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Literature summary for 2.6.1.42 extracted from

  • Goto, M.; Miyahara, I.; Hirotsu, K.; Conway, M.; Yennawar, N.; Islam, M.M.; Hutson, S.M.
    Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin (2005), J. Biol. Chem., 280, 37246-37256.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
cytosolic isoform in complex with gabapentin or 4-methylvalerate, mitochondrial isoform in complex with gabapentin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
gabapentin inhibition is isoform-specific Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O15382 cytosolic and mitochondrial isoforms
-

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3
-
gabapentin cytosolic isoform, reduced Homo sapiens
3.5
-
gabapentin cytosolic isoform, oxidized Homo sapiens
65.4
-
gabapentin mitochondrial isoform, reduced Homo sapiens
389.2
-
gabapentin mitochondrial isoform, oxidized Homo sapiens