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Literature summary for 2.6.1.42 extracted from

  • Kido, R.
    Pancreatic branched-chain-amino-acid aminotransferase (1988), Methods Enzymol., 166, 275-281.
    View publication on PubMed

General Stability

General Stability Organism
2-mercaptoethanol protects against inactivation by sulfhydryl reagents Homo sapiens
2-mercaptoethanol protects against inactivation by sulfhydryl reagents Rattus norvegicus
2-mercaptoethanol protects against inactivation by sulfhydryl reagents Canis lupus familiaris

Inhibitors

Inhibitors Comment Organism Structure
hydrazine
-
Canis lupus familiaris
hydrazine
-
Homo sapiens
hydrazine
-
Rattus norvegicus
hydroxylamine
-
Canis lupus familiaris
hydroxylamine
-
Homo sapiens
hydroxylamine
-
Rattus norvegicus
KCN
-
Homo sapiens
additional information no inhibition with isonicotinic acid hydrazide or KCN Canis lupus familiaris
additional information not inhibited by isonicotinic acid and semicarbazide Homo sapiens
additional information no inhibition with isonicotinic acid hydrazide or KCN Rattus norvegicus
p-chloromercuribenzoate isoenzyme I, complete inhibition, isoenzyme III only partially inhibited Canis lupus familiaris
p-chloromercuribenzoate isoenzyme I, complete inhibition, isoenzyme III only partially inhibited Homo sapiens
p-chloromercuribenzoate 5 mM, complete inhibition Rattus norvegicus
Semicarbazide isoenzyme II is somewhat sensitive, isoenzyme I is not Canis lupus familiaris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme III, leucine as amino group donor Homo sapiens
1
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme III, isoleucine as amino group donor Canis lupus familiaris
1.1
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme III, isoleucine as amino group donor Homo sapiens
1.4
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme III, leucine as amino group donor Canis lupus familiaris
1.7
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme III, valine as amino group donor Homo sapiens
1.7
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme III, valine as amino group donor Canis lupus familiaris
2.1
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme I, leucine as amino group donor Canis lupus familiaris
2.3
-
L-leucine pH 8.0, 37°C, isoenzyme III, 2-oxoglutarate as amino group acceptor Canis lupus familiaris
2.7
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme I, valine as amino group donor Canis lupus familiaris
3
-
L-valine pH 8.0, 37°C, isoenzyme III, 2-oxoglutarate as amino group acceptor Canis lupus familiaris
3
-
L-isoleucine pH 8.0, 37°C, isoenzyme III, 2-oxoglutarate as amino group acceptor Homo sapiens
3.6
-
L-leucine pH 8.0, 37°C, isoenzyme I, 2-oxoglutarate as amino group acceptor Canis lupus familiaris
4
-
2-oxoglutarate pH 8.0, 37°C, leucine as amino group donor Rattus norvegicus
4.2
-
L-isoleucine pH 8.0, 37°C, isoenzyme III, 2-oxoglutarate as amino group acceptor Canis lupus familiaris
4.8
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme I, isoleucine as amino group donor Homo sapiens
5
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme I, valine as amino group donor Homo sapiens
6.8
-
L-leucine pH 8.0, 37°C, isoenzyme III, 2-oxoglutarate as amino group acceptor Homo sapiens
7.4
-
L-valine pH 8.0, 37°C, isoenzyme I, 2-oxoglutarate as amino group acceptor Canis lupus familiaris
7.6
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme I, leucine as amino group donor Homo sapiens
8.3
-
L-valine pH 8.0, 37°C, isoenzyme III, 2-oxoglutarate as amino group acceptor Homo sapiens
10
-
2-oxoglutarate pH 8.0, 37°C, isoenzyme I, isoleucine as amino group donor Canis lupus familiaris
10.3
-
L-isoleucine pH 8.0, 37°C, isoenzyme I, 2-oxoglutarate as amino group acceptor Homo sapiens
11.1
-
L-leucine pH 8.0, 37°C Rattus norvegicus
12.5
-
2-oxoglutarate pH 8.0, 37°C, valine as amino group donor Rattus norvegicus
14.2
-
2-oxoglutarate pH 8.0, 37°C, isoleucine as amino group donor Rattus norvegicus
22.2
-
L-isoleucine pH 8.0, 37°C Rattus norvegicus
22.2
-
L-isoleucine pH 8.0, 37°C, isoenzyme I, 2-oxoglutarate as amino group acceptor Canis lupus familiaris
25
-
L-leucine pH 8.0, 37°C, isoenzyme I, 2-oxoglutarate as amino group acceptor Homo sapiens
30.8
-
L-valine pH 8.0, 37°C, isoenzyme I, 2-oxoglutarate as amino group acceptor Homo sapiens
143
-
L-valine pH 8.0, 37°C, 2-oxoglutarate as amino group acceptor Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
2 * 35000, SDS-PAGE Rattus norvegicus
39000
-
2 * 39000, isoenzyme I, SDS-PAGE Canis lupus familiaris
43000
-
2 * 43000, isoenzyme III, SDS-PAGE Canis lupus familiaris
68000
-
gel filtration Rattus norvegicus
79000
-
sucrose density gradient centrifugation Rattus norvegicus
80000
-
isoenzyme I, gel filtration Homo sapiens
80000
-
isoenzyme I, gel filtration Canis lupus familiaris
90000
-
isoenzyme III, gel filtration Homo sapiens
96000
-
isoenzyme III, gel filtration Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-isoleucine + 2-oxoglutarate Homo sapiens
-
3-methyl-2-oxopentanoate + L-glutamate
-
r
L-isoleucine + 2-oxoglutarate Rattus norvegicus
-
3-methyl-2-oxopentanoate + L-glutamate
-
r
L-valine + 2-oxoglutarate Rattus norvegicus
-
3-methyl-2-oxobutanoate + L-glutamate
-
r

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
dog
-
Homo sapiens
-
human
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Rattus norvegicus
-
Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
Homo sapiens
-
pancreas
-
Rattus norvegicus
-
pancreas
-
Canis lupus familiaris
-
skeletal muscle
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
21.8
-
-
Rattus norvegicus
74
-
-
Canis lupus familiaris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-isoleucine + 2-oxoglutarate
-
Homo sapiens 3-methyl-2-oxopentanoate + L-glutamate
-
r
L-isoleucine + 2-oxoglutarate
-
Rattus norvegicus 3-methyl-2-oxopentanoate + L-glutamate
-
r
L-isoleucine + 2-oxoglutarate
-
Canis lupus familiaris L-glutamate + 3-methyl-2-oxopentanoate
-
?
L-leucine + 2-oxoglutarate
-
Homo sapiens 4-methyl-2-oxopentanoate + L-glutamate
-
r
L-leucine + 2-oxoglutarate
-
Rattus norvegicus 4-methyl-2-oxopentanoate + L-glutamate
-
r
L-leucine + 2-oxoglutarate
-
Canis lupus familiaris L-glutamate + 4-methyl-2-oxopentanoate
-
?
L-valine + 2-oxoglutarate
-
Homo sapiens 3-methyl-2-oxobutanoate + L-glutamate
-
r
L-valine + 2-oxoglutarate
-
Rattus norvegicus 3-methyl-2-oxobutanoate + L-glutamate
-
r
L-valine + 2-oxoglutarate
-
Rattus norvegicus 2-oxoisopentanoate + L-glutamate
-
r
L-valine + 2-oxoglutarate
-
Canis lupus familiaris L-glutamate + 3-methyl-2-oxobutanoate
-
?

Subunits

Subunits Comment Organism
dimer
-
Homo sapiens
dimer 2 * 35000, SDS-PAGE Rattus norvegicus
dimer 2 * 43000, isoenzyme III, SDS-PAGE Canis lupus familiaris
dimer 2 * 39000, isoenzyme I, SDS-PAGE Canis lupus familiaris

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50 65 labile to heat, activity is completely lost by heating at 65°C for 1 min, about 30% is lost within 1 min at 50°C and about 70% within 10 min Rattus norvegicus
65
-
not inactivated by heating for 10 min Homo sapiens
65
-
not inactivated by heating for 10 min Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
Rattus norvegicus
8
-
isoenzyme III Homo sapiens
8.5 9.5 isoenzyme III Canis lupus familiaris
9
-
isoenzyme I Homo sapiens
9
-
isoenzyme I Canis lupus familiaris