, 25C
25
L-glutamate
-
pH 8.0, 37C, valine as amino group donor
28.3
L-glutamate
-
pH 8.0, 25C, 4-methyl-2-oxopentanoate as amino group acceptor
0.31
L-isoleucine
-
pH not specified in the publication, 25C
0.31
L-isoleucine
-
SlBCAT2, pH not specified in the publication, 25C
0.34
L-isoleucine
in 50mM Tris-HCl buffer, pH 8.0, at 37C; pH 8.0, 37C
0.34
L-isoleucine
-
SlBCAT6, pH not specified in the publication, 25C
0.42
L-isoleucine
-
pH 8.0, 25C, 2-oxoglutarate as amino group acceptor
0.43
L-isoleucine
-
pH 8.0, 37C
0.43
L-isoleucine
-
SlBCAT4, pH not specified in the publication, 25C
0.52
L-isoleucine
-
pH 8.0, 37C
0.65
L-isoleucine
-
pH not specified in the publication, 25C
0.67
L-isoleucine
-
pH 8.2, 37C, brain enzyme
0.67
L-isoleucine
-
SlBCAT1, pH not specified in the publication, 25C
0.84
L-isoleucine
-
pH 8.2, 37C
0.84
L-isoleucine
-
SpBCAT1, pH not specified in the publication, 25C
0.9
L-isoleucine
-
-
1.3
L-isoleucine
-
mitochondria of AS-30D cell, pH 7.8, 37C
1.4
L-isoleucine
-
pH and temperature not specified in the publication
2.7
L-isoleucine
-
pH 8.0, 25C, 2-oxoglutarate as amino group acceptor
2.85
L-isoleucine
-
cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37C
3
L-isoleucine
-
pH 8.0, 37C, isoenzyme III, 2-oxoglutarate as amino group acceptor
3.03
L-isoleucine
-
pH 8.0, 37C
3.2
L-isoleucine
-
SlBCAT5, pH not specified in the publication, 25C
3.8
L-isoleucine
-
pH 8.6, 25C
4.2
L-isoleucine
-
pH 8.0, 37C, isoenzyme III, 2-oxoglutarate as amino group acceptor
4.9
L-isoleucine
-
SlBCAT3, pH not specified in the publication, 25C
6.16
L-isoleucine
-
cosubstrate 2-oxoglutarate, pH 7.4, 37C
10.3
L-isoleucine
-
pH 8.0, 37C, isoenzyme I, 2-oxoglutarate as amino group acceptor
22.2
L-isoleucine
-
pH 8.0, 37C, isoenzyme I, 2-oxoglutarate as amino group acceptor
22.2
L-isoleucine
-
pH 8.0, 37C
0.2
L-leucine
-
SlBCAT2, pH not specified in the publication, 25C
0.21
L-leucine
-
SlBCAT6, pH not specified in the publication, 25C
0.24
L-leucine
-
pH not specified in the publication, 25C
0.25
L-leucine
-
pH 8.0, 37C
0.3
L-leucine
-
pH 8.0, 30C
0.3
L-leucine
-
pH 8.4, 25C, 2-oxoglutarate as amino group acceptor
0.56
L-leucine
-
pH 8.2, 37C, brain enzyme
0.56
L-leucine
-
SlBCAT1, pH not specified in the publication, 25C
0.57
L-leucine
-
SlBCAT4, pH not specified in the publication, 25C
0.58
L-leucine
-
pH 8.0, 37C
0.62
L-leucine
-
pH 8.4, 25C, 2-oxoglutarate as amino group acceptor
0.67
L-leucine
-
pH not specified in the publication, 25C
0.75
L-leucine
-
pH 8.2, 37C
0.79
L-leucine
-
-
0.8
L-leucine
-
pH 8.4, 30C
0.84
L-leucine
-
SpBCAT1, pH not specified in the publication, 25C
1
L-leucine
-
mitochondria of AS-30D cell, pH 7.8, 37C
1.1
L-leucine
-
pH and temperature not specified in the publication
1.2
L-leucine
-
pH 8.0, 30C, activated with beta-mercaptoethanol
1.66
L-leucine
-
no further commentaries on experimental conditions
1.8
L-leucine
-
SlBCAT5, pH not specified in the publication, 25C
1.82
L-leucine
-
pH 8.0, 37C
2.2
L-leucine
-
pH 8.0, 25C
2.2
L-leucine
-
pH 8.0, 25C, 2-oxoglutarate as amino group acceptor
2.3
L-leucine
-
pH 8.0, 37C, isoenzyme III, 2-oxoglutarate as amino group acceptor
2.5
L-leucine
-
cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37C
2.7
L-leucine
-
SlBCAT3, pH not specified in the publication, 25C
3.6
L-leucine
-
pH 8.0, 37C, isoenzyme I, 2-oxoglutarate as amino group acceptor
3.8
L-leucine
-
pH 8.6, 25C
4.86
L-leucine
-
-
6.02
L-leucine
-
cosubstrate 2-oxoglutarate, pH 7.4, 37C
6.8
L-leucine
-
pH 8.0, 37C, isoenzyme III, 2-oxoglutarate as amino group acceptor
11.1
L-leucine
-
pH 8.0, 37C
25
L-leucine
-
pH 8.0, 37C, isoenzyme I, 2-oxoglutarate as amino group acceptor
0.93
L-methionine
-
-
19
L-methionine
-
pH 8.0, 25C, 2-oxoglutarate as amino group acceptor
1.7
L-norleucine
-
pH 8.3, 37C, 4-methyl-2-oxopentanoate as amino group acceptor
4.7
L-norvaline
-
pH 8.3, 37C, 4-methyl-2-oxopentanoate as amino group acceptor
0.1
L-phenylalanine
-
pH and temperature not specified in the publication
0.89
L-phenylalanine
-
pH 8.0, 25C
0.89
L-phenylalanine
-
pH 8.0, 25C, 2-oxoglutarate as amino group acceptor
2
L-phenylalanine
-
pH 8.0, 37C
7.44
L-phenylalanine
-
cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37C
2.8
L-tryptophan
-
pH and temperature not specified in the publication
2.9
L-tryptophan
-
pH 8.0, 37C
72
L-tryptophan
-
pH 8.0, 25C, 2-oxoglutarate as amino group acceptor
1.1
L-tyrosine
-
pH and temperature not specified in the publication
7
L-tyrosine
-
pH 8.0, 25C, 2-oxoglutarate as amino group acceptor
0.22
L-valine
-
pH 8.0, 37C
0.29
L-valine
-
-
0.35
L-valine
-
pH not specified in the publication, 25C
0.56
L-valine
-
pH not specified in the publication, 25C
1
L-valine
-
SlBCAT1, pH not specified in the publication, 25C
1.2
L-valine
-
SlBCAT6, pH not specified in the publication, 25C
1.32
L-valine
-
SpBCAT1, pH not specified in the publication, 25C
1.4
L-valine
-
pH8.2, 37C, brain enzyme
1.4
L-valine
-
SlBCAT2, pH not specified in the publication, 25C; SlBCAT4, pH not specified in the publication, 25C
1.77
L-valine
-
cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37C
2
L-valine
-
SlBCAT3, pH not specified in the publication, 25C
2.1
L-valine
-
mitochondria of AS-30D cell, pH 7.8, 37C
2.6
L-valine
-
SlBCAT5, pH not specified in the publication, 25C
2.7
L-valine
-
pH 8.0, 25C
2.8
L-valine
-
pH and temperature not specified in the publication
2.96
L-valine
-
pH 8.4, 25C, 2-oxoglutarate as amino group acceptor
3
L-valine
-
pH 8.0, 37C, isoenzyme III, 2-oxoglutarate as amino group acceptor
3.13
L-valine
-
pH 8.0, 37C
4.3
L-valine
-
pH 8.2, 37C
5.79
L-valine
-
cosubstrate 2-oxoglutarate, pH 7.4, 37C
6.45
L-valine
-
pH 8.0, 37C, 2-oxoglutarate as amino group acceptor
7.4
L-valine
-
pH 8.0, 37C, isoenzyme I, 2-oxoglutarate as amino group acceptor
8.3
L-valine
-
pH 8.0, 37C, isoenzyme III, 2-oxoglutarate as amino group acceptor
11
L-valine
-
pH 8.6, 25C
30.8
L-valine
-
pH 8.0, 37C, isoenzyme I, 2-oxoglutarate as amino group acceptor
143
L-valine
-
pH 8.0, 37C, 2-oxoglutarate as amino group acceptor
1.2
phenylpyruvate
-
pH 7.5, 25C
1.4
prephenate
-
pH 7.5, 25C
30.72
pyruvate
-
pH 8.3, 37C, leucine as amino group donor
8.4
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
pH 7.4, 23C, recombinant BCATm
0.06
trimethylpyruvate
-
pH 8.0, 37C
0.09
trimethylpyruvate
-
pH 8.0, 37C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2.9
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid
Enterobacter sp.
-
pH 8.0, 37C
4.11
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid
Escherichia coli
-
pH 8.0, 37C
250
2-oxoglutarate
Homo sapiens
-
mutant enzyme C315A
270
2-oxoglutarate
Homo sapiens
-
mutant enzyme C315A/C318A
340
2-oxoglutarate
Homo sapiens
-
wild type enzyme
360
2-oxoglutarate
Homo sapiens
-
mutant enzyme C318A
11.7
3-methyl-2-oxobutanoic acid
Solanum pennellii
-
pH not specified in the publication, 25C
22.1
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT5, pH not specified in the publication, 25C
23
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
23.4
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
pH not specified in the publication, 25C
46.5
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C
60.6
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
84.3
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
109.8
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
12.45
3-methyl-2-oxobutyric acid
Enterobacter sp.
-
pH 8.0, 37C
16.84
3-methyl-2-oxobutyric acid
Escherichia coli
-
pH 8.0, 37C
16.3
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
18.4
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
22.7
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
23.6
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C; SlBCAT5, pH not specified in the publication, 25C
67.6
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
83.9
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
pH not specified in the publication, 25C
84.8
3-methyl-2-oxopentanoic acid
Solanum pennellii
-
pH not specified in the publication, 25C
12.15
3-methyl-2-oxovaleric acid
Enterobacter sp.
-
pH 8.0, 37C
13.75
3-methyl-2-oxovaleric acid
Escherichia coli
-
pH 8.0, 37C
11.7
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
16.3
4-methyl-2-oxopentanoic acid
Solanum pennellii
-
pH not specified in the publication, 25C
28.1
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C
28.7
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
35
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
54.6
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT5, pH not specified in the publication, 25C
84.8
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
173.8
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
pH not specified in the publication, 25C
6.61
4-methyl-2-oxovaleric acid
Escherichia coli
-
pH 8.0, 37C
17.32
4-methyl-2-oxovaleric acid
Enterobacter sp.
-
pH 8.0, 37C
50.1
L-glutamate
Homo sapiens
-
mutant enzyme C315A/C318A
52
L-glutamate
Homo sapiens
-
mutant enzyme C315A
141
L-glutamate
Homo sapiens
-
mutant enzyme C335S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
208
L-glutamate
Homo sapiens
-
mutant enzyme C335S/C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
265
L-glutamate
Homo sapiens
-
mutant enzyme C318A
290
L-glutamate
Homo sapiens
-
wild type enzyme
403
L-glutamate
Homo sapiens
-
mutant enzyme C221S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
517
L-glutamate
Homo sapiens
-
mutant enzyme C242S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
741
L-glutamate
Homo sapiens
-
mutant enzyme C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
1035
L-glutamate
Homo sapiens
-
mutant enzyme C293S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
1075
L-glutamate
Homo sapiens
-
wild type enzyme, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
1157
L-glutamate
Homo sapiens
-
mutant enzyme C235S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
7.6
L-isoleucine
Solanum lycopersicum
-
pH not specified in the publication, 25C
7.6
L-isoleucine
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
20
L-isoleucine
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C; SlBCAT6, pH not specified in the publication, 25C
40.8
L-isoleucine
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
46.5
L-isoleucine
Solanum pennellii
-
pH not specified in the publication, 25C
48
L-isoleucine
Escherichia coli
-
pH 8.0, 25C
69.9
L-isoleucine
Solanum pennellii
-
SpBCAT1, pH not specified in the publication, 25C
70.5
L-isoleucine
Homo sapiens
-
mutant enzyme C315A/C318A
72
L-isoleucine
Homo sapiens
-
mutant enzyme C315A
163
L-isoleucine
Solanum lycopersicum
-
SlBCAT5, pH not specified in the publication, 25C
174
L-isoleucine
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C
319
L-isoleucine
Homo sapiens
-
mutant enzyme C318A
341
L-isoleucine
Homo sapiens
-
mutant enzyme C335S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
371
L-isoleucine
Homo sapiens
-
wild type enzyme
419
L-isoleucine
Homo sapiens
-
mutant enzyme C335S/C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
503
L-isoleucine
Homo sapiens
-
mutant enzyme C221S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
529
L-isoleucine
Homo sapiens
-
mutant enzyme C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
779
L-isoleucine
Homo sapiens
-
mutant enzyme C235S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
843
L-isoleucine
Homo sapiens
-
mutant enzyme C293S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
870
L-isoleucine
Homo sapiens
-
mutant enzyme C242S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
1075
L-isoleucine
Homo sapiens
-
wild type enzyme, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
8.1
L-leucine
Solanum lycopersicum
-
pH not specified in the publication, 25C
8.1
L-leucine
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
15.7
L-leucine
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
17.9
L-leucine
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
39.1
L-leucine
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
40.8
L-leucine
Solanum pennellii
-
pH not specified in the publication, 25C
60.8
L-leucine
Homo sapiens
-
mutant enzyme C315A/C318A
65
L-leucine
Homo sapiens
-
mutant enzyme C315A
78
L-leucine
Escherichia coli
-
pH 8.0, 25C
80.2
L-leucine
Solanum pennellii
-
SpBCAT1, pH not specified in the publication, 25C
118
L-leucine
Solanum lycopersicum
-
SlBCAT5, pH not specified in the publication, 25C
121
L-leucine
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C
213
L-leucine
Homo sapiens
-
mutant enzyme C335S/C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
253
L-leucine
Homo sapiens
-
mutant enzyme C335S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
286
L-leucine
Homo sapiens
-
mutant enzyme C221S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
310
L-leucine
Homo sapiens
-
mutant enzyme C318A
337
L-leucine
Homo sapiens
-
wild type enzyme
430
L-leucine
Homo sapiens
-
mutant enzyme C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
651
L-leucine
Homo sapiens
-
mutant enzyme C242S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
756
L-leucine
Homo sapiens
-
mutant enzyme C235S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
803
L-leucine
Homo sapiens
-
mutant enzyme C293S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
898
L-leucine
Homo sapiens
-
wild type enzyme, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
17
L-methionine
Escherichia coli
-
pH 8.0, 25C
2.9
L-phenylalanine
Escherichia coli
-
pH 8.0, 25C
3.7
L-tryptophan
Escherichia coli
-
pH 8.0, 25C
2.2
L-tyrosine
Escherichia coli
-
pH 8.0, 25C
3.8
L-valine
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
19
L-valine
Escherichia coli
-
pH 8.0, 25C
20.6
L-valine
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
24
L-valine
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
28.1
L-valine
Solanum lycopersicum
-
pH not specified in the publication, 25C
39.1
L-valine
Solanum pennellii
-
pH not specified in the publication, 25C
50.5
L-valine
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
55
L-valine
Solanum pennellii
-
SpBCAT1, pH not specified in the publication, 25C
111
L-valine
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C
123
L-valine
Solanum lycopersicum
-
SlBCAT5, pH not specified in the publication, 25C
170
L-valine
Homo sapiens
-
mutant enzyme C335S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
188
L-valine
Homo sapiens
-
mutant enzyme C315A
197
L-valine
Homo sapiens
-
mutant enzyme C315A/C318A
230
L-valine
Homo sapiens
-
mutant enzyme C318A
277
L-valine
Homo sapiens
-
wild type enzyme
292
L-valine
Homo sapiens
-
mutant enzyme C335S/C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
443
L-valine
Homo sapiens
-
mutant enzyme C221S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
597
L-valine
Homo sapiens
-
mutant enzyme C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
688
L-valine
Homo sapiens
-
mutant enzyme C242S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
838
L-valine
Homo sapiens
-
mutant enzyme C235S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
1111
L-valine
Homo sapiens
-
mutant enzyme C293S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
1236
L-valine
Homo sapiens
-
wild type enzyme, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
2.2
trimethylpyruvate
Escherichia coli
-
pH 8.0, 37C
2.59
trimethylpyruvate
Enterobacter sp.
-
pH 8.0, 37C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.3
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid
Enterobacter sp.
-
pH 8.0, 37C
14395
0.56
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid
Escherichia coli
-
pH 8.0, 37C
14395
2
3-methyl-2-oxobutanoic acid
Solanum pennellii
-
pH not specified in the publication, 25C
3156
4
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
3156
5
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
pH not specified in the publication, 25C
3156
15
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
3156
20
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT5, pH not specified in the publication, 25C
3156
70
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C
3156
164
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
3156
730
3-methyl-2-oxobutanoic acid
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
3156
10.27
3-methyl-2-oxobutyric acid
Escherichia coli
-
pH 8.0, 37C
19740
15.96
3-methyl-2-oxobutyric acid
Enterobacter sp.
-
pH 8.0, 37C
19740
1
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
3009
6
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
3009
11
3-methyl-2-oxopentanoic acid
Solanum pennellii
-
pH not specified in the publication, 25C
3009
17
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
pH not specified in the publication, 25C
3009
120
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C; SlBCAT5, pH not specified in the publication, 25C
3009
131
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
3009
140
3-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
3009
13.89
3-methyl-2-oxovaleric acid
Escherichia coli
-
pH 8.0, 37C
15535
19.29
3-methyl-2-oxovaleric acid
Enterobacter sp.
-
pH 8.0, 37C
15535
1
4-methyl-2-oxopentanoic acid
Solanum pennellii
-
pH not specified in the publication, 25C
2785
2
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
2785
11
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
2785
38
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
pH not specified in the publication, 25C
2785
80
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C
2785
85
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
2785
130
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
2785
160
4-methyl-2-oxopentanoic acid
Solanum lycopersicum
-
SlBCAT5, pH not specified in the publication, 25C
2785
15.74
4-methyl-2-oxovaleric acid
Escherichia coli
-
pH 8.0, 37C
19739
17.85
4-methyl-2-oxovaleric acid
Enterobacter sp.
-
pH 8.0, 37C
19739
31
L-glutamate
Homo sapiens
-
mutant enzyme C221S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C; mutant enzyme C335S/C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
41
40
L-glutamate
Homo sapiens
-
mutant enzyme C242S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
41
43
L-glutamate
Homo sapiens
-
mutant enzyme C335S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
41
62
L-glutamate
Homo sapiens
-
mutant enzyme C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
41
103
L-glutamate
Homo sapiens
-
mutant enzyme C293S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
41
108
L-glutamate
Homo sapiens
-
wild type enzyme, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
41
126
L-glutamate
Homo sapiens
-
mutant enzyme C235S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
41
25
L-isoleucine
Solanum lycopersicum
-
pH not specified in the publication, 25C
311
25
L-isoleucine
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
311
36
L-isoleucine
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C
311
47
L-isoleucine
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
311
51
L-isoleucine
Solanum lycopersicum
-
SlBCAT5, pH not specified in the publication, 25C
311
59
L-isoleucine
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
311
61
L-isoleucine
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
311
70
L-isoleucine
Solanum pennellii
-
pH not specified in the publication, 25C
311
83
L-isoleucine
Solanum pennellii
-
SpBCAT1, pH not specified in the publication, 25C
311
1118
L-isoleucine
Homo sapiens
-
mutant enzyme C221S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
311
1364
L-isoleucine
Homo sapiens
-
mutant enzyme C335S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
311
1496
L-isoleucine
Homo sapiens
-
mutant enzyme C335S/C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
311
2071
L-isoleucine
Homo sapiens
-
mutant enzyme C242S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
311
2107
L-isoleucine
Homo sapiens
-
mutant enzyme C293S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
311
2116
L-isoleucine
Homo sapiens
-
mutant enzyme C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
311
3359
L-isoleucine
Homo sapiens
-
wild type enzyme, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
311
3895
L-isoleucine
Homo sapiens
-
mutant enzyme C235S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
311
31
L-leucine
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
127
40
L-leucine
Solanum lycopersicum
-
pH not specified in the publication, 25C
127
40
L-leucine
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
127
45
L-leucine
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C
127
61
L-leucine
Solanum pennellii
-
pH not specified in the publication, 25C
127
66
L-leucine
Solanum lycopersicum
-
SlBCAT5, pH not specified in the publication, 25C
127
70
L-leucine
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
127
75
L-leucine
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
127
95
L-leucine
Solanum pennellii
-
SpBCAT1, pH not specified in the publication, 25C
127
474
L-leucine
Homo sapiens
-
mutant enzyme C335S/C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
127
505
L-leucine
Homo sapiens
-
mutant enzyme C335S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
127
1059
L-leucine
Homo sapiens
-
mutant enzyme C221S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
127
1302
L-leucine
Homo sapiens
-
mutant enzyme C242S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
127
1652
L-leucine
Homo sapiens
-
mutant enzyme C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
127
2294
L-leucine
Homo sapiens
-
mutant enzyme C293S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
127
2494
L-leucine
Homo sapiens
-
wild type enzyme, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
127
3151
L-leucine
Homo sapiens
-
mutant enzyme C235S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
127
3
L-valine
Solanum lycopersicum
-
SlBCAT2, pH not specified in the publication, 25C
246
15
L-valine
Solanum lycopersicum
-
SlBCAT4, pH not specified in the publication, 25C
246
20
L-valine
Solanum lycopersicum
-
SlBCAT6, pH not specified in the publication, 25C
246
42
L-valine
Solanum pennellii
-
SpBCAT1, pH not specified in the publication, 25C
246
47
L-valine
Solanum lycopersicum
-
SlBCAT5, pH not specified in the publication, 25C
246
50
L-valine
Solanum lycopersicum
-
SlBCAT1, pH not specified in the publication, 25C
246
56
L-valine
Solanum lycopersicum
-
SlBCAT3, pH not specified in the publication, 25C
246
70
L-valine
Solanum pennellii
-
pH not specified in the publication, 25C
246
80
L-valine
Solanum lycopersicum
-
pH not specified in the publication, 25C
246
89
L-valine
Homo sapiens
-
mutant enzyme C335S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
246
132
L-valine
Homo sapiens
-
mutant enzyme C335S/C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
246
201
L-valine
Homo sapiens
-
mutant enzyme C221S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
246
313
L-valine
Homo sapiens
-
mutant enzyme C242S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
246
579
L-valine
Homo sapiens
-
mutant enzyme C293S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
246
597
L-valine
Homo sapiens
-
mutant enzyme C338S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
246
618
L-valine
Homo sapiens
-
wild type enzyme, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
246
1397
L-valine
Homo sapiens
-
mutant enzyme C235S, in 25 mM potassium phosphate buffer at pH 7.8, at 37C
246
24.44
trimethylpyruvate
Escherichia coli
-
pH 8.0, 37C
19741
43.16
trimethylpyruvate
Enterobacter sp.
-
pH 8.0, 37C
19741
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1.9
2-oxoglutarate
-
6.3-fold purified enzyme, pH and temperature not specified in the publication
2.1
4-methyl-2-oxopentanoate
-
pH 8.3, 25C
3.8
alpha-Ketoisocaproate
-
pH 8.0, 30C
0.01424
carboxymethoxylamine
-
uncompetitive component of mixed-type inhibition, pH 7.4, 37C
0.0209
carboxymethoxylamine
-
competitive component of mixed-type inhibition, pH 7.4, 37C
1.3
gabapentin
cytosolic isoform, reduced
3.5
gabapentin
cytosolic isoform, oxidized
65.4
gabapentin
mitochondrial isoform, reduced
389.2
gabapentin
mitochondrial isoform, oxidized
6
Isocaproic acid
-
unactivated enzyme
14
Isocaproic acid
-
activated enzyme
0.011
O-(t-butyl)hydroxylamine
-
competitive component of mixed-type inhibition, pH 7.4, 37C
0.0856
O-(t-butyl)hydroxylamine
-
uncompetitive component of mixed-type inhibition, pH 7.4, 37C
0.0216
O-allylhydroxylamine
-
competitive component of mixed-type inhibition, pH 7.4, 37C
0.2
O-allylhydroxylamine
-
or higher, uncompetitive component of mixed-type inhibition, pH 7.4, 37C
0.0082
O-Benzylhydroxylamine
-
competitive component of mixed-type inhibition, pH 7.4, 37C
0.0841
O-Benzylhydroxylamine
-
uncompetitive component of mixed-type inhibition, pH 7.4, 37C
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0025
5-bromo-N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
Homo sapiens
-
IC50: 0.0025 mM
0.015
5-bromo-N'-(phenylsulfonyl)-1H-indole-2-carbohydrazide
Homo sapiens
-
IC50: 0.015 mM
0.0042
5-chloro-N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
Homo sapiens
-
IC50: 0.0042 mM
0.0057
5-chloro-N'-[(2-chlorophenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
Homo sapiens
-
IC50: 0.0057 mM
0.00116
5-chloro-N'-[(2-methylphenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
Homo sapiens
-
IC50: 0.00116 mM
0.0012
5-chloro-N'-[(3-methylphenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
Homo sapiens
-
IC50: 0.0012 mM
0.0008
5-chloro-N'-[[2-(trifluoromethyl)phenyl]sulfonyl]-1-benzofuran-2-carbohydrazide
Homo sapiens
-
IC50: 0.0008 mM, potent inhibitor
0.0128
5-methoxy-N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
Homo sapiens
-
IC50: 0.0128 mM
0.0568
5-methoxy-N'-(phenylsulfonyl)-1H-indole-2-carbohydrazide
Homo sapiens
-
IC50: 0.0568 mM
0.0183
N'-(phenylsulfonyl)-1-benzofuran-2-carbohydrazide
Homo sapiens
-
IC50: 0.0183 mM
0.036
N'-(phenylsulfonyl)-1H-indole-2-carbohydrazide
Homo sapiens
-
IC50: 0.036 mM
0.00235
N'-(phenylsulfonyl)dibenzo[b,d]furan-2-carbohydrazide
Homo sapiens
-
IC50: 0.00235 mM
0.0333
N'-(phenylsulfonyl)quinoline-3-carbohydrazide
Homo sapiens
-
IC50: 0.0333 mM
0.0133
N'-(phenylsulfonyl)quinoline-6-carbohydrazide
Homo sapiens
-
IC50: 0.0133 mM
0.0129
N'-[(2-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
Homo sapiens
-
IC50: 0.0129 mM
0.0032
N'-[(2-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
Homo sapiens
-
IC50: 0.0032 mM
0.035
N'-[(3-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
Homo sapiens
-
IC50: above 0.035 mM
0.0028
N'-[(3-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
Homo sapiens
-
IC50: 0.0028 mM
0.0372
N'-[(4-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
Homo sapiens
-
IC50: 0.0372 mM
0.051
N'-[(4-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
Homo sapiens
-
IC50: 0.051 mM
0.01
NH4+
Mycobacterium tuberculosis
-
pH 7.5, 37C
0.042
O-Benzylhydroxylamine
Mycobacterium smegmatis
A0R066
pH 7.5, 37C
0.065
O-Benzylhydroxylamine
Mycobacterium tuberculosis
-
pH 7.5, 37C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.012
-
SlBCAT2, substrate L-valine, pH not specified in the publication, 25C
0.018
-
L-isoleucine, pH not specified in the publication, 25C; L-leucine, pH not specified in the publication, 25C
0.018
-
SlBCAT2, substrate L-isoleucine, pH not specified in the publication, 25C; SlBCAT2, substrate L-leucine, pH not specified in the publication, 25C
0.03
-
3-methyl-2-oxobutanoic acid, pH not specified in the publication, 25C
0.03
-
SlBCAT1, substrate 4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.036
-
SlBCAT6, substrate L-leucine, pH not specified in the publication, 25C
0.042
-
4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.042
-
SlBCAT1, substrate 3-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C; SlBCAT4, substrate L-leucine, pH not specified in the publication, 25C
0.048
-
SlBCAT4, substrate 3-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C; SlBCAT4, substrate L-isoleucine, pH not specified in the publication, 25C; SlBCAT4, substrate L-valine, pH not specified in the publication, 25C; SlBCAT6, substrate L-isoleucine, pH not specified in the publication, 25C
0.054
-
SlBCAT5, substrate 3-methyl-2-oxobutanoic acid, pH not specified in the publication, 25C
0.06
-
SlBCAT1, substrate 3-methyl-2-oxobutanoic acid, pH not specified in the publication, 25C; SlBCAT3, substrate 3-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C; SlBCAT5, substrate 3-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C; SlBCAT6, substrate 3-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C; SlBCAT6, substrate L-valine, pH not specified in the publication, 25C
0.066
-
3-methyl-2-oxobutanoic acid, pH not specified in the publication, 25C; L-valine, pH not specified in the publication, 25C
0.066
-
SlBCAT3, substrate 4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.072
-
SlBCAT6, substrate 4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.084
-
SlBCAT4, substrate 4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.096
-
L-leucine, pH not specified in the publication, 25C; L-valine, pH not specified in the publication, 25C
0.096
-
SlBCAT1, substrate L-isoleucine, pH not specified in the publication, 25C; SlBCAT1, substrate L-leucine, pH not specified in the publication, 25C
0.114
-
L-isoleucine, pH not specified in the publication, 25C
0.114
-
SlBCAT3, substrate 3-methyl-2-oxobutanoic acid, pH not specified in the publication, 25C
0.12
-
SlBCAT1, substrate L-valine, pH not specified in the publication, 25C
0.132
-
SlBCAT5, substrate 4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.14
-
SpBCAT1, substrate L-valine, pH not specified in the publication, 25C
0.15
-
SlBCAT4, substrate 3-methyl-2-oxobutanoic acid, pH not specified in the publication, 25C
0.17
-
SlBCAT2, substrate 3-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.17
-
SpBCAT1, substrate L-isoleucine, pH not specified in the publication, 25C
0.2
-
3-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.2
-
SpBCAT1, substrate L-leucine, pH not specified in the publication, 25C
0.21
-
3-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.21
-
SlBCAT2, substrate 3-methyl-2-oxobutanoic acid, pH not specified in the publication, 25C; SlBCAT2, substrate 4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.264
-
SlBCAT3, substrate L-valine, pH not specified in the publication, 25C
0.276
-
SlBCAT6, substrate 3-methyl-2-oxobutanoic acid, pH not specified in the publication, 25C
0.282
-
SlBCAT5, substrate L-leucine, pH not specified in the publication, 25C
0.288
-
SlBCAT3, substrate L-leucine, pH not specified in the publication, 25C
0.294
-
SlBCAT5, substrate L-valine, pH not specified in the publication, 25C
0.39
-
SlBCAT5, substrate L-isoleucine, pH not specified in the publication, 25C
0.41
-
4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25C
0.414
-
SlBCAT3, substrate L-isoleucine, pH not specified in the publication, 25C
0.7
-
substrate L-phenylalanine
0.7273
-
brain enzyme, substrate L-leucine
1.74
glycine, pH 8.0, 3C
1.82
-
heart muscle enzyme, substrate L-leucine
2.17
-
substrate L-phenylalanine, cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37C
2.4
-
substrate L-methionine
2.58
-
substrate L-valine, cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37C
3.65
-
substrate L-leucine, cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37C
4.22
-
substrate 4-methylthio-2-oxo-butanoate, cosubstrate leucine, pH 7.4, 37C
4.28
-
substrate L-isoleucine, cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37C
5.23
L-tryptophan, pH 8.0, 3C
5.7
-
substrate L-glutamate, cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37C
7
-
regenerating liver, pH 7.8, 37C
11.1
-
pH 7.4, 37C
11.82
-
substrate L-valine, cosubstrate 2-oxoglutarate, pH 7.4, 37C
12.8
-
substrate 2-oxoglutarate, cosubstrate L-leucine, pH 7.4, 37C
13.44
-
substrate L-leucine, cosubstrate 2-oxoglutarate, pH 7.4, 37C
14.35
-
substrate L-isoleucine, cosubstrate 2-oxoglutarate, pH 7.4, 37C
15.9
-
substrate L-valine + 2-oxoglutarate
18.6
-
mitochondria of AS-30D cell, pH 7.8, 37C
25
-
cytoplasmic enzyme
25
-
substrate L-valine
25.3
-
in presence of 2-mercaptoethanol
27
-
substrate L-leucine
27.3
-
substrate L-isoleucine + 2-oxoglutarate
45.2
-
-
47
-
substrate L-isoleucine
48.8
-
mitochondrial enzyme
50 - 53
-
-
77.03
L-valine, pH 8.0, 3C
85
-
recombinant cytosolic enzyme
86.84
L-leucine, pH 8.0, 3C
89.81
-
-
94
substrate L-isoleucine + 2-oxoglutarate
104.6
L-isoleucine, pH 8.0, 3C
125
-
recombinant mitochondrial enzyme
180
substrates 2-oxoisocaproate and L-glutamate, pH 8.3, 25C
additional information
-
specific activity 4660 units, 1 unit is defined as the change of absorbance units at 348 nm and 37 within 30 min
additional information
-
final preparation, specific activity 23.9 U/mg
additional information
62.5% activity with 2-oxoisovalerate, 34.9% activity with 3-methyl-2-oxovalerate, 22.7% activity with 2-oxo-4-methylthiobutyrate, 57.1% activity with 2-oxohexanoate, 51.0% activity with 2-oxovalerate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.2
-
and 4% NaCl, 13% of maximum activity
8
-
brain enzyme
8
-
isoenzyme III
8 - 8.7
-
-
8.3
-
isoenzyme AT-II
8.3 - 8.5
-
-
8.5
-
cytoplasmic enzyme
8.5 - 9.5
-
isoenzyme III
8.6
-
-
8.6
-
isoenzyme AT-I
8.7
-
heart enzyme
8.7
-
using valine in the reverse reaction
8.8
-
mitochondrial enzyme
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4.6 - 9
-
-
6 - 10
-
-
6 - 9
-
58% activity at pH 6.0, 78% activity at pH 9.0
6.5 - 10
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30 - 60
-
-
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4.9
-
isoelectric focusing
6.47
calculated from sequence of cDNA
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
endothelial cells
Manually annotated by BRENDA team
-
hepatoma cell, expresses only mitochondrial isoform
Manually annotated by BRENDA team
-
neurons of adult animal
Manually annotated by BRENDA team
highest levels of BCAT transcripts are found in open flowers
Manually annotated by BRENDA team
-
; mature green fruit
Manually annotated by BRENDA team
-
cytosolic enzyme form
Manually annotated by BRENDA team
-
mitochondrial isoform, secretory epithelia throughout digestive tract, cytosolic isoform, autonomic innervation of digestive tract
Manually annotated by BRENDA team
-
heart muscle
Manually annotated by BRENDA team
-
heart muscle
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
-
-
-
Manually annotated by BRENDA team
-
neurons of adult animal, strong expression in the mossy fiber pathway of hippocampal formation
Manually annotated by BRENDA team
-
mitochondrial isoform, secretory cells of
Manually annotated by BRENDA team
-
predominant expression of isoform Atbcat-1
Manually annotated by BRENDA team
highest levels of BCAT transcripts are found in young leaves
Manually annotated by BRENDA team
-
negligible activity in adult, high activity in fetal liver
Manually annotated by BRENDA team
-
regenerating liver after partial hepatectomy, enzyme activity between day 3 and 6
Manually annotated by BRENDA team
-
mitochondrial isoform, myofibrils
Manually annotated by BRENDA team
-
cytosolic isoform, axons of sciatic nerve
Manually annotated by BRENDA team
-
mitochondrial enzyme form
Manually annotated by BRENDA team
-
mitochondrial isoform, secretory cells of
Manually annotated by BRENDA team
-
predominant expression of isoform Atbcat-1
Manually annotated by BRENDA team
-
mitochondrial isoform
Manually annotated by BRENDA team
-
mitochondrial isoform, secretory cells of
Manually annotated by BRENDA team
-
mitochondrial isoform, secretory cells of
Manually annotated by BRENDA team
additional information
-
no overlap in distribution of mitochndrial and cytosolic isoform, mitochondrial isoform is not found in liver
Manually annotated by BRENDA team
additional information
-
isoforms Atbcat-1, Atbcat-3 are expressed in all tissues, isoforms Atbcat-4, Atbcat-6 mainly in tissues associated with transport function and meristematic tissues
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
granule cells of the cerebellar cortex and dentate gyrus
Manually annotated by BRENDA team
-
of Purkinje cells and hippocampal pyramidal basket cells
Manually annotated by BRENDA team
-
isoforms Atbcat-4, Atbcat-6
Manually annotated by BRENDA team
-
mainly located in the cytoplasm
Manually annotated by BRENDA team
-
inner membrane-matrix
Manually annotated by BRENDA team
-
mitochondrial matrix
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
-
-
-
Manually annotated by BRENDA team
-
granule cells of the cerebellar cortex and dentate gyrus
-
Manually annotated by BRENDA team
recombinant enzyme, expressed in transfected cells
Manually annotated by BRENDA team
-
isoforms Atbcat-2, Atbcat-3, Atbcat-5
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
UNIPROT
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Brucella abortus (strain 2308)
Burkholderia pseudomallei (strain 1710b)
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)