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Literature summary for 2.4.1.41 extracted from

  • Hennebicq, S.; Tetaert, D.; Soudan, B.; Briand, G.; Richet, C.; Demeyer, D.; Gagnon, J.; Petillot, Y.; Degand, P.
    Polypeptide:N-acetylgalactosaminyltransferase activities towards the mucin MUC5AC peptide motif using microsomal preparations of normal and tumoral digestive mucosa (1998), Biochimie, 80, 69-73.
    View publication on PubMed
Search for more literature for 2.4.1.41

Application

Application Comment Organism
medicine cancer cells compared to normal cells exhibit altered glycosyltransferase activities, enzyme is a new tool for the investigation of motif peptide O-glycosylation alterations in pathological situations Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell ascending right part, low enzyme expression, decreased activity compared to normal colon, mono-glycosylates MUC5AC peptide Homo sapiens
-
colonic mucosa ascending right part, high enzyme expression, 2fold higher activity than in stomach Homo sapiens
-
gastric cancer cell high enzyme expression in tumoral gastric tissue displaying intestinal metaplasia, increased activity compared to normal stomach, di-glycosylates MUC5AC peptide Homo sapiens
-
gastric mucosa stomach fundus, 2fold lower activity than in colon, mono-glycosylates MUC5AC peptide Homo sapiens
-
additional information existence of more than one form of GalNAc-Ts which are expressed differentially in the gastrointestinal tract Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0025
-
 tumoral colon enzyme, MUC5AC peptide Homo sapiens
0.0031
-
 normal stomach enzyme, MUC5AC peptide Homo sapiens
0.0044
-
 tumoral stomach and normal colon enzyme, MUC5AC peptide Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-galactosamine + apomucin acceptor: apomucin motif encoded by the MUC5AC gene Homo sapiens UDP + N-acetyl-D-galactosaminyl-apomucin
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide acceptor: human MUC5AC peptide Thr-Thr-Ser-Ala-Pro-Thr-Thr-Ser Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens