Cloned (Comment) | Organism |
---|---|
recombinant BCATm and BCATc | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoisocaproate | - |
Homo sapiens | |
benzothiazolyl-L-cysteine | inhibits the L-leucine-2-oxoglutarate tranamination reaction of both isoenzymes | Homo sapiens | |
beta-chloro-L-alanine | rapidly inactivated by the beta-lyase substrate | Homo sapiens | |
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine | rapidly inactivated by the beta-lyase substrate | Homo sapiens | |
S-(1,2-dichlorovinyl)-L-cysteine | rapidly inactivated by the beta-lyase substrate | Homo sapiens | |
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine | rapidly inactivated by the beta-lyase substrate | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.6 | - |
beta-chloro-L-alanine | pH 7.4, 23°C, recombinant BCATm | Homo sapiens | |
8.4 | - |
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine | pH 7.4, 23°C, recombinant BCATm | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
41730 | - |
2 * 41730, recombinant BCATm, homodimer | Homo sapiens |
43400 | - |
2 * 43400, recombinant BCATc, homodimer | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-chloro-L-alanine + ? | - |
Homo sapiens | 3-chloropyruvate + ? | - |
? | |
additional information | recombinant human BCATm and BCATc have beta-lyase activity towards 3 toxic L-cysteine S-conjugates, S-(1,1,2,2-tetrafluoroethyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-cysteine and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine and toward 3-chloro-L-alanine, BCATm is also active toward benzothiazolyl-L-cysteine, pyruvate formed from beta-lyase substrates | Homo sapiens | ? | - |
? | |
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + ? | - |
Homo sapiens | S-(1,1,2,2-tetrafluoroethyl)-2-oxo-3-thiopropanoate + ? | - |
? | |
S-(1,2-dichlorovinyl)-L-cysteine + ? | - |
Homo sapiens | S-(1,2-dichlorovinyl)-2-oxo-3-thiopropanoate + ? | - |
? | |
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine + ? | - |
Homo sapiens | S-(2-chloro-1,1,2-trifluoroethyl)-2-oxo-3-thiopropanoate + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 43400, recombinant BCATc, homodimer | Homo sapiens |
dimer | 2 * 41730, recombinant BCATm, homodimer | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
BCATc | - |
Homo sapiens |
BCATm | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |