Information on EC 2.4.1.41 - polypeptide N-acetylgalactosaminyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.4.1.41
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RECOMMENDED NAME
GeneOntology No.
polypeptide N-acetylgalactosaminyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
mucin core 1 and core 2 O-glycosylation
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mucin core 3 and core 4 O-glycosylation
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Mucin type O-glycan biosynthesis
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase
Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.
CAS REGISTRY NUMBER
COMMENTARY hide
9075-15-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
several isozymes
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
erythropoietin T + UDP-Gal
erythropoietin T-nGalNAc + UDP
show the reaction diagram
hCG-beta + UDP-Gal
hCG-beta-nGalNAc + UDP
show the reaction diagram
-
-
-
?
IgA hinge + UDP-Gal
IgA hinge-nGal + UDP
show the reaction diagram
-
-
-
?
IgA hinge + UDP-GalNAc
IgA hinge-nGalNAc + UDP
show the reaction diagram
IgA hinge-4GalNAc + UDP-GalNAc
IgA hinge-nGalNAc + UDP
show the reaction diagram
-
-
-
?
MUC1 + UDP-GalNAc
MUC1-nGalNAc + UDP
show the reaction diagram
MUC1-2GalNAc + UDP-GalNAc
MUC1-nGalNAc + UDP
show the reaction diagram
-
-
-
?
MUC1a' + UDP-GalNAc
MUC1a'-nGalNAc + UDP
show the reaction diagram
-
-
-
?
MUC1b' + UDP-GalNAc
MUC1b'-nGalNAc + UDP
show the reaction diagram
-
-
-
?
MUC2 + UDP-GalNAc
MUC2-nGalNAc + UDP
show the reaction diagram
-
-
-
?
MUC2-6GalNAc + UDP-GalNAc
MUC2-nGalNAc + UDP
show the reaction diagram
-
-
-
?
MUC5AC + UDP-GalNAc
GalNAc-Thr9-MUC5AC + UDP
show the reaction diagram
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hT2CD, hT2: glycosylation site selection driven by and substrate binding through its catalytic domain, hT10: not catalysed by hT10 because hT10 does not recognize naked peptides
preferred site for glycosylation by hT2 and hT2CD compared to Thr-3, Thr-10 and Thr-13
-
?
MUC5AC glycopeptides + UDP-GalNAc
GalNAc-MUC5AC + UDP
show the reaction diagram
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hT2: site preference of glycosylation depends on location of pre-existing GalNAc and is mediated by its lectin domain which directs glycosylation 10 residues N- or C-terminal to an extant GalNAc residue and aids site selection only when potential site is N-terminal to an extant GalNAc residue not C-terminal, Thr-9 is no preferred site of glycosylation, hT10: must recognize existing GalNAc residues via its catalytic domain which directs selection to the glycosylation site immediately N-terminal to the present GalNAc,
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-
?
MUC5AC-13 + UDP-GalNAc
GalNAc-Thr12-MUC5AC-13 + UDP
show the reaction diagram
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hT10, hT10CD, hT10CD-hT2LD
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-
?
MUC5AC-13 + UDP-GalNAc
GalNAc-Thr3-MUC5AC-13 + UDP
show the reaction diagram
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hT2: substrate binding through its catalytic domain, hT10: transfer of only single GalNAc residues
predominant product of hT2 and hT10
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?
MUC5AC-13 + UDP-GalNAc
GalNAc-Thr9-MUC5AC-13 + UDP
show the reaction diagram
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hT2, hT2CD: no initial burst phase during catalysis
not preferred by hT2, preferred by hT2CD
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?
MUC5AC-3 + UDP-GalNAc
GalNAc-Thr13-MUC5AC-3 + UDP
show the reaction diagram
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hT2: no initial burst phase during catalysis, substrate binding through its catalytic domain, hT10: transfer of only single GalNAc residues
hT2: preferred site for glycosylation, mediated by enhanced product release through lectin domain, hT10: predominant product
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?
MUC5AC-3 + UDP-GalNAc
GalNAc-Thr2-MUC5AC + UDP
show the reaction diagram
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hT10CD, hT10CD-hT2LD, hT10: catalysis faster than for MUCAC-9
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-
?
MUC5AC-3 + UDP-GalNAc
GalNAc-Thr9-MUC5AC-3 + UDP
show the reaction diagram
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hT2, hT2CD
not preferred by hT2, hT2CD: preferred site for glycosylation, lack of lectin domain in hT2CD results in rate-limiting product release
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?
MUC5AC-3,13 + UDP-GalNAc
GalNAc-Ser-5-MUC5AC-3,13 + UDP
show the reaction diagram
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hT2, not catalysed by hT2CD and hT2CD-hT10LD
preferred site by hT2
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?
MUC5AC-3,13 + UDP-GalNAc
GalNAc-Thr2,12-MUC5AC-3,13 + UDP
show the reaction diagram
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hT10, hT10CD, hT10CD-hT2LD
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-
?
MUC5AC-9 + UDP-GalNAc
GalNAc-Thr2-MUC5AC-9 + UDP
show the reaction diagram
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not catalysed by hT10CD and hT10CD-hT2LD, hT10: catalysis slower than for MUC5AC-3
preferred site of glycosylation by hT10
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?
MUC7 + UDP-GalNAc
MUC7-nGalNAc + UDP
show the reaction diagram
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-
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?
OSM fragment + UDP-Gal
OSM fragment-nGalNAc + UDP
show the reaction diagram
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-
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?
UDP-alpha-GalNAc + polypeptide
GalNAc-alpha-polypeptide + UDP
show the reaction diagram
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major mucin-type O-glycan in embryonic tracheal system along the apical region and luman of the tracheal tubes O-glycan, detectable by lectins Jacalin, soybean agglutinin and Vicia villosa agglutinin
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?
UDP-galactose + Muc1 peptide
UDP + galactosyl-Muc1 peptide
show the reaction diagram
UDP-galactose + Muc2 peptide
UDP + galactosyl-Muc2 peptide
show the reaction diagram
UDP-galactose + PTTTPITTTTK
UDP + galactosyl-PTTTPITTTTK
show the reaction diagram
UDP-GalNAc + Ac-TPPA
UDP + Ac-(GalNAcalpha1-)TPPA
show the reaction diagram
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pH 7.5, 37C
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?
UDP-GalNAc + apomucin
UDP + GalNAc-mucin
show the reaction diagram
apomucin is a deglycosylated bovine submaxillary mucin, mutants W328Y, W328F, W328A, W316H and W316A are inactive, mutants W316Y and W316F show 40% and 20% activity, respectively, relative to wild-type
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?
UDP-GalNAc + AQPTPPP
UDP + AQP-(GalNAcalpha1-)TPPP
show the reaction diagram
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pH 7.5, 37C, 0.2 mM, 100% activity
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?
UDP-GalNAc + EA2
GalNAc-EA2 + UDP
show the reaction diagram
UDP-GalNAc + GAGA(X)3T(X)3AGAGK
GAGA(X)3(GalNAc)T(X)3AGAGK + UDP
show the reaction diagram
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-
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?
UDP-GalNAc + GAGA(X)3T(X)3AGAGK
UDP + GAGA(X)3(GalNAc)T(X)3AGAGK
show the reaction diagram
UDP-GalNAc + GAGA(X)5T(X)5AGAGK
GAGA(X)5(GalNAc)T(X)5AGAGK + UDP
show the reaction diagram
UDP-GalNAc + GAGA(X)5T(X)5AGAGK
UDP + GAGA(X)5(GalNAc)T(X)5AGAGK
show the reaction diagram
UDP-GalNAc + GAGA(X)nT(X)nAGAGK
GAGA(X)n(GalNAc)T(X)nAGAGK + UDP
show the reaction diagram
UDP-GalNAc + GVVPTVVPG
UDP + GVVP(GalNAc)TVVPG
show the reaction diagram
GVVPTVVPG is a synthetic peptide with threonine as acceptor site, weaker acceptor substrate for wild-type and truncated version P-T1/delta42 as PPDAATAAPL
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?
UDP-GalNAc + HGVTSAPDTRPAPGSTAPPA
UDP + ?
show the reaction diagram
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?
UDP-GalNAc + N-acetyl-4-benzoyl-L-Phe-L-Pro-L-Tyr-L-Pro-L-Pro-L-Pro-NH2
UDP + N-acetyl-4-benzoyl-L-Phe-L-Pro-L-(GalNAcalpha1-)Tyr-L-Pro-L-Pro-L-Pro-NH2
show the reaction diagram
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pH 7.5, 37C
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?
UDP-GalNAc + polypeptide
GalNAc-alpha-polypeptide + UDP
show the reaction diagram
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glycosylation at Thr or Ser
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?
UDP-GalNAc + PPDAATAAPL
UDP + PPDAA(GalNAc)TAAPL
show the reaction diagram
PPDAATAAPL is a synthetic peptide with threonine as acceptor site, efficient acceptor substrate for wild-type and truncated version P-T1/delta42
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?
UDP-GalNAc + PRFODSSSKAPPPLPSPSRLPG
GalNAc-PRFODSSSKAPPPLPSPSRLPG + UDP
show the reaction diagram
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-
-
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?
UDP-GalNAc + PTTTPISTTTMVTPTPTPTC
UDP + ?
show the reaction diagram
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-
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?
UDP-GalNAc + PTTTPITTTG
UDP + P-(GalNAcalpha1-)TTTPITTTG + P-(GalNAcalpha1-)TTTPI-(GalNAcalpha1-)TTTG
show the reaction diagram
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pH 7.5, 37C, 0.2 mM, 26% activity relative to AQPTPPP
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?
UDP-GalNAc + selectin
GalNAc-selectin + UDP
show the reaction diagram
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reduced expression of cell surface E- and P-selectins (fourfold and fivefold) and L-selectins on immune cells of ppGalNAcT-1 deficient mice
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?
UDP-GalNAc + TPTGTQTPTG
UDP + TPTG-(GalNAcalpha1-)TQTPTG
show the reaction diagram
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pH 7.5, 37C, 0.2 mM, 8% activity relative to AQPTPPP
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-
?
UDP-GalNAc + TTTVTPTPTG
UDP + TTTV-(GalNAcalpha1-)TPTPTG + T-(GalNAcalpha1-)TTV-(GalNAcalpha1-)TPTPTG + T-(GalNAcalpha1-)T-(GalNAcalpha1-)TV-(GalNAcalpha1-)TP-(GalNAcalpha1-)TPTG + T-(GalNAcalpha1-)TTV-(GalNAcalpha1-)TP-(GalNAcalpha1-)TP-(GalNAcalpha1-)TG + TT-(GalNAcalpha1-)TV-(GalNAcalpha1-)TPTPTG + ?
show the reaction diagram
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pH 7.5, 37C, 0.2 mM, 109% activity relative to AQPTPPP
monoglycosylated product appears after 30 min, higher glycosylated products appear with increasing time of incubation
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?
UDP-GalNAc + TVTPTPTPTG
UDP + TVTP-(GalNAcalpha1-)TPTPTG
show the reaction diagram
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pH 7.5, 37C, 0.2 mM, 145% activity relative to AQPTPPP
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-
?
UDP-GalNAc + VLTTTATTPTA
UDP + ?
show the reaction diagram
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-
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?
UDP-N-acetyl-alpha-D-galactosamine + (glycosylated GTTPSPVPTTSTTSAP)
UDP + ?
show the reaction diagram
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natural-type (alpha-GalNAc-O-Thr) and unnatural-type (beta-GalNAc-O-Thr, alpha-Fuc-O-Thr and beta-GlcNAc-O-Thr) glycosylated
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?
UDP-N-acetyl-alpha-D-galactosamine + Ac-CIRIQRGPGRAFVTIGKIGNMR
UDP + ?
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + Ac-QATEYEYLDYDFLPETEPPEM
UDP + ?
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + AHGVTSAPDTR
UDP + ?
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + GAGAEAPTPAPAGAGK
UDP + ?
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + GTTAKPTTLKPTE
UDP + ?
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + ?
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + GT[GalNAc]TPSPVPTTSTTSAP
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + GT[GalNAc]TPSPVPTTST[GalNAc]TSAP
show the reaction diagram
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glycosylation at Thr-3 and Thr-13
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?
UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + GT[GalNAc]TP[GalNAc]SPVPTTSTTSAP
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTST[GalNAc]TSAP
UDP + ?
show the reaction diagram
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-
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?
UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTST[GalNAc]TSAP
UDP + GT[GalNAc]TPSPVPTTST[GalNAc]TSAP
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTST[GalNAc]TSAP
UDP + GT[GalNAc]TP[GalNAc]SPVPTTST[GalNAc]TSAP
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTSTTSAP
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTSTTSAP
UDP + GT[GalNAc]TPSPVPTTS[GalNAc]T[GalNAc]TSAP
show the reaction diagram
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-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTSTTSAP
UDP + G[GalNAc]T[GalNAc]TPSPVPTTST[GalNAc]TSAP
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTST[GalNAc]TSAP
UDP + GT[GalNAc]TPSPVPTTS[GalNAc]T[GalNAc]TSAP
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + neuroglycan
UDP + N-acetyl-alpha-D-galactosaminyl-neuroglycan
show the reaction diagram
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-
-
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?
UDP-N-acetyl-alpha-D-galactosamine + PDTRPAPGSTAPPAC
UDP + ?
show the reaction diagram
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-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide ActR-IIB
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide ActR-IIB
show the reaction diagram
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-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide angiopoietin-like 3
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide angiopoietin-like 3
show the reaction diagram
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-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide biotin-EA2
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide biotin-EA2
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide biotin-EA2-2
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide biotin-EA2-2
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 1
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 1
show the reaction diagram
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sequence APPAHPGPTPGPRPAPG
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 10
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 10
show the reaction diagram
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sequence APPAHPGPTIGPRPAPG
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 11
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 11
show the reaction diagram
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sequence APPAHPGPTPRPRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 12
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 12
show the reaction diagram
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sequence APPAHHGPTPGPRPAPG
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 13
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 13
show the reaction diagram
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sequence APPAHPVPTPGPRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 14
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 14
show the reaction diagram
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sequence APPAHPGLTPGPRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 15
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 15
show the reaction diagram
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sequence APPAHHVVTERYRPAPG
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 16
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 16
show the reaction diagram
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sequence APPAHDFVTPAPRPAPG
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 17
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 17
show the reaction diagram
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sequence APPAHDFPTPAPRPAPG
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 18
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 18
show the reaction diagram
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sequence APPAHPFVTPAPRPAPG
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 19
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 19
show the reaction diagram
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sequence APPAHIFVTPAPRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 2
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 2
show the reaction diagram
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sequence APPAHPGVTPGPRPAPG
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 20
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 20
show the reaction diagram
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sequence APPAHVFVTPAPRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 21
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 21
show the reaction diagram
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sequence APPAHDGVTPAPRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 22
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 22
show the reaction diagram
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sequence APPAHPGPTPAPRPAPG
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 23
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 23
show the reaction diagram
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sequence PSSSPISSSSSVSPSPSPSGSQSK
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 3
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 3
show the reaction diagram
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sequence APPAHPGPTPGYRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 4
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 4
show the reaction diagram
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sequence APPAHPGPTPGHRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 5
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 5
show the reaction diagram
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sequence APPAHPGPTPGHRPAPG
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 6
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 6
show the reaction diagram
-
sequence APPAHPGVTPGYRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 7
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 7
show the reaction diagram
-
sequence APPAHPGITPGPRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 8
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 8
show the reaction diagram
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sequence APPAHPGFTPGPRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 9
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 9
show the reaction diagram
-
sequence APPAHPGPTEGPRPAPG
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2-biotin
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2-biotin
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide FGF23
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide FGF23
show the reaction diagram
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-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPIV
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPIV
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPIV-C
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPIV-C
show the reaction diagram
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-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPV
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPV
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPV-C
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPV-C
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide GRA2-biotin
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GRA2-biotin
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1
show the reaction diagram
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-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide MUC13
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide MUC13
show the reaction diagram
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isoform GALNT14 contributes to the glycosylation of peptide MUC13, which is significantly higher in ovarian cancer cells compared with the normal/benign ovary tissues
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?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1a
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1a
show the reaction diagram
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sequence APPAHGVTSAPDTRPAPGC
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-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1a'
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1a'
show the reaction diagram
-
sequence AHGVTSAPDTR
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1fr1
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1fr1
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1fr2
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1fr2
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1fr3
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1fr3
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc2
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc2
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc5Ac
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc5Ac
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide MUC5AC-3,13-biotin
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide MUC5AC-3,13-biotin
show the reaction diagram
UDP-N-acetyl-alpha-D-galactosamine + polypeptide OPSS1
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide OPSS1
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide OPSS4
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide OPSS4
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide RNApII
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide RNApII
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + PSTPPTPSPSTPPTPSPS
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + SPTTSTPISSTPQPTS
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + A1 protein
UDP + N-acetyl-D-galactosaminyl-A1 protein
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + Ac-CIRIQRGPGRAFVTIGKIGNMR
UDP + N-acetyl-D-galactosaminylated Ac-CIRIQRGPGRAFVTIGKIGNMR
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-galactosamine + Ac-PFVTHPGYD
UDP + N-acetyl-D-galactosaminylated Ac-PFVTHPGYD
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-galactosamine + Ac-QATEYEYLDYDFLPETEPPEM
UDP + N-acetyl-D-galactosaminylated Ac-QATEYEYLDYDFLPETEPPEM
show the reaction diagram
UDP-N-acetyl-D-galactosamine + AcTPPP
UDP + N-acetyl-D-galactosaminyl-AcTPPP
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + AHGVTSAPDTR
UDP + N-acetyl-D-galactosaminylated AHGVTSAPDTR
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-galactosamine + AHGVVTSAPDTR
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + ANTPSFPTATSPAPPI
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + apoantifreeze glycoproteins
UDP + N-acetyl-D-galactosaminyl-apoantifreeze glycoproteins
show the reaction diagram
-
apoantifreeze glycoprotein of high molecular weight accepts GalNAc much faster than apoantifreeze glycoprotein 8
-
-
?
UDP-N-acetyl-D-galactosamine + apofetuin
UDP + N-acetyl-D-galactosaminyl-apofetuin
show the reaction diagram
-
lowest rate of transfer
-
-
?
UDP-N-acetyl-D-galactosamine + apomucin
UDP + N-acetyl-D-galactosaminyl-apomucin
show the reaction diagram
UDP-N-acetyl-D-galactosamine + AWIPTPPPIPG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + bone sialoprotein
UDP + UDP-N-acetyl-D-galactosaminyl-bone sialoprotein
show the reaction diagram
-
preferred substrate of isozyme ppGalNAcT-1, glycosylation of Thr101, Ser131, Thr199, and Ser214, glycosylation pattern, overview
-
-
?
UDP-N-acetyl-D-galactosamine + CPPTPSATTPAPPSSSAPPETTAA
UDP + N-acetyl-D-galactosaminylated CPPTPSATTPAPPSSSAPPETTAA
show the reaction diagram
UDP-N-acetyl-D-galactosamine + deglycosylated ovine submaxillary mucin
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + DSTTPAPTTK
UDP + N-acetyl-D-galactosaminylated DSTTPAPTTK
show the reaction diagram
UDP-N-acetyl-D-galactosamine + DSTTPAPTTK
UDP + N-acetyl-D-galactosaminylated-DSTTPAPTTK
show the reaction diagram
mucin derived substrate, acceptor substrate
-
-
?
UDP-N-acetyl-D-galactosamine + fibronectin
UDP + N-acetyl-D-galactosaminyl-fibronectin
show the reaction diagram
-
fibronectin is a physiological substrate for GalNAc-T3
-
-
?
UDP-N-acetyl-D-galactosamine + GAGAPGPTPGPAGAGK
UDP + GAGAPGP-(N-acetyl-D-galactosaminylT)-PGPAGAGK
show the reaction diagram
-
optimal isozyme ppGalNAc T2 peptide substrate
-
-
?
UDP-N-acetyl-D-galactosamine + GAGPGTXASSVGVTGAPGSG
UDP + ?
show the reaction diagram
-
low activity
-
-
?
UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide
UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide
show the reaction diagram
UDP-N-acetyl-D-galactosamine + GKPRPYSPRPTSHPRPIRV
UDP + ?
show the reaction diagram
i.e. drosocin, low activity, enzyme form PGANT8
-
-
-
UDP-N-acetyl-D-galactosamine + GSPAGDVGAPAVDSGASQAAG
UDP + ?
show the reaction diagram
-
low activity
-
-
?
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTS-(O-GalNAc)T-SAP
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSA
UDP + N-acetyl-D-galactosaminyl-[GTTPSPVPTTSTTSA]
show the reaction diagram
-
i.e. Muc5Ac peptide
-
-
?
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAk
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + HGVTSAPDTRP
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + HIV-V3 peptide
UDP + N-acetyl-D-galactosaminyl-HIV-V3 peptide
show the reaction diagram
UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide
UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide
show the reaction diagram
UDP-N-acetyl-D-galactosamine + immunoglobulin A1
UDP + N-acetyl-D-galactosaminyl-immunoglobulin A1
show the reaction diagram
-
O-linked glycosylation of the human IgA1 hinge region by ppGalNAc-T2, synthetic IgA hinge peptide: ppGalNAc-T2 shows strongest activity and is able to transfer GalNAc to almost all possible glycosylation sites, other ppGalNAc-Ts show extremely weak activities
-
-
?
UDP-N-acetyl-D-galactosamine + ITTTTTPLPTG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + kappa-casein
UDP + N-acetyl-D-galactosaminyl-kappa-casein
show the reaction diagram
UDP-N-acetyl-D-galactosamine + LGEPLGLAPSSSP
UDP + ?
show the reaction diagram
-
low activity
-
-
?
UDP-N-acetyl-D-galactosamine + LPPVTTTPAPG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + MPTAGTPPPIG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC4AC-13
UDP + ?
show the reaction diagram
enzyme form PGANT2
-
-
?
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + myelin basic protein
UDP + N-acetyl-D-galactosaminyl-myelin basic protein
show the reaction diagram
UDP-N-acetyl-D-galactosamine + osteopontin
UDP + N-acetyl-D-galactosaminyl-osteopontin
show the reaction diagram
UDP-N-acetyl-D-galactosamine + P-(O-GalNAc)T-TDSTTPAPTTK
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + PADVTTAAPGG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + PGGDSSSYQPG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + PGLPPTTPAVTTTATP
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + PHMAQVTVGPGL
UDP + N-acetyl-D-galactosaminyl-PHMAQVTVGPGL
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + PITTTTTVTPG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + polypeptide
UDP + N-acetyl-D-galactosaminyl-polypeptide
show the reaction diagram
UDP-N-acetyl-D-galactosamine + PPAHGVTSAPG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + PPDAATAAPLR
UDP + N-acetyl-D-galactosaminyl-PPDAATAAPLR
show the reaction diagram
-
i.e. EPO-T peptide
-
-
?
UDP-N-acetyl-D-galactosamine + PPETTAAPPTG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + PPVVPFTPLPG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + PRFQDSSSSKAPPPSLPSPSRL
UDP + N-actetyl-D-galactosaminylated PRFQDSSSSKAPPPSLPSPSRL
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + PRFQDSSSSKAPPPSLPSPSRLPG
UDP + N-acetyl-D-galactosaminylated PRFQDSSSSKAPPPSLPSPSRLPG
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-galactosamine + PSPPITTTTTG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + PSTPPTPSPSTPPTPSPS
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + PTTDS-(O-GalNAc)T-TPAPTTK
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTT
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + PTTTPISTTMVTPTPTPTC
UDP + N-actetyl-D-galactosaminylated PTTTPISTTMVTPTPTPTC
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + PTTTPISTTTMVTPTPTPTC
UDP + N-acetyl-D-galactosaminylated PTTTPISTTTMVTPTPTPTC
show the reaction diagram
mucin derived substrate
-
-
?
UDP-N-acetyl-D-galactosamine + PTTTPITTTTTV
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + PTTTPITTTTTVTPTPTPTGTQT
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + PTTTPSPPITG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + QATEYEYLDYDFLPEC
UDP + N-acetyl-D-galactosaminylated QATEYEYLDYDFLPEC
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-galactosamine + rhodanese
UDP + N-acetyl-D-galactosaminyl-rhodanese
show the reaction diagram
-
reduced and carboxylmethylated bovine rhodanese, at a lower rate than with myelin basic protein
-
-
?
UDP-N-acetyl-D-galactosamine + RPAPGSTAPPA
UDP + N-acetyl-D-galactosaminylated RPAPGSTAPPA
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-galactosamine + SATTPAPPSSG
UDP + ?
show the reaction diagram
-
preferred substrate
-
-
?
UDP-N-acetyl-D-galactosamine + SDAESSGPVPG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + SEVTTTLVPAG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + SPTTSTPISSTPQPTS
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + STPSTPSTPSTPSTP
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + subtilisin
UDP + N-acetyl-D-galactosaminyl-subtilisin
show the reaction diagram
-
reduced and carboxylmethylated bacterial subtilisin, at a lower rate than with myelin basic protein or bovine rhodanese
-
-
?
UDP-N-acetyl-D-galactosamine + SVLVLTTVSVPPSPASAGPSV
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + syndecan-3
UDP + N-acetyl-D-galactosaminyl-syndecan-3
show the reaction diagram
syndecan-3 may be a natural substrate for GalNAc-T13
-
-
?
UDP-N-acetyl-D-galactosamine + TAPPAHGVTSAPDTRPAPGSTAPP
UDP + N-acetyl-D-galactosaminylated TAPPAHGVTSAPDTRPAPGSTAPP
show the reaction diagram
UDP-N-acetyl-D-galactosamine + TSAPGTTPSPG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + TTAAPPTPSAG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + TTPLPTTTPSG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + TTSTTSAPGTG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + TTTTTTPKPTG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + TTTVTPTPTPG
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + TVPVTGPTAPALVQSVTPPT
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + VESDRSTTTTQAP
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + VLTTTATTPTA
UDP + ?
show the reaction diagram
UDP-N-acetyl-D-galactosamine + VPETASSKTATGDSFS
UDP + ?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-alpha-D-galactosamine + polypeptide
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2
show the reaction diagram
-
sequence PTTDSTTPAPTTK
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide MUC13
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide MUC13
show the reaction diagram
-
isoform GALNT14 contributes to the glycosylation of peptide MUC13, which is significantly higher in ovarian cancer cells compared with the normal/benign ovary tissues
-
-
?
UDP-N-acetyl-D-galactosamine + bone sialoprotein
UDP + UDP-N-acetyl-D-galactosaminyl-bone sialoprotein
show the reaction diagram
-
preferred substrate of isozyme ppGalNAcT-1, glycosylation of Thr101, Ser131, Thr199, and Ser214, glycosylation pattern, overview
-
-
?
UDP-N-acetyl-D-galactosamine + fibronectin
UDP + N-acetyl-D-galactosaminyl-fibronectin
show the reaction diagram
-
fibronectin is a physiological substrate for GalNAc-T3
-
-
?
UDP-N-acetyl-D-galactosamine + kappa-casein
UDP + N-acetyl-D-galactosaminyl-kappa-casein
show the reaction diagram
-
glycosylation of kappa-casein occurs after casein micelle formation triggered by the accumulation of Ca2+ in vivo
-
-
?
UDP-N-acetyl-D-galactosamine + osteopontin
UDP + N-acetyl-D-galactosaminyl-osteopontin
show the reaction diagram
-
preferred substrate of isozyme ppGalNAcT-1, glycosylation pattern, overview
-
-
?
UDP-N-acetyl-D-galactosamine + polypeptide
UDP + N-acetyl-D-galactosaminyl-polypeptide
show the reaction diagram
UDP-N-acetyl-D-galactosamine + syndecan-3
UDP + N-acetyl-D-galactosaminyl-syndecan-3
show the reaction diagram
Q8IUC8
syndecan-3 may be a natural substrate for GalNAc-T13
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE